Intrathecal co-administration of morphine and nimodipine produces higher antinociceptive effect by synergistic interaction as evident by injecting different doses of each drug in rats

European Journal of Pharmacology

Volumn 561, Issue 1-3, 2007, Pages 46-53

  Gupta, Himanshu ^a   Verma, Dilip ^a   Ahuja, Rajesh K ^a   Srivastava, Deep N ^a   Wadhwa, Shashi ^a   Ray, Subrata Basu ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Analgesia; Intraspinal; L type voltage sensitive calcium channel; Potentiation; Spinal cord; Tail flick latency

Indexed keywords

CALCIUM CHANNEL L TYPE; MORPHINE; NALOXONE; NIMODIPINE; SODIUM CHLORIDE;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG EFFICACY; DRUG POTENTIATION; LATENT PERIOD; MALE; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; SPINAL CORD; TAIL FLICK TEST; WISTAR RAT;

ANALGESICS, OPIOID; ANIMALS; CALCIUM CHANNEL BLOCKERS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION ROUTES; DRUG SYNERGISM; INJECTIONS, SPINAL; MALE; MORPHINE; MOTOR ACTIVITY; NALOXONE; NARCOTIC ANTAGONISTS; NIMODIPINE; PAIN; PAIN MEASUREMENT; RATS; RATS, WISTAR; RECEPTORS, OPIOID, MU; TAIL;

EID: 33947225154     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.01.023     Document Type: Article

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