메뉴 건너뛰기




Volumn 17, Issue 4, 1999, Pages 387-399

Matrix metalloproteinase inhibitors: Applications in oncology

Author keywords

Angiogenesis; Arthritis; Cancer; Clinical trials; Collagenase; Matrix metalloproteinase inhibitors

Indexed keywords

CYTOTOXIC AGENT; GEMCITABINE; MARIMASTAT; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; SCLEROPROTEIN;

EID: 0033494157     PISSN: 01676997     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1006386406584     Document Type: Review
Times cited : (92)

References (84)
  • 1
    • 0026522287 scopus 로고
    • The role of proteolytic enzymes in cancer invasion and metastasis
    • Duffy M: The role of proteolytic enzymes in cancer invasion and metastasis. Clin Exp Metastasis 10: 145-155, 1992
    • (1992) Clin Exp Metastasis , vol.10 , pp. 145-155
    • Duffy, M.1
  • 2
    • 0024421549 scopus 로고
    • Metalloproteinases and cancer invasion and metastasis
    • Murphy G, Reynolds J, Hembrey R: Metalloproteinases and cancer invasion and metastasis (letter). Int J Cancer 44: 757-760, 1989
    • (1989) Int J Cancer , vol.44 , pp. 757-760
    • Murphy, G.1    Reynolds, J.2    Hembrey, R.3
  • 3
    • 0032512914 scopus 로고    scopus 로고
    • Mechanisms of tumour metastasis
    • Meyer T, Hart IR: Mechanisms of tumour metastasis. Eur J Cancer 34: 214-221, 1998
    • (1998) Eur J Cancer , vol.34 , pp. 214-221
    • Meyer, T.1    Hart, I.R.2
  • 4
    • 0019195010 scopus 로고
    • Metastatic potential correlates with enzymatic degradation of basement membrane collagen
    • Liotta L, Tryggvason K, Garbisa S, Hart I, Foltz C, Shafie S: Metastatic potential correlates with enzymatic degradation of basement membrane collagen. Nature 284: 67-68, 1980
    • (1980) Nature , vol.284 , pp. 67-68
    • Liotta, L.1    Tryggvason, K.2    Garbisa, S.3    Hart, I.4    Foltz, C.5    Shafie, S.6
  • 5
    • 0026131489 scopus 로고
    • Augmentation of type IV collagenase, laminin receptor and Ki67 proliferation antigen associated with human colon, gastric and breast carcinoma progression
    • D'Errico A, Garbisa S, Liotta L, Castronovo V, Stetler-Stevenson W, Grigioni W: Augmentation of type IV collagenase, laminin receptor and Ki67 proliferation antigen associated with human colon, gastric and breast carcinoma progression. Mod Pathol 4: 239-246, 1991
    • (1991) Mod Pathol , vol.4 , pp. 239-246
    • D'Errico, A.1    Garbisa, S.2    Liotta, L.3    Castronovo, V.4    Stetler-Stevenson, W.5    Grigioni, W.6
  • 8
    • 0030801093 scopus 로고    scopus 로고
    • Imbalance of expression of matrix metalloproteinase (MMPs) and tissue inhibitors of the matrix metalloproteinases (TIMPs) in human pancreatic carcinoma
    • Bramhall S, Neoptolemos J, Stamp G, Lemoine N: Imbalance of expression of matrix metalloproteinase (MMPs) and tissue inhibitors of the matrix metalloproteinases (TIMPs) in human pancreatic carcinoma. J Pathol 182: 347-355, 1997
    • (1997) J Pathol , vol.182 , pp. 347-355
    • Bramhall, S.1    Neoptolemos, J.2    Stamp, G.3    Lemoine, N.4
  • 9
    • 0031824909 scopus 로고    scopus 로고
    • Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancer
    • Murray G, Duncan M, O'Neil P, McKay J, Melvin W, Fothergill J: Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancer. J Pathol 185: 256-261, 1998
    • (1998) J Pathol , vol.185 , pp. 256-261
    • Murray, G.1    Duncan, M.2    O'Neil, P.3    McKay, J.4    Melvin, W.5    Fothergill, J.6
  • 10
    • 0031850120 scopus 로고    scopus 로고
    • Matrix metalloproteinases in gastrointestinal cancer
    • Brown P: Matrix metalloproteinases in gastrointestinal cancer. Gut 43: 161-163, 1998
    • (1998) Gut , vol.43 , pp. 161-163
