The N-terminal subdomain of insulin-like growth factor (IGF) binding protein 6. Structure and interaction with IGFs

Biochemistry

Volumn 46, Issue 11, 2007, Pages 3065-3074

  Chandrashekaran, Indu R ^a   Yao, Shenggen ^a   Wang, Chunxiao C ^a,e   Bansal, Paramjit S ^b   Alewood, Paul F ^b   Forbes, Briony E ^c   Wallace, John C ^c   Bach, Leon A ^d   Norton, Raymond S ^a  

^a WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c UNIVERSITY OF ADELAIDE   (Australia)

^d MONASH UNIVERSITY   (Australia)

^e ALFRED HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING SITES; ENZYME INHIBITION; GROWTH KINETICS; INSULIN; LIGANDS; METAL IONS;

CYSTEINES; DISULFIDE LINKAGES; INSULIN LIKE GROWTH FACTOR (IGF); STRUCTURE-FUNCTION RELATIONSHIPS;

PROTEIN FOLDING;

SOMATOMEDIN; SOMATOMEDIN B; SOMATOMEDIN BINDING PROTEIN 1; SOMATOMEDIN BINDING PROTEIN 2; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN BINDING PROTEIN 4; SOMATOMEDIN BINDING PROTEIN 5; SOMATOMEDIN BINDING PROTEIN 6; SOMATOMEDIN C;

AMINO TERMINAL SEQUENCE; ARTICLE; BETA SHEET; DISULFIDE BOND; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 6; INSULIN-LIKE GROWTH FACTOR I; INSULIN-LIKE GROWTH FACTOR II; LANTHANOID SERIES ELEMENTS; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; SOMATOMEDINS;

EID: 33947403972     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0619876     Document Type: Article

References (46)

