Vitamin D supplementation and fracture incidence in elderly persons: A randomized, placebo-controlled clinical trial

Annals of Internal Medicine

Volumn 124, Issue 4, 1996, Pages 400-406

  Lips, Paul ^a,b   Graafmans, Wilco C ^a,c   Ooms, Marcel E ^a,c   Bezemer, P Dick ^a,c   Bouter, Lex M ^a,c  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

COLECALCIFEROL;

AGED; ARTICLE; CALCIUM INTAKE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; FEMALE; FRACTURE; HIP FRACTURE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VITAMIN INTAKE;

EID: 0030038417     PISSN: 00034819     EISSN: None     Source Type: Journal    
DOI: 10.7326/0003-4819-124-4-199602150-00003     Document Type: Article

References (30)

1. McKenna MJ. Differences in vitamin D status between countries in young adults and the elderly Am J Med 1992,93.69-77
2. Lips P, Obrant KJ. The pathogenesis and treatment of hip fractures Osteoporosis Int 1991,1:218-31
3. Lips P, van Ginkel FC, Jongen MJ, Rubertus A, van der Vijgh WJ, Netelenbos JC. Determinants of vitamin D status in patients with hip fracture and in elderly control subjects Am J Clin Nutr 1987,46 1005-10.
4. Holick MF. Vitamin D and the skin, photobiology, physiology and therapeutic efficacy for psoriasis In. Heersche DN, Kanis JA, eds Bone and Mineral Research. Amsterdam- Elsevier; 1990 313-66
5. Parfitt AM, Gallagher JC, Heaney RP, Johnston CC, Neer R, Whedon GD. Vitamin D and bone health in the elderly Am J Clin Nutr 1982;36(5 Suppl):1014-31
6. Lips P. Vitamin D nutrition in the elderly problems and recommendations In Norman AW. Bouillon R, Thomasset M, eds Vitamin D. Gene Regulation, Structure-Function Analysis and Clinical Application New York Walter de Gruyter, 1991 757-64
7. Bouillon RA, Auwerx JH, Lissens WD, Pelemans WK. Vitamin D status in the elderiy seasonal substrate deficiency causes 1,25-dihydroxycholecalciferol deficiency. Am J Clin Nutr 1987,45,755-63.
8. Lips P, Hackeng WH, Jongen MJ, van Ginkel FC, Netelenbos JC. Seasonal variation in serum concentrations of parathyroid hormone in elderly people J Clin Endocrinol Metab 1983,57 204-6
9. Krall EA, Sahyoun N, Tannenbaum S, Dallai GE, Dawson-Hughes B. Effect of vitamin D intake on seasonal variations in parathyroid hormone secretion in postmenopausal women. N Engl J Med. 1989,321 1777-83
10. Lips P, Wiersinga A, van Ginkel FC, Jongen MJ, Netelenbos JC. Hackeng WH, et al. The effect of vitamin D supplementation on vitamin D status and parathyroid function in elderly subjects J Clin Endocrinol Metab. 1988, 67.644-50.
11. Lips P, Netelenbos JC, Jongen MJ, van Ginkel FC, Althuis AL, van Schaik CL, et al. Histomorphometric profile and vitamin D status in patients with femoral neck fracture Metab Bone Dis Relat Res 1982;4:85-93
12. Khaw KT, Sneyd MJ, Compston J. Bone density, parathyroid hormone and 25-hydroxyvitamin D concentrations in middle aged women BMJ. 1992,305 273-7.
13. Ooms ME, Lips P. Roos JC. van der Vijgh WJ, Popp-Snijders C, Bezemer PD, et al. Vitamin D status and sex hormone binding globulin determinants of bone turnover and bone mineral density in elderly women J Bone Miner Res 1995;10:1177-84.
14. Dawson-Hughes B. Dallai GE, Krall EA, Harris S. Sokoll LJ. Falconer G. Effect of vitamin D supplementation on wintertime and overall bone loss in healthy postmenopausal women Ann Intern Med 1991,115 505-12
15. Melton LJ 3d, Eddy DM, Johnston CC Jr. Screening for osteoporosis Ann Intern Med 1990,112.516-28
16. Riggs BL, Hodgson SF, O'Fallon WM, Chao EY, Wahner HW, Muhs JM, et al. Effect of fluoride treatment on the fracture rate in postmenopausal women with osteoporosis N Engl J Med 1990,322 802-9
17. Mosekilde L, Mosekilde L, Danielsen CC. Biomechanical competence of vertebral trabecular bone in relation to ash density and age in normal individuals Bone 1987,8 79-85.
18. Cummings SR, Nevitt MC. A hypothesis: the causes of hip fractures J Gerontol 1989,44:107-11
19. Kanis JA. Treatment of osteoporotic fracture. Lancet 1984,1:27-33
20. Lips P, van Ginkel FC, Netelenbos JC, Wiersinga A. van der Vijgh WJ. Lower mobility and markers of bone resorption in the elderly Bone Miner. 1990,9:49-57.
21. Ooms ME, Roos JC, Bezemer PD, van der Vijgh WJ, Bouter LM, Lips P. Prevention of bone loss by vitamin D supplementation in elderly women a randomized double-blind trial J Clin Endocrinol Metab 1995;80 1052-8
22. Jongen MJ, Kuiper S, van der Vijgh WJ, Lips P, Netelenbos JC. Improvement in the simultaneous determination of calcidiol and calcitriol in human serum or plasma J Clin Chem Clin Biochem 1988;26:25-8
23. Armitage P, Berry G. Statistical Methods in Medical Research 2d ed Boston Blackwell Scientific, 1987
24. Chapuy MC, Chapuy P. Meunier PJ. Calcium and vitamin D supplements effects on calcium metabolism in eiderly people Am J Clin Nutr 1987,46 324-8
25. Himmelstein S, Clemens TL, Rubin A, Lindsay R. Vitamin D supplementation in elderly nursing home residents increases 25(OH)D but not 1,25(OH)2D Am J Clin Nutr. 1990,52:701-6
26. Cummings SR, Black DM, Nevitt MC. Browner W, Cauley J, Ensrud K, et al. Bone density at various sites for prediction of hip fractures. The Study of Osteoporotic Fractures Research Group Lancet 1993,341 72-5
27. Ooms ME. Osteoporosis in Elderly Women: Vitamin D Deficiency and Other Risk Factors [PhD Thesis] Amsterdam Vrije Universiteit; 1994
28. Heikinheimo RJ, Inkovaara JA, Harju EJ, Haavisto MV, Kaarela RH, Kataja JM, et al. Annual injection of vitamin D and fractures of aged bones Calcif Tissue Int 1992;51 105-10
29. Chapuy MC, Arlot ME, Duboeuf F, Brun J. Crouzet B, Arnaud S, et al. Vitamin D3 and calcium to prevent hip fractures in the elderly women N Engl J Med. 1992,327:1637-42
30. Lips P, Chapuy MC, Dawson-Hughes B, Pols HA. International comparison of serum 25-hydroxyvitamin D measurements [Abstract], J Bone Miner Res 1995,10 S496