The APOB -516C/T polymorphism is associated with differences in insulin sensitivity in healthy males during the consumption of diets with different fat content

British Journal of Nutrition

Volumn 97, Issue 4, 2007, Pages 622-627

  Pérez Martínez, Pablo ^a   Pérez Jiménez, Francisco ^a   Ordovás, José María ^b   Moreno, Juan Antonio ^a   Moreno, Rafael ^a   Fuentes, Francisco ^a   Ruano, Juan ^a   Gómez, Purificación ^a   Marín, Carmen ^a   López Miranda, José ^a  

^a HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^b TUFTS UNIVERSITY   (United States)

Author keywords

Apolipoprotein B polymorphism; Insulin sensitivity; Monounsaturated fatty acids; Nutrigenetics

Indexed keywords

APOLIPOPROTEIN B; CYSTEINE; FATTY ACID; GLUCOSE; INSULIN; MONOUNSATURATED FATTY ACID; SATURATED FATTY ACID; TYROSINE;

ADULT; ALLELE; ARTICLE; CARBOHYDRATE DIET; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; FAT INTAKE; FATTY ACID BLOOD LEVEL; FEMALE; GENETIC POLYMORPHISM; GLUCOSE BLOOD LEVEL; HETEROZYGOTE; HOMOZYGOTE; HUMAN; HUMAN EXPERIMENT; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; NORMAL HUMAN; PATHOGENESIS; PROMOTER REGION; RANDOMIZED CONTROLLED TRIAL; SEX DIFFERENCE; STATISTICAL SIGNIFICANCE; STEADY STATE; VOLUNTEER;

ADULT; APOLIPOPROTEINS; APOLIPOPROTEINS B; BLOOD GLUCOSE; CROSS-OVER STUDIES; DIET; DIETARY FATS; FEMALE; HUMANS; INSULIN RESISTANCE; LIPIDS; MALE; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS);

EID: 33947534883     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114507659005     Document Type: Article

References (28)

