-
1
-
-
11144228243
-
-
(a) Julemont, F.; de Levai, X.; Michaux, C.; Renard, J. F.; Winum, J. Y.; Montera, J. L.; Damas, J.; Donge, J. M.; Pirotte, B. J. Med. Chem. 2004, 47, 6749.
-
(2004)
J. Med. Chem
, vol.47
, pp. 6749
-
-
Julemont, F.1
de Levai, X.2
Michaux, C.3
Renard, J.F.4
Winum, J.Y.5
Montera, J.L.6
Damas, J.7
Donge, J.M.8
Pirotte, B.9
-
2
-
-
0035846169
-
-
(b) Zhu, G. D.; Arendsen, D. L.; Gunawardana, I. W.; Boyd, S. A.; Steward, A. O.; Fry, D. G.; Cool, B. L.; Kifle, L.; Schaefer, B.; Meuth, J.; Marsh, K. D.; Kemph-Grote, A. J.; Kilgannon, P.; Gallatin, W. M.; Okasinski, G. F. J. Med. Chem. 2001, 44, 3469.
-
(2001)
J. Med. Chem
, vol.44
, pp. 3469
-
-
Zhu, G.D.1
Arendsen, D.L.2
Gunawardana, I.W.3
Boyd, S.A.4
Steward, A.O.5
Fry, D.G.6
Cool, B.L.7
Kifle, L.8
Schaefer, B.9
Meuth, J.10
Marsh, K.D.11
Kemph-Grote, A.J.12
Kilgannon, P.13
Gallatin, W.M.14
Okasinski, G.F.15
-
3
-
-
4444282620
-
-
(c) Baker, W. R.; Cai, S.; Dimitroff, M.; Fang, L.; Huh, K. K.; Ryckman, D. R.; Shang, X.; Shawar, R. M.; Therrien, J. H. J. Med. Chem. 2004, 47, 4693.
-
(2004)
J. Med. Chem
, vol.47
, pp. 4693
-
-
Baker, W.R.1
Cai, S.2
Dimitroff, M.3
Fang, L.4
Huh, K.K.5
Ryckman, D.R.6
Shang, X.7
Shawar, R.M.8
Therrien, J.H.9
-
4
-
-
33847780849
-
-
Wallace & Tiernan, Inc. Substituted 1-(m-aminophenyl)-2- pyridones. U.S. Patent 2,947,755, August 2, 1960
-
(d) Wallace & Tiernan, Inc. Substituted 1-(m-aminophenyl)-2- pyridones. U.S. Patent 2,947,755, August 2, 1960.
-
-
-
-
5
-
-
33847771486
-
-
Satoshi, N, Nagato, S, Ueno, K, Kawano, K, Norimine, Y, Ito, K, Hanada, T, Ueno, M, Amino, H, Ogo, M, Hatakeyama, S, Urawa, Y, Naka, H, Groom, A. J, Rivers, L, Smith, Terrence Esiai Co. Ltd, 1,2-Dihydropyridine Compounds, Process for Preparation of the Same and Use Thereof. Patent WO0196308, December 20, 2001
-
(e) Satoshi, N.; Nagato, S.; Ueno, K.; Kawano, K.; Norimine, Y.;.Ito, K.; Hanada, T.; Ueno, M.; Amino, H.; Ogo, M.; Hatakeyama, S.; Urawa, Y.; Naka, H.; Groom, A. J.; Rivers, L.; Smith, Terrence (Esiai Co. Ltd.). 1,2-Dihydropyridine Compounds, Process for Preparation of the Same and Use Thereof. Patent WO0196308, December 20, 2001.
-
-
-
-
6
-
-
33847773689
-
-
Alonso-Alija, C, Michels, M, Schirok, H, Schlemmer, K. H, Bell, J, Gitzgerald, M. F, Dodd, S, Gill, A, Bayer AG, Monocyclic Aroylpyridinones as Antiinflammatory Agents. Patent WO03076405, September 18, 2003
-
(f) Alonso-Alija, C.; Michels, M.; Schirok, H.; Schlemmer, K. H.; Bell, J.; Gitzgerald, M. F.; Dodd, S.; Gill, A. (Bayer AG). Monocyclic Aroylpyridinones as Antiinflammatory Agents. Patent WO03076405, September 18, 2003.
-
-
-
-
7
-
-
33847782837
-
D.; Anthony,
-
N. J, Gomez, R. P, Tran, L. O, Merck & Co. Inc, Inhibitors of Farnesyl-Protein Transferase. Patent WO9828980, July 9, 1998
-
(g) Young, S. D.; Anthony, N. J.; Gomez, R. P.; Tran, L. O. (Merck & Co. Inc.). Inhibitors of Farnesyl-Protein Transferase. Patent WO9828980, July 9, 1998.
-
-
-
Young, S.1
-
8
-
-
4344644437
-
-
(a) Qu, J.; Kohl, C.; Potek, M.; Mullen, K. Angew. Chem., Int. Ed. 2004, 43, 1528.
-
(2004)
Angew. Chem., Int. Ed
, vol.43
, pp. 1528
-
-
Qu, J.1
Kohl, C.2
Potek, M.3
Mullen, K.4
-
9
-
-
0004061172
-
-
4th ed, Blackwell Science Ltd, Oxford, UK
-
(b) Joule, J. A., Mills, K. Heterocyclic Chemistry, 4th ed.; Blackwell Science Ltd.: Oxford, UK, 2000; pp 86-88.
