Testosterone and coronary vascular tone: Implications in coronary artery disease

Journal of Endocrinological Investigation

Volumn 26, Issue 2, 2003, Pages 181-186

  Wynne, F L ^a   Khalil, Raouf A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Androgens; Coronary artery; Endothelium; Signal transduction; Smooth muscle

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 4 AMINOPYRIDINE; ANDROGEN; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL STIMULATING AGENT; CALCIUM ION; CYCLIC GMP; GLIBENCLAMIDE; INDOMETACIN; LIPOPROTEIN; N(G) NITROARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PHENYLEPHRINE; POTASSIUM CHANNEL BLOCKING AGENT; PROSTAGLANDIN F2 ALPHA; PROSTAGLANDIN SYNTHASE INHIBITOR; PROTEIN KINASE; SEX HORMONE; TESTOSTERONE; TETRYLAMMONIUM;

ATHEROGENESIS; BLOOD VESSEL TONE; CORONARY ARTERY DISEASE; DRUG EFFECT; DRUG MEGADOSE; ENDOTHELIUM; FEMALE; GENOME; HORMONE RECEPTOR INTERACTION; HUMAN; HYPERPOLARIZATION; INCIDENCE; LIPOPROTEIN BLOOD LEVEL; MALE; NONHUMAN; REVIEW; SEX DIFFERENCE; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CONTRACTION; VASOCONSTRICTION; VASODILATATION;

EID: 0037313895     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03345150     Document Type: Review

References (23)

1. Dickerman R.D., McConathy W.J., Zachariah N.Y. Testosterone, sex hormone-binding globulin, lipoproteins, and vascular disease risk. J. Cardiovasc. Risk 1997, 4: 363-366.
2. Reckelhoff JF., Zhang H., Srivastava K., Granger J.P. Gender differences in hypertension in spontaneously hypertensive rats: Role of androgens and androgen receptor. Hypertension 1999, 34: 920-923.
3. Thompson P.D., Ahlberg A.W., Moyna N.M. et al. Effect of intravenous testosterone on myocardial ischemia in men with coronary artery disease. Am. Heart J. 2002, 143: 249-256.
4. English K.M., Mandour O., Steeds R.P., Diver M.J., Jones T.H., Channer K.S. Men with coronary artery disease have lower levels of androgens than men with normal coronary angiograms. Eur. Heart J. 2000, 21: 890-894.
5. Tripathy D., Shah P., Lakshmy R., Reddyu K.S. Effect of testosterone replacement on whole body glucose utilisation and other cardiovascular risk factors in males with idiopathic hypogonadotrophic hypogonadism. Horm. Metab. Res. 1998, 30: 642-645.
6. Higashiura K., Mathur R.S., Halushka P.V. Gender-related differences in androgen regulation of thromboxane A2 receptors in rat aortic smooth-muscle cells. J. Cardiovasc. Pharmacol. 1997, 29: 311-315.
7. Schror K., Morinellii T.A., Masuda A., Matsuda K., Mathur R.S., Halushka P.V. Testosterone treatment enhances thromboxane A2 mimetic induced coronary artery vasoconstriction in guinea pigs. Eur. J. Clin. Invest. 1994, 24: 50-52.
8. Quann A., Teoh H., Man R.Y. Acute exposure to a low level of testosterone impairs relaxation in porcine coronary arteries. Clin. Exp. Pharmacol. Physiol. 1999, 26: 830-832.
9. Farhat M.Y., Wolfe R., Vargas R., Foegh M.L., Ramwell P.W. Effect of testosterone treatment on vasoconstrictor response of left anterior descending coronary artery in male and female pigs. J. Cardiovasc. Pharmacol. 1995, 25: 495-500.
10. Rosano G.M., Leonardo F., Pagnotta P. et al. Acute anti-ischemic effect of testosterone in men with coronary artery disease. Circulation 1999, 99: 1666-1670.
11. Webb C.M., McNeill J.G., Hayward C.S., De Zeigler D., Collins P. Effects of testosterone on coronary vasomotor regulation in men with coronary heart disease. Circulation 1999, 100: 1690-1696.
12. Yue P., Chatterjee K., Beale C., Poole-Wilson P.A., Collins P. Testosterone relaxes rabbit coronary arteries and aorta. Circulation 1995, 91: 1154-1160.
13. Chou T.M., Sudhir K., Hutchison S.J. et al. Testosterone induces dilation of canine coronary conductance and resistance arteries in vivo. Circulation 1996, 94: 2614-2619.
14. 2+ entry mechanisms of coronary vasoconstriction. Arterioscler. Thromb. Vasc. Biol. 1999, 19: 1034-1040.
15. Murphy J.G., Khalil R.A. Decreased [Ca2+]i during inhibition of coronary smooth muscle contraction by 17β-estradiol, progesterone, and testosterone. J. Pharmacol. Exp. Ther. 1999, 291: 44-52.
16. Teoh H., Quan A., Man R.Y. Acute impairment of relaxation by low levels of testosterone in porcine coronary arteries. Cardiovasc. Res. 2000, 45: 1010-1018.
17. Deenadayalu V.P., White R.E., Stallone J.N., Gao X., Garcia A.J. Testosterone relaxes coronary arteries by opening the large-conductance, calcium-activated potassium channel. Am. J. Physiol. Heart Circ. Physiol. 2001, 281: H1720
18. Honda H., Unemoto T., Kogo H. Different mechanisms for testosterone-induced relaxation of aorta between normotensive and spontaneously hypertensive rats. Hypertension 1999, 34: 1232-1236.
19. i in vascular smooth muscle cells of female rat. Am. J. Physiol. Cell Physiol. 2000, 278: C834-C844.
20. + channel activation. J. Appl. Physiol. 2001, 91: 2742-2750.
21. Kanashiro C.A., Khalil R.A. Gender-related distinctions in protein kinase C activity in rat vascular smooth muscle. Am. J. Physiol. Cell Physiol. 2001, 280: C34-C45.
22. English K.M., Jones R.D., Jones T.H., Morice A.H., Channer K.S. Aging reduces the responsiveness of coronary arteries from male Wistar rats to the vasodilatory action of testosterone. Clin. Sci. (Lond). 2000, 99: 77-82.
23. Rako S. Testosterone deficiency: A key factor in the increased cardiovascular risk to women following hysterectomy or with natural aging? J. Womens Health 1998, 7: 825-829.