-
1
-
-
0026522287
-
The role of proteolytic enzymes in cancer invasion and metastasis
-
Duffy M: The role of proteolytic enzymes in cancer invasion and metastasis. Clin Exp Metastasis 10: 145-155, 1992
-
(1992)
Clin Exp Metastasis
, vol.10
, pp. 145-155
-
-
Duffy, M.1
-
2
-
-
0024421549
-
Metalloproteinases and cancer invasion and metastasis
-
Murphy G, Reynolds J, Hembrey R: Metalloproteinases and cancer invasion and metastasis (letter). Int J Cancer 44: 757-760, 1989
-
(1989)
Int J Cancer
, vol.44
, pp. 757-760
-
-
Murphy, G.1
Reynolds, J.2
Hembrey, R.3
-
3
-
-
0032512914
-
Mechanisms of tumour metastasis
-
Meyer T, Hart IR: Mechanisms of tumour metastasis. Eur J Cancer 34: 214-221, 1998
-
(1998)
Eur J Cancer
, vol.34
, pp. 214-221
-
-
Meyer, T.1
Hart, I.R.2
-
4
-
-
0019195010
-
Metastatic potential correlates with enzymatic degradation of basement membrane collagen
-
Liotta L, Tryggvason K, Garbisa S, Hart I, Foltz C, Shafie S: Metastatic potential correlates with enzymatic degradation of basement membrane collagen. Nature 284: 67-68, 1980
-
(1980)
Nature
, vol.284
, pp. 67-68
-
-
Liotta, L.1
Tryggvason, K.2
Garbisa, S.3
Hart, I.4
Foltz, C.5
Shafie, S.6
-
5
-
-
0026131489
-
Augmentation of type IV collagenase, laminin receptor and Ki67 proliferation antigen associated with human colon, gastric and breast carcinoma progression
-
D'Errico A, Garbisa S, Liotta L, Castronovo V, Stetler-Stevenson W, Grigioni W: Augmentation of type IV collagenase, laminin receptor and Ki67 proliferation antigen associated with human colon, gastric and breast carcinoma progression. Mod Pathol 4: 239-246, 1991
-
(1991)
Mod Pathol
, vol.4
, pp. 239-246
-
-
D'Errico, A.1
Garbisa, S.2
Liotta, L.3
Castronovo, V.4
Stetler-Stevenson, W.5
Grigioni, W.6
-
6
-
-
0026802371
-
Correlation of serum metalloproteinase levels with lung cancer metastasis and response to therapy
-
Garbisa S, Scagliotti G, Masiero L, Di Francesco C, Caenazzo C, Onisto M, Micela M, Stetler-Stevenson W, Liotta L: Correlation of serum metalloproteinase levels with lung cancer metastasis and response to therapy. Cancer Res 52: 4548-4549, 1991
-
(1991)
Cancer Res
, vol.52
, pp. 4548-4549
-
-
Garbisa, S.1
Scagliotti, G.2
Masiero, L.3
Di Francesco, C.4
Caenazzo, C.5
Onisto, M.6
Micela, M.7
Stetler-Stevenson, W.8
Liotta, L.9
-
7
-
-
0027965584
-
Correlation between stromelysin 3 mRNA level and outcome of human breast cancer
-
Engel G, Hesselmeyer K, Auer G, Backdahl M, Eriksson E, Linder S: Correlation between stromelysin 3 mRNA level and outcome of human breast cancer. Int J Cancer 58: 830-835, 1993
-
(1993)
Int J Cancer
, vol.58
, pp. 830-835
-
-
Engel, G.1
Hesselmeyer, K.2
Auer, G.3
Backdahl, M.4
Eriksson, E.5
Linder, S.6
-
8
-
-
0030801093
-
Imbalance of expression of matrix metalloproteinase (MMPs) and tissue inhibitors of the matrix metalloproteinases (TIMPs) in human pancreatic carcinoma
-
Bramhall S, Neoptolemos J, Stamp G, Lemoine N: Imbalance of expression of matrix metalloproteinase (MMPs) and tissue inhibitors of the matrix metalloproteinases (TIMPs) in human pancreatic carcinoma. J Pathol 182: 347-355, 1997
-
(1997)
J Pathol
, vol.182
, pp. 347-355
-
-
Bramhall, S.1
Neoptolemos, J.2
Stamp, G.3
Lemoine, N.4
-
9
-
-
0031824909
-
Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancer
-
Murray G, Duncan M, O'Neil P, McKay J, Melvin W, Fothergill J: Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancer. J Pathol 185: 256-261, 1998
-
(1998)
J Pathol
, vol.185
, pp. 256-261
-
-
Murray, G.1
Duncan, M.2
O'Neil, P.3
McKay, J.4
Melvin, W.5
Fothergill, J.6
-
10
-
-
0031850120
-
Matrix metalloproteinases in gastrointestinal cancer
-
Brown P: Matrix metalloproteinases in gastrointestinal cancer. Gut 43: 161-163, 1998
-
(1998)
Gut
, vol.43
, pp. 161-163
-
-
Brown, P.1
-
11
-
-
0033061405
-
Matrix metalloproteinases and their inhibitors
-
Kugler A: Matrix metalloproteinases and their inhibitors. Antican Res 19: 1589-1592, 1999
-
(1999)
Antican Res
, vol.19
, pp. 1589-1592
-
-
Kugler, A.1
-
12
-
-
0026717181
-
Suppression of invasion by inducible expression of TIMP-1 in B 16-F10 melanoma cells
-
Khokha R, Zimmer M, Graham S, Lala P, Waterhouse P: Suppression of invasion by inducible expression of TIMP-1 in B 16-F10 melanoma cells. J Natl Cancer Inst 84: 1017-1022, 1992
-
(1992)
J Natl Cancer Inst
, vol.84
, pp. 1017-1022
-
-
Khokha, R.1
Zimmer, M.2
Graham, S.3
Lala, P.4
Waterhouse, P.5
-
13
-
-
0026573378
-
Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloprotineases
-
DeClerck Y, Perez N, Shimada H, Boone T, Langley K, Taylor S: Inhibition of invasion and metastasis in cells transfected with an inhibitor of metalloprotineases. Cancer Res 52: 701-708, 1992
