Intradermal injection of heat-killed Mycobacterium vaccae in dogs with atopic dermatitis: A multicentre pilot study

Veterinary Dermatology

Volumn 18, Issue 2, 2007, Pages 87-93

  Gutzwiller, Meret E Ricklin ^a   Reist, Martin ^b,d   Peel, John E ^b   Seewald, Wolfgang ^c   Brunet, Laura Rosa ^d   Roosje, Petra J ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b Centre de Recherche Santé Animale   (Switzerland)

^c NOVARTIS PHARMA AG   (Switzerland)

^d SR Pharma   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CANIS FAMILIARIS; CORYNEBACTERINEAE; MUS; MYCOBACTERIUM; MYCOBACTERIUM VACCAE;

EID: 33847791000     PISSN: 09594493     EISSN: 13653164     Source Type: Journal    
DOI: 10.1111/j.1365-3164.2007.00579.x     Document Type: Article

References (42)

1. Hillier A, Griffin CE. The ACVD task force on canine atopic dermatitis (I): incidence and prevalence. Veterinary Immunology and Immunopathology 2001; 81: 147-51.
2. Cookson WO, Moffat MF. Asthma: an epidemic in the absence of infection? Science 1997; 275: 41-2.
3. Olivry T, DeBoer DJ, Griffin CE et al. The ACVD task force on canine atopic dermatitis: forewords and lexicon. Veterinary Immunology and Immunopathology 2001; 81: 143-6.
4. Marsella R, Olivry T, Nicklin C et al. Pilot investigation of a model for canine atopic dermatitis: environmental house dust mite challenge of high-IgE-producing beagles, mite hypersensitive dogs with atopic dermatitis and normal dogs. Veterinary Dermatology 2006; 17: 24-35.
5. Marsella R, Olivry T, Maeda S. Cellular and cytokine kinetics after epicutaneous allergen challenge (atopy patch testing) with house dust mites in high-IgE beagles. Veterinary Dermatology 2006; 17: 111-20.
6. Nuttall TJ, Knight PA, McAleese SM et al. T-helper 1, T-helper 2 and immunosuppressive cytokines in canine atopic dermatitis. Veterinary Immunology and Immunopathology 2002; 87: 379-84.
7. Olivry T, Dean GA, Tompkins MB et al. Toward a canine model of atopic dermatitis: amplification of cytokine-gene transcripts in the skin of atopic dogs. Experimental Dermatology 1999; 8: 204-11.
8. Leung DY, Boguniewicz M, Howell MD et al. New insights into atopic dermatitis. Journal of Clinical Investigation 2004; 113: 651-7.
9. Steffan J, Favrot C, Mueller R. A systematic review and meta-analysis of the efficacy and safety of cyclosporin for the treatment of atopic dermatitis in dogs. Veterinary Dermatology 2006; 17: 3-16.
10. Olivry T, Mueller RS. Evidence-based veterinary dermatology: a systematic review of the pharmacotherapy of canine atopic dermatitis. Veterinary Dermatology 2003; 14: 121-46.
11. Griffin CE, Hillier A. The ACVD task force on canine atopic dermatitis (XXIV): allergen-specific immunotherapy. Veterinary Immunology and Immunopathology 2001; 81: 363-83.
12. Boguniewicz M, Leung DY. Atopic dermatitis. Journal of Allergy and Clinical Immunology 2006; 117: S475-80.
13. von Mutius E. The environmental predictors of allergic disease. Journal of Allergy and Clinical Immunology 2000; 105: 9-19.
14. Bach J-F. The effect of infections on susceptibility to autoimmune and allergic diseases. New England Journal of Medicine 2002; 347: 911-20.
15. Riedler J, Braun-Fahrlander C, Eder W et al. Exposure to farming in early life and development of asthma and allergy: a crosssectional survey. Lancet 2001; 358: 1129-33.
16. Braun-Fahrlander C, Riedler J, Herz U et al. Environmental exposure to endotoxin and its relation to asthma in school-age children. New England Journal of Medicine 2002; 347: 869-77.
17. Shirakawa T, Enomoto T, Shimazu S et al. The inverse association between tuberculin responses and atopic disorder. Science 1997; 275: 77-9.
18. Matricardi PM, Yazdanbakhsh M. Mycobacteria and atopy, 6 years later: a fascinating, still unfinished, business. Clinical and Experimental Allergy 2003; 33: 717-20.
19. Pastore S, Mascia F, Girolomoni G. The contribution of keratinocytes to the pathogenesis of atopic dermatitis. European Journal of Dermatology 2006; 16: 125-31.
20. Akdis M, Blaser K, Akdis CA. T regulatory cells in allergy: novel concepts in the pathogenesis, prevention, and treatment of allergic diseases. Journal of Allergy and Clinical Immunology 2005; 116: 961-8.
21. Rook GAW, Adams V, Hunt J et al. Mycobacteria and other environmental organisms as immunomodulators for immunoregulatory disorders. Springer Seminars in Immunopathology 2004; 25: 237-55.
22. Zuany-Amorim C, Sawicka E, Manlius C et al. Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells. Nature Medicine 2002; 8: 625-9.
23. Adams VC, Hunt JR, Martinelli R et al. Mycobacterium vaccae induces a population of pulmonary CD11c+ cells with regulatory potential in allergic mice. European Journal of Immunology 2004; 34: 631-8.
24. Taylor A, Verhagen J, Blaser K et al. Mechanisms of immune suppression by interleukin-10 and transforming growth factor-beta: the role of T regulatory cells. Immunology 2006; 117: 433-42.
25. Akdis M, Verhagen J, Taylor A et al. Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells. Journal of Experimental Medicine 2004; 199: 1567-75.
26. Arkwright PD, David TJ. Intradermal administration of a killed Mycobacterium vaccae suspension (SRL 172) is associated with improvement in atopic dermatitis in children with moderate-to-severe disease. Journal of Allergy and Clinical Immunology 2001; 107: 531-4.
27. Camporota L, Corkhill A, Long H et al. The effects of Mycobacterium vaccae on allergen-induced airway responses in atopic asthma. European Respiratory Journal 2003; 21: 287-93.
28. Sinke JD, Rutten VP, Willemse T. Immune dysregulation in atopic dermatitis. Veterinary Immunology and Immunopathology 2002; 87: 351-6.
29. Marsella R, Nicklin C, Lopez J. Atopy patch test reactions in high-IgE beagles to different sources and concentrations of house dust mites. Veterinary Dermatology 2005; 16: 308-14.
30. Willemse T. Atopic skin disease. A review and reconsideration of diagnostic criteria. Journal of Small Animal Practice 1986; 27: 771-8.
31. Prélaud P, Guaguère E, Alhaidari Z et al. Re-evaluation of diagnostic criteria of canine atopic dermatitis. Révue de Médicine Vétérinaire 1998; 149: 1057-64.
32. DeBoer DJ, Hillier A. The ACVD task force on atopic dermatitis (XV): fundamental concepts in clinical diagnosis. Veterinary Immunology and Immunopathology 2001; 81: 271-6.
33. Olivry T, Rivierre C, Jackson HA et al. Cyclosporine decreases skin lesions and pruritus in dogs with atopic dermatitis: a blinded randomized prednisolone-controlled trial. Veterinary Dermatology 2002; 13: 77-87.
34. Arkwright PD, David TJ. Effect of Mycobacterium vaccae on atopic dermatitis in children of different ages. British Journal of Dermatology 2003; 149: 1029-34.
35. DeBoer DJ. Canine atopic dermatitis: new targets, new therapies. Journal of Nutrition 2004; 134: 2056S-61S.
36. McEwan NA, Kalna G, Mellor D. A comparison of adherence by four strains of Staphylococcus intermedius and Staphylococcus hominis to canine corneocytes collected from normal dogs and dogs suffering from atopic dermatitis. Research in Veterinary Science 2005; 78: 193-8.
37. Hendricks A, Schuberth HJ, Schueler K et al. Frequency of superantigen-producing Staphylococcus intermedius isolates from canine pyoderma and proliferation-inducing potential of superantigens in dogs. Research in Veterinary Science 2002; 73: 273-7.
38. Zuany-Amorim C, Manlius C, Trifilieff A et al. Long-term protective and antigen-specific effect of heat-killed Mycobacterium vaccae in a murine model of allergic pulmonary inflammation. Journal of Immunology 2002; 169: 1492-9.
39. Leung DY, Eichenfield LF, Boguniewicz M. Atopic dermatitis (atopic eczema). In: Freedberg, IM, Eisen, AZ, Wolff, K, et al. eds. Dermatology in General Medicine, 6th edn. New York, NY, McGraw-Hill 2003; 1180-94.
40. Colombo S, Hill PB, Shaw DJ et al. Effectiveness of low dose immunotherapy in the treatment of canine atopic dermatitis: a prospective, double-blinded, clinical study. Veterinary Dermatology 2005; 16: 162-70.
41. Germain PA, Prélaud P, Bensignor E. CADESI (Canine atopic dermatitis extent and severity index) reproducibility. Révue de Médicine Vétérinaire 2005; 156: 382-5.
42. Zemann B, Schwaerzler C, Griot-Wenk M et al. Oral administration of specific antigens to allergy-prone infant dogs induces IL-10 and TGF-beta expression and prevents allergy in adult life. Journal of Allergy and Clinical Immunology 2003; 111: 1069-75.