Further Studies of the Influence of Apolipoprotein B Alleles on Glucose and Lipid Metabolism

Human Biology

Volumn 75, Issue 5, 2003, Pages 687-703

  Bentzen, Joan ^a   Poulsen, Pernille ^b   Vaag, Allan ^c   Fenger, Mogens ^a  

^a HVIDOVRE HOSPITAL   (Denmark)

^b ODENSE UNIVERSITY HOSPITAL   (Denmark)

^c STENO DIABETES CENTER   (Denmark)

Author keywords

Allele sharing; Apolipoprotein B polymorphisms; Genetic interactions; Glucose and lipid metabolism; Twins; Type 2 diabetes

Indexed keywords

APOLIPOPROTEIN B; FATTY ACID; GLUCOSE; INSULIN; LIPID;

ADULT; AGED; ALLELE; ARTICLE; BODY MASS; CALCULATION; DENMARK; DIZYGOTIC TWINS; FEMALE; GENE INTERACTION; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENOTYPE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TOLERANCE TEST; HUMAN; HUMAN TISSUE; IMPAIRED GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LINKAGE ANALYSIS; LIPID BLOOD LEVEL; LIPID METABOLISM; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MONOZYGOTIC TWINS; MULTIVARIATE ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RESTRICTION MAPPING;

EID: 1642536532     PISSN: 00187143     EISSN: None     Source Type: Journal    
DOI: 10.1353/hub.2003.0070     Document Type: Article

References (50)