-
(1992)
Cancer Res
, vol.52
, pp. 701-708
-
-
DeClerck, Y.1
Perez, N.2
Shimada, H.3
Boone, T.4
Langley, K.5
Taylor, S.6
-
14
-
-
0027383944
-
TIMP-2 inhibits bFGF-induced human microvascular endothelial cell proliferation
-
Murphy A, Unsworth E, Stetler-Stevenson W: TIMP-2 inhibits bFGF-induced human microvascular endothelial cell proliferation. J Cell Physiol 157: 351-358, 1993
-
(1993)
J Cell Physiol
, vol.157
, pp. 351-358
-
-
Murphy, A.1
Unsworth, E.2
Stetler-Stevenson, W.3
-
15
-
-
0028275891
-
Inhibition of angiogenesis by tissue inhibitor of metalloproteinase
-
Johnson J, Kim H, Chesler L, Bouck N, Polverini P: Inhibition of angiogenesis by tissue inhibitor of metalloproteinase. J Cell Physiol 160: 194-202, 1994
-
(1994)
J Cell Physiol
, vol.160
, pp. 194-202
-
-
Johnson, J.1
Kim, H.2
Chesler, L.3
Bouck, N.4
Polverini, P.5
-
16
-
-
0033067863
-
Matrix-degrading proteases and angiogenesis during development and tumor formation
-
Werb Z, Vu TH, Rinkenberger JL, Coussens LM: Matrix-degrading proteases and angiogenesis during development and tumor formation. Apmis 107: 11-18, 1999
-
(1999)
Apmis
, vol.107
, pp. 11-18
-
-
Werb, Z.1
Vu, T.H.2
Rinkenberger, J.L.3
Coussens, L.M.4
-
17
-
-
0026027556
-
Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
-
Liotta L, Steeg P, Stetley-Stevenson W: Cancer metastasis and angiogenesis: an imbalance of positive and negative regulation. Cell 65: 327-336, 1991
-
(1991)
Cell
, vol.65
, pp. 327-336
-
-
Liotta, L.1
Steeg, P.2
Stetley-Stevenson, W.3
-
18
-
-
33749871965
-
The experimental study of tumor progression
-
Foulds L: The experimental study of tumor progression. Cancer Res 14: 327-339, 1964
-
(1964)
Cancer Res
, vol.14
, pp. 327-339
-
-
Foulds, L.1
-
19
-
-
0024504371
-
In vitro angiogenesis on the human amniotic membrane: Requirement for bFGF-induced proteinases
-
Mignatti P, Tsuboi R, Robbins E, Rifkin D: In vitro angiogenesis on the human amniotic membrane: Requirement for bFGF-induced proteinases. J Cell Biol 108: 671-682, 1989
-
(1989)
J Cell Biol
, vol.108
, pp. 671-682
-
-
Mignatti, P.1
Tsuboi, R.2
Robbins, E.3
Rifkin, D.4
-
20
-
-
0026083903
-
Tumor angiogenesis correlates with metastasis in invasive breast carcinoma
-
Weidner N, Semple J, Welch W, Folkman J: Tumor angiogenesis correlates with metastasis in invasive breast carcinoma. N Eng J Med 324: 1-8, 1991
-
(1991)
N Eng J Med
, vol.324
, pp. 1-8
-
-
Weidner, N.1
Semple, J.2
Welch, W.3
Folkman, J.4
-
21
-
-
0030656475
-
Role of matrix metalloproteinases and their inhibitors in pancreatic cancer
-
Evans JD, Ghaneh P, Kawesha A, Neoptolemos JP: Role of matrix metalloproteinases and their inhibitors in pancreatic cancer. Digestion 58: 520-528, 1997
-
(1997)
Digestion
, vol.58
, pp. 520-528
-
-
Evans, J.D.1
Ghaneh, P.2
Kawesha, A.3
Neoptolemos, J.P.4
-
22
-
-
0031842208
-
Matrix metalloproteinases in cancer: Prognostic markers and targets for therapy
-
Duffy MJ, McCarthy K: Matrix metalloproteinases in cancer: prognostic markers and targets for therapy. Int J Oncol 12: 1343-1348, 1998
-
(1998)
Int J Oncol
, vol.12
, pp. 1343-1348
-
-
Duffy, M.J.1
McCarthy, K.2
-
24
-
-
0030484702
-
Role of integrins in angiogenesis
-
Brooks PC: Role of integrins in angiogenesis. Eur J Cane 32A: 2423-2429, 1996
-
(1996)
Eur J Cane
, vol.32 A
, pp. 2423-2429
-
-
Brooks, P.C.1
-
25
-
-
0010712792
-
Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity
-
Brooks PC, Silletti S, von Schalscha TL, Friedlander M, Cheresh DA: Disruption of angiogenesis by PEX, a noncatalytic metalloproteinase fragment with integrin binding activity. Cell 92: 391-400, 1998
-
(1998)
Cell
, vol.92
, pp. 391-400
-
-
Brooks, P.C.1
Silletti, S.2
Von Schalscha, T.L.3
Friedlander, M.4
Cheresh, D.A.5
-
26
-
-
0032529241
-
Remodeling of collagen matrix by human tumor cells requires activation and cell surface association of matrix metalloproteinase-2
-
Deruygina E, Bourdon M, Reisfeld R, Strongin A: Remodeling of collagen matrix by human tumor cells requires activation and cell surface association of matrix metalloproteinase-2. Cancer Res 58: 3743-3750, 1998
-
(1998)
Cancer Res
, vol.58
, pp. 3743-3750
-
-
Deruygina, E.1
Bourdon, M.2
Reisfeld, R.3
Strongin, A.4
-
27
-
-
0032401846
-
SPARC/Osteonectin induces matrix metalloproteinase 2 activation in human breast cancer cell lines
-
Gilles C, Bassuk J, Pulyaeva H, Sage E, Foidart J-M, Thompson E: SPARC/Osteonectin induces matrix metalloproteinase 2 activation in human breast cancer cell lines. Cancer Res 58: 5529-5536, 1998
-
(1998)
