Comparative QSAR studies on PAMPA/modified PAMPA for high throughput profiling of drug absorption potential with respect to Caco-2 cells and human intestinal absorption

Journal of Computer-Aided Molecular Design

Volumn 21, Issue 1-3, 2007, Pages 3-22

  Verma, Rajeshwar P ^a   Hansch, Corwin ^a   Selassie, Cynthia D ^a  

^a POMONA COLLEGE   (United States)

Author keywords

Bio mimetic artificial membrane permeation assay (BAMPA); Caco 2 cells; Human intestinal absorption; Hydrophobicity; PAMPA BBB assay; Parallel artificial membrane permeability assays (PAMPA); Quantitative structure activity relationship (QSAR)

Indexed keywords

CELLS; COMPUTATIONAL CHEMISTRY; THROUGHPUT;

ARTIFICIAL MEMBRANES; BIO-MIMETIC ARTIFICIAL MEMBRANE PERMEATION ASSAY; BIO-MIMETICS; CACO-2 CELLS; HUMAN INTESTINAL ABSORPTIONS; MEMBRANE PERMEABILITY; MEMBRANE PERMEATION; PARALLEL ARTIFICIAL MEMBRANE PERMEABILITY ASSAY; PARALLEL ARTIFICIAL MEMBRANE PERMEABILITY ASSAY-BBB ASSAY; QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP;

ASSAYS;

ACETYLSALICYLIC ACID; ACICLOVIR; ALPRAZOLAM; ALPRENOLOL; AMITRIPTYLINE; ATROPINE; BETAMETHASONE; BIOMIMETIC MATERIAL; CARBAMAZEPINE; CEFIXIME; CEFOXITIN; CEFTRIAXONE; CHLORAMBUCIL; CHLORAMPHENICOL; CHLOROQUINE; CHLORPROPAMIDE; CHLORPROTHIXENE; CIMETIDINE; CLONAZEPAM; COCAINE; CODEINE; CORTICOSTERONE; COUMARIN; DAPSONE; DIAZEPAM; DIFLUNISAL; DIHYDROCODEINE; PARACETAMOL; PHENAZONE; UNINDEXED DRUG;

ARTICLE; ARTIFICIAL MEMBRANE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG SCREENING; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERMETHOD COMPARISON; MATHEMATICAL ANALYSIS; MEMBRANE PERMEABILITY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

EID: 33947273155     PISSN: 0920654X     EISSN: 15734951     Source Type: Journal    
DOI: 10.1007/s10822-006-9101-z     Document Type: Article

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