Neutralization of the haemorrhagic activities of viperine snake venoms and venom metalloproteinases using synthetic peptide inhibitors and chelators

Toxicon

Volumn 49, Issue 5, 2007, Pages 734-739

  Howes, J M ^a   Theakston, R D G ^a   Laing, G D ^a  

^a LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

Author keywords

Chelator; Echis; Haemorrhagic activity; Metalloproteinase; Peptide inhibitor; Snake venom

Indexed keywords

CGS 27023A; CHELATING AGENT; EDETIC ACID; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; MARIMASTAT; METAL ION; METALLOPROTEINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PRINOMASTAT; SYNTHETIC PEPTIDE; TANOMASTAT; VIPER VENOM;

ANIMAL EXPERIMENT; ARTICLE; BLEEDING; CONTROLLED STUDY; ENVENOMATION; EVALUATION; INHIBITION KINETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SNAKE;

ANIMALS; CHELATING AGENTS; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, LIQUID; EDETIC ACID; EGTAZIC ACID; ETHYLENEDIAMINES; EVALUATION STUDIES; HEMORRHAGE; HYDROXAMIC ACIDS; METALLOPROTEASES; MICE; MOLECULAR STRUCTURE; ORGANIC CHEMICALS; PROTEIN KINASE INHIBITORS; PYRAZINES; SNAKE BITES; STATISTICS, NONPARAMETRIC; SULFONAMIDES; VIPER VENOMS;

ECHIS; ECHIS CARINATUS; ECHIS OCELLATUS; MAMMALIA; VIPERINAE;

EID: 33947302585     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2006.11.020     Document Type: Article

References (40)

