Hepatoprotective constituents in plants 15: Protective effects of natural-occurring flavonoids and miscellaneous phenolic compounds as determined in an HepG2 cell cytotoxicity assay

Journal of Natural Medicines

Volumn 60, Issue 1, 2006, Pages 36-41

  Kinjo, Junei ^a   Hitoshi, Masahiro ^a   Tsuchihashi, Ryota ^a   Korematsu, Yoshiaki ^a   Miyakoshi, Masazumi ^b   Murakami, Toshiyuki ^b   Niiho, Daisuke ^b   Mizutani, Kenji ^b   Tanaka, Takashi ^c   Nonaka, Genichiro ^d   Nohara, Toshihiro ^e   Okawa, Masafumi ^a   Okabe, Hikaru ^a  

^a FUKUOKA UNIVERSITY   (Japan)

^b Maruzen Pharmaceuticals Co Ltd   (Japan)

^c NAGASAKI UNIVERSITY   (Japan)

^d Usaien Pharmaceutical Company Ltd   (Japan)

^e KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Catechin; Flavonoid; Hepatoprotective; HepG2 cell; Phenolic compound; tert Butyl hydroperoxide

Indexed keywords

2', 5', 6',7 TETRAHYDROXYFLAVANONE; 2', 5', 6',7 TETRAHYDROXYFLAVANONOL; 2', 5', 6',7 TETRAHYDROXYFLAVONE; 6 C GLUCOSYL,8 C ARABINOSYL CHRYSIN; 7 O GALLOYLCATECHIN; AMPELOPSIN; ASTILBIN; BAICALEIN; BAICALIN; CATECHIN; EPICATECHIN; EPICATECHIN GALLATE; EPIGALLOCATECHIN; EPIGALLOCATECHIN GALLATE; FLAVANOL DERIVATIVE; FLAVONE DERIVATIVE; FLAVONOID; GALLOCATECHIN; GALLOCATECHIN GALLATE; GANHUANGENIN; GLYCYRRHIZIC ACID; KAEMPFEROL; OROXYLIN A; OROXYLIN A GLUCURONIDE; PHENOL DERIVATIVE; QUERCETIN; TAXIFOLIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; WOGONIN; WOGONOSIDE;

ARTICLE; CELL ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; HUMAN; HUMAN CELL; LIVER CELL; LIVER PROTECTION; STRUCTURE ACTIVITY RELATION;

EID: 33947581338     PISSN: 13403443     EISSN: 18610293     Source Type: Journal    
DOI: 10.1007/s11418-005-0002-6     Document Type: Article

References (19)

1. SABE Van Acker GP Van Balen D Van den Berg A Bast WJF Van der Vijgh 1998 Influence of iron chelation on the antioxidant activity of flavonoids Biochem Pharmacol 56 935 943
2. C Marena M Lampertico 1991 Preliminary clinical development of Silipide: a new complex of silybin in toxic liver disorders Planta Med 57 Suppl 2 A124 A125
3. A Koda 1993 Pharmacological effects of Scutellaria baicalensis, particularly on baicalin and baicalein as the components of the crude drug Gendai Toyo Igaku 14 95 100
4. L Patrick 1999 Hepatitis C: epidemiology and review of complementary/alternative medicine treatments Altern Med Rev 4 220 238
5. J Kinjo T Hirakawa R Tsuchihashi T Nagao M Okawa T Nohara H Okabe 2003 Hepatoprotective constituents in plants 14 Effects of soyasapogenol B, sophoradiol, and their glucuronides on the cytotoxicity of tert-butyl hydroperoxide to HepG2 cells Biol Pharm Bull 26 1357 1360
6. J Kinjo T Nagao T Tanaka G Nonaka M Okawa T Nohara H Okabe 2002 Activity-guided fractionation of green tea extract with antiproliferative activity against human stomach cancer cells Biol Pharm Bull 25 1238 1240
7. J Kinjo T Nagao T Tanaka G Nonaka H Okabe 2001 Antiproliferative constituents in the plants 8 Seeds of Rhynchosia volubilis Biol Pharm Bull 24 1443 1445
8. Korematsu Y, Nagao T, Kinjo J, Okabe H, (2002) Abstracts of papers. In: The 49th Annu Meet Jpn Soc Pharmacognosy. Fukuoka, p 215
9. M Okawa J Kinjo T Nohara M Ono 2001 DPPH (1, 1-diphenyl-2-picrylhydrazyl) radical scavenging activity of flavonoids obtained from some medicinal plants Biol Pharm Bull 24 1202 1205
10. Kataoka S, Masuda K, Mizutani K, Tanaka O, Kozuka M, Tokuda H, Nishino H, (1995) In: Abstracts of papers. 42th Annu Meet Jpn Soc Pharmacognosy. Fukuyama, p 179
11. Tamura K, Miyoshi S, Sogabe T, Miyakoshi M, Niiho D, Kohbara T, Mizutani K, Tanaka O, Ikeda T, (2001) Abstracts of papers. 48th Ann Meet Jpn Soc Pharmacognosy. Kanazawa, p 100
12. M Ishimatsu T Tanaka G Nonaka I Nishioka M Nishizawa T Yamagishi 1989 Isolation and characterization of novel dimeric and trimeric hydrolyzable tannins, nuphrins C, D, E and F, from Nuphar japonicum Chem Pharm Bull 37 1735 1743
13. R Saijyo G Nonaka I Nishioka IS Chen TH Hwang 1989 Isolation and characterization of hydrolyzable tannins from Mallotus japonicus and M Philippinensis Chem Pharm Bull 37 2940 2947
14. Kinjo J, Hitoshi M, Eguchi M, Miyata C, Matsushita K, Nagao T, Okabe H, Tsuchihashi R, Okawa M, Nohara T, (2002) Abstracts of papers. 49th Ann Meet Jpn Soc Pharmacognosy. Fukuoka, p 217
15. Lancaster MV, Fields RD (1996) US Patent 5501959
16. MI Thabrew RD Hughes IG McFarlane 1997 Screening of hepatoprotective plant components using a HepG2 cell cytotoxicity assay J Pharm Pharmacol 49 1132 1135
17. RD Fields MV Lancaster 1993 Dual-attribute continuous monitoring of cell proliferation/cytotoxicity Am Biotech Lab 11 48 50
18. HP Ammon MA Wahl 1991 Pharmacology of Curcuma longa Planta Med 57 1 7
19. MP Miguez I Anundi LA Sainz-Pardo KO Lindros 1994 Hepatoprotective mechanism of silymarin: no evidence for involvement of cytochrome P450 2E1 Chem Biol Interact 91 51 63