Overexpression of hippocampal Ca2+/calmodulin-dependent protein kinase II improves spatial memory

Journal of Neuroscience Research

Volumn 85, Issue 4, 2007, Pages 735-739

  Poulsen, D J ^a   Standing, D ^b   Bullshields, K ^b   Spencer, K ^b   Micevych, P E ^c   Babcock, A M ^b  

^a UNIVERSITY OF MONTANA   (United States)

^b MONTANA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adeno associated virus; Hippocampus; Learning; Water maze

Indexed keywords

ADENOVIRUS VECTOR; CALMODULIN DEPENDENT PROTEIN KINASE II; PROTEIN KINASE (CALCIUM,CALMODULIN) II; UNCLASSIFIED DRUG; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE TYPE 2; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; PROTEIN KINASE (CALCIUM,CALMODULIN);

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE SEQUENCE; HIPPOCAMPUS; IMMUNOREACTIVITY; LOCOMOTION; MALE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPATIAL MEMORY; ADENO ASSOCIATED VIRUS; ANIMAL; ANIMAL BEHAVIOR; DEPTH PERCEPTION; EXPLORATORY BEHAVIOR; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; MAZE TEST; MEMORY; METABOLISM; MOTOR ACTIVITY; PHYSIOLOGY; REACTION TIME; WESTERN BLOTTING;

ANIMALS; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; DEPENDOVIRUS; EXPLORATORY BEHAVIOR; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MAZE LEARNING; MEMORY; MOTOR ACTIVITY; RATS; REACTION TIME; SPACE PERCEPTION;

EID: 33947278970     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21163     Document Type: Article

References (23)

1. Babcock AM, Baker DA, Lovac R. 1993. Locomotor activity in the ischemic gerbil. Brain Res 625:351-354.
2. Babcock AM, Liu H, Paden CM, Churn SB, Pittman AJ. 1999. In vivo glutamate neurotoxicity is associated with reductions in calcium/calmodulin- dependent protein kinase II immunoreactivity. J Neurosci Res 56:36-43.
3. 2+/calmodulin-dependent protein kinase II by RNA interference. Mol Ther 11:899-905.
4. 2+/calmodulin- dependent kinase II alpha-subunit mutation. Proc Natl Acad Sci U S A 92:6852-6855.
5. T286A and CREB alphaDelta-mice. Science 279:867-869.
6. Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. 2001. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411:494-498.
7. Elgersma Y, Fedorov NB, Ikonen S, Choi ES, Elgersma M, Carvalho OM, Giese KP, Silva AJ. 2002. Inhibitory autophosphorylation of CaMKII controls PSD association, plasticity, and learning. Neuron 36: 493-505.
8. Elgersma Y, Sweatt JD, Giese KP. 2004. Mouse genetic approaches to investigating calcium/calmodulin-dependent protein kinase II function in plasticity and cognition. J Neurosci 24:8410-8415.
9. 2+/calmodulin-dependent protein kinase in rat brain. Neuroscience 5:3270-3277.
10. Fukunaga K, Miyamoto E. 2000. A working model of CaM kinase II activity in hippocampal long-term potentiation and memory. Neurosci Res 38:3-17.
11. Gerlai R. 1996. Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype? Trends Neurosci 19:177-181.
12. Gerlai R. 2001. Gene targeting: technical confounds and potential solutions in behavioral brain research. Behav Brain Res 125:13-21.
13. 286 of the alpha calcium-calmodulin kinase II in LTP and learning. Science 279:870-873.
14. Hommel JD, Sears RM, Georgescu D, Simmons DL, DiLeone RJ. 2003. Local gene knockdown in the brain using viral-mediated RNA interference. Nat Med 9:1539-1544.
15. Mayford M, Wang J, Kandel ER, O'Dell TJ. 1995. CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP. Cell 81:891-904.
16. Mayford M, Bach ME, Huang YY, Wang L, Hawkins RD, Kandel ER. 1996. Control of memory formation through regulated expression of αCaMKII transgene. Science 274:1678-1683.
17. Meng F, Guo J, Zhang Q, Song B, Zhang G. 2003. Autophosphorylated calcium/calmodulin-dependent protein kinase II alpha (CaMKII alpha) reversibly targets to and phosphorylates N-methyl-D-aspartate receptor subunit 2B (NR2B) in cerebral ischemia and reperfusion in hippocampus of rats. Brain Res 967:161-169.
18. 2+-triggered molecular switch. Cell 44:861-870.
19. Peel AL, Klein RL. 2000. Adeno-associated virus vectors: activity and applications in the CNS. J Neurosci Methods 98:95-104.
20. Silva AJ, Paylor R, Wehner JM, Tonegawa S. 1992. Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice. Science 257:206-211.
21. Sun Y, Jin K, Clark KR, Peel A, Mao XO, Chang Q, Simon RP, Greenberg DA. 2003. Adeno-associated virus-mediated delivery of BCL-w gene improves outcome after transient focal cerebral ischemia. Gene Ther 10:115-122.
22. Wang H, Shimizu E, Tang YP, Cho M, Kyin M, Zuo W, Robinson DA, Alaimo PJ, Zhang C, Morimoto H, Zhuo M, Feng R, Shokat KM, Tsien JZ. 2003. Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain. Proc Natl Acad Sci U S A 100:4287-4292.
23. Zolotukhin S, Byrne BJ, Mason E, Zolotukhin I, Potter M, Chesnut K, Summerford C, Samulski RJ, Muzyczka N. 1999. Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield. Gene Ther 6:973-985.