    • Brown, P.1
  • 11
    • 0033061405 scopus 로고    scopus 로고
    • Matrix metalloproteinases and their inhibitors
    • Kugler A: Matrix metalloproteinases and their inhibitors. Antican Res 19: 1589-1592, 1999
    • (1999) Antican Res , vol.19 , pp. 1589-1592
    • Kugler, A.1
  • 12
    • 0026717181 scopus 로고
    • Suppression of invasion by inducible expression of TIMP-1 in B 16-F10 melanoma cells
    • Khokha R, Zimmer M, Graham S, Lala P, Waterhouse P: Suppression of invasion by inducible expression of TIMP-1 in B 16-F10 melanoma cells. J Natl Cancer Inst 84: 1017-1022, 1992
    • (1992) J Natl Cancer Inst , vol.84 , pp. 1017-1022
    • Khokha, R.1    Zimmer, M.2    Graham, S.3    Lala, P.4    Waterhouse, P.5
  • 13
    • 0026573378 scopus 로고
    • Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloprotineases
    • DeClerck Y, Perez N, Shimada H, Boone T, Langley K, Taylor S: Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloprotineases. Cancer Res 52: 701-708, 1992
    • (1992) Cancer Res , vol.52 , pp. 701-708
    • DeClerck, Y.1    Perez, N.2    Shimada, H.3    Boone, T.4    Langley, K.5    Taylor, S.6
  • 14
    • 0027383944 scopus 로고
    • TIMP-2 inhibits bFGF-induced human microvascular endothelial cell proliferation
    • Murphy A, Unsworth E, Stetler-Stevenson W: TIMP-2 inhibits bFGF-induced human microvascular endothelial cell proliferation. J Cell Physiol 157: 351-358, 1993
    • (1993) J Cell Physiol , vol.157 , pp. 351-358
    • Murphy, A.1    Unsworth, E.2    Stetler-Stevenson, W.3
  • 15
    • 0028275891 scopus 로고
    • Inhibition of angiogenesis by tissue inhibitor of metalloproteinase
    • Johnson J, Kim H, Chesler L, Bouck N, Polverini P: Inhibition of angiogenesis by tissue inhibitor of metalloproteinase. J Cell Physiol 160: 194-202, 1994
    • (1994) J Cell Physiol , vol.160 , pp. 194-202
    • Johnson, J.1    Kim, H.2    Chesler, L.3    Bouck, N.4    Polverini, P.5
  • 16
    • 0033067863 scopus 로고    scopus 로고
    • Matrix-degrading proteases and angiogenesis during development and tumor formation
    • Werb Z, Vu TH, Rinkenberger JL, Coussens LM: Matrix-degrading proteases and angiogenesis during development and tumor formation. Apmis 107: 11-18, 1999
    • (1999) Apmis , vol.107 , pp. 11-18
    • Werb, Z.1    Vu, T.H.2    Rinkenberger, J.L.3    Coussens, L.M.4
  • 17
    • 0026027556 scopus 로고
    • Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
    • Liotta L, Steeg P, Stetley-Stevenson W: Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 65: 327-336, 1991
    • (1991) Cell , vol.65 , pp. 327-336
    • Liotta, L.1    Steeg, P.2    Stetley-Stevenson, W.3
  • 18
    • 33749871965 scopus 로고
    • The experimental study of tumor progression
    • Foulds L: The experimental study of tumor progression. Cancer Res 14: 327-339, 1964
    • (1964) Cancer Res , vol.14 , pp. 327-339
    • Foulds, L.1
  • 19
    • 0024504371 scopus 로고
    • In vitro angiogenesis on the human amniotic membrane: Requirement for bFGF-induced proteinases
    • Mignatti P, Tsuboi R, Robbins E, Rifkin D: In vitro angiogenesis on the human amniotic membrane: Requirement for bFGF-induced proteinases. J Cell Biol 108: 671-682, 1989
    • (1989) J Cell Biol , vol.108 , pp. 671-682
    • Mignatti, P.1    Tsuboi, R.2    Robbins, E.3    Rifkin, D.4
  • 20
    • 0026083903 scopus 로고
    • Tumor angiogenesis correlates with metastasis in invasive breast carcinoma
    • Weidner N, Semple J, Welch W, Folkman J: Tumor angiogenesis correlates with metastasis in invasive breast carcinoma. N Eng J Med 324: 1-8, 1991
    • (1991) N Eng J Med , vol.324 , pp. 1-8