1. Beckett R.P., and Whittaker M. Matrix metalloproteinase inhibitors. Curr. Opin. Ther. Pat. 8 (1998) 259-282
2. Bjarnason J.B., and Tu A.T. Haemorrhagic toxins from Western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in haemorrhagic toxin e. Biochemistry 17 (1978) 3395-3404
3. Borkow G., Gutiérrez J.M., and Ovadia M. Isolation and characterization of synergistic hemorrhagins from the venom of the snake Bothrops asper. Toxicon 31 (1993) 1137-1150
4. Borkow G., Gutiérrez J.M., and Ovadia M. Inhibition of the hemorrhagic activity of Bothrops asper venom by a novel neutralizing mixture. Toxicon 35 (1997) 865-877
5. Chau I., Rigg A., and Cunningham D. Matrix metalloproteinase inhibitors-an emphasis on gastrointestinal malignancies. Crit. Rev. Oncol. Hematol. 45 (2003) 151-176
6. Cheng M., De B., Almstead N.G., Pikul S., Dowty M.E., Dietsch C.R., Dunaway C.M., Gu F., Hsieh L.C., Janusz M.J., Taiwo Y.O., and Natchus M.G. Design, synthesis, and biological evaluation of matrix metalloproteinase inhibitors derived from a modified proline scaffold. J. Med. Chem. 42 (1999) 5426-5436
7. Chippaux J.P., Stock R.P., and Alagon A. Report of the 2nd International Conference on Envenomations in Africa (Deuxieme Colloque International sur les envenomations en Afrique). Toxicon 46 (2005) 115-118
8. Escalante T., Franceschi A., Rucavado A., and Gutierrez J.M. Effectiveness of batimastat, a synthetic inhibitor of matrix metalloproteinases, in neutralizing local tissue damage induced by BaP1, a hemorrhagic metalloproteinase from the venom of the snake Bothrops asper. Biochem. Pharmacol. 60 (2000) 269-274
9. Galis Z.S., and Khatri J.J. Matrix metalloproteinases in vascular remodelling and atherogenesis: the good, the bad, and the ugly. Circ. Res. 90 (2002) 251-262
10. Gay C.C., Leiva L.C., Marunak S., Teibler P., and Acosta de Perez O. Proteolytic, edematogenic and myotoxic activities of a hemorrhagic metalloproteinase isolated from Bothrops alternatus venom. Toxicon 46 (2005) 546-554
11. Gong W., Zhu X., Liu S., Teng M., and Niu L. Crystal structures of acutolysin A, a three-disulfide hemorrhagic zinc metalloproteinase from the snake venom of Agkistrodon acutus. J. Mol. Biol. 283 (1998) 657-668
12. Gutiérrez J.M., and Rucavado A. Snake venom metalloproteinases: their role in the pathogenesis of local tissue damage. Biochimie 82 (2000) 841-850
13. Gutiérrez J.M., Romero M., Diaz C., Borkow G., and Ovadia M. Isolation and characterization of a metalloproteinase with weak hemorrhagic activity from the venom of the snake Bothrops asper (terciopelo). Toxicon 33 (1995) 19-29
14. Gutiérrez J.M., Leon G., Rojas G., Lomonte B., Rucavado A., and Chaves F. Neutralization of local tissue damage induced by Bothrops asper (terciopelo) snake venom. Toxicon 36 (1998) 1529-1538
15. Gutierrez J.M., Rojas E., Quesada L., Leon G., Nunez J., Laing G.D., Sasa M., Renjifo J.M., Nasidi A., Warrell D.A., Theakston R.D.G., and Rojas G. Pan-African polyspecific antivenom produced by caprylic acid purification of horse IgG: an alternative to the antivenom crisis in Africa. Trans. Roy. Soc. Trop. Med. Hyg. 99 (2005) 468-475
16. Harrison R.A., Oliver J., Hasson S.S., Bharati K., and Theakston R.D.G. Novel sequences encoding venom C-type lectins are conserved in phylogenetically and geographically distinct Echis and Bitis viper species. Gene 315 (2003) 95-102
17. Harrison R.A., Wuster W., and Theakston R.D.G. The conserved structure of snake venom toxins confers extensive immunological cross-reactivity to toxin-specific antibody. Toxicon 41 (2003) 441-449
18. Harrison R.A. Development of venom toxin-specific antibodies by DNA immunisation: rationale and strategies to improve therapy of viper envenoming. Vaccine 22 (2004) 1648-1655
19. Heath E.I., and Grochow L.B. Clinical potential of matrix metalloprotease inhibitors in cancer therapy. Drugs 59 (2000) 1043-1055
20. Hidalgo M., and Eckhardt S.G. Development of matrix metalloproteinase inhibitors in cancer therapy. J. Natl. Cancer Instrum. 93 (2001) 178-193
21. Howes J.-M., Wilkinson M.C., Theakston R.D.G., and Laing G.D. The purification and partial characterisation of two novel metalloproteinases from the venom of the West African carpet viper, Echis ocellatus. Toxicon 42 (2003) 21-27
22. Howes J.-M., Kamiguti A.S., Theakston R.D.G., Wilkinson M.C., and Laing G.D. Effects of three novel metalloproteinases from the venom of the West African saw-scaled viper, Echis carinatus on blood coagulation and platelets. Biochim. Biophys. Act. Gen. Sub. 1724 (2005) 194-202
23. Iddon D., Theakston R.D.G., and Ownby C.L. A study of local necrosis induced by Naja nigricollis (spitting cobra) venom using simple histological staining techniques. Toxicon 25 (1987) 665-672
24. Jagadeesha D.K., Shashidhara murthy R., Girish K.S., and Kemparaju K. A non-toxic anticoagulant metalloprotease: purification and characterization from Indian cobra (Naja naja naja) venom. Toxicon 40 (2002) 667-675
25. Jia L.G., Wang X.M., Shannon J.D., Bjarnason J.B., and Fox J.W. Function of disintegrin-like/cysteine-rich domains of atrolysin A. Inhibition of platelet aggregation by recombinant protein and peptide antagonists. J. Biol. Chem. 272 (1997) 13094-13102
26. Laing G.D., Renjifo J.M., Ruiz F., Harrison R.A., Nasidi A., Gutierrez J.-M., Rowley P.D., Warrell D.A., and Theakston R.D.G. A new pan-African polyspecific antivenom developed in response to the antivenom crisis in Africa. Toxicon 42 (2003) 35-41
27. Lalloo D.G., and Theakston R.D.G. Snake antivenoms. J. Toxin. 41 (2003) 277-290
28. Leon G., Estrada R., Chaves F., Rojas G., Ovadia M., and Gutierrez J.M. Inhibition by CaNa2EDTA of local tissue damage induced by Bothrops asper (terciopelo) venom: application in horse immunization for antivenom production. Toxicon 36 (1998) 321-331
29. Mazzi M.V., Marcussi S., Carlos G.B., Stabeli R.G., Franco J.J., Ticli F.K., Cintra A.C., Franca S.C., Soares A.M., and Sampaio S.V. A new hemorrhagic metalloprotease from Bothrops jararacussu snake venom: isolation and biochemical characterization. Toxicon 44 (2004) 215-223
30. Moura-da-Silva A.M., Laing G.D., Paine M.J.I., Dennison J.M.T.J., Politi V., Crampton J.M., and Theakston R.D.G. Processing of pro-tumour necrosis factor-α. Eur. J. Immunol. 26 (1996) 2000-2005
31. Nagase H., and Woessner Jr. J.F. Matrix metalloproteinases. J. Biol. Chem, 274 (1999) 21491-21494
32. Pugh R.N.H., and Theakston R.D.G. A clinical study of viper bite poisoning. Ann. Trop. Med. Parasitol. 81 (1987) 135-149
33. Rucavado A., Escalante T., Franceschi A., Chaves F., Leon G., Cury Y., Ovadia M., and Gutiérrez J.M. Inhibition of local hemorrhage and dermonecrosis induced by Bothrops asper snake venom: effectiveness of early in situ administration of the peptidomimetic metalloproteinase inhibitor batimastat and the chelating agent CaNa2EDTA. Am. J. Trop. Med. Hyg. 63 (2000) 313-319
34. Rucavado A., Escalante T., and Gutiérrez J.M. Effect of the metalloproteinase inhibitor batimastat in the systemic toxicity induced by Bothrops asper snake venom: understanding the role of metalloproteinases in envenomation. Toxicon 43 (2004) 417-424
35. Sugita K. Recent advances in inhibitors of matrix metalloproteinases for cancer therapy. IDrugs 2 (1999) 327-339
36. Tan N.-H., and Ponnudurai G. A comparative study of the biological properties of venoms of some old world vipers (subfamily viperinae). Int. J. Biochem. 24 (1992) 331-336
37. Theakston R.D.G., and Reid H.A. Development of simple assay procedures for the characterisation of snake venoms. Bull. WHO 61 (1983) 949-956
38. Warrell D.A., Davidson N.McD., Greenwood B.M., Omerod L.D., Pope H.M., Watkins B.J., and Prentice C.R.M. Poisoning by bites of the saw-scaled or Carpet viper (Echis carinatus) in Nigeria. Quart. J. Med. 181 (1977) 33-62
39. Yip D., Ahmad A., Karapetis C.S., Hawkins C.A., and Harper P.G. Matrix metalloproteinase inhibitors: applications in oncology. Invest. New Drugs 17 (1999) 387-399
40. Zhang D., Botos I., Gomis-Ruth F.X., Doll R., Blood C., Njoroge F.G., Fox J.W., Bode W., and Meyer E.F. Structural interaction of natural and synthetic inhibitors with the venom metalloproteinase, atrolysin C (form d). Proc. Natl. Acad. Sci. USA 91 (1994) 8447-8451