메뉴 건너뛰기




Volumn 55, Issue 5, 2007, Pages 2020-2027

Molecular mechanisms of (-)-epicatechin and chlorogenic acid on the regulation of the apoptotic and survival/proliferation pathways in a human hepatoma cell line

Author keywords

AKT PI3 klnase pathway; Apoptosis; Bcl 2 family proteins; Caspases; Cell viability; Dietary phenols; ERK; HepG2 cells

Indexed keywords

CATECHIN; CHLOROGENIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE;

EID: 33947606180     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf062556x     Document Type: Article
Times cited : (126)

References (35)
  • 2
    • 0142166328 scopus 로고    scopus 로고
    • Cancer chemoprevention with dietary phytochemicals
    • Surh, Y.-J. Cancer chemoprevention with dietary phytochemicals. Nat. Rev. Cancer. 2003, 3, 768-780.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 768-780
    • Surh, Y.-J.1
  • 5
    • 0036740112 scopus 로고    scopus 로고
    • Tea catechins protect against lead-induced cytotoxicity, lipid peroxidation, and membrane fluidity in HepG2 cells
    • Chen, L.; Yang, X.; Jiao, H.; Zhao, B. Tea catechins protect against lead-induced cytotoxicity, lipid peroxidation, and membrane fluidity in HepG2 cells. Toxicol. Sci. 2002, 69, 149-156.
    • (2002) Toxicol. Sci , vol.69 , pp. 149-156
    • Chen, L.1    Yang, X.2    Jiao, H.3    Zhao, B.4
  • 6
    • 3142536557 scopus 로고    scopus 로고
    • Prooxidant property of green tea polyphenols epicatechin and epigallocatechin-3-gallate: Implications for anticancer properties
    • Azam, S.; Hadi, N.; Khan, N. U.; Hadi, S. M. Prooxidant property of green tea polyphenols epicatechin and epigallocatechin-3-gallate: implications for anticancer properties. Toxicol. in Vitro 2004, 18, 555-561.
    • (2004) Toxicol. in Vitro , vol.18 , pp. 555-561
    • Azam, S.1    Hadi, N.2    Khan, N.U.3    Hadi, S.M.4
  • 7
    • 29744436287 scopus 로고    scopus 로고
    • Protective effect of ellagic and chlorogenic acids against oxidative stress in PC12 cells
    • Pavlica, S.; Gebhardt, R. Protective effect of ellagic and chlorogenic acids against oxidative stress in PC12 cells. Free Radical Res. 2005, 39, 1377-1390.
    • (2005) Free Radical Res , vol.39 , pp. 1377-1390
    • Pavlica, S.1    Gebhardt, R.2
  • 8
    • 0034730948 scopus 로고    scopus 로고
    • Differences of four catechins in cell cycle arrest and induction of apoptosis in LoVo cells
    • Tan, X.; Hu, D.; Li, S.; Han, Y.; Zhang, Y.; Zhou, D. Differences of four catechins in cell cycle arrest and induction of apoptosis in LoVo cells. Cancer Lett. 2000, 158, 1-6.
    • (2000) Cancer Lett , vol.158 , pp. 1-6
    • Tan, X.1    Hu, D.2    Li, S.3    Han, Y.4    Zhang, Y.5    Zhou, D.6
  • 9
    • 0035951399 scopus 로고    scopus 로고
    • Induction of apoptosis by green tea catechins in human prostate cancer DU145 cells
    • Chung, L. Y.; Cheung, T. C; Kong, S. K.; Fung, K. P.; Choy, Y. M.; Chan, Z. Y.; Kwok, T. T. Induction of apoptosis by green tea catechins in human prostate cancer DU145 cells. Life Sci. 2001, 68, 1207-1214.
    • (2001) Life Sci , vol.68 , pp. 1207-1214
    • Chung, L.Y.1    Cheung, T.C.2    Kong, S.K.3    Fung, K.P.4    Choy, Y.M.5    Chan, Z.Y.6    Kwok, T.T.7
  • 12
    • 33745764186 scopus 로고    scopus 로고
