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Volumn 46, Issue 5, 2007, Pages 1778-1788

A reductionist biomimetic model system that demonstrates highly effective Zn(II)-catalyzed cleavage of an RNA model

Author keywords

[No Author keywords available]

Indexed keywords

2 (HYDROXYPROPYL) 4 NITROPHENYL PHOSPHATE; 2-(HYDROXYPROPYL)-4-NITROPHENYL PHOSPHATE; 4 NITROPHENOL; 4-NITROPHENOL; ALCOHOL; METHANOL; NITROPHENOL; ORGANOMETALLIC COMPOUND; ORGANOPHOSPHORUS COMPOUND; UNCLASSIFIED DRUG; ZINC;

EID: 33947400529     PISSN: 00201669     EISSN: None     Source Type: Journal    
DOI: 10.1021/ic062065u     Document Type: Article
Times cited : (21)

References (100)
  • 4
    • 21844455264 scopus 로고    scopus 로고
    • (d) Weston, J. Chem. Rev. 2005, 105, 2151.
    • (2005) Chem. Rev , vol.105 , pp. 2151
    • Weston, J.1
  • 5
  • 35
    • 20644450999 scopus 로고    scopus 로고
    • and references therein
    • (m) Suh, J.; Hong, S. H. J. Am. Chem. Soc. 1998, 120, 12545 and references therein.
    • (1998) J. Am. Chem. Soc , vol.120 , pp. 12545
    • Suh, J.1    Hong, S.H.2
  • 51
    • 0033586658 scopus 로고    scopus 로고
    • 3.
    • 3.
  • 52
    • 33947427646 scopus 로고    scopus 로고
    • A criterion for a bifunctional behavior of the metal-bound hydroxide catalyst is that the second-order rate constant for a given process exceeds that of HO- itself. Whereas there are some reports where the dinuclear Zn2+ or Cu2+ complexes can be more effective than hydroxide in promoting the hydrolysis of phosphates diesters such as bis(p-nitrophenyl) phosphate4v or 2′, 3′-cyclicAMP,4u there are few where the complexes effect the cyclization of 1 much better than HO
    • -.
  • 54
    • 33947371400 scopus 로고    scopus 로고
    • spH is used.
    • spH is used.
  • 55
    • 33947420566 scopus 로고    scopus 로고
    • -1).
    • -1).
  • 56
    • 33947405864 scopus 로고    scopus 로고
    • Although it can be equally applied to science, reductionism is a term coined in the art world where it is believed by some that Most significant painting, has been reductive, for the artist's] analysis breaks the original complete scene into parts or separate dimensions of visual experience; reductionism is the concentration on or the preoccupation with the refinement of one dimension or aspect, see: Vitz, P. C, Glimcher, A. B. Modern Art and Modern Science, The Parallel Analysis of Vision; Praeger: New York, 1984; pp 6-29
    • Although it can be equally applied to science, reductionism is a term coined in the art world where it is believed by some that "Most significant painting... has been reductive, [for the artist's] analysis breaks the original complete scene into parts or separate dimensions of visual experience; reductionism is the concentration on or the preoccupation with the refinement of one dimension or aspect", see: Vitz, P. C.; Glimcher, A. B. Modern Art and Modern Science, The Parallel Analysis of Vision; Praeger: New York, 1984; pp 6-29.
  • 59
    • 4644340182 scopus 로고    scopus 로고
    • e is a bulk macroscopic property resulting from an isotropic average of a large number of solvent molecules, whereas the situation within the active site of an enzyme, due to the molecular dimensions, is controlled more by specific interactions. See: Richard, J. P.; Ames, T. L. Bioorg. Chem. 2004, 32, 354.
    • e is a bulk macroscopic property resulting from an isotropic average of a large number of solvent molecules, whereas the situation within the active site of an enzyme, due to the molecular dimensions, is controlled more by specific interactions. See: Richard, J. P.; Ames, T. L. Bioorg. Chem. 2004, 32, 354.
  • 61
    • 33947426857 scopus 로고    scopus 로고
    • 19b. (b) Chin, K. O. A.; Morrow, J. R. Inorg. Chem. 1994, 33, 5036.
    • 19b. (b) Chin, K. O. A.; Morrow, J. R. Inorg. Chem. 1994, 33, 5036.
  • 62