Cancer Res
, vol.58
, pp. 5529-5536
-
-
Gilles, C.1
Bassuk, J.2
Pulyaeva, H.3
Sage, E.4
Foidart, J.-M.5
Thompson, E.6
-
28
-
-
0029586589
-
Matrix metalloproteinase inhibition: A review of anti-tumour activity
-
Brown PD, Giavazzi R: Matrix metalloproteinase inhibition: a review of anti-tumour activity. Ann Oncol 6: 967-974, 1995
-
(1995)
Ann Oncol
, vol.6
, pp. 967-974
-
-
Brown, P.D.1
Giavazzi, R.2
-
29
-
-
0028939303
-
Inhibition of angiogenesis and murine haemangioma growth by batimastat, a synthetic inhibitor of matrix metailoproteinases
-
Taraboletti G, Garofalo A, Belotti D, Drudis T, Borsolti P, Scanziani E, Brown P, Giavazzi R: Inhibition of angiogenesis and murine haemangioma growth by batimastat, a synthetic inhibitor of matrix metailoproteinases. J Natl Cancer Inst 87: 293-298, 1995
-
(1995)
J Natl Cancer Inst
, vol.87
, pp. 293-298
-
-
Taraboletti, G.1
Garofalo, A.2
Belotti, D.3
Drudis, T.4
Borsolti, P.5
Scanziani, E.6
Brown, P.7
Giavazzi, R.8
-
30
-
-
0033597726
-
The stromal proteinase MMP3/stromelysin-l promotes mammary carcinogenesis
-
Sternlicht M, Lochter A, Sympson C, Huey B, Rougler J, Gray J, Pinkel D, Bissell M, Werb Z: The stromal proteinase MMP3/stromelysin-l promotes mammary carcinogenesis. Cell 98: 137-146, 1999
-
(1999)
Cell
, vol.98
, pp. 137-146
-
-
Sternlicht, M.1
Lochter, A.2
Sympson, C.3
Huey, B.4
Rougler, J.5
Gray, J.6
Pinkel, D.7
Bissell, M.8
Werb, Z.9
-
31
-
-
0030806173
-
Changing views of the role of matrix metalloproteinases in metastasis
-
Chambers AF, Matrisian LM: Changing views of the role of matrix metalloproteinases in metastasis. J Natl Cancer Inst 89: 1260-1270, 1997
-
(1997)
J Natl Cancer Inst
, vol.89
, pp. 1260-1270
-
-
Chambers, A.F.1
Matrisian, L.M.2
-
32
-
-
0030055518
-
Tumour marker levels during marimastat therapy
-
Gore M, A'Hern R, Stankiewicz M, Slevin M: Tumour marker levels during marimastat therapy (letter). Lancet 348: 263-264, 1996
-
(1996)
Lancet
, vol.348
, pp. 263-264
-
-
Gore, M.1
A'Hern, R.2
Stankiewicz, M.3
Slevin, M.4
-
33
-
-
0033034041
-
Clinical studies with matrix metalloproteinase inhibitors
-
Brown PD: Clinical studies with matrix metalloproteinase inhibitors. Apmis 107: 174-180, 1999
-
(1999)
Apmis
, vol.107
, pp. 174-180
-
-
Brown, P.D.1
-
34
-
-
0028129059
-
Inhibition of the metastatic spread and growth of B 16-BL6 murine melanoma by a synthetic matrix metalloproteinase inhibitor
-
Chirivi RG, Garofalo A, Crimmin MJ, Bawden LJ, Stoppacciaro A, Brown PD, Giavazzi R: Inhibition of the metastatic spread and growth of B 16-BL6 murine melanoma by a synthetic matrix metalloproteinase inhibitor. Int J Cancer 58: 460-464, 1994
-
(1994)
Int J Cancer
, vol.58
, pp. 460-464
-
-
Chirivi, R.G.1
Garofalo, A.2
Crimmin, M.J.3
Bawden, L.J.4
Stoppacciaro, A.5
Brown, P.D.6
Giavazzi, R.7
-
35
-
-
0029841408
-
Therapeutic effect of the matrix metalloproteinase inhibitor, batimastat, in a human colorectal cancer ascites model
-
Watson SA, Morris TM, Parsons SL, Steele Rl, Brown PD: Therapeutic effect of the matrix metalloproteinase inhibitor, batimastat, in a human colorectal cancer ascites model. Brit J Cancer 74: 1354-1358, 1996
-
(1996)
Brit J Cancer
, vol.74
, pp. 1354-1358
-
-
Watson, S.A.1
Morris, T.M.2
Parsons, S.L.3
Steele, R.L.4
Brown, P.D.5
-
36
-
-
0343976861
-
A synthetic matrix metalloproteinase inhibitor decreases tumour burden and prolongs survival of mice bearing human ovarian carcinoma xenograft
-
Davies B, Brown P, East N, Crimmin M, Balkwill F: A synthetic matrix metalloproteinase inhibitor decreases tumour burden and prolongs survival of mice bearing human ovarian carcinoma xenograft. Cancer Res 56: 715-720, 1993
-
(1993)
Cancer Res
, vol.56
, pp. 715-720
-
-
Davies, B.1
Brown, P.2
East, N.3
Crimmin, M.4
Balkwill, F.5
-
37
-
-
0002244576
-
Phase I study of the matrix metalloproteinase inhibitor batimastat (BE-94) in patients with malignant pleural effusions
-
Macauley V, O'Byrne K, Saunders M, Salisbury A, Long L, Gleeson F, Ganeson T, Harris A, Talbot D: Phase I study of the matrix metalloproteinase inhibitor batimastat (BE-94) in patients with malignant pleural effusions (Abstract). Br J Cancer 71: 11, 1995
-
(1995)
Br J Cancer
, vol.71
, pp. 11
-
-
Macauley, V.1
O'Byrne, K.2
Saunders, M.3
Salisbury, A.4
Long, L.5
Gleeson, F.6
Ganeson, T.7
Harris, A.8
Talbot, D.9
-
38
-
-
0030484843
-
Experimental and clinical studies on the use of matrix metalloproteinase inhibitors for the treatment of cancer
-
Talbot DC, Brown PD: Experimental and clinical studies on the use of matrix metalloproteinase inhibitors for the treatment of cancer. Eur J Cancer 32A: 2528-2533, 1996