    • Weidner, N.1    Semple, J.2    Welch, W.3    Folkman, J.4
  • 21
    • 0030656475 scopus 로고    scopus 로고
    • Role of matrix metalloproteinases and their inhibitors in pancreatic cancer
    • Evans JD, Ghaneh P, Kawesha A, Neoptolemos JP: Role of matrix metalloproteinases and their inhibitors in pancreatic cancer. Digestion 58: 520-528, 1997
    • (1997) Digestion , vol.58 , pp. 520-528
    • Evans, J.D.1    Ghaneh, P.2    Kawesha, A.3    Neoptolemos, J.P.4
  • 22
    • 0031842208 scopus 로고    scopus 로고
    • Matrix metalloproteinases in cancer: Prognostic markers and targets for therapy
    • Duffy MJ, McCarthy K: Matrix metalloproteinases in cancer: prognostic markers and targets for therapy. Int J Oncol 12: 1343-1348, 1998
    • (1998) Int J Oncol , vol.12 , pp. 1343-1348
    • Duffy, M.J.1    McCarthy, K.2
  • 24
    • 0030484702 scopus 로고    scopus 로고
    • Role of integrins in angiogenesis
    • Brooks PC: Role of integrins in angiogenesis. Eur J Cane 32A: 2423-2429, 1996
    • (1996) Eur J Cane , vol.32 A , pp. 2423-2429
    • Brooks, P.C.1
  • 25
    • 0010712792 scopus 로고    scopus 로고
    • Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity
    • Brooks PC, Silletti S, von Schalscha TL, Friedlander M, Cheresh DA: Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity. Cell 92: 391-400, 1998
    • (1998) Cell , vol.92 , pp. 391-400
    • Brooks, P.C.1    Silletti, S.2    Von Schalscha, T.L.3    Friedlander, M.4    Cheresh, D.A.5
  • 26
    • 0032529241 scopus 로고    scopus 로고
    • Remodeling of collagen matrix by human tumor cells requires activation and cell surface association of matrix metalloproteinase-2
    • Deruygina E, Bourdon M, Reisfeld R, Strongin A: Remodeling of collagen matrix by human tumor cells requires activation and cell surface association of matrix metalloproteinase-2. Cancer Res 58: 3743-3750, 1998
    • (1998) Cancer Res , vol.58 , pp. 3743-3750
    • Deruygina, E.1    Bourdon, M.2    Reisfeld, R.3    Strongin, A.4
  • 27
    • 0032401846 scopus 로고    scopus 로고
    • SPARC/Osteonectin induces matrix metalloproteinase 2 activation in human breast cancer cell lines
    • Gilles C, Bassuk J, Pulyaeva H, Sage E, Foidart J-M, Thompson E: SPARC/Osteonectin induces matrix metalloproteinase 2 activation in human breast cancer cell lines. Cancer Res 58: 5529-5536, 1998
    • (1998) Cancer Res , vol.58 , pp. 5529-5536
    • Gilles, C.1    Bassuk, J.2    Pulyaeva, H.3    Sage, E.4    Foidart, J.-M.5    Thompson, E.6
  • 28
    • 0029586589 scopus 로고
    • Matrix metalloproteinase inhibition: A review of anti-tumour activity
    • Brown PD, Giavazzi R: Matrix metalloproteinase inhibition: a review of anti-tumour activity. Ann Oncol 6: 967-974, 1995
    • (1995) Ann Oncol , vol.6 , pp. 967-974
    • Brown, P.D.1    Giavazzi, R.2
  • 31
    • 0030806173 scopus 로고    scopus 로고
    • Changing views of the role of matrix metalloproteinases in metastasis
    • Chambers AF, Matrisian LM: Changing views of the role of matrix metalloproteinases in metastasis. J Natl Cancer Inst 89: 1260-1270, 1997
    • (1997) J Natl Cancer Inst , vol.89 , pp. 1260-1270
    • Chambers, A.F.1    Matrisian, L.M.2
  • 32
    • 0030055518 scopus 로고    scopus 로고
    • Tumour marker levels during marimastat therapy
    • Gore M, A'Hern R, Stankiewicz M, Slevin M: Tumour marker levels during marimastat therapy (letter). Lancet 348: 263-264, 1996
    • (1996) Lancet , vol.348 , pp. 263-264
    • Gore, M.1    A'Hern, R.2    Stankiewicz, M.3    Slevin, M.4
  • 33
    • 0033034041 scopus 로고    scopus 로고
    • Clinical studies with matrix metalloproteinase inhibitors
    • Brown PD: Clinical studies with matrix metalloproteinase inhibitors. Apmis 107: 174-180, 1999