1. Bach, L. A. (1999) The insulin-like growth factor system: basic and clinical aspects, Aust. N.Z. J. Med. 29, 355-361.
2. Yu, H., and Rohan, T. (2000) Role of the insulin-like growth factor family in cancer development and progression, J. Natl. Cancer Inst. 92, 1472-1489.
3. Bach, L. A., and Rechler, M. M. (1995) Insulin-like growth factor binding proteins, Diabetes Rev. 3, 38-61.
4. Baxter, R. C. (2000) Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities, Am. J. Physiol. Endocrinol. Metab. 278, 967-976.
5. Bach, L. A. (2005) IGFBP-6 five years on; not so 'forgotten'?, Growth Hormone IGF Res. 15, 185-192.
6. Bach, L. A., Headey, S. J., and Norton, R. S. (2005) IGF-binding proteins-the pieces are falling into place, Trends Endocrinol. Metab. 16, 228-234.
7. Neumann, G. M., and Bach, L. A. (1999) The N-terminal disulfide linkages of human insulin-like growth factor binding protein-6 (hIGFBP-6) and hIGFBP-1 are different as determined by mass spectrometry, J. Biol. Chem. 274, 14587-14594.
8. Kalus, W., Zweckstetter, M., Renner, C., Sanchez, Y., Georgescu, J., Grol, M., Demuth, D., Schumacher, R., Dony, C., Lang, K., and Holak, T. A. (1998) Structure of the IGF-binding domain of the insulin like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions, EMBO J. 22, 6558-6572.
9. Headey, S. J., Keizer, D. W., Yao, S., Brasier, G., Kantharidis, P., Bach, L. A., and Norton, R. S. (2004) C-terminal domain of insulin-like growth factor (IGF) binding protein-6: structure and interaction with IGF-II, Mol. Endocrinol. 18, 2740-2750.
10. Sala, A., Capaldi, S., Campagnoli, M., Faggion, B., Labo, S., Perduca, M., Romano, A., Carrizo, M. E., Valli, M., Visai, L., Minchiotti, L., Galliano, M., and Monaco, H. L. (2005) Structure and properties of the C-terminal domain of insulin-like growth factor-binding protein-1 isolated from human amniotic fluid, J. Biol. Chem. 280, 29812-29819.
11. Kuang, Z., Yao, S., Keizer, D. W., Wang, C. C., Bach, L. A., Forbes, B. E., Wallace, J. C., and Norton, R. S. (2006) Structure, dynamics and heparin binding of the C-terminal domain of insulin-like growth factor binding protein-2 (IGFBP-2), J. Mol. Biol. 364, 690-704.
12. Siwanowicz, I., Popowicz, G. M., Wisniewska, M., Huber, R., Kuenkele, K. P., Lang, K., Engh, R. A., and Holak, T. A. (2005) Structural basis for the regulation of insulin-like growth factors by IGF binding proteins, Structure 13, 155-167.
13. Sitar, T., Popowicz, G. M., Siwanowicz, I., Huber, R., and Holak, T. A. (2006) Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins, Proc. Natl. Acad. Sci. U.S.A. 103, 13028-13033.
14. Zesławski, W., Beisel, H. G., Kamionka, M., Engh, R. A., Huber, R., Lang, K., and Holak, T. A. (2001) The interaction of insulin-like growth factor-I with the N-terminal domain of IGFBP-5, EMBO J. 20, 3638-3644.
15. Sackett, R. L., and McCusker, R. H. (1998) Multivalent cations depress ligand affinity of insulin-like growth factor-binding proteins-3 and -5 on human GM-10 fibroblast cell surfaces, J. Cell. Biochem. 69, 364-375.
16. Sackett, R. L., and McCusker, R. H. (1998) Multivalent cations depress ligand binding to cell-associated insulin-like growth factor binding protein-5 on human glioblastoma cells, Endocrinology 139, 1943-1951.
17. Bax, A., Griffey, R. H., and Hawkins, B. L. (1983) Correlation of proton and N-15 chemical shifts by multiple quantum NMR, J. Magn. Reson. 55, 301-315.
18. Bax, A., and Grzesiek, S. (1993) Methodological advances in protein NMR, Acc. Chem. Res. 26, 131-138.
19. Yao, S., Howlett, G. J., and Norton, R. S. (2000) Peptide self-association in aqueous trifluoroethanol monitored by pulsed field gradient NMR diffusion measurements, J. Biomol. NMR 16, 109-119.
20. 15N chemical shift referencing in biomolecular NMR, J. Biomol. NMR 6, 135-140.
21. Bartels, C., Xia, T., Billeter, M., Güntert, P., and Wüthrich, K. (1995) The program XEASY for computer-supported NMR spectral analysis of biological macromolecules, J. Biomol. NMR 6, 1-10.
22. Herrmann, T., Güntert, P., and Wüthrich, K. (2002) Protein NMR structure determination with automated NOE assignment using the new software CANDID and the torsion angle dynamics algorithm DYANA, J. Mol. Biol. 319, 209-227.
23. Schwieters, C. D., Kuszewski, J. J., Tjandra, N., and Clore, G. M. (2003) The X-PLOR-NIH NMR molecular structure determination package, J. Magn. Reson. 160, 65-73.
24. Laskowski, R. A., Rullmann, J. A., MacArthur, M. W., Kaptein, R., and Thornton, M. (1996) AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR, J. Biomol. NMR 8, 477-486.
25. Koradi, R., Billeter, M., and Wüthrich, K. (1996) MOLMOL: a program for display and analysis of macromolecular structures, J. Mol. Graphics 14, 51-55.
