The effect of a methyl or 2-fluoroethyl substituent at the N-3 position of thymidine, 3′-fluoro-3′-deoxythymidine and 1-β-D- arabinosylthymine on their antiviral and cytostatic activity in cell culture

Antiviral Chemistry and Chemotherapy

Volumn 17, Issue 1, 2006, Pages 17-23

  Balzarini, Jan ^a   Celen, Sofie ^b   Karlsson, Anna ^c   De Groot, Tjibbe ^b   Verbruggen, Alfons ^b   Bormans, Guy ^b  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

ara T; FLT; HIV; HSV; N 3 substituted Thd analogues; Thymidine kinase

Indexed keywords

1 BETA DEXTRO ARABINOSYLTHYMINE; 3' FLUOROTHYMIDINE; N 3 (2 FLUOROETHYL) 1 BETA DEXTRO ARABINOSYLTHYMINE; N 3 (2 FLUOROETHYL) 3' FLUORO 3' DEOXYTHYMIDINE; N 3 (2 FLUOROETHYL)THYMIDINE; N 3 METHYL 1 BETA DEXTRO ARABINOSYLTHYMINE; N 3 METHYL 3' FLUORO 3' DEOXYTHYMIDINE; N 3 METHYLTHYMIDINE; THYMIDINE DERIVATIVE; THYMINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; CYTOSTASIS; DRUG INHIBITION; DRUG STRUCTURE; DRUG SYNTHESIS; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

EID: 33344457445     PISSN: 09563202     EISSN: None     Source Type: Journal    
DOI: 10.1177/095632020601700103     Document Type: Article

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