Altered synaptic input and GABAB receptor function in spinal superficial dorsal horn neurons in rats with diabetic neuropathy

Journal of Physiology

Volumn 579, Issue 3, 2007, Pages 849-861

  Wang, Xiu Li ^a,b   Zhang, Hong Mei ^a   Chen, Shao Rui ^a   Pan, Hui Lin ^a  

^a UNIVERSITY OF TEXAS   (United States)

^b HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; BACLOFEN; PRESYNAPTIC RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIABETIC NEUROPATHY; DRUG MECHANISM; EXCITATORY POSTSYNAPTIC POTENTIAL; INHIBITORY POSTSYNAPTIC POTENTIAL; MALE; NERVE CELL PLASTICITY; NEUROMODULATION; NEUROPATHIC PAIN; NEUROPATHOLOGY; NONHUMAN; POSTSYNAPTIC INHIBITION; PRESYNAPTIC INHIBITION; PRIORITY JOURNAL; RAT; RECEPTOR BLOCKING; SENSORY NERVE; SPINAL CORD DORSAL HORN; SPINAL CORD NERVE CELL; SPRAGUE DAWLEY RAT; STREPTOZOCIN DIABETES; ANIMAL CELL; CENTRAL NERVOUS SYSTEM SENSITIZATION; DORSAL ROOT; GABAERGIC TRANSMISSION; GLUTAMATERGIC SYNAPSE; MONOSYNAPTIC POTENTIAL; SPINAL CORD DORSAL HORN NERVE CELL; STREPTOZOTOCIN-INDUCED DIABETIC NEUROPATHY; SYNAPTIC TRANSMISSION; WHOLE CELL PATCH CLAMP;

ANIMALS; BACLOFEN; BICUCULLINE; DIABETIC NEUROPATHIES; DISEASE MODELS, ANIMAL; EXCITATORY POSTSYNAPTIC POTENTIALS; GABA AGONISTS; GABA ANTAGONISTS; GLUTAMIC ACID; GLYCINE; INTERNEURONS; MALE; NEURAL INHIBITION; POSTERIOR HORN CELLS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-B; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 33947165254     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2006.126102     Document Type: Article

References (45)