    • (1999) Apmis , vol.107 , pp. 174-180
    • Brown, P.D.1
  • 34
    • 0028129059 scopus 로고
    • Inhibition of the metastatic spread and growth of B 16-BL6 murine melanoma by a synthetic matrix metalloproteinase inhibitor
    • Chirivi RG, Garofalo A, Crimmin MJ, Bawden LJ, Stoppacciaro A, Brown PD, Giavazzi R: Inhibition of the metastatic spread and growth of B 16-BL6 murine melanoma by a synthetic matrix metalloproteinase inhibitor. Int J Cancer 58: 460-464, 1994
    • (1994) Int J Cancer , vol.58 , pp. 460-464
    • Chirivi, R.G.1    Garofalo, A.2    Crimmin, M.J.3    Bawden, L.J.4    Stoppacciaro, A.5    Brown, P.D.6    Giavazzi, R.7
  • 35
    • 0029841408 scopus 로고    scopus 로고
    • Therapeutic effect of the matrix metalloproteinase inhibitor, batimastat, in a human colorectal cancer ascites model
    • Watson SA, Morris TM, Parsons SL, Steele Rl, Brown PD: Therapeutic effect of the matrix metalloproteinase inhibitor, batimastat, in a human colorectal cancer ascites model. Brit J Cancer 74: 1354-1358, 1996
    • (1996) Brit J Cancer , vol.74 , pp. 1354-1358
    • Watson, S.A.1    Morris, T.M.2    Parsons, S.L.3    Steele, R.L.4    Brown, P.D.5
  • 36
    • 0343976861 scopus 로고
    • A synthetic matrix metalloproteinase inhibitor decreases tumour burden and prolongs survival of mice bearing human ovarian carcinoma xenograft
    • Davies B, Brown P, East N, Crimmin M, Balkwill F: A synthetic matrix metalloproteinase inhibitor decreases tumour burden and prolongs survival of mice bearing human ovarian carcinoma xenograft. Cancer Res 56: 715-720, 1993
    • (1993) Cancer Res , vol.56 , pp. 715-720
    • Davies, B.1    Brown, P.2    East, N.3    Crimmin, M.4    Balkwill, F.5
  • 38
    • 0030484843 scopus 로고    scopus 로고
    • Experimental and clinical studies on the use of matrix metalloproteinase inhibitors for the treatment of cancer
    • Talbot DC, Brown PD: Experimental and clinical studies on the use of matrix metalloproteinase inhibitors for the treatment of cancer. Eur J Cancer 32A: 2528-2533, 1996
    • (1996) Eur J Cancer , vol.32 A , pp. 2528-2533
    • Talbot, D.C.1    Brown, P.D.2
  • 41
    • 0343938120 scopus 로고
    • Galardin, a potent metalloproteinase inhibitor, prolongs survival time in a B16-F10 melanoma experimental metastasis model
    • Tressler RJ, Wee J, Summers B et al.: Galardin, a potent metalloproteinase inhibitor, prolongs survival time in a B16-F10 melanoma experimental metastasis model (Abstract). Clin Exp Metastasis 12: 28, 1994
    • (1994) Clin Exp Metastasis , vol.12 , pp. 28
    • Tressler, R.J.1    Wee, J.2    Summers, B.3
  • 42
    • 0031882946 scopus 로고    scopus 로고
    • Results of single and repeat dose studies of the oral matrix metalloproteinase inhibitor marimastat in healthy male volunteers
    • Millar AW, Brown PD, Moore J, Galloway WA, Cornish AG, Lenehan TJ, Lynch KP: Results of single and repeat dose studies of the oral matrix metalloproteinase inhibitor marimastat in healthy male volunteers. Brit J Clin Pharm 45: 21-26, 1998
    • (1998) Brit J Clin Pharm , vol.45 , pp. 21-26
    • Millar, A.W.1    Brown, P.D.2    Moore, J.3    Galloway, W.A.4    Cornish, A.G.5    Lenehan, T.J.6    Lynch, K.P.7
  • 44
    • 14444284598 scopus 로고    scopus 로고
    • Combined analysis of studies of the effects of the matrix metalloproteinase inhibitor marimastat on serum tumor markers in advanced cancer: Selection of a biologically active and tolerable dose for longer-term studies