    • 0033011842 scopus 로고    scopus 로고
    • Interesting studies of this reaction showing the dramatic effects of metal ion in nonaqueous media have also been reported, however, without detailed analysis or consideration of pH effects: (a) Kondo, S.-I, Yoshida, K, Yano, Y. J. Chem. Res, Synop. 1999, 106. Authors reported that Zn(II) and Cu(II) accelerate the cyclization of 1 in acetonitrile by 10 5-6-fold relative to the situation without metal ion, but the addition of even a few percent of water slows down the reaction due to a weakening of the electrophilicity of the metal ions
    • 5-6-fold relative to the situation without metal ion, but the addition of even a few percent of water slows down the reaction "due to a weakening of the electrophilicity of the metal ions".
  • 63
    • 0033531363 scopus 로고    scopus 로고
    • 239. Authors describe a Zr(IV) complex promoting the cyclization of 1 benzene-methanol
    • (b) Stulz, E.; Leuman, C. Chem. Commun. 1999, 239. Authors describe a Zr(IV) complex promoting the cyclization of 1 in benzene-methanol.
    • (1999) Chem. Commun
    • Stulz, E.1    Leuman, C.2
  • 65
    • 0042329190 scopus 로고    scopus 로고
    • spH, definition of terms, and titration of metal ions in methanol see: Gibson, G.; Neverov, A. A.; Brown, R. S. Can. J. Chem. 2003, 81, 495.
    • spH, definition of terms, and titration of metal ions in methanol see: Gibson, G.; Neverov, A. A.; Brown, R. S. Can. J. Chem. 2003, 81, 495.
  • 66
    • 33947359578 scopus 로고    scopus 로고
    • spH and titration of metal ions in ethanol see: Gibson, G. T. T.; Mohamed, M. F.; Neverov, A. A.; Brown, R. S. Inorg. Chem., in press.
    • spH and titration of metal ions in ethanol see: Gibson, G. T. T.; Mohamed, M. F.; Neverov, A. A.; Brown, R. S. Inorg. Chem., in press.
  • 67
    • 0343588496 scopus 로고    scopus 로고
    • 2O) is 7.3.
    • 2O) is 7.3.
  • 68
    • 0037945185 scopus 로고    scopus 로고
    • -1 at 25°C.
    • -1 at 25°C.
  • 72
    • 33947385542 scopus 로고    scopus 로고
    • Equation 1 was obtained from the equations for equilibrium binding and for conservation of mass by using the commercially available MAPLE software, Maple V, Release 5; Waterloo Maple, Inc, Waterloo, ON, Canada
    • Equation 1 was obtained from the equations for equilibrium binding and for conservation of mass by using the commercially available MAPLE software, Maple V, Release 5; Waterloo Maple, Inc.: Waterloo, ON, Canada.
  • 74
    • 33947364929 scopus 로고    scopus 로고
    • 2, added in the indicated order, is 8.2.
    • 2, added in the indicated order, is 8.2.
  • 76
    • 33947407808 scopus 로고    scopus 로고
    • -1.
    • -1.
  • 77
    • 0004270702 scopus 로고
    • 4th ed, McGraw-Hill, Inc, New York
    • Levine, I. N. Physical Chemistry, 4th ed.; McGraw-Hill, Inc.: New York, 1978; pp 276-281.
    • (1978) Physical Chemistry , pp. 276-281
    • Levine, I.N.1
  • 78
    • 0003422522 scopus 로고
    • The Physical Chemistry of Electrolytic Solutions
    • 3rd ed, Reinhold Publishing: New York
    • Harned, H. S.; Owen, B. B. The Physical Chemistry of Electrolytic Solutions; ACS Monograph Series 137, 3rd ed.; Reinhold Publishing: New York, 1957; p 161.
    • (1957) ACS Monograph Series , vol.137 , pp. 161
    • Harned, H.S.1    Owen, B.B.2
  • 96
    • 33947427261 scopus 로고    scopus 로고
    • -1.
    • -1.
  • 97
    • 25844462886 scopus 로고    scopus 로고
    • Feng, G.; Marque-Rivas, J. C.; Torres, Martín de Rosales, R.; Williams, N. H. J. Am Chem. Soc. 2005, 127, 13470.
    • Feng, G.; Marque-Rivas, J. C.; Torres, Martín de Rosales, R.; Williams, N. H. J. Am Chem. Soc. 2005, 127, 13470.
  • 100
    • 33750626211 scopus 로고    scopus 로고
    • 6-fold acceleration over the background reaction at pH 7.4.
    • 6-fold acceleration over the background reaction at pH 7.4.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.