-
(1996)
Eur J Cancer
, vol.32 A
, pp. 2528-2533
-
-
Talbot, D.C.1
Brown, P.D.2
-
40
-
-
0028625431
-
Low molecular weight inhibitors in corneal ulceration
-
Galardy RE, Cassabonne ME, Giese C, Gilbert JH, Lapierre F, Lopez H, Schaefer ME, Stack R, Sullivan M, Summers B: Low molecular weight inhibitors in corneal ulceration. Am NY Acad Sci 732: 315-323, 1994
-
(1994)
Am NY Acad Sci
, vol.732
, pp. 315-323
-
-
Galardy, R.E.1
Cassabonne, M.E.2
Giese, C.3
Gilbert, J.H.4
Lapierre, F.5
Lopez, H.6
Schaefer, M.E.7
Stack, R.8
Sullivan, M.9
Summers, B.10
-
41
-
-
0343938120
-
Galardin, a potent metalloproteinase inhibitor, prolongs survival time in a B16-F10 melanoma experimental metastasis model
-
Tressler RJ, Wee J, Summers B et al.: Galardin, a potent metalloproteinase inhibitor, prolongs survival time in a B16-F10 melanoma experimental metastasis model (Abstract). Clin Exp Metastasis 12: 28, 1994
-
(1994)
Clin Exp Metastasis
, vol.12
, pp. 28
-
-
Tressler, R.J.1
Wee, J.2
Summers, B.3
-
42
-
-
0031882946
-
Results of single and repeat dose studies of the oral matrix metalloproteinase inhibitor marimastat in healthy male volunteers
-
Millar AW, Brown PD, Moore J, Galloway WA, Cornish AG, Lenehan TJ, Lynch KP: Results of single and repeat dose studies of the oral matrix metalloproteinase inhibitor marimastat in healthy male volunteers. Brit J Clin Pharm 45: 21-26, 1998
-
(1998)
Brit J Clin Pharm
, vol.45
, pp. 21-26
-
-
Millar, A.W.1
Brown, P.D.2
Moore, J.3
Galloway, W.A.4
Cornish, A.G.5
Lenehan, T.J.6
Lynch, K.P.7
-
43
-
-
0033119677
-
A pilot study of the safety and effects of the matrix metalloproteinase inhibitor marimastat in gastric cancer
-
Tierney GM, Griffin NR, Stuart RC, Kasem M, Lynch KP, Lury JT, Brown PD, Millar AW, Steele RJC, Parsons SL: A pilot study of the safety and effects of the matrix metalloproteinase inhibitor marimastat in gastric cancer. Eur J Cancer 35: 563-568, 1999
-
(1999)
Eur J Cancer
, vol.35
, pp. 563-568
-
-
Tierney, G.M.1
Griffin, N.R.2
Stuart, R.C.3
Kasem, M.4
Lynch, K.P.5
Lury, J.T.6
Brown, P.D.7
Millar, A.W.8
Steele, R.J.C.9
Parsons, S.L.10
-
44
-
-
14444284598
-
Combined analysis of studies of the effects of the matrix metalloproteinase inhibitor marimastat on serum tumor markers in advanced cancer: Selection of a biologically active and tolerable dose for longer-term studies
-
Nemunaitis J, Poole C, Primrose J, Rosemurgy A, Malfetano J, Brown P, Berrington A, Cornish A, Lynch K, Rasmussen H, Kerr D, Cox D.: Combined analysis of studies of the effects of the matrix metalloproteinase inhibitor marimastat on serum tumor markers in advanced cancer: selection of a biologically active and tolerable dose for longer-term studies. Clin Can Res 4: 1101-1109, 1998
-
(1998)
Clin Can Res
, vol.4
, pp. 1101-1109
-
-
Nemunaitis, J.1
Poole, C.2
Primrose, J.3
Rosemurgy, A.4
Malfetano, J.5
Brown, P.6
Berrington, A.7
Cornish, A.8
Lynch, K.9
Rasmussen, H.10
Kerr, D.11
Cox, D.12
-
45
-
-
0032983844
-
Marimastat (BB2516): Current status of development
-
Steward WP: Marimastat (BB2516): current status of development. Cancer Chemotherapy & Pharmacology 43: S56-S60, 1999
-
(1999)
Cancer Chemotherapy & Pharmacology
, vol.43
-
-
Steward, W.P.1
-
46
-
-
0030839472
-
Matrix metalloproteinase inhibition as a novel anticancer strategy: A review with special focus on batimastat and marimastat
-
Rasmussen HS, McCann PP: Matrix metalloproteinase inhibition as a novel anticancer strategy: a review with special focus on batimastat and marimastat. Pharmacol Thera 75: 69-75, 1997
-
(1997)
Pharmacol Thera
, vol.75
, pp. 69-75
-
-
Rasmussen, H.S.1
McCann, P.P.2
-
47
-
-
0031716672
-
Dupuytren's disease and frozen shoulder induced by treatment with a matrix metalloproteinase inhibitor
-
Hutchinson JW, Tierney GM, Parsons SL, Davis TR: Dupuytren's disease and frozen shoulder induced by treatment with a matrix metalloproteinase inhibitor. J Bone Joint Surg -British Volume 80: 907-908, 1998
-
(1998)
J Bone Joint Surg -British Volume
, vol.80
, pp. 907-908
-
-
Hutchinson, J.W.1
Tierney, G.M.2
Parsons, S.L.3
Davis, T.R.4
-
48
-
-
0013271858
-
First placebo controlled safety review of marimastat: A potential new therapeutic class
-
Rasmussen H, Rugg T, Brookes C, Baillet M, Harris J: First placebo controlled safety review of marimastat: a potential new therapeutic class (Abstract). Proc Am Soc Clin Oncol 18: 193a, 1999
-
(1999)
Proc am Soc Clin Oncol
, vol.18
-
-
Rasmussen, H.1
Rugg, T.2
Brookes, C.3
Baillet, M.4
Harris, J.5
-
49
-
-
0343541020
-
-
British Biotech PLC: Results of marimastat Study 128-pancreatic cancer monotherapy trial (Press release). February