    • Nemunaitis J, Poole C, Primrose J, Rosemurgy A, Malfetano J, Brown P, Berrington A, Cornish A, Lynch K, Rasmussen H, Kerr D, Cox D.: Combined analysis of studies of the effects of the matrix metalloproteinase inhibitor marimastat on serum tumor markers in advanced cancer: selection of a biologically active and tolerable dose for longer-term studies. Clin Can Res 4: 1101-1109, 1998
    • (1998) Clin Can Res , vol.4 , pp. 1101-1109
    • Nemunaitis, J.1    Poole, C.2    Primrose, J.3    Rosemurgy, A.4    Malfetano, J.5    Brown, P.6    Berrington, A.7    Cornish, A.8    Lynch, K.9    Rasmussen, H.10    Kerr, D.11    Cox, D.12
  • 45
    • 0032983844 scopus 로고    scopus 로고
    • Marimastat (BB2516): Current status of development
    • Steward WP: Marimastat (BB2516): current status of development. Cancer Chemotherapy & Pharmacology 43: S56-S60, 1999
    • (1999) Cancer Chemotherapy & Pharmacology , vol.43
    • Steward, W.P.1
  • 46
    • 0030839472 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibition as a novel anticancer strategy: A review with special focus on batimastat and marimastat
    • Rasmussen HS, McCann PP: Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat. Pharmacol Thera 75: 69-75, 1997
    • (1997) Pharmacol Thera , vol.75 , pp. 69-75
    • Rasmussen, H.S.1    McCann, P.P.2
  • 47
    • 0031716672 scopus 로고    scopus 로고
    • Dupuytren's disease and frozen shoulder induced by treatment with a matrix metalloproteinase inhibitor
    • Hutchinson JW, Tierney GM, Parsons SL, Davis TR: Dupuytren's disease and frozen shoulder induced by treatment with a matrix metalloproteinase inhibitor. J Bone Joint Surg -British Volume 80: 907-908, 1998
    • (1998) J Bone Joint Surg -British Volume , vol.80 , pp. 907-908
    • Hutchinson, J.W.1    Tierney, G.M.2    Parsons, S.L.3    Davis, T.R.4
  • 48
    • 0013271858 scopus 로고    scopus 로고
    • First placebo controlled safety review of marimastat: A potential new therapeutic class
    • Rasmussen H, Rugg T, Brookes C, Baillet M, Harris J: First placebo controlled safety review of marimastat: a potential new therapeutic class (Abstract). Proc Am Soc Clin Oncol 18: 193a, 1999
    • (1999) Proc am Soc Clin Oncol , vol.18
    • Rasmussen, H.1    Rugg, T.2    Brookes, C.3    Baillet, M.4    Harris, J.5
  • 49
    • 0343541020 scopus 로고    scopus 로고
    • British Biotech PLC: Results of marimastat Study 128-pancreatic cancer monotherapy trial (Press release). February
    • British Biotech PLC: Results of marimastat Study 128-pancreatic cancer monotherapy trial (Press release). February 1999, http://www.britishbiotech.com/news/british _biotech_news99.htm
    • (1999)
  • 51
    • 0343541019 scopus 로고    scopus 로고
    • British Biotech Pie: Results of marimastat Study 145 in gastric cancer (Press release), July
    • British Biotech Pie: Results of marimastat Study 145 in gastric cancer (Press release), July 1999, http://www.britishbiotech. com/news/british_biotech_news99.htm
    • (1999)
  • 52
    • 0000100112 scopus 로고    scopus 로고
    • A phase I study of the matrix metalloproteinase inhibitor, marimastat, administered concurrently with carboplatin, to patients with relapsed ovarian cancer
    • Adams M, Thomas H: A phase I study of the matrix metalloproteinase inhibitor, marimastat, administered concurrently with carboplatin, to patients with relapsed ovarian cancer (Abstract). Proc Am Soc Clin One 17: 217a, 1998
    • (1998) Proc am Soc Clin One , vol.17
    • Adams, M.1    Thomas, H.2
  • 53
  • 54
    • 0003209128 scopus 로고    scopus 로고
    • Phase I/II study of combination antiangiogenesis therapy with marimastat, captopril and fragmin
    • Jones P, Elliot M, Dobbs N, Kakkar D, Ganesan T, Harris A: Phase I/II study of combination antiangiogenesis therapy with marimastat, captopril and fragmin (Abstract). Proc Am Soc Clin Oncol 18: 447a, 1999
