The intrinsically unstructured domain of PC4 modulates the activity of the structured core through inter- and intramolecular interactions

Biochemistry

Volumn 45, Issue 15, 2006, Pages 5067-5081

  Jonker, Hendrik R A ^a   Wechselberger, Rainer W ^a   Boelens, Rolf ^a   Kaptein, Rob ^a   Folkers, Gert E ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BIOCHEMISTRY; DNA; DOCKING; NUCLEAR MAGNETIC RESONANCE; SUBSTRATES;

INTRAMOLECULAR INTERACTIONS; PC4 MODULATES; STRUCTURED CORE; UNSTRUCTURED DOMAIN;

PROTEINS;

CORE PROTEIN; DOUBLE STRANDED DNA; POSITIVE COFACTOR 4; PROTEIN VP16; SINGLE STRANDED DNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ACTIVATION DOMAIN; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; DNA DENATURATION; HERPES SIMPLEX VIRUS; MODULATION; MOLECULAR INTERACTION; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN DOMAIN; PROTEIN STRUCTURE; STRUCTURED PROTEIN DOMAIN; UNSTRUCTURED PROTEIN DOMAIN;

BINDING SITES; DNA; DNA, SINGLE-STRANDED; DNA-BINDING PROTEINS; HERPES SIMPLEX VIRUS PROTEIN VMW65; HUMANS; LYSINE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

HERPES; SIMPLEXVIRUS;

EID: 33645935390     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi052531b     Document Type: Article

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