-
British Biotech PLC: Results of marimastat Study 128-pancreatic cancer monotherapy trial (Press release). February 1999, http://www.britishbiotech.com/news/british _biotech_news99.htm
-
(1999)
-
-
-
50
-
-
0000511054
-
A randomized study comparing marimastat to gemcitabine as first line therapy in patients with non-resectable pancreatic cancer
-
Rosemurgy A, Buckels J, Charnley R, Winston R, Steward W, Staddon A, Curtis L, Rugg T, Rasmussen H: A randomized study comparing marimastat to gemcitabine as first line therapy in patients with non-resectable pancreatic cancer (Abstract). Proc Am Soc Clin Oncol 18: 261a, 1999
-
(1999)
Proc am Soc Clin Oncol
, vol.18
-
-
Rosemurgy, A.1
Buckels, J.2
Charnley, R.3
Winston, R.4
Steward, W.5
Staddon, A.6
Curtis, L.7
Rugg, T.8
Rasmussen, H.9
-
51
-
-
0343541019
-
-
British Biotech Pie: Results of marimastat Study 145 in gastric cancer (Press release), July
-
British Biotech Pie: Results of marimastat Study 145 in gastric cancer (Press release), July 1999, http://www.britishbiotech. com/news/british_biotech_news99.htm
-
(1999)
-
-
-
52
-
-
0000100112
-
A phase I study of the matrix metalloproteinase inhibitor, marimastat, administered concurrently with carboplatin, to patients with relapsed ovarian cancer
-
Adams M, Thomas H: A phase I study of the matrix metalloproteinase inhibitor, marimastat, administered concurrently with carboplatin, to patients with relapsed ovarian cancer (Abstract). Proc Am Soc Clin One 17: 217a, 1998
-
(1998)
Proc am Soc Clin One
, vol.17
-
-
Adams, M.1
Thomas, H.2
-
53
-
-
0000203704
-
Pilot Pharmacokinetic Study of Marimastat (MAR) in combination with carboplatin (C)/paclitaxel (T) in patients with metastatic or locally advanced inoperable non-small cell lung cancer (NSCLC)
-
Anderson I, Supko J, Eder J, Vasconvelles M, Shapiro G, Skarin A, Shipp M, Janicek M, Lynch C, Lopez M, Bowers M, Rasmussen H: Pilot Pharmacokinetic Study of Marimastat (MAR) in combination with carboplatin (C)/paclitaxel (T) in patients with metastatic or locally advanced inoperable non-small cell lung cancer (NSCLC) (Abstract). Proc Am Soc Clin Oncol 18: 187a, 1999
-
(1999)
Proc am Soc Clin Oncol
, vol.18
-
-
Anderson, I.1
Supko, J.2
Eder, J.3
Vasconvelles, M.4
Shapiro, G.5
Skarin, A.6
Shipp, M.7
Janicek, M.8
Lynch, C.9
Lopez, M.10
Bowers, M.11
Rasmussen, H.12
-
54
-
-
0003209128
-
Phase I/II study of combination antiangiogenesis therapy with marimastat, captopril and fragmin
-
Jones P, Elliot M, Dobbs N, Kakkar D, Ganesan T, Harris A: Phase I/II study of combination antiangiogenesis therapy with marimastat, captopril and fragmin (Abstract). Proc Am Soc Clin Oncol 18: 447a, 1999
-
(1999)
Proc am Soc Clin Oncol
, vol.18
-
-
Jones, P.1
Elliot, M.2
Dobbs, N.3
Kakkar, D.4
Ganesan, T.5
Harris, A.6
-
55
-
-
0000947129
-
Preclinical and clinical pharmacology of matrix metalloproteinase inhibitors (MMPI's)
-
Grochow LB: Preclinical and clinical pharmacology of matrix metalloproteinase inhibitors (MMPI's) (Abstract). Ann Oncol 9 (Suppl2): 11, 1998
-
(1998)
Ann Oncol
, vol.9
, Issue.2 SUPPL.
, pp. 11
-
-
Grochow, L.B.1
-
56
-
-
0000520907
-
Pre-clinical drug safety profile for the antimetastatic matrix metalloproteinase inhibitory agent BAY 12-9566
-
Clemens GR, Detzer K, Bomhard E, von Keutz E: Pre-clinical drug safety profile for the antimetastatic matrix metalloproteinase inhibitory agent BAY 12-9566 (Abstract). Ann Oncol 9 (Suppl 2): 74, 1998
-
(1998)
Ann Oncol
, vol.9
, Issue.2 SUPPL.
, pp. 74
-
-
Clemens, G.R.1
Detzer, K.2
Bomhard, E.3
Von Keutz, E.4
-
57
-
-
0001845325
-
Activity of the matrix metalloproteinase inhibitor BAY 12-9566 against murine subcutaneous metastatic in vivo models
-
Hibner B, Bull C, Flynn C, Eberwein D, Garrison T, Casazza A, Carter C, Gibson N: Activity of the matrix metalloproteinase inhibitor BAY 12-9566 against murine subcutaneous metastatic in vivo models (Abstract). Ann Oncol 9: 75, 1998
-
(1998)
Ann Oncol
, vol.9
, pp. 75
-
-
Hibner, B.1
Bull, C.2
Flynn, C.3
Eberwein, D.4
Garrison, T.5
Casazza, A.6
Carter, C.7
Gibson, N.8
-
58
-
-
0002287775
-
Anti-invasive and anti-metastatic activity of the novel MMP Inhibitor BAY 12-9566 in subcutaneous and orthotopic models using the human colon carcinoma, HCT 116
-
Flynn C, Bull C, Matherne C, Eberwein D, Gibson N, Hibner B: Anti-invasive and anti-metastatic activity of the novel MMP Inhibitor BAY 12-9566 in subcutaneous and orthotopic models using the human colon carcinoma, HCT 116 (Abstract). Ann Oncol 9 (Suppl 2): 75, 1998
-
(1998)
Ann Oncol
, vol.9
, Issue.2 SUPPL.