    • (1999) Proc am Soc Clin Oncol , vol.18
    • Jones, P.1    Elliot, M.2    Dobbs, N.3    Kakkar, D.4    Ganesan, T.5    Harris, A.6
  • 55
    • 0000947129 scopus 로고    scopus 로고
    • Preclinical and clinical pharmacology of matrix metalloproteinase inhibitors (MMPI's)
    • Grochow LB: Preclinical and clinical pharmacology of matrix metalloproteinase inhibitors (MMPI's) (Abstract). Ann Oncol 9 (Suppl2): 11, 1998
    • (1998) Ann Oncol , vol.9 , Issue.2 SUPPL. , pp. 11
    • Grochow, L.B.1
  • 56
    • 0000520907 scopus 로고    scopus 로고
    • Pre-clinical drug safety profile for the antimetastatic matrix metalloproteinase inhibitory agent BAY 12-9566
    • Clemens GR, Detzer K, Bomhard E, von Keutz E: Pre-clinical drug safety profile for the antimetastatic matrix metalloproteinase inhibitory agent BAY 12-9566 (Abstract). Ann Oncol 9 (Suppl 2): 74, 1998
    • (1998) Ann Oncol , vol.9 , Issue.2 SUPPL. , pp. 74
    • Clemens, G.R.1    Detzer, K.2    Bomhard, E.3    Von Keutz, E.4
  • 57
    • 0001845325 scopus 로고    scopus 로고
    • Activity of the matrix metalloproteinase inhibitor BAY 12-9566 against murine subcutaneous metastatic in vivo models
    • Hibner B, Bull C, Flynn C, Eberwein D, Garrison T, Casazza A, Carter C, Gibson N: Activity of the matrix metalloproteinase inhibitor BAY 12-9566 against murine subcutaneous metastatic in vivo models (Abstract). Ann Oncol 9: 75, 1998
    • (1998) Ann Oncol , vol.9 , pp. 75
    • Hibner, B.1    Bull, C.2    Flynn, C.3    Eberwein, D.4    Garrison, T.5    Casazza, A.6    Carter, C.7    Gibson, N.8
  • 58
    • 0002287775 scopus 로고    scopus 로고
    • Anti-invasive and anti-metastatic activity of the novel MMP Inhibitor BAY 12-9566 in subcutaneous and orthotopic models using the human colon carcinoma, HCT 116
    • Flynn C, Bull C, Matherne C, Eberwein D, Gibson N, Hibner B: Anti-invasive and anti-metastatic activity of the novel MMP Inhibitor BAY 12-9566 in subcutaneous and orthotopic models using the human colon carcinoma, HCT 116 (Abstract). Ann Oncol 9 (Suppl 2): 75, 1998
    • (1998) Ann Oncol , vol.9 , Issue.2 SUPPL. , pp. 75
    • Flynn, C.1    Bull, C.2    Matherne, C.3    Eberwein, D.4    Gibson, N.5    Hibner, B.6
  • 59
    • 0000976105 scopus 로고    scopus 로고
    • Phase I study of the matrix metalloproteinase inhibitor (MMPI) BAY 12-9566 in patients with advanced cancer
    • Hirte H, Goel R, Bennett K, Elias I, Shah A, Seymour L: Phase I study of the matrix metalloproteinase inhibitor (MMPI) BAY 12-9566 in patients with advanced cancer (Abstract). Ann Oncol 9: 75, 1998
    • (1998) Ann Oncol , vol.9 , pp. 75
    • Hirte, H.1    Goel, R.2    Bennett, K.3    Elias, I.4    Shah, A.5    Seymour, L.6
  • 63
    • 0342670768 scopus 로고    scopus 로고
    • Planned and completed NCIC CTG trials with bay 12-9566, a novel metalloproteinase inhibitor (MMPI)
    • Seymour L, Hirte H, Goel R, Moore M, Elias I, Kumor K, Humphrey R: Planned and completed NCIC CTG trials with bay 12-9566, a novel metalloproteinase inhibitor (MMPI) (Abstract). Ann Oncol 9: 76, 1998
    • (1998) Ann Oncol , vol.9 , pp. 76
    • Seymour, L.1    Hirte, H.2    Goel, R.3    Moore, M.4    Elias, I.5    Kumor, K.6    Humphrey, R.7
  • 64
    • 0006456794 scopus 로고    scopus 로고
    • AG3340, a novel MMP inhibitor, has a superior therapeutic index to carboplatin in nude mice bearing chemoresistant human MV522 lung cancer tumors
    • Shalinsky D, Brekken J, Zou H, Bloom L, McDermott C, Appelt K: AG3340, a novel MMP inhibitor, has a superior therapeutic index to carboplatin in nude mice bearing chemoresistant human MV522 lung cancer tumors (Abstract). Ann Oncol 9: 73, 1998