1. Ataka T, Kumamoto E, Shimoji K & Yoshimura M (2000). Baclofen inhibits more effectively C-afferent than Aδ-afferent glutamatergic transmission in substantia gelatinosa neurons of adult rat spinal cord slices. Pain 86, 273-282.
2. Boulton AJ, Gries FA & Jervell JA (1998). Guidelines for the diagnosis and outpatient management of diabetic peripheral neuropathy. Diabet Med 15, 508-514.
3. Brown MJ & Asbury AK (1984). Diabetic neuropathy. Ann Neurol 15, 2-12.
4. Burchiel KJ, Russell LC, Lee RP & Sima AA (1985). Spontaneous activity of primary afferent neurons in diabetic BB/Wistar rats. A possible mechanism of chronic diabetic neuropathic pain. Diabetes 34, 1210-1213.
5. Calcutt NA & Chaplan SR (1997). Spinal pharmacology of tactile allodynia in diabetic rats. Br J Pharmacol 122, 1478-1482.
6. B receptor binding in the spinal cord dorsal horn following peripheral inflammation or neurectomy. Brain Res 679, 289-297.
7. Cervero F & Iggo A (1980). The substantia gelatinosa of the spinal cord: A critical review. Brain 103, 717-772.
8. Chen X & Levine JD (2001). Hyper-responsivity in a subset of C-fiber nociceptors in a model of painful diabetic neuropathy in the rat. Neuroscience 102, 185-192.
9. Chen SR & Pan HL (2002). Hypersensitivity of spinothalamic tract neurons associated with diabetic neuropathic pain in rats. J Neurophysiol 87, 2726-2733.
10. Chen SR & Pan HL (2003 a). Antinociceptive effect of morphine, but not mu opioid receptor number, is attenuated in the spinal cord of diabetic rats. Anesthesiology 99, 1409-1414.
11. Chen SR & Pan HL (2003 b). Spinal GABA B receptors mediate antinociceptive actions of cholinergic agents in normal and diabetic rats. Brain Res 965, 67-74.
12. Chen SR & Pan HL (2003 c). Up-regulation of spinal muscarinic receptors and increased antinociceptive effect of intrathecal muscarine in diabetic rats. J Pharmacol Exp Ther 307, 676-681.
13. Chen SR, Sweigart KL, Lakoski JM & Pan HL (2002). Functional mu opioid receptors are reduced in the spinal cord dorsal horn of diabetic rats. Anesthesiology 97, 1602-1608.
14. Chu DC, Albin RL, Young AB & Penney JB (1990). Distribution and kinetics of GABA B binding sites in rat central nervous system: A quantitative autoradiographic study. Neuroscience 34, 341-357.
15. Courteix C, Bardin M, Chantelauze C, Lavarenne J & Eschalier A (1994). Study of the sensitivity of the diabetes-induced pain model in rats to a range of analgesics. Pain 57, 153-160.
16. Daulhac L, Mallet C, Courteix C, Etienne M, Duroux E, Privat AM, Eschalier A & Fialip J (2006). Diabetes-induced mechanical hyperalgesia involves spinal MAPKs activation in neurons and microglia via NMDA-dependent mechanisms. Mol Pharmacol 70, 1246-1254.
17. Dirig DM & Yaksh TL (1995). Intrathecal baclofen and muscimol, but not midazolam, are antinociceptive using the rat-formalin model. J Pharmacol Exp Ther 275, 219-227.
18. B receptors in spinal cord and dorsal root ganglia of the rat. Neuroscience 138, 1277-1287.
19. Fromm GH (1994). Baclofen as an adjuvant analgesic. J Pain Symptom Manage 9, 500-509.
20. B(2) -deficient mice. J Neurosci 24, 6086-6097.
21. 2+ transients in the rat substantia gelatinosa neurons after ligation of L5-L6 spinal nerves. Neuroreport 11, 4055-4061.
22. Iyadomi M, Iyadomi I, Kumamoto E, Tomokuni K & Yoshimura M (2000). Presynaptic inhibition by baclofen of miniature EPSCs and IPSCs in substantia gelatinosa neurons of the adult rat spinal dorsal horn. Pain 85, 385-393.
23. 2+ concentration in the spinal dorsal horn in an animal model of neuropathic pain. Pain 68, 85-96.
24. Khan GM, Chen SR & Pan HL (2002). Role of primary afferent nerves in allodynia caused by diabetic neuropathy in rats. Neuroscience 114, 291-299.
25. B receptors in spinal glutamate release and cholinergic analgesia in rats. J Physiol 543, 807-818.
26. Malcangio M & Bowery NG (1993). Gamma-aminobutyric acidB, but not gamma-aminobutyric acidA receptor activation, inhibits electrically evoked substance P-like immunoreactivity release from the rat spinal cord in vitro. J Pharmacol Exp Ther 266, 1490-1496.
27. Malcangio M & Tomlinson DR (1998). A pharmacologic analysis of mechanical hyperalgesia in streptozotocin/diabetic rats. Pain 76, 151-157.
28. Moore KA, Kohno T, Karchewski LA, Scholz J, Baba H & Woolf CJ (2002). Partial peripheral nerve injury promotes a selective loss of GABAergic inhibition in the superficial dorsal horn of the spinal cord. J Neurosci 22, 6724-6731.
29. 2-adrenergic receptors. J Neurophysiol 87, 1938-1947.
30. Pan YZ & Pan HL (2004). Primary afferent stimulation differentially potentiates excitatory and inhibitory inputs to spinal lamina II outer and inner neurons. J Neurophysiol 91, 2413-2421.
31. Polgar E, Hughes DI, Arham AZ & Todd AJ (2005). Loss of neurons from laminas I-III of the spinal dorsal horn is not required for development of tactile allodynia in the spared nerve injury model of neuropathic pain. J Neurosci 25, 6658-6666.
32. Price GW, Kelly JS & Bowery NG (1987). The location of GABAB receptor binding sites in mammalian spinal cord. Synapse 1, 530-538.
33. Price GW, Wilkin GP, Turnbull MJ & Bowery NG (1984). Are baclofen-sensitive GABAB receptors present on primary afferent terminals of the spinal cord?Nature 307, 71-74.
34. Slonimski M, Abram SE & Zuniga RE (2004). Intrathecal baclofen in pain management. Reg Anesth Pain Med 29, 269-276.
35. Smith GD, Harrison SM, Birch PJ, Elliott PJ, Malcangio M & Bowery NG (1994). Increased sensitivity to the antinociceptive activity of (+/ -)-baclofen in an animal model of chronic neuropathic, but not chronic inflammatory hyperalgesia. Neuropharmacology 33, 1103-1108.
36. Tomiyama M, Furusawa K, Kamijo M, Kimura T, Matsunaga M & Baba M (2005). Upregulation of mRNAs coding for AMPA and NMDA receptor subunits and metabotropic glutamate receptors in the dorsal horn of the spinal cord in a rat model of diabetes mellitus. Brain Res Mol Brain Res 136, 275-281.
37. B receptor protein and mRNA distribution in rat spinal cord and dorsal root ganglia. Eur J Neurosci 12, 3201-3210.
38. B receptor variants. Neuron 50, 589-601.
39. Waldvogel HJ, Faull RL, Jansen KL, Dragunow M, Richards JG, Mohler H & Streit P (1990). GABA, GABA receptors and benzodiazepine receptors in the human spinal cord: An autoradiographic and immunohistochemical study at the light and electron microscopic levels. Neuroscience 39, 361-385.
40. Wang XL, Zhang HM, Li DP, Chen SR & Pan HL (2006). Dynamic regulation of glycinergic input to spinal dorsal horn neurones by muscarinic receptor subtypes in rats. J Physiol 571, 403-413.
41. Yang L, Zhang FX, Huang F, Lu YJ, Li GD, Bao L, Xiao HS & Zhang X (2004). Peripheral nerve injury induces trans-synaptic modification of channels, receptors and signal pathways in rat dorsal spinal cord. Eur J Neurosci 19, 871-883.
42. Yoshimura M & Jessell TM (1989). Primary afferent-evoked synaptic responses and slow potential generation in rat substantia gelatinosa neurons in vitro. J Neurophysiol 62, 96-108.
43. Yoshimura M & Nishi S (1993). Blind patch-clamp recordings from substantia gelatinosa neurons in adult rat spinal cord slices: pharmacological properties of synaptic currents. Neuroscience 53, 519-526.
44. Yoshimura M & Nishi S (1995). Primary afferent-evoked glycine- and GABA-mediated IPSPs in substantia gelatinosa neurones in the rat spinal cord in vitro. J Physiol 482, 29-38.
45. Zhang HM, Li DP, Chen SR & Pan HL (2005). M2, M3, and M4 receptor subtypes contribute to muscarinic potentiation of GABAergic inputs to spinal dorsal horn neurons. J Pharmacol Exp Ther 313, 697-704.