, pp. 75
-
-
Flynn, C.1
Bull, C.2
Matherne, C.3
Eberwein, D.4
Gibson, N.5
Hibner, B.6
-
59
-
-
0000976105
-
Phase I study of the matrix metalloproteinase inhibitor (MMPI) BAY 12-9566 in patients with advanced cancer
-
Hirte H, Goel R, Bennett K, Elias I, Shah A, Seymour L: Phase I study of the matrix metalloproteinase inhibitor (MMPI) BAY 12-9566 in patients with advanced cancer (Abstract). Ann Oncol 9: 75, 1998
-
(1998)
Ann Oncol
, vol.9
, pp. 75
-
-
Hirte, H.1
Goel, R.2
Bennett, K.3
Elias, I.4
Shah, A.5
Seymour, L.6
-
60
-
-
0000100115
-
Phase I study of the metalloproteinase inhibitor Bayer 12-9566
-
Goel R, Hirte H, Shah A, Major P, Waterfield S, Holohan S, Bennett K, Elias I, Seymour L: Phase I study of the metalloproteinase inhibitor Bayer 12-9566 (Abstract). Proc Am Soc Clin Oncol 17: 217a, 1998
-
(1998)
Proc am Soc Clin Oncol
, vol.17
-
-
Goel, R.1
Hirte, H.2
Shah, A.3
Major, P.4
Waterfield, S.5
Holohan, S.6
Bennett, K.7
Elias, I.8
Seymour, L.9
-
61
-
-
0000100116
-
Phase I study of BAY 12-9566 - A matrix metalloproteinase inhibitor (MMPI)
-
Erlichman C, Adjei A, Alberts S, Sloan J, Goldberg R, Pilot H, Rubin J: Phase I study of BAY 12-9566 - a matrix metalloproteinase inhibitor (MMPI) (Abstract). Proc Am Soc Clin Oncol 17: 217a, 1998
-
(1998)
Proc am Soc Clin Oncol
, vol.17
-
-
Erlichman, C.1
Adjei, A.2
Alberts, S.3
Sloan, J.4
Goldberg, R.5
Pilot, H.6
Rubin, J.7
-
62
-
-
0000993867
-
A phase I and pharmacokinetic study of the oral matric metalloproteinase inhibitor BAY 12-9566 in combination with paclitaxel and carboplatin
-
Tolcher A, Rowinsky E, Rizzo J, Britten C, Siu L, Humphrey R, Smetzer L, Sorenson M, Von Hoff D, Eckhardt S: A phase I and pharmacokinetic study of the oral matric metalloproteinase inhibitor BAY 12-9566 in combination with paclitaxel and carboplatin (Abstract). Proc Am Soc Clin Oncol 18: 160a, 1999
-
(1999)
Proc am Soc Clin Oncol
, vol.18
-
-
Tolcher, A.1
Rowinsky, E.2
Rizzo, J.3
Britten, C.4
Siu, L.5
Humphrey, R.6
Smetzer, L.7
Sorenson, M.8
Von Hoff, D.9
Eckhardt, S.10
-
63
-
-
0342670768
-
Planned and completed NCIC CTG trials with bay 12-9566, a novel metalloproteinase inhibitor (MMPI)
-
Seymour L, Hirte H, Goel R, Moore M, Elias I, Kumor K, Humphrey R: Planned and completed NCIC CTG trials with bay 12-9566, a novel metalloproteinase inhibitor (MMPI) (Abstract). Ann Oncol 9: 76, 1998
-
(1998)
Ann Oncol
, vol.9
, pp. 76
-
-
Seymour, L.1
Hirte, H.2
Goel, R.3
Moore, M.4
Elias, I.5
Kumor, K.6
Humphrey, R.7
-
64
-
-
0006456794
-
AG3340, a novel MMP inhibitor, has a superior therapeutic index to carboplatin in nude mice bearing chemoresistant human MV522 lung cancer tumors
-
Shalinsky D, Brekken J, Zou H, Bloom L, McDermott C, Appelt K: AG3340, a novel MMP inhibitor, has a superior therapeutic index to carboplatin in nude mice bearing chemoresistant human MV522 lung cancer tumors (Abstract). Ann Oncol 9: 73, 1998
-
(1998)
Ann Oncol
, vol.9
, pp. 73
-
-
Shalinsky, D.1
Brekken, J.2
Zou, H.3
Bloom, L.4
McDermott, C.5
Appelt, K.6
-
65
-
-
0002815897
-
A phase I study of AG3340, a matrix metalloproteinase (MMP) inhibitor, in patients having advanced cancer
-
Hande K, Wilding G, Ripple G, Fry J, Arzoomanian R, Dixon M, Yuen G, Collier M: A phase I study of AG3340, a matrix metalloproteinase (MMP) inhibitor, in patients having advanced cancer (Abstract). Ann Oncol 9: 74, 1998
-
(1998)
Ann Oncol
, vol.9
, pp. 74
-
-
Hande, K.1
Wilding, G.2
Ripple, G.3
Fry, J.4
Arzoomanian, R.5
Dixon, M.6
Yuen, G.7
Collier, M.8
-
66
-
-
0002815897
-
Phase I study of AG3340, a matrix metalloprotease inhibitor, in combination with mitoxantrone/prednisone in patients having advanced prostate cancer
-
Wilding G, Small E, Ripple G, Keller M, Yuen G, Collier M: Phase I study of AG3340, a matrix metalloprotease inhibitor, in combination with mitoxantrone/prednisone in patients having advanced prostate cancer (Abstract). Ann Oncol 9: 74, 1998
-
(1998)
Ann Oncol
, vol.9
, pp. 74
-
-
Wilding, G.1
Small, E.2
Ripple, G.3
Keller, M.4
Yuen, G.5
Collier, M.6
-
67
-
-
0000603394
-
Phase I study of the matrix metalloproteinase inhibitor AG3340 in combination with paclitaxel and carboplatin for the treatment of patients with advanced solid tumors
-
