Baclofen inhibits more effectively C-afferent than Aδ-afferent glutamatergic transmission in substantia gelatinosa neurons of adult rat spinal cord slices

Pain

Volumn 86, Issue 3, 2000, Pages 273-282

  Ataka, Toyofumi ^a,b   Kumamoto, Eiichi ^a   Shimoji, Koki ^b   Yoshimura, Megumu ^a  

^a SAGA UNIVERSITY   (Japan)

^b NIIGATA UNIVERSITY   (Japan)

Author keywords

Antinociception; C afferent fiber; GABA(B) receptor; Patch clamp; Spinal cord; Substantia gelatinosa

Indexed keywords

3 AMINOPROPYL(DIETHOXYMETHYL)PHOSPHINIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; BACLOFEN;

ACTION POTENTIAL; ANIMAL CELL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; NERVE FIBER C; NEUROTRANSMISSION; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; SENSORY NERVE; SPINAL CORD; SUBSTANTIA GELATINOSA;

ANIMALS; BACLOFEN; EXCITATORY POSTSYNAPTIC POTENTIALS; GABA AGONISTS; GLUTAMIC ACID; MALE; NERVE FIBERS; NERVE FIBERS, MYELINATED; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; SUBSTANTIA GELATINOSA; SYNAPTIC TRANSMISSION;

EID: 0034213921     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(00)00255-4     Document Type: Article

References (46)

