Chemical synthesis and biological activities of 16α-derivatives of 5α-androstane-3α,17β-diol as antiandrogens

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 8, 2007, Pages 3003-3018

  Roy, Jenny ^a   Breton, Rock ^a   Martel, Céline ^a   Labrie, Fernand ^a   Poirier, Donald ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

Androgen receptor; Androstane; Chemical synthesis; Prostate cancer; Steroid

Indexed keywords

16ALPHA (3' CHLOROPROPYL) 5ALPHA ANDROSTANE 3ALPHA,17BETA DIOL; ANDROSTANE DERIVATIVE; ANDROSTANOLONE; ANTIANDROGEN; CARBENE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; PROSTATE CANCER; SYNTHESIS;

ANDROGEN ANTAGONISTS; ANDROSTANE-3,17-DIOL; ANTINEOPLASTIC AGENTS, HORMONAL; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; INDICATORS AND REAGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; RECEPTORS, ANDROGEN; SPECTROPHOTOMETRY, INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33947141560     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.02.007     Document Type: Article

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