Histamine H3-receptor signaling in cardiac sympathetic nerves: Identification of a novel MAPK-PLA2-COX-PGE2-EP3R pathway

Biochemical Pharmacology

Volumn 73, Issue 8, 2007, Pages 1146-1156

  Levi, Roberto ^a   Seyedi, Nahid ^a   Schaefer, Ulrich ^a   Estephan, Rima ^a   Mackins, Christina J ^a   Tyler, Eleanor ^a   Silver, Randi B ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Cardiac synaptosomes; G i subunit; H3 receptor induced attenuation of norepinephrine exocytosis; Isolated sympathetic nerve endings; Langendorff perfused guinea pig hearts; MAPK PLA2 COX PGE2 EP3 receptor cascade

Indexed keywords

ADENYLATE CYCLASE; CALCIUM CHANNEL N TYPE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; HISTAMINE H3 RECEPTOR; IMETIT; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NORADRENALIN; OMEGA CONOTOXIN GVIA; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; RECEPTOR SUBUNIT; SULPROSTONE;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; EXOCYTOSIS; GUINEA PIG; HEART MUSCLE CELL; ISOLATED HEART; NONHUMAN; NORADRENALIN RELEASE; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; REGULATORY MECHANISM; SYMPATHETIC NERVE; SYNAPTOSOME; ADRENERGIC SYSTEM; ANIMAL; CELL FRACTIONATION; ENZYME ACTIVATION; HEART; INNERVATION; MALE; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; DINOPROSTONE; ENZYME ACTIVATION; EXOCYTOSIS; GUINEA PIGS; HEART; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; NOREPINEPHRINE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; RECEPTORS, HISTAMINE H3; SIGNAL TRANSDUCTION; SUBCELLULAR FRACTIONS; SYMPATHETIC NERVOUS SYSTEM;

EID: 33947185692     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2007.01.001     Document Type: Article

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