    • Inhibitory effect of phenolic acids on the proliferation of 3T3-L1 preadipocytes in relation to their antioxidant activity
    • Hsu, C. L.; Huang, S. L.; Yen, G. C. Inhibitory effect of phenolic acids on the proliferation of 3T3-L1 preadipocytes in relation to their antioxidant activity. J. Agric. Food Chem. 2006, 54, 4191-4197.
    • (2006) J. Agric. Food Chem , vol.54 , pp. 4191-4197
    • Hsu, C.L.1    Huang, S.L.2    Yen, G.C.3
  • 15
    • 17644390182 scopus 로고    scopus 로고
    • Response of the antioxidant defense system to tert-butyl hydroperoxide and hydrogen peroxide in a human hepatoma cell line (HepG2)
    • Alia, M.; Ramos, S.; Mateos, R.; Bravo, L.; Goya, L. Response of the antioxidant defense system to tert-butyl hydroperoxide and hydrogen peroxide in a human hepatoma cell line (HepG2). J. Biochem. Mol. Toxicol. 2005, 19, 119-128.
    • (2005) J. Biochem. Mol. Toxicol , vol.19 , pp. 119-128
    • Alia, M.1    Ramos, S.2    Mateos, R.3    Bravo, L.4    Goya, L.5
  • 16
    • 0017064979 scopus 로고
    • A fluorometric method for determination of oxidised and reduced glutathione in tissues
    • Hissin, P.; Hilf, R. A fluorometric method for determination of oxidised and reduced glutathione in tissues. Anal. Biochem. 1976, 74, 214-226.
    • (1976) Anal. Biochem , vol.74 , pp. 214-226
    • Hissin, P.1    Hilf, R.2
  • 17
    • 0034874036 scopus 로고    scopus 로고
    • Activation of caspases occurs downstream from radical oxygen species production, Bcl-xL down-regulation, and early cytochrome C release in apoptosis induced by transforming growth factor beta in rat fetal hepatocytes
    • Herrera, B.; Fernandez, M.; Alvarez, A.; Roncero, C; Benito, M.; Gil, J.; Fabregat, I. Activation of caspases occurs downstream from radical oxygen species production, Bcl-xL down-regulation, and early cytochrome C release in apoptosis induced by transforming growth factor beta in rat fetal hepatocytes. Hepatology 2001, 34, 548-556.
    • (2001) Hepatology , vol.34 , pp. 548-556
    • Herrera, B.1    Fernandez, M.2    Alvarez, A.3    Roncero, C.4    Benito, M.5    Gil, J.6    Fabregat, I.7
  • 18
    • 13944281987 scopus 로고    scopus 로고
    • Comparative effects of food-derived polyphenols on the viability and apoptosis of a human hepatoma cell line (HepG2)
    • Ramos, S.; Alia, M.; Bravo, L.; Goya, L. Comparative effects of food-derived polyphenols on the viability and apoptosis of a human hepatoma cell line (HepG2). J. Agric. Food Chem. 2005, 53, 1271-1280.
    • (2005) J. Agric. Food Chem , vol.53 , pp. 1271-1280
    • Ramos, S.1    Alia, M.2    Bravo, L.3    Goya, L.4
  • 19
    • 0035146929 scopus 로고    scopus 로고
    • Life-or-death decisions by the Bcl-2 protein family
    • Adams, J.; Cory, S. Life-or-death decisions by the Bcl-2 protein family. Trends Biochem. Sci. 2001, 26, 61-66.
    • (2001) Trends Biochem. Sci , vol.26 , pp. 61-66
    • Adams, J.1    Cory, S.2
  • 20
    • 0036185848 scopus 로고    scopus 로고
    • The protein kinase B/Akt signalling pathway in human malignancy
    • Nicholson, K.; Anderson, N. The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal. 2002, 14, 381-395.
    • (2002) Cell Signal , vol.14 , pp. 381-395
    • Nicholson, K.1    Anderson, N.2
  • 21
    • 0034881019 scopus 로고    scopus 로고
    • Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals
    • Ballif, B.; Blenis, J. Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals. Cell Growth Differ. 2001, 12, 397-408.
    • (2001) Cell Growth Differ , vol.12 , pp. 397-408
    • Ballif, B.1    Blenis, J.2
  • 22
    • 11844277731 scopus 로고    scopus 로고
    • Differential in vitro cytotoxicity of (-)-epicatechin gallate (ECG) to cancer and normal cells from the human oral cavity
    • Babich, H.; Krupka, M. E.; Nissim, H. A.; Zuckerbraun, H. L. Differential in vitro cytotoxicity of (-)-epicatechin gallate (ECG) to cancer and normal cells from the human oral cavity. Toxicol. in Vitro 2005, 19, 231-242.
    • (2005) Toxicol. in Vitro , vol.19 , pp. 231-242
    • Babich, H.1    Krupka, M.E.2    Nissim, H.A.3    Zuckerbraun, H.L.4
  • 23
    • 0035313981 scopus 로고    scopus 로고
    • The MEK1-ERK map kinase pathway and the PI 3-kinase-Akt pathway independently mediate anti-apoptotic signals in HepG2 liver cancer cells
    • Mitsui, H.; Takuwa, N.; Maruyama, T.; Maekawa, H.; Hirayama, M.; Sawatari, T.; Hashimoto, N.; Takuwa, Y.; Kimura, S. The MEK1-ERK map kinase pathway and the PI 3-kinase-Akt pathway independently mediate anti-apoptotic signals in HepG2 liver cancer cells. Int. J. Cancer. 2001, 92, 55-62.
    • (2001) Int. J. Cancer , vol.92 , pp. 55-62
    • Mitsui, H.1    Takuwa, N.2    Maruyama, T.3    Maekawa, H.4    Hirayama, M.5    Sawatari, T.6    Hashimoto, N.7    Takuwa, Y.8    Kimura, S.9
  • 24
    • 23044442718 scopus 로고    scopus 로고
    • Inhibition of activator protein-1, NF-κTB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid
    • Feng, R.; Lu, Y.; Bowman, L. L.; Qian, Y.; Castranova, V.; Ding, M. Inhibition of activator protein-1, NF-κTB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid. J. Biol. Chem. 2005, 280, 27888-27895.
    • (2005) J. Biol. Chem , vol.280 , pp. 27888-27895
    • Feng, R.1    Lu, Y.2    Bowman, L.L.3    Qian, Y.4    Castranova, V.5    Ding, M.6
  • 25
    • 0033805296 scopus 로고    scopus 로고
    • Triggering and modulation of apoptosis by oxidative stress
    • Chandra, J.; Samali, A.; Orrenius, S. Triggering and modulation of apoptosis by oxidative stress. Free Radical Biol. Med. 2000, 29, 323-333.
    • (2000) Free Radical Biol. Med , vol.29 , pp. 323-333
    • Chandra, J.1    Samali, A.2    Orrenius, S.3
  • 27
    • 0033980354 scopus 로고    scopus 로고
    • Comparative chemopreventive mechanisms of green tea and selected polyphenol extracts measured by in vitro bioassays
    • Steele, V.; Kelloff, G.; Balentine, D.; Boone, C; Mehta, R.; Bagheri, D.; Sigman, C; Zhu, S.; Sharma, S. Comparative chemopreventive mechanisms of green tea and selected polyphenol extracts measured by in vitro bioassays. Carcinogenesis. 2000, 21, 63-67.
    • (2000) Carcinogenesis , vol.21 , pp. 63-67
    • Steele, V.1    Kelloff, G.2    Balentine, D.3    Boone, C.4    Mehta, R.5    Bagheri, D.6    Sigman, C.7    Zhu, S.8    Sharma, S.9
  • 28
    • 0035868353 scopus 로고    scopus 로고
    • Epicatechin and its in vivo metabolite, 3′-O-methyl epicatechin, protect human fibroblasts from oxidative-stress induced cell death involving caspase-3 activation