D'Olimpio J, Hande K, Collier M, Michelson G, Paradiso L, Clendeninn N: Phase I study of the matrix metalloproteinase inhibitor AG3340 in combination with paclitaxel and carboplatin for the treatment of patients with advanced solid tumors (Abstract). Proc Am Soc Clin Oncol 18: 160, 1999
-
(1999)
Proc am Soc Clin Oncol
, vol.18
, pp. 160
-
-
D'Olimpio, J.1
Hande, K.2
Collier, M.3
Michelson, G.4
Paradiso, L.5
Clendeninn, N.6
-
68
-
-
0003263997
-
A novel approach to studying the efficacy of AG3340, a selective inhibitor of matrix metalloproteases (MMPs)
-
Collier M, Shepherd F, Ahmann F, Keller M, Michelson G, Paridiso L, Clendeninn N: A novel approach to studying the efficacy of AG3340, a selective inhibitor of matrix metalloproteases (MMPs) (Abstract). Proc Am Soc Clin Oncol 18: 482a, 1999
-
(1999)
Proc am Soc Clin Oncol
, vol.18
-
-
Collier, M.1
Shepherd, F.2
Ahmann, F.3
Keller, M.4
Michelson, G.5
Paridiso, L.6
Clendeninn, N.7
-
69
-
-
0005485030
-
Antiangiogenic properties of a novel shark cartilage extract: Potential role in the treatment of psoriasis
-
Dupont E, Savard PE, Jourdain C, Juneau C, Thibodeau A, Ross N, Marenus K, Maes DH, Pelletier G, Sauder DN: Antiangiogenic properties of a novel shark cartilage extract: potential role in the treatment of psoriasis. J Cutaneous Med Surg 2: 146-152, 1998
-
(1998)
J Cutaneous Med Surg
, vol.2
, pp. 146-152
-
-
Dupont, E.1
Savard, P.E.2
Jourdain, C.3
Juneau, C.4
Thibodeau, A.5
Ross, N.6
Marenus, K.7
Maes, D.H.8
Pelletier, G.9
Sauder, D.N.10
-
70
-
-
0343976854
-
AE-941 (Neovastat), an inhibitor of angiogenesis: Phase I/II lung cancer clinical trial results
-
Latreille J, Riviere M, Batist G, Falardeau P, Dupont E: AE-941 (Neovastat), an inhibitor of angiogenesis: Phase I/II lung cancer clinical trial results. Ann Oncol 9, 1998
-
(1998)
Ann Oncol
, pp. 9
-
-
Latreille, J.1
Riviere, M.2
Batist, G.3
Falardeau, P.4
Dupont, E.5
-
71
-
-
0343105126
-
AE-941 (Neovastat), an inhibitor of angiogenesis: Phase I/II cancer clinical trial results
-
Riveriere M, Latreille J, Farlardeau, Batist G, Dupont E: AE-941 (Neovastat), an inhibitor of angiogenesis: Phase I/II cancer clinical trial results (Abstract). Cancer Invest 17, 1999
-
(1999)
Cancer Invest
, pp. 17
-
-
Riveriere, M.1
Latreille, J.2
Farlardeau3
Batist, G.4
Dupont, E.5
-
72
-
-
0000436339
-
A phase one pharmacokinetic study of CGS27023A, a matrix metalloproteinase inhibitor
-
Levitt NC, Eskens F, Propper DJ, Harris AL, Denis L, Ganesan TS, Mather RA, McKinley L, Planting A, Talbot DC, Van Beurden V, Van der Burg M.: A phase one pharmacokinetic study of CGS27023A, a matrix metalloproteinase inhibitor (Abstract). Proc Am Soc Clin Oncol 17: 213a, 1998
-
(1998)
Proc am Soc Clin Oncol
, vol.17
-
-
Levitt, N.C.1
Eskens, F.2
Propper, D.J.3
Harris, A.L.4
Denis, L.5
Ganesan, T.S.6
Mather, R.A.7
McKinley, L.8
Planting, A.9
Talbot, D.C.10
Van Beurden, V.11
Van Der Burg, M.12
-
73
-
-
0343105125
-
Combination therapy of matrix metalloproteinase inhibitor and cytotoxic agent reduces peritoneal dissemination of gastric carcinoma model in vivo
-
Igarashi N, Otani Y, Yokoyama T, Kimata M, Kubota T, Kitajima M: Combination therapy of matrix metalloproteinase inhibitor and cytotoxic agent reduces peritoneal dissemination of gastric carcinoma model in vivo (Abstract). Proc Am Assoc Can Res 39: 308, 1998
-
(1998)
Proc am Assoc Can Res
, vol.39
, pp. 308
-
-
Igarashi, N.1
Otani, Y.2
Yokoyama, T.3
Kimata, M.4
Kubota, T.5
Kitajima, M.6
-
75
-
-
0030868574
-
Collagenase-3 (matrix metalloprotease 13) is preferentially localized in the deep later of human arthritic cartilage in situ: In vitro mimicking effect by transforming growth factor beta
-
Moldovan F, Pelletier J-P, Hambor J, Cloutier J-M, MartelPelletier J: Collagenase-3 (matrix metalloprotease 13) is preferentially localized in the deep later of human arthritic cartilage in situ: in vitro mimicking effect by transforming growth factor beta. Arthritis Rheum 40: 1653-1661, 1997
-
(1997)
Arthritis Rheum
, vol.40
, pp. 1653-1661
-
-
Moldovan, F.1
Pelletier, J.-P.2
Hambor, J.3
Cloutier, J.-M.4
Martelpelletier, J.5
-
76
-
-
0026604634
-
Detection of stromelysin and collagenase in synovial fluid from patients with rheumatoid arthritis and posttraumatic knee injury
-
Walakovits L, Moore V, Bhardwaj N, Gallick G, Lark M: Detection of stromelysin and collagenase in synovial fluid from patients with rheumatoid arthritis and posttraumatic knee injury. Arthritis Rheum 35: 35-42, 1992