1. Aalto-Setala, K., H. Gylling, E. Helve et al. 1989. Genetic polymorphism of the apolipoprotein B gene locus influences serum LDL cholesterol level in familial hypercholesterolemia. Hum. Genet. 82:305-307.
2. Aalto-Setala, K., M.J. Tikkanen, M.R. Taskinen et al. 1988. XbaI and C/g polymorphisms of the Apolipoprotein B gene locus are associated with serum cholesterol and LDL-cholesterol levels in Finland. Atherosclerosis 74:47-54.
3. Altman, D.G. 1999. Comparing groups-Categorical data. In Practical Statistics for Medical Research. London, UK: Chapman & Hall/CRC, 229-276.
4. Anderson, J.L., C.H. Bunker, C.E. Aston et al. 1997. Relationship of two apolipoprotein B polymorphisms with serum lipoprotein and lipid levels in African blacks. Hum. Biol. 69:793-807.
5. Bentzen, J., T. Jørgensen, and M. Fenger. 2002a. The effect of six polymorphisms in the apolipoprotein B gene on parameters of lipid metabolism in a Danish population. Clin. Genet. 61:126-134.
6. Bentzen, J., E. Poulsen, A. Vaag et al. 2002b. The influence of the polymorphism in apolipoprotein B Codon 2488 on insulin and lipid levels in a Danish twin population. Diabet. Med. 19:12-18.
7. Betteridge, J. 1994. Diabetic dyslipidemia. Am. J. Med. 96:25S-31S.
8. Bøhn, M., A. Bakken, J. Erikssen et al. 1993. XbaI polymorphism in DNA at the apolipoprotein B locus is associated with myocardial infarction (MI). Clin. Genet. 44:241-248.
9. Boren, J., U. Ekström, B. Ågren et al. 2001. The molecular mechanism for the genetic disorder familial defective apolipoprotein B 100. J. Biol. Chem. 276:9214-9218.
10. Breguet, G., R. Bütler, E. Bütler-Brunner et al. 1990. A worldwide population study of the Ag-system haplotypes, a genetic polymorphism of human low-density lipoprotein. Am. J. Hum. Genet. 46:502-517.
11. Cavalli, S.A., M.H. Hirata, L.A. Salazar et al. 2000. Apolipoprotein B gene polymorphisms: Prevalence and impact on serum lipid concentrations in hypercholesterolemic individuals from Brazil. Clin. Chim. Acta 302:189-203.
12. Chauffert, M., J. Larghero, K. Ngohou-Botum et al. 1997. DNA polymorphisms of apolipoprotein B in the population of Senegal. Ann. Hum. Genet. 61:525-529.
13. Christiansen, F., and M. Feldman. 1986. Population distribution of alleles and genotypes. In Population Genetics. Oxford, UK: Blackwell Scientific Publications. 73-103.
14. Corbo, R.M., T. Vilardo, E. Mantuano et al. 1997. Apolipoprotein B and E, and Angiotensin 1-Converting Enzyme (ACE): Genetic polymorphisms in Italian women with Coronary Artery Disease (CAD) and their relationship with plasma lipid and apolipoprotein levels. Clin. Genet. 52:77-82.
15. Corbo, R.M., A. Vilardo, M. Ruggeri et al. 1999. Apolipoprotein E genotype and plasma levels in Coronary Artery Disease. A case-control study in the Italian population. Clin. Biochem. 32:217-222.
16. De Benedictis, G., G. Rose, R. Mazzei et al. 1991. EcoRI-RFLP of the Apo B gene: A study in a sample group from south Italy. Ann. Hum. Genet. 55 (Pt 2):103-113.
17. Delghandi, M., R. Thangarajah, M. Nilsen et al. 1999. DNA polymorphisms of the apolipoprotein B gene (XbaI, EcoRI, and MspI RFLPs) in Norwegians at risk of atherosclerosis and healthy controls. Acta Cardiol. 54:215-225.
18. Elston, R.C., S. Buxbaum, K.B. Jacobs et al. 2000. Haseman and Elston revisited. Genet. Epidemiol. 19:1-17.
19. Evans, A., W. Zhang, J. Moreel et al. 1993. Polymorphisms of the apolipoprotein B and E genes and their relationship to lipid variables in healthy Chinese men. Hum. Genet. 92:191-197.
20. Friedewald, W.T., R.I. Levy, and D.S. Fredricson. 1972. Estimation of the concentration of low-density lipoprotein cholesterol in plasma without use of the preparative ultracentrifuge. Clin. Chem. 18:459-502.
21. Fruchart, J.C., P. Duriez, and B. Staels. 1999. Peroxisome Proliferator-Activated Receptor-Alpha activators regulate genes governing lipoprotein metabolism, vascular inflammation and atherosclerosis. Curr. Opin. Lipidol. 10:245-257.
22. Ghusn, H., R. Arem, M. Frazier et al. 1996. Restriction fragment length polymorphism of the human apo B and apo A11 gene regions among type II diabetics. Res. Commun. Mol. Pathol. Pharmacol. 93:25-32.
23. Glisic, S., I. Savic, and D. Alavantic. 1995. Apolipoprotein B gene DNA polymorphisms (EcoRI and MspI) and serum lipid levels in the Serbian healthy population: Interaction of rare alleles and smoking and cholesterol levels. Genet. Epidemiol. 12:499-508.
24. Hansen, P.S. 1998. Familial defective apolipoprotein B-100. Dan. Med. Bull. 45:370-382.