    • Spencer, J.; Schroeter, H.; Kuhnle, G.; Srai, S.; Tyrrell, R.; Hahn, U.; Rice-Evans, C. Epicatechin and its in vivo metabolite, 3′-O-methyl epicatechin, protect human fibroblasts from oxidative-stress induced cell death involving caspase-3 activation. Biochem. J. 2001, 354, 493-500.
    • (2001) Biochem. J , vol.354 , pp. 493-500
    • Spencer, J.1    Schroeter, H.2    Kuhnle, G.3    Srai, S.4    Tyrrell, R.5    Hahn, U.6    Rice-Evans, C.7
  • 29
    • 33745913944 scopus 로고    scopus 로고
    • Protocatechuic acid induces cell death in HepG2 hepatocellular carcinoma cells through a c-Jun N-terminal kinase-dependent mechanism
    • Yip, E. C. H.; Chan, A. S. L.; Pang, H.; Wong, Y. H. Protocatechuic acid induces cell death in HepG2 hepatocellular carcinoma cells through a c-Jun N-terminal kinase-dependent mechanism. Cell. Biol. Toxicol. 2006, 22, 293-302.
    • (2006) Cell. Biol. Toxicol , vol.22 , pp. 293-302
    • Yip, E.C.H.1    Chan, A.S.L.2    Pang, H.3    Wong, Y.H.4
  • 30
    • 33645458952 scopus 로고    scopus 로고
    • Green tea polyphenol epigallocatechin-3-gallate protects cells against peroxynitrite-induced cytotoxicity: Modulatory effect of cellular G6PD status
    • Ho, H.; Wei, T.; Cheng, M.; Chiu, D. Green tea polyphenol epigallocatechin-3-gallate protects cells against peroxynitrite-induced cytotoxicity: modulatory effect of cellular G6PD status. J. Agric. Food Chem. 2006, 54, 1638-1645.
    • (2006) J. Agric. Food Chem , vol.54 , pp. 1638-1645
    • Ho, H.1    Wei, T.2    Cheng, M.3    Chiu, D.4
  • 31
    • 17144366551 scopus 로고    scopus 로고
    • Antiproliferative plant and synthetic polyphenolics are specific inhibitors of vertebrates inositol-1,4,5-triphosphate 3-kinases and inositol polyphosphate multikinase
    • Mayr, G. W.; Windhorst, S.; Hillemeier, K. Antiproliferative plant and synthetic polyphenolics are specific inhibitors of vertebrates inositol-1,4,5-triphosphate 3-kinases and inositol polyphosphate multikinase. J. Biol. Chem. 2005, 280, 13229-13240.
    • (2005) J. Biol. Chem , vol.280 , pp. 13229-13240
    • Mayr, G.W.1    Windhorst, S.2    Hillemeier, K.3
  • 34
    • 33746671438 scopus 로고    scopus 로고
    • Li, H.-L.; Huang, Y.; Zhang, C.-N.; Liu, G.; Wei, Y.-S.; Wang, A. B.; Liu, Y.-Q.; Hui, R.-T.; Wei, C; Williams, G. M.; Liu, D.-P.; Liang, C.-C. Epigallocatechin-3-gallate inhibits cardiac hypertrophy through blocking reactive oxidative species-dependent and -independent signal pathways. Free Radical Biol. Med. 2006, 40, 1756-1775.
    • Li, H.-L.; Huang, Y.; Zhang, C.-N.; Liu, G.; Wei, Y.-S.; Wang, A. B.; Liu, Y.-Q.; Hui, R.-T.; Wei, C; Williams, G. M.; Liu, D.-P.; Liang, C.-C. Epigallocatechin-3-gallate inhibits cardiac hypertrophy through blocking reactive oxidative species-dependent and -independent signal pathways. Free Radical Biol. Med. 2006, 40, 1756-1775.
  • 35
    • 0034655603 scopus 로고    scopus 로고
    • Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor κB in cancer cells versus normal cells
    • Ahmad, N.; Gupta, S.; Mukhtar, H. Green tea polyphenol epigallocatechin-3-gallate differentially modulates nuclear factor κB in cancer cells versus normal cells. Arch. Biochem. Biophys. 2000, 376, 338-346.
    • (2000) Arch. Biochem. Biophys , vol.376 , pp. 338-346
    • Ahmad, N.1    Gupta, S.2    Mukhtar, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.