26. Torres, A. M., Forbes, B. E., Aplin, S. E., Wallace, J. C., Francis, G. L., and Norton, R. S. (1995) Solution structure of human insulin-like growth factor II. Relationship to receptor and binding protein interactions, J. Mol. Biol. 248, 385-401.
27. Headey, S. J., Keizer, D. W., Yao, S., Wallace, J. C., Bach, L. A., and Norton, R. S. (2004) Binding site for the C-domain of insulin-like growth factor (IGF) binding protein-6 on IGF-II; implications for inhibition of IGF actions, FEBS Lett. 568, 19-22.
28. 2) double half filter, J. Magn. Reson. 85, 586-594.
29. Pellecchia, M., Sebbel, P., Hermanns, U., Wüthrich, K., and Glockshuber, R. (1999) Pilus chaperone FimC-adhesin FimH interactions mapped by TROSY-NMR, Nat. Struct. Biol. 6, 336-339.
30. Klaus, W., Broger, C., Gerber, P., and Senn, H. (1993) Determination of the disulphide bonding pattern in proteins by local and global analysis of nuclear magnetic resonance data. Application to flavoridin, J. Mol. Biol. 232, 897-906.
31. Sabo, J. K., Keizer, D. W., Feng, Z. P., Casey, J. L., Parisi, K., Coley, A. M., Foley, M., and Norton, R. S. (2007) Mimotopes of apical membrane antigen 1: structures of phage-derived peptides recognized by the inhibitory monoclonal antibody 4G2dc1 and design of a more active analogue, Infect. Immun. 75, 61-73.
32. Keizer, D. W., Miles, L. A., Li, F., Nair, M., Anders, R. F., Coley, A. M., Foley, M., and Norton, R. S. (2003) Structures of phage-display peptides that bind to the malarial surface protein, apical membrane antigen 1, and block erythrocyte invasion, Biochemistry 42, 9915-9923.
33. Bertini, I., Donaire, A., Jimenez, B., Luchinat, C., Parigi, G., Piccioli, M., and Poggi, L. (2001) Paramagnetism-based versus classical constraints: an analysis of the solution structure of Ca Ln calbindin D9k, J. Biomol. NMR 21, 85-98.
34. Lee, L., and Sykes, B. D. (1983) Use of lanthanide-induced nuclear magnetic resonance shifts for determination of protein structure in solution: EF calcium binding site of carp parvalbumin, Biochemistry 22, 4366-4373.
35. Bertini, I., Luchinat, C., Parigi, G., and Pierattelli, R. (2005) NMR spectroscopy of paramagnetic metalloproteins, ChemBioChem 6, 1536-1549.
36. Denley, A., Wang, C. C., McNeil, K. A., Walenkamp, M. J., van Duyvenvoorde, H., Wit, J. M., Wallace, J. C., Norton, R. S., Karperien, M., and Forbes, B. E. (2005) Structural and functional characteristics of the Val44Met insulin-like growth factor I missense mutation: correlation with effects on growth and development, Mol. Endocrinol. 19, 711-721.
37. Huang, X., Yang, X., Luft, B. J., and Koide, S. (1998) NMR identification of epitopes of Lyme disease antigen OspA to monoclonal antibodies, J. Mol. Biol. 281, 61-67.
38. Ding, W., Huang, X., Yang, X., Dunn, J. J., Luft, B. J., Koide, S., and Lawson, C. L. (2000) Structural identification of a key protective B-cell epitope in Lyme disease antigen OspA, J. Mol. Biol. 302, 1153-1164.
39. Fielding, L. (2003) NMR methods for the determination of protein-ligand dissociation constants, Curr. Top. Med. Chem. 3, 39-53.
40. Dunker, A. K., Lawson, J. D., Brown, C. J., Williams, R. M., Romero, P., Oh, J. S., Oldfield, C. J., Campen, A. M., Ratliff, C. M., Hipps, K. W., J., A., Nissen, M. S., Reeves, R., Kang, C., Kissinger, C. R., Bailey, R. W., Griswold, M. D., Chiu, W., Garner, E. C., and Obradovic, Z. (2001) Intrinsically disordered protein, J. Mol. Graphics Modell. 19, 26-59.
41. Dyson, H. J., and Wright, P. E. (2005) Intrinsically unstructured proteins and their functions, Nat. Rev. Mol. Cell Biol. 6, 197-208.
42. Jonker, H. R., Wechselberger, R. W., Boelens, R., Kaptein, R., and Folkers, G. E. (2006) The intrinsically unstructured domain of PC4 modulates the activity of the structured core through inter- and intramolecular interactions, Biochemistry 45, 5067-5081.
43. Headey, S. J., Leeding, K. S., Norton, R. S., and Bach, L. A. (2004) Contributions of the N- and C-terminal domains of IGF binding protein-6 to IGF binding, J. Mol. Endocrinol. 33, 377-386.
44. Shoemaker, B. A., Portman, J. J., and Wolynes, P. G. (2000) Speeding molecular recognition by using the folding funnel: the fly-casting mechanism, Proc. Natl. Acad. Sci. U.S.A. 97, 8868-8873.
45. Levy, Y., Cho, S. S., Onuchic, J. N., and Wolynes, P. G. (2005) A survey of flexible protein binding mechanisms and their transition states using native topology based energy landscapes, J. Mol. Biol. 346, 1121-1145.
46. 1H chemical shifts obtained as a function of temperature and trifluoroethanol concentration for the peptide series GGXGG, J. Biomol. NMR 5, 14-24.