1. Baba H., Doubell T.P., Woolf C.J. Peripheral inflammation facilitates Aβ fiber-mediated synaptic input to the substantia gelatinosa of the adult rat spinal cord. J Neurosci. 19:1999;859-867.
2. B receptor antagonists: from synthesis to therapeutic applications. Trends Pharmacol Sci. 14:1993;391-394.
3. B antagonist CGP55845. Neuropharmacology. 32:1993;1437-1440.
4. B receptors. Trends Pharmacol Sci. 14:1993;259-261.
5. B receptors as potential targets for drugs able to prevent excessive excitatory amino acid transmission in the spinal cord. Eur J Pharmacol. 362:1998;143-148.
6. B receptor pharmacology. Annu Rev Pharmacol Toxicol. 33:1993;109-147.
7. B receptor site distribution in the rat central nervous system. Neuroscience. 20:1987;365-383.
8. Canavero S., Bonicalzi V. The neurochemistry of central pain: evidence from clinical studies, hypothesis and therapeutic implications. Pain. 74:1998;109-114.
9. Coggeshall R.E., Carlton S.M. Receptor localization in the mammalian dorsal horn and primary afferent neurons. Brain Res Rev. 24:1997;28-66.
10. B receptors on Aδ and C primary afferents. Br J Pharmacol. 81:1984;327-333.
11. Dickenson A.H., Brewer C.M., Hayes N.A. Effects of topical baclofen on C fibre-evoked neuronal activity in the rat dorsal horn. Neuroscience. 14:1985;557-562.
12. Dolphin A.C., Scott R.H. Calcium channel currents and their inhibition by (-)-baclofen in rat sensory neurones: modulation by guanine nucleotides. J Physiol. 386:1987;1-17.
13. B receptors in the hippocampus have different pharmacological properties. Neuron. 1:1988;585-591.
14. Hammond D.L., Washington J.D. Antagonism of L-baclofen-induced antinociception by CGP 35348 in the spinal cord of the rat. Eur J Pharmacol. 234:1993;255-262.
15. Hao J.-X., Xu X.-J., Yu Y.-X., Seiger Å., Wiesenfeld-Hallin Z. Baclofen reverses the hypersensitivity of dorsal horn wide dynamic range neurons to mechanical stimulation after transient spinal cord ischemia; implications for a tonic GABAergic inhibitory control of myelinated fiber input. J Neurophysiol. 68:1992;392-396.
16. Hwang J.H., Yaksh T.L. The effect of spinal GABA receptor agonists on tactile allodynia in a surgically-induced neuropathic pain model in the rat. Pain. 70:1997;15-22.
17. Iyadomi M., Iyadomi I., Kumamoto E., Tomokuni K., Yoshimura M. Presynaptic inhibition by baclofen of miniature EPSCs and IPSCs in substantia gelatinosa neurons of the adult rat spinal dorsal horn. Pain. 85:(3):2000;385-393.
18. Kangrga I., Jiang M., Randić M. Actions of (-)-baclofen on rat dorsal horn neurons. Brain Res. 562:1991;265-275.
19. B receptors uncovers similarity to metabotropic glutamate receptors. Nature. 386:1997;239-246.
20. B-receptor subtypes assemble into functional heteromeric complexes. Nature. 396:1998;683-687.
21. B receptors. Pharmacol Ther. 67:1995;187-246.
22. Kohno T., Kumamoto E., Higashi H., Shimoji K., Yoshimura M. Actions of opioids on excitatory and inhibitory transmission in substantia gelatinosa of adult rat spinal cord. J Physiol. 518:1999;803-813.
23. Kumamoto E. The pharmacology of amino-acid responses in septal neurons. Prog Neurobiol. 52:1997;197-259.
24. B receptors in the neonatal rat spinal cord in vitro. Brain Res. 717:1996;76-80.
25. B receptor agonists and antagonists. Clin Neuropharmacol. 18:1995;285-305.
26. Malcangio M., Bowery N.G. GABA and its receptors in the spinal cord. Trends Pharmacol Sci. 17:1996;457-462.
27. Nakatsuka T., Park J.-S., Kumamoto E., Tamaki T., Yoshimura M. Plastic changes in sensory inputs to rat substantia gelatinosa neurons following peripheral inflammation. Pain. 82:1999;39-47.
28. Park J.-S., Nakatsuka T., Nagata K., Higashi H., Yoshimura M. Reorganization of the primary afferent termination in the rat spinal dorsal horn during post-natal development. Dev Brain Res. 113:1999;29-36.
29. B receptors present on primary afferent terminals of the spinal cord? Nature. 307:1984;71-74.
30. B receptor binding sites in mammalian spinal cord. Synapse. 1:1987;530-538.
31. Schneider S.P., Perl E.R. Comparison of primary afferent and glutamate excitation of neurons in the mammalian spinal dorsal horn. J Neurosci. 8:1988;2062-2073.
32. Sugiura Y., Lee C.L., Perl E.R. Central projections of identified, unmyelinated (C) afferent fibers innervating mammalian skin. Science. 234:1986;358-361.
33. Taira T., Kawamura H., Tanikawa T., Iseki H., Kawabatake H., Takakura K. A new approach to control central deafferentation pain: spinal intrathecal baclofen. Stereotact Funct Neurosurg. 65:1995;101-105.
34. B antagonists. Br J Pharmacol. 118:1996;1153-1160.
35. Villière V., McLachlan E.M. Electrophysiological properties of neurons in intact rat dorsal root ganglia classified by conduction velocity and action potential duration. J Neurophysiol. 76:1996;1924-1941.
36. Wang M.Y., Dun N.J. Phaclofen-insensitive presynaptic inhibitory action of (±)-baclofen in neonatal rat motoneurones in vitro. Br J Pharmacol. 99:1990;413-421.
37. Willis W.D. Jr, Coggeshall R.E. Sensory Mechanisms of the Spinal Cord. 1991;Plenum Press, New York.
38. Wilson P.R., Yaksh T.L. Baclofen is antinociceptive in the spinal intrathecal space of animals. Eur J Pharmacol. 51:1978;323-330.
39. Wu L.-G., Saggau P. Presynaptic inhibition of elicited neurotransmitter release. Trends Neurosci. 20:1997;204-212.
40. Yajiri Y., Yoshimura M., Okamoto M., Takahashi H., Higashi H. A novel slow excitatory postsynaptic current in substantia gelatinosa neurons of the rat spinal cord in vitro. Neuroscience. 76:1997;673-688.
41. Yang K., Kumamoto E., Furue H., Li Y.-Q., Yoshimura M. Action of capsaicin on dorsal root-evoked synaptic transmission to substantia gelatinosa neurons in adult rat spinal cord slices. Brain Res. 830:1999;268-273.
42. Yoshimura M. Slow synaptic transmission in the spinal dorsal horn. Prog Brain Res. 113:1996;443-462.
43. Yoshimura M., Jessell T.M. Primary afferent-evoked synaptic responses and slow potential generation in rat substantia gelatinosa neurons in vitro. J Neurophysiol. 62:1989;96-108.
44. Yoshimura M., Jessell T. Amino acid-mediated EPSPs at primary afferent synapses with substantia gelatinosa neurones in the rat spinal cord. J Physiol. 430:1990;315-335.
45. Yoshimura M., Nishi S. Blind patch-clamp recordings from substantia gelatinosa neurons in adult rat spinal cord slices: pharmacological properties of synaptic currents. Neuroscience. 53:1993;519-526.
46. Yoshimura M., Nishi S. Primary afferent-evoked glycine- and GABA-mediated IPSPs in substantia gelatinosa neurones in the rat spinal cord in vitro. J Physiol. 482:1995;29-38.