    • (1998) Ann Oncol , vol.9 , pp. 73
    • Shalinsky, D.1    Brekken, J.2    Zou, H.3    Bloom, L.4    McDermott, C.5    Appelt, K.6
  • 65
    • 0002815897 scopus 로고    scopus 로고
    • A phase I study of AG3340, a matrix metalloproteinase (MMP) inhibitor, in patients having advanced cancer
    • Hande K, Wilding G, Ripple G, Fry J, Arzoomanian R, Dixon M, Yuen G, Collier M: A phase I study of AG3340, a matrix metalloproteinase (MMP) inhibitor, in patients having advanced cancer (Abstract). Ann Oncol 9: 74, 1998
    • (1998) Ann Oncol , vol.9 , pp. 74
    • Hande, K.1    Wilding, G.2    Ripple, G.3    Fry, J.4    Arzoomanian, R.5    Dixon, M.6    Yuen, G.7    Collier, M.8
  • 66
    • 0002815897 scopus 로고    scopus 로고
    • Phase I study of AG3340, a matrix metalloprotease inhibitor, in combination with mitoxantrone/prednisone in patients having advanced prostate cancer
    • Wilding G, Small E, Ripple G, Keller M, Yuen G, Collier M: Phase I study of AG3340, a matrix metalloprotease inhibitor, in combination with mitoxantrone/prednisone in patients having advanced prostate cancer (Abstract). Ann Oncol 9: 74, 1998
    • (1998) Ann Oncol , vol.9 , pp. 74
    • Wilding, G.1    Small, E.2    Ripple, G.3    Keller, M.4    Yuen, G.5    Collier, M.6
  • 67
    • 0000603394 scopus 로고    scopus 로고
    • Phase I study of the matrix metalloproteinase inhibitor AG3340 in combination with paclitaxel and carboplatin for the treatment of patients with advanced solid tumors
    • D'Olimpio J, Hande K, Collier M, Michelson G, Paradiso L, Clendeninn N: Phase I study of the matrix metalloproteinase inhibitor AG3340 in combination with paclitaxel and carboplatin for the treatment of patients with advanced solid tumors (Abstract). Proc Am Soc Clin Oncol 18: 160, 1999
    • (1999) Proc am Soc Clin Oncol , vol.18 , pp. 160
    • D'Olimpio, J.1    Hande, K.2    Collier, M.3    Michelson, G.4    Paradiso, L.5    Clendeninn, N.6
  • 70
    • 0343976854 scopus 로고    scopus 로고
    • AE-941 (Neovastat), an inhibitor of angiogenesis: Phase I/II lung cancer clinical trial results
    • Latreille J, Riviere M, Batist G, Falardeau P, Dupont E: AE-941 (Neovastat), an inhibitor of angiogenesis: Phase I/II lung cancer clinical trial results. Ann Oncol 9, 1998
    • (1998) Ann Oncol , pp. 9
    • Latreille, J.1    Riviere, M.2    Batist, G.3    Falardeau, P.4    Dupont, E.5
  • 71
    • 0343105126 scopus 로고    scopus 로고
    • AE-941 (Neovastat), an inhibitor of angiogenesis: Phase I/II cancer clinical trial results
    • Riveriere M, Latreille J, Farlardeau, Batist G, Dupont E: AE-941 (Neovastat), an inhibitor of angiogenesis: Phase I/II cancer clinical trial results (Abstract). Cancer Invest 17, 1999
    • (1999) Cancer Invest , pp. 17
    • Riveriere, M.1    Latreille, J.2    Farlardeau3    Batist, G.4    Dupont, E.5
  • 73
    • 0343105125 scopus 로고    scopus 로고
    • Combination therapy of matrix metalloproteinase inhibitor and cytotoxic agent reduces peritoneal dissemination of gastric carcinoma model in vivo
    • Igarashi N, Otani Y, Yokoyama T, Kimata M, Kubota T, Kitajima M: Combination therapy of matrix metalloproteinase inhibitor and cytotoxic agent reduces peritoneal dissemination of gastric carcinoma model in vivo (Abstract). Proc Am Assoc Can Res 39: 308, 1998
    • (1998) Proc am Assoc Can Res , vol.39 , pp. 308
    • Igarashi, N.1    Otani, Y.2    Yokoyama, T.3    Kimata, M.4    Kubota, T.5    Kitajima, M.6
  • 75
    • 0030868574 scopus 로고    scopus 로고
    • Collagenase-3 (matrix metalloprotease 13) is preferentially localized in the deep later of human arthritic cartilage in situ: In vitro mimicking effect by transforming growth factor beta