25. Hansen, P., L. Gerdes, I. Klausen et al. 1993. Polymorphisms in the apolipoprotein B-100 gene contributes to normal variation in plasma lipids in 464 Danish men born in 1948. Hum. Genet. 91:45-50.
26. Hosking, J.L., R. Bais, S.K. Sobecki et al. 1992. Lipid parameters and apolipoprotein B RFLP studies: Comparison of normal and coronary heart disease groups as defined by angiography. Clin. Biochem. 25:303-308.
27. Houlston, R.S., C. Snowden, M.F. Laker et al. 1991. Variation in the apolipoprotein B gene and development of type 2 diabetes mellitus. Dis. Markers 9:87-96.
28. Iso, H., S. Harada, T. Shimamoto et al. 1996. Polymorphism of the apolipoprotein B gene and blood lipid concentrations in Japanese and Caucasian population samples. Atherosclerosis 126:233-241.
29. Kwiterovich, P.O., Jr. 2000. The metabolic pathways of high-density lipoprotein, low-density lipoprotein, and triglycerides: A current review. Am. J. Cardiol. 86:5L-10L.
30. Leren, T.P., K.S. Bakken, V. Hoel et al. 1998. Screening for mutations of the apolipoprotein B gene causing hypocholesterolemia. Hum. Genet. 102:44-49.
31. Lynch, M., and B. Walsh. 1998a. Mapping and characterizing QTLs: Outbred populations. In Genetics and Analysis of Quantitative Traits. Sunderland, MA: Sinauer Associates, 491-532.
32. Lynch, M., and B. Walsh. 1998b. Properties of single loci. In Genetics and Analysis of Quantitative Traits. Sunderland, MA: Sinauer Associates, 51-76.
33. Mann, C.J., T.A. Anderson, J. Read et al. 1999. The structure of vitellogenin provides a molecular model for the assembly and secretion of atherogenic lipoproteins. J. Mol. Biol. 285:391-408.
34. Matthews, D.R., J.P. Hosker, A.S. Rudenski et al. 1985. Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419.
35. Monsalve, M.V., R. Young, J. Jobsis et al. 1988. DNA Polymorphisms of the gene for apolipoprotein B in patients with peripheral arterial disease. Atherosclerosis 70:123-129.
36. Myant, N.B., J. Gallagher, M. Barbir et al. 1989. Restriction fragment length polymorphisms in the apo B gene in relation to coronary artery disease. Atherosclerosis 77:193-201.
37. Pallaud, C., M. Maurice, S. Cheng et al. 1999. Multilocus approach to cardiovascular risk. Scand. J. Clin. Lab. Invest. Suppl. 230:168-176.
38. Paulweber, B., W. Friedl, F. Krempler et al. 1990. Association of DNA polymorphism at the apolipoprotein B gene locus with coronary heart disease and serum very low density lipoprotein levels. Arteriosclerosis 10:17-24.
39. Poulsen, P., K.O. Kyvik, A. Vaag et al. 1999. Heritability of type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance-A population-based twin study. Diabetologia 42:139-145.
40. Report of a WHO consultation. Definition, diagnosis and classification of Diabetes Mellitus and its complications. 1999. Geneva. Switzerland, World Health Organization. Department of Non-communicable Disease Surveillance.
41. Robinson, M.T., R. Bütler, and R.M. Krauss. 1991. Association of a genetic polymorphism in human apolipoprotein B-100 with intermediate density lipoprotein concentrations. Clin. Genet. 40:178-195.
42. Rother, A.L., and C.D. Collard. 2001. Atherosclerosis and the genetic basis of lipoprotein disease. Best Practice and Research Clinical Anaesthesiology 15:169-183.
43. Saha, N., M.C. Tong, J.S. Tay et al. 1992. DNA polymorphisms of the apolipoprotein B gene in Chinese coronary artery disease patients. Clin. Genet. 42:164-170.
44. Segrest, J.P., M.K. Jones, H. De Loof et al. 2001. Structure of apolipoprotein B-100 in low density lipoprotein. J. Lipid Res. 42:1346-1367.
45. Sniderman, A.D., and K. Cianflone. 1999. Lipids and vascular disease: What we do and do not know. Clin. Chim. Acta 286:7-22.
46. Ukkola, O., M.J. Savolainen, P.I. Salmela et al. 1993. Apolipoprotein B gene DNA polymorphisms are associated with macro- and microangiopathy in non-insulin-dependent diabetes mellitus. Clin. Genet. 44:177-184.
47. Weir, B.S. 1996. Disequilibrium. In Genetic Data Analysis II. Sunderland, MA: Sinauer Associates, 91-140.
48. Wu, J.H., M.-S. Wen, S.-K. Lo et al. 1993. DNA polymorphisms of apolipoprotein B in the population of Taiwan. J. Formos. Med. Assoc. 92 330-335.
49. Xu, C.F., N. Nanjee, M.J. Tikkanen et al. 1989. Apolipoprotein B amino acid 3611 substitution from arginine to glutamine creates the Ag (h/i) epitope: The polymorphism is not associated with differences in serum cholesterol and apolipoprotein B levels. Hum. Genet. 82:322-326.
50. Ziegler, A. 2001. The new Haseman-Elston method and the weighted pairwise correlation statistics are variations on the same theme. Biometrical Journal 43:697-702.