-
(2000)
Heterocyclic Chemistry
, pp. 86-88
-
-
Joule, J.A.1
Mills, K.2
-
11
-
-
0026730571
-
-
(d) Afarinkia, K.; Vinader, V.; Nelson, T. D.; Posner, G. H. Tetrahedron 1992, 48, 9111.
-
(1992)
Tetrahedron
, vol.48
, pp. 9111
-
-
Afarinkia, K.1
Vinader, V.2
Nelson, T.D.3
Posner, G.H.4
-
12
-
-
33746283734
-
-
Burgos, C. H.; Barder, T. E.; Huang, X.; Buchwald, S. L. Angew. Chem., Int. Ed. 2006, 45, 4321.
-
(2006)
Angew. Chem., Int. Ed
, vol.45
, pp. 4321
-
-
Burgos, C.H.1
Barder, T.E.2
Huang, X.3
Buchwald, S.L.4
-
13
-
-
24144441333
-
Palladium-Catalyzed Aromatic Carbon-Nitrogen Bond Formation
-
2nd ed, de Meijere, A, Diederich, F, Eds, Wiley-VCH: Weinheim, Germany
-
Jiang, L.; Buchwald, S. L. Palladium-Catalyzed Aromatic Carbon-Nitrogen Bond Formation. In Metal-Catalyzed Cross-Coupling Reactions, 2nd ed.; de Meijere, A., Diederich, F., Eds.; Wiley-VCH: Weinheim, Germany, 2004; pp 699-760.
-
(2004)
Metal-Catalyzed Cross-Coupling Reactions
, pp. 699-760
-
-
Jiang, L.1
Buchwald, S.L.2
-
14
-
-
9644277114
-
-
For reviews of Cu-catalyzed nucleophilic substitution reactions of aryl halides, see: a
-
For reviews of Cu-catalyzed nucleophilic substitution reactions of aryl halides, see: (a) Beletskaya, I. P.; Cheprakov, A. V. Coord. Chem. Rev. 2004, 2337.
-
(2004)
Coord. Chem. Rev
, pp. 2337
-
-
Beletskaya, I.P.1
Cheprakov, A.V.2
-
15
-
-
0345708168
-
-
(b) Ley, S. V.; Thomas, A. W. Angew. Chem., Int. Ed. 2003, 42, 5400.
-
(2003)
Angew. Chem., Int. Ed
, vol.42
, pp. 5400
-
-
Ley, S.V.1
Thomas, A.W.2
-
18
-
-
0033615795
-
-
(a) Mederski, W. W. K. R.; Lefort, M.; Germann, M.; Kux, D. Tetrahedron 1999, 55, 12757.
-
(1999)
Tetrahedron
, vol.55
, pp. 12757
-
-
Mederski, W.W.K.R.1
Lefort, M.2
Germann, M.3
Kux, D.4
-
19
-
-
33847782364
-
-
(b) Lam, Y. S. P.; Clark, C. G.; Sauber, S.; Adams, J.; Averill, K. M.; Chan, D. M. T.; Combs, A. Synthesis 2000, 674.
-
(2000)
Synthesis
, pp. 674
-
-
Lam, Y.S.P.1
Clark, C.G.2
Sauber, S.3
Adams, J.4
Averill, K.M.5
Chan, D.M.T.6
Combs, A.7
-
20
-
-
0037090044
-
-
Lam, P. Y. S.; Vincent, G.; Bonne, D.; Clark, C. G. Tetrahedron Lett. 2002, 43, 3091.
-
(2002)
Tetrahedron Lett
, vol.43
, pp. 3091
-
-
Lam, P.Y.S.1
Vincent, G.2
Bonne, D.3
Clark, C.G.4
-
21
-
-
33748959946
-
-
Ikegai, K.; Nagata, Y.; Mukaiyama, T. Bull. Chem. Soc. Jpn. 2006, 79, 761.
-
(2006)
Bull. Chem. Soc. Jpn
, vol.79
, pp. 761
-
-
Ikegai, K.1
Nagata, Y.2
Mukaiyama, T.3
-
24
-
-
9244225109
-
-
(c) Cristau, H. J.; Cellier, P. P.; Spindler, J. F.; Taillefer, M. Chem. Eur. J. 2004, 10, 5607.
-
(2004)
Chem. Eur. J
, vol.10
, pp. 5607
-
-
Cristau, H.J.1
Cellier, P.P.2
Spindler, J.F.3
Taillefer, M.4
-
26
-
-
14344256681
-
-
(e) Wang, P. S.; Liang, C. K.; Leung, M. Tetrahedron 2005, 61, 2931.
-
(2005)
Tetrahedron
, vol.61
, pp. 2931
-
-
Wang, P.S.1
Liang, C.K.2
Leung, M.3
-
27
-
-
33748954624
-
-
Filipski, K. J.; Kohrt, J. T.; Casimiro-Garcia, A.; Van, Huis, C. A.; Dudley, d. A.; Cody, W. L.; Bigge, C. F.; Desiraju, S.; Sun, S.; Maiti, S. N.; Jaber, M. R.; Edmunds, J. J. Tetrahedron Lett. 2006, 47, 7677.
-
(f) Filipski, K. J.; Kohrt, J. T.; Casimiro-Garcia, A.; Van, Huis, C. A.; Dudley, d. A.; Cody, W. L.; Bigge, C. F.; Desiraju, S.; Sun, S.; Maiti, S. N.; Jaber, M. R.; Edmunds, J. J. Tetrahedron Lett. 2006, 47, 7677.
-
-
-
-
28
-
-
0037009958
-
-
Antilla, J. C.; Klapars, A.; Buchwald, S. L. J Am. Chem. