Differential effects of ionizing radiation and platinum-derivative chemotherapy on apoptotic pathways in testicular germ cells

International Journal of Radiation Biology

Volumn 83, Issue 4, 2007, Pages 269-278

  Chater, Sonia ^a,b,c   Amara, Souheila ^a,b,c   Moussata, Driffa ^a,b,c   Bozec, Aline ^a,b,c   Omezzine, Asma ^a,b,c   Romestaing, Pascale ^d   Chapet, Olivier ^d   Gerard, Jean Pierre ^d   Mornex, Françoise ^d   Benahmed, Mohamed ^a,b,c   Mauduit, Claire ^a,b,c,d  

^a INSERM   (France)

^b UNIVERSITÉ DE LYON   (France)

^c UNIVERSITÉ LYON 1   (France)

^d CENTRE HOSPITALIER LYON SUD   (France)

Author keywords

AIF; Apoptosis; Caspases; Germ cells; IAP; Ionizing radiations; Oxaliplatin; Testis; X rays

Indexed keywords

APOPTOSIS INDUCING FACTOR; CASPASE 3; MESSENGER RNA; OXALIPLATIN; PLATINUM DERIVATIVE; PROTEIN P53; X LINKED INHIBITOR OF APOPTOSIS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; GAMMA IRRADIATION; GERM CELL TUMOR; IONIZING RADIATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELLS, CULTURED; MALE; MICE; ORGANOPLATINUM COMPOUNDS; PYRIDINES; RADIATION DOSAGE; RADIATION, IONIZING; SIGNAL TRANSDUCTION; SPERMATOZOA; TESTIS;

MUS;

EID: 33947112353     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.1080/09553000701227573     Document Type: Article

References (32)

1. Arango D, Wilson AJ, Shi Q, Corner GA, Aranes MJ, Nicholas C, Lesser M, Mariadason JM, Augenlicht LH. 2004. Molecular mechanisms of action and prediction of response to oxaliplatin in colorectal cancer cells. British Journal of Cancer 91:1931-1946.
2. Beumer TL, Roepers-Gajadien HL, Gademan IS, Lock TM, Kal HB, De Rooij DG. 2000. Apoptosis regulation in the testis: involvement of Bcl-2 family members. Molecular Reproduction and Development 56:353-359.
3. Beumer TL, Roepers-Gajadien HL, Gademan IS, van Buul PP, Gil-Gomez G, Rutgers DH, de Rooij DG. 1998. The role of the tumor suppressor p53 in spermatogenesis. Cell Death Differentiation 5:669-677.
4. Cande C, Cecconi F, Dessen P, Kroemer G. 2002. Apoptosis-inducing factor (AIF): Key to the conserved caspaseindependent pathways of cell death? Journal of Cell Science 115:4727-4734.
5. Cho HJ, Jeong HG, Lee JS, Woo ER, Hyun JW, Chung MH, You HJ. 2002. Oncogenic H-Ras enhances DNA repair through the Ras/phosphatidylinositol 3-kinase/Rac1 pathway in NIH3T3 cells. Evidence for association with reactive oxygen species. Journal of Biological Chemistry 277:19358-19366.
6. Deveraux QL, Reed JC. 1999. IAP family proteins - suppressors of apoptosis. Genes and Development 13:239-252.
7. Dym M, Clermont Y. 1970. Role of spermatogonia in the repair of the seminiferous epithelium following X-irradiation of the rat testis. American Journal of Anatomy 128:265-282.
8. Embree-Ku M, Venturini D, Boekelheide K. 2002. Fas is involved in the p53-dependent apoptotic response to ionizing radiation in mouse testis. Biology of Reproduction 66:1456-1461.
9. Hasegawa M, Wilson G, Russell LD, Meistrich ML. 1997. Radiation-induced cell death in the mouse testis: Relationship to apoptosis. Radiation Research 147:457-467.
10. Hasegawa M, Zhang Y, Niibe H, Terry NH, Meistrich ML. 1998. Resistance of differentiating spermatogonia to radiation-induced apoptosis and loss in p53-deficient mice. Radiation Research 149:263-270.
11. Hengartner MO. 2000. The biochemistry of apoptosis. Nature 407:770-776.
12. Henriksen K, Kulmala J, Toppari J, Mehrotra K, Parvinen M. 1996. Stage-specific apoptosis in the rat seminiferous epithelium: quantification of irradiation effects. Journal of Andrology 17:394-402.
13. Huang HL, Fang LW, Lu SP, Chou CK, Luh TY, Lai MZ. 2003. DNA-damaging reagents induce apoptosis through reactive oxygen species-dependent Fas aggregation. Oncogene 22:8168-8177.
14. Joshi DS, Yick J, Murray D, Meistrich ML. 1990. Stage-dependent variation in the radiosensitivity of DNA in developing male germ cells. Radiation Research 121:274-281.
15. Lee J, Richburg JH, Shipp EB, Meistrich ML, Boekelheide K. 1999. The Fas system, a regulator of testicular germ cell apoptosis, is differentially up-regulated in Sertoli cell versus germ cell injury of the testis. Endocrinology 140:852-858.
16. Liston P, Fong WG, Korneluk RG. 2003. The inhibitors of apoptosis: there is more to life than Bcl2. Oncogene 22:8568-8580.
17. Luo FR, Wyrick SD, Chaney SG. 1999. Biotransformations of oxaliplatin in rat blood in vitro. Journal of Biochemical Molecular Toxicology 13:159-169.
18. Mauduit C, Siah A, Foch M, Chapet O, Clippe S, Gerard JP, Benahmed M. 2001. Differential expression of growth factors in irradiated mouse testes. International Journal of Radiation Oncology, Biology, Physics 50:203-212.
19. Meistrich ML, Finch M, da Cunha MF, Hacker U, Au WW. 1982. Damaging effects of 14 chemotherapeutic drugs on mouse testis cells. Cancer Research 42:122-131.
20. Nunez G, Benedict MA, Hu Y, Inohara N. 1998. Caspases: The proteases of the apoptotic pathway. Oncogene 17:3237-3245.
21. Oakberg EF. 1955. Sensitivity and time of degeneration of spermatogenic cells irradiated in various stages of maturation of the mouse. Radiation Research 2:369-391.
22. Odorisio T, Rodriguez TA, Evans EP, Clarke AR, Burgoyne PS. 1998. The meiotic checkpoint monitoring synapsis eliminates spermatocytes via p53-independent apoptosis. Nature Genetic 18:257-261.
23. Oliver RT. 1998. Germ cell cancer of the testis. Current Opinion in Oncology 10:266-272.
24. Omezzine A, Chater S, Mauduit C, Florin A, Tabone E, Chuzel F, Bars R, Benahmed M. 2003. Long-term apoptotic cell death process with increased expression and activation of caspase-3 and -6 in adult rat germ cells exposed in utero to flutamide. Endocrinology 144:648-661.
25. Pogach LM, Lee Y, Gould S, Giglio W, Meyenhofer M, Huang HF. 1989. Characterization of cis-platinum-induced Sertoli cell dysfunction in rodents. Toxicology and Applied Pharmacology 98:350-361.
26. Rugo RE, Secretan MB, Schiestl RH. 2002. X radiation causes a persistent induction of reactive oxygen species and a delayed reinduction of TP53 in normal human diploid fibroblasts. Radiation Research 158:210-219.
27. Salvesen GS, Duckett CS. 2002. IAP proteins: Blocking the road to death's door. Nature Reviews Molecular Cell Biology 3:401-410.
28. Schuler M, Green DR. 2005. Transcription, apoptosis and p53: Catch-22. Trends in Genetics 21:182-187.
29. Sjoblom T, Lahdetie J. 1996. Expression of p53 in normal and gamma-irradiated rat testis suggests a role for p53 in meiotic recombination and repair. Oncogene 12:2499-2505.
30. van der Meer Y, Huiskamp R, Davids JA, van der Tweel I, de Rooij DG. 1992. The sensitivity to X rays of mouse spermatogonia that are committed to differentiate and of differentiating spermatogonia. Radiation Research 130:296-302.
31. van Gurp M, Festjens N, van Loo G, Saelens X, Vandenabeele P. 2003. Mitochondrial intermembrane proteins in cell death. Biochemical and Biophysical Research Communications 304:487-497.
32. Wang D, Lippard SJ. 2005. Cellular processing of platinum anticancer drugs. Nature Reviews Drug Discovery 4:307-320.