Phosphorylation of sodium channels mediated by protein kinase-C modulates inhibition by topiramate of tetrodotoxin-sensitive transient sodium current

British Journal of Pharmacology

Volumn 150, Issue 6, 2007, Pages 792-797

  Curia, G ^a,b   Aracri, P ^a   Colombo, E ^a   Scalmani, P ^a   Mantegazza, M ^a   Avanzini, G ^a   Franceschetti, S ^a  

^a DEPARTMENT OF NEUROSURGERY   (Italy)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Antiepileptic drug; PKC; Sodium channel; Topiramate; Transient Na + current

Indexed keywords

GLYCEROL 2 ACETATE 1 OLEATE; PROTEIN KINASE C; SODIUM CHANNEL; TETRODOTOXIN; TOPIRAMATE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DISSOCIATION; DRUG EFFECT; ENZYME ACTIVATION; HYPERPOLARIZATION; NERVE CELL; NONHUMAN; PATCH CLAMP; PERFUSION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SENSORIMOTOR CORTEX; SODIUM CURRENT; STEADY STATE; WHOLE CELL;

ANIMALS; ANTICONVULSANTS; BRAIN; DIGLYCERIDES; FRUCTOSE; MEMBRANE POTENTIALS; MOTOR CORTEX; PATCH-CLAMP TECHNIQUES; PHOSPHORYLATION; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNELS; TETRODOTOXIN;

EID: 33947303190     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0707144     Document Type: Article

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