Induction of apoptosis of osteoclasts by targeting transcription factors with decoy molecules

Annals of the New York Academy of Sciences

Volumn 1091, Issue , 2006, Pages 509-516

  Piva, Roberta ^a   Penolazzi, Letizia ^a   Zennaro, Margherita ^a   Bianchini, Ercolina ^a   Magri, Eros ^a   Borgatti, Monica ^a   Lampronti, Ilaria ^a   Lambertini, Elisabetta ^a   Tavanti, Elisa ^a   Gambari, Roberto ^a,b  

^a UNIVERSITY OF FERRARA   (Italy)

^b Section of Molecular Biology   (Italy)

Author keywords

Estrogen receptor; Gene therapy; NF B; Osteoclast; PNA; Transcription

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CALCITONIN; CASPASE 3; ESTROGEN; ESTROGEN RECEPTOR ALPHA; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 18; INTERLEUKIN 4; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; OLIGONUCLEOTIDE; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PROSTAGLANDIN E2; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR; OLIGODEOXYRIBONUCLEOTIDE; TRANSCRIPTION FACTOR;

AMINO ACID SEQUENCE; APOPTOSIS; BONE DEVELOPMENT; BONE REMODELING; CELL FUNCTION; CONFERENCE PAPER; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG TARGETING; ENZYME ACTIVITY; GENE THERAPY; GENETIC ANALYSIS; HUMAN; IN VIVO STUDY; NONHUMAN; OSTEOCLAST; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; BIOMIMETICS; CHEMISTRY; DRUG DELIVERY SYSTEM; METABOLISM; PHYSIOLOGY; REVIEW; SYNTHESIS;

ANIMALIA;

APOPTOSIS; BIOMIMETICS; DRUG DELIVERY SYSTEMS; HUMANS; OLIGODEOXYRIBONUCLEOTIDES; OSTEOCLASTS; TRANSCRIPTION FACTORS;

EID: 33947585567     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1378.092     Document Type: Conference Paper

References (25)

1. MORISHITA, R. et al. 1997. In vivo transfection of cis element "decoy" against nuclear factor-kB binding site prevents myocardial infarction. Nat. Med. 3: 894-899.
2. MANN, M.J. & V.J. DZAU. 2000. Therapeutic application of transcriptional factor decoy oligonucleotides. J. Clin. Invest. 106: 1071-1075.
3. BOYLE, W.J., W.S. SIMONET & D.L. LACEY. 2003. Osteoclast differentiation and activation. Nature 423: 337-342.
4. CHAISSON, M.L. et al. 2004. Osteoclast differentiation is impaired in the absence of inhibitor of kappa B kinase alpha. J. Biol. Chem. 279: 54841-54848.
5. BOYCE, B.F. et al. 2005. Roles for NF-kappaB and c-Fos in osteoclasts. J. Bone Miner. Metab. 23: 11-15.
6. PIVA, R. et al. 2005. Induction of apoptosis of human primary osteoclasts treated with a transcription factor decoy mimicking a promoter region of estrogen receptor alpha. Apoptosis 10: 1079-1094.
7. KRASSAS, G.E. & P. PAPADOPOULOU. 2001. Oestrogen action on bone cells. J. Musculoskelet. Neuronal Interact. 2: 143-151.
8. SYED, F. & K. SUNDEEP. 2005. Mechanisms of sex steroid effects on bone. Biochem. Biophys. Res. Commun. 328: 688-696.
9. TOMITA, T. et al. 2000. Transcription factor decoy for NF-kB inhibits cytokine and adhesion molecule expressions in synovial cells derived from rheumatoid arthritis. Rheumatology 39: 749-757.
10. BORGATTI, M. et al. 2004. Peptide nucleic acids (PNA)-DNA chimeras targeting transcription factors as a tool to modify gene expression. Curr. Drug Targets 5: 735-744.
11. GAMBARI, R. 2004. New trends in the development of transcription factor decoy (TFD) pharmacotherapy. Curr. Drug Targets 5: 419-430.
12. PENOLAZZI, L. et al. 2002. Decoy oligodeoxynucleotides targeting NF-kappaB transcription factors: induction of apoptosis in human primary osteoclasts. Biochem. Pharmacol. 66: 1189-1198.
13. PENOLAZZI, L. et al. 2006. Local in vivo administration of a decoy oligonucleotide targeting NF-kappa B induces apoptosis of osteoclasts after application of orthodontic forces to rat teeth. Int. J. Mol. Med. 18: 807-811.
14. PENOLAZZI, L. et al. 2006. In vivo local transfection of a cis element decoy mimicking an estrogen receptor alpha gene promoter region induces apoptosis of osteoclasts following application of orthodontic forces to rat teeth. Apoptosis 11: 1653-1656.
15. GAMBARI, R. 2004. Biological activity and delivery of peptide nucleic acids (PNA)-DNA chimeras for transcription factor decoy (TFD) pharmacotherapy. Curr. Med. Chem. 11: 1253-1263.
16. NIELSEN, P. et al. 1991. Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide. Science 254: 1497-1500.
17. NIELSEN, P.E. & M. EGHOLM. 1999. An introduction to peptide nucleic acid. Curr. Issues Mol. Biol. 1: 89-104.
18. EGHOLM, M. et al. 1993. PNAhybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules. Nature 365: 566-568.
19. NIELSEN, P.E. 2004. PNA technology. Mol. Biotechnol. 26: 233-248.
20. MISCHIATI, C. et al. 1999. Interaction of the human NF-kappaB p52 transcription factor with DNA-PNA hybrids mimicking the NF-kappaB binding sites of the human immunodeficiency virus type 1 promoter. J. Biol. Chem. 274: 33114-33122.
21. ROMANELLI, A. et al. 2001. Molecular interactions with nuclear factor kappaB (NFkappaB) transcription factors of a PNA-DNA chimera mimicking NF-kappaB binding sites. Eur. J. Biochem. 268: 6066-6075.
22. BORGATTI, M. et al. 2003. Transcription factor decoy molecules based on a peptide nucleic acid (PNA)-DNA chimera mimicking Sp1 binding sites. J. Biol. Chem. 278: 7500-7509.
23. BORGATTI, M. et al. 2002. Cationic liposomes as delivery systems for doublestranded PNA-DNA chimeras exhibiting decoy activity against NF-kappaB transcription factors. Biochem. Pharmacol. 64: 609-616.
24. BORGATTI, M. et al. 2003. Resistance of decoy PNA-DNA chimeras to enzymatic degradation in cellular extracts and serum. Oncol. Res. 13: 279-287.
25. PENOLAZZI, L. et al. 2004. Peptide nucleic acid-DNA decoy chimeras targeting NF-kappaB transcription factors: induction of apoptosis in human primary osteoclasts. Int. J. Mol. Med. 14: 145-152.