    • Moldovan F, Pelletier J-P, Hambor J, Cloutier J-M, MartelPelletier J: Collagenase-3 (matrix metalloprotease 13) is preferentially localized in the deep later of human arthritic cartilage in situ: in vitro mimicking effect by transforming growth factor beta. Arthritis Rheum 40: 1653-1661, 1997
    • (1997) Arthritis Rheum , vol.40 , pp. 1653-1661
    • Moldovan, F.1    Pelletier, J.-P.2    Hambor, J.3    Cloutier, J.-M.4    Martelpelletier, J.5
  • 76
    • 0026604634 scopus 로고
    • Detection of stromelysin and collagenase in synovial fluid from patients with rheumatoid arthritis and posttraumatic knee injury
    • Walakovits L, Moore V, Bhardwaj N, Gallick G, Lark M: Detection of stromelysin and collagenase in synovial fluid from patients with rheumatoid arthritis and posttraumatic knee injury. Arthritis Rheum 35: 35-42, 1992
    • (1992) Arthritis Rheum , vol.35 , pp. 35-42
    • Walakovits, L.1    Moore, V.2    Bhardwaj, N.3    Gallick, G.4    Lark, M.5
  • 77
    • 0027287364 scopus 로고
    • Elevated metalloproteinase and tissue inhibitor of metalloproteinase mRNA in human osteoarthritic synovia
    • Zafarullah M, Pelletier J-P, Cloutier J-M, Martel-Pelletier J: Elevated metalloproteinase and tissue inhibitor of metalloproteinase mRNA in human osteoarthritic synovia. J Rheumatol 20: 693-697, 1993
    • (1993) J Rheumatol , vol.20 , pp. 693-697
    • Zafarullah, M.1    Pelletier, J.-P.2    Cloutier, J.-M.3    Martel-Pelletier, J.4
  • 78
    • 0028854885 scopus 로고
    • Immunolocalisation studies on six matrix metalloproteinases and their inhibitors, TIMP-1 and TIMP-2, in synovia from patients with osteo- And rheumatoid arthritis
    • Hembry R, Bagga M, Reynolds J, Hamblen D: Immunolocalisation studies on six matrix metalloproteinases and their inhibitors, TIMP-1 and TIMP-2, in synovia from patients with osteo- and rheumatoid arthritis. Ann Rheum Dis 54: 25-32, 1995
    • (1995) Ann Rheum Dis , vol.54 , pp. 25-32
    • Hembry, R.1    Bagga, M.2    Reynolds, J.3    Hamblen, D.4
  • 81
    • 0031654554 scopus 로고    scopus 로고
    • Ro 32-3555, an orally active collagenase selective inhibitor, prevents structural damage in the STR/ORT mouse model of osteoarthritis
    • Brewster M, Lewis E, Wilson K, Greenham A, Bottomley K: Ro 32-3555, an orally active collagenase selective inhibitor, prevents structural damage in the STR/ORT mouse model of osteoarthritis. Arthritis Rheum 41: 1639-1644, 1998
    • (1998) Arthritis Rheum , vol.41 , pp. 1639-1644
    • Brewster, M.1    Lewis, E.2    Wilson, K.3    Greenham, A.4    Bottomley, K.5
  • 82
    • 0002338012 scopus 로고    scopus 로고
    • The tolerability and pharmacokinetics of the cartilage protective agent (R032-3555) in healthy male volunteers
    • Wood N, Aitken M, Harris S, Kitchener S, McClelland G, Sharp S: The tolerability and pharmacokinetics of the cartilage protective agent (R032-3555) in healthy male volunteers (Abstract). Brit J Clin Pharm 42: 676P-677P, 1996
    • (1996) Brit J Clin Pharm , vol.42
    • Wood, N.1    Aitken, M.2    Harris, S.3    Kitchener, S.4    McClelland, G.5    Sharp, S.6
  • 84
    • 0026636356 scopus 로고
    • Relation of neovascularisation to metastasis of non-small cell lung cancer
    • Macchiarini P, Fontanini G, Hardin M, Squartini F, Angeletti C: Relation of neovascularisation to metastasis of non-small cell lung cancer. Lancet 340: 145-146, 1992
    • (1992) Lancet , vol.340 , pp. 145-146
    • Macchiarini, P.1    Fontanini, G.2    Hardin, M.3    Squartini, F.4    Angeletti, C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.