1. 2. Clin Chem 9, 2026-2030.
2. Association of Official Analytical Chemists (1990) Official Methods of Analysis, 15th ed. Arlington, VA: Association of Official Analytical Chemists.
3. Bentzen J, Poulsen P, Vaag A & Fenger M (2003) Further studies of the influence of apolipoprotein B alleles on glucose and lipid metabolism. Hum Biol 75, 687-703.
4. Boekholdt SM, Peters RJ, Fountoulaki K, Kastelein JJ & Sijbrands EJ (2003) Molecular variation at the apolipoprotein B gene locus in relation to lipids and cardiovascular disease: A systematic meta-analysis. Hum Genet 113, 417-425.
5. Bucolo G & David H (1973) Quantitative determination of serum triglycerides by the use of enzymes. Clin Chem 19, 476-482.
6. Friedewald WT, Levy RI & Fredrickson DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of a preparative ultracentrifuge. Clin Chem 18, 499-502.
7. Gerhard GT, Ahmann A, Meeuws K, McMurry MP, Duell PB & Connor WE (2004) Effects of a low-fat diet compared with those of a high-monounsaturated fat diet on body weight, plasma lipids and lipoproteins, and glycemic control in type 2 diabetes. Am J Clin Nutr 80, 668-673.
8. Harano Y, Ohgaku S, Hidaka H, Haneda K, Kikkawa R, Shigeta Y & Abe H (1977) Glucose, insulin and somatostatin infusion for the determination of insulin sensitivity. J Clin Endocrinol Metab 45, 1124-1127.
9. Hu FB, van Dam RM & Liu S (2001) Diet and risk of type II diabetes: The role of types of fat and carbohydrate. Diabetologia 44, 805-817.
10. Human Nutrition Information Service (1987) Department of Agriculture composition of foods. In Agriculture Handbook no. 8. Washington, DC: US Government Printing Office.
11. Laws A, Jeppesen JL, Maheux PC, Schaaf P, Chen YD & Reaven GM (1994) Resistance to insulin-stimulated glucose uptake and dyslipidemia in Asian Indians. Arterioscler Thromb 14, 917-922.
12. Masson LF, McNeill G & Avenell A (2003) Genetic variation and the lipid response to dietary intervention: A systematic review. Am J Clin Nutr 77, 1098-1111.
13. Ordovas JM & Corella D (2004a) Nutritional genomics. Annu Rev Genomics Hum Genet 5, 71-118.
14. Ordovas JM & Corella D (2004b) Genes, diet and plasma lipids: The evidence from observational studies. World Rev Nutr Diet 93, 41-76.
15. Perez-Jimenez F, Lopez-Miranda J & Pinillos MD (2001) A Mediterranean and a high-carbohydrate diet improve glucose metabolism in healthy young individuals. Diabetologia 44, 2038-2043.
16. Perez-Martinez P, Lopez-Miranda J, Ordovas JM, Bellido C, Marin C, Gomez P, Paniagua JA, Moreno JA, Fuentes F & Perez-Jimenez F (2004) Postprandial lipemia is modified by the presence of the polymorphism present in the exon 1 variant at the SR-BI gene locus. J Mol Endocrinol 32, 237-245.
17. Perez-Martinez P, Perez-Jimenez F, Ordovas JM, Bellido C, Moreno JA, Gomez P, Marin C, Fernandez de la Puebla RA, Paniagua JA & Lopez-Miranda J (in press) The APOB-516C/T polymorphism has no effect on lipid and apolipoprotein response following changes in dietary fat intake in a healthy population. Nutr Metab Cardiovasc Dis.
18. Rantala M, Rantala TT, Savolainen MJ, Friedlander Y & Kesaniemi YA (2000) Apolipoprotein B gene polymorphisms and serum lipids: meta-analysis of the role of genetic variation in responsiveness to diet. Am J Clin Nutr 71, 713-724.
19. Reaven GM (2003) The insulin resistance syndrome. Curr Atheroscler Rep 5, 364-371.
20. Riepponem P, Marniemi J & Rautaoja T (1987) Immunoturbidimetric determination of apolipoproteins A-I and B in serum. Scand J Clin Lab Invest 47, 739-744.
21. Rivellese AA, De Natale C & Lilli S (2002) Type of dietary fat and insulin resistance. Ann N Y Acad Sci 967, 329-335.
22. Ruiz-Gutierrez V, Prada JL & Perez-Jimenez F (1993) Determination of fatty acid and triacylglycerol composition of human very-low-density lipoproteins. J Chromatogr 622, 117-124.
23. Shimizu S, Inoue K, Tani Y & Yamada H (1979) Enzymatic microdetermination of serum free fatty acids. Anal Biochem 98, 341-345.
24. Sposito AC, Gonbert S, Turpin G, Chapman MJ & Thillet J (2004) Common promoter C516T polymorphism in the apoB gene is an independent predictor of carotid atherosclerotic disease in subjects presenting a broad range of plasma cholesterol levels. Arterioscler Thromb Vasc Biol 24, 2192-2195.
25. Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, Keinanen-Kiukaanniemi S, Laakso M, Louheranta A & Rastas MFinnish Diabetes Prevention Study Group (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344, 1343-1350.
26. van't Hooft FM, Jormsjo S, Lundahl B, Tornvall P, Eriksson P & Hamsten A (1999) A functional polymorphism in the apolipoprotein B promoter that influences the level of plasma low density lipoprotein. J Lipid Res 40, 1686-1694.
27. Varela G (1980) Food Composition Tables (Tablas de Composición de Alimentos). Madrid: Instituto de Nutrición CSIC.
28. Vessby B, Unsitupa M, Hermansen K, Riccardi G, Rivellese AA, Tapsell LC, Nalsen C, Berglund L, Louheranta A & Rasmussen BM (2001) Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU Study. Diabetologia 44, 312-319.