-
(1992)
Arthritis Rheum
, vol.35
, pp. 35-42
-
-
Walakovits, L.1
Moore, V.2
Bhardwaj, N.3
Gallick, G.4
Lark, M.5
-
77
-
-
0027287364
-
Elevated metalloproteinase and tissue inhibitor of metalloproteinase mRNA in human osteoarthritic synovia
-
Zafarullah M, Pelletier J-P, Cloutier J-M, Martel-Pelletier J: Elevated metalloproteinase and tissue inhibitor of metalloproteinase mRNA in human osteoarthritic synovia. J Rheumatol 20: 693-697, 1993
-
(1993)
J Rheumatol
, vol.20
, pp. 693-697
-
-
Zafarullah, M.1
Pelletier, J.-P.2
Cloutier, J.-M.3
Martel-Pelletier, J.4
-
78
-
-
0028854885
-
Immunolocalisation studies on six matrix metalloproteinases and their inhibitors, TIMP-1 and TIMP-2, in synovia from patients with osteo- And rheumatoid arthritis
-
Hembry R, Bagga M, Reynolds J, Hamblen D: Immunolocalisation studies on six matrix metalloproteinases and their inhibitors, TIMP-1 and TIMP-2, in synovia from patients with osteo- and rheumatoid arthritis. Ann Rheum Dis 54: 25-32, 1995
-
(1995)
Ann Rheum Dis
, vol.54
, pp. 25-32
-
-
Hembry, R.1
Bagga, M.2
Reynolds, J.3
Hamblen, D.4
-
79
-
-
0030896096
-
Inhibition of bovine nasal cartilage degradation by selective matix metalloproteinase inhibitors
-
Bottomley K, Borkakoti N, Bradshaw D, Brown P, Broadhurst M, Budd J, Elliot L, Eyers P, Hallan T, Handa B, Hill C, James M.: Inhibition of bovine nasal cartilage degradation by selective matix metalloproteinase inhibitors. Biochem J 323: 483-488, 1997
-
(1997)
Biochem J
, vol.323
, pp. 483-488
-
-
Bottomley, K.1
Borkakoti, N.2
Bradshaw, D.3
Brown, P.4
Broadhurst, M.5
Budd, J.6
Elliot, L.7
Eyers, P.8
Hallan, T.9
Handa, B.10
Hill, C.11
James, M.12
-
80
-
-
8244221001
-
Re-32-3555, an orally active collagenase inhibitor, prevents cartilage breakdown in vitro and in vivo
-
Lewis E, Bishop J, Bottomley D, Bradshaw D, Brewster M, Broadhurst M, Brown P, Budd J, Elliott L, Greenham A, Johnson W, Nixon J.: Re-32-3555, an orally active collagenase inhibitor, prevents cartilage breakdown in vitro and in vivo. Brit J Pharm 121: 540-546, 1997
-
(1997)
Brit J Pharm
, vol.121
, pp. 540-546
-
-
Lewis, E.1
Bishop, J.2
Bottomley, D.3
Bradshaw, D.4
Brewster, M.5
Broadhurst, M.6
Brown, P.7
Budd, J.8
Elliott, L.9
Greenham, A.10
Johnson, W.11
Nixon, J.12
-
81
-
-
0031654554
-
Ro 32-3555, an orally active collagenase selective inhibitor, prevents structural damage in the STR/ORT mouse model of osteoarthritis
-
Brewster M, Lewis E, Wilson K, Greenham A, Bottomley K: Ro 32-3555, an orally active collagenase selective inhibitor, prevents structural damage in the STR/ORT mouse model of osteoarthritis. Arthritis Rheum 41: 1639-1644, 1998
-
(1998)
Arthritis Rheum
, vol.41
, pp. 1639-1644
-
-
Brewster, M.1
Lewis, E.2
Wilson, K.3
Greenham, A.4
Bottomley, K.5
-
82
-
-
0002338012
-
The tolerability and pharmacokinetics of the cartilage protective agent (R032-3555) in healthy male volunteers
-
Wood N, Aitken M, Harris S, Kitchener S, McClelland G, Sharp S: The tolerability and pharmacokinetics of the cartilage protective agent (R032-3555) in healthy male volunteers (Abstract). Brit J Clin Pharm 42: 676P-677P, 1996
-
(1996)
Brit J Clin Pharm
, vol.42
-
-
Wood, N.1
Aitken, M.2
Harris, S.3
Kitchener, S.4
McClelland, G.5
Sharp, S.6
-
83
-
-
0001148519
-
Disease modification by RS-130830, a collagenase-3 selective inhibitor in experimental osteoarthritis (OA)
-
Lollini L, Haller J, Eugui E, Womble S, Martin R, Campbell J, Hendricks T, Broka C, Moskowitz R, Van Wart H, Caulfield J: Disease modification by RS-130830, a collagenase-3 selective inhibitor in experimental osteoarthritis (OA) (Abstract). Arthritis Rheum 40: 341, 1997
-
(1997)
Arthritis Rheum
, vol.40
, pp. 341
-
-
Lollini, L.1
Haller, J.2
Eugui, E.3
Womble, S.4
Martin, R.5
Campbell, J.6
Hendricks, T.7
Broka, C.8
Moskowitz, R.9
Van Wart, H.10
Caulfield, J.11
-
84
-
-
0026636356
-
Relation of neovascularisation to metastasis of non-small cell lung cancer
-
Macchiarini P, Fontanini G, Hardin M, Squartini F, Angeletti C: Relation of neovascularisation to metastasis of non-small cell lung cancer. Lancet 340: 145-146, 1992
-
(1992)
Lancet
, vol.340
, pp. 145-146
-
-
Macchiarini, P.1
Fontanini, G.2
Hardin, M.3
Squartini, F.4
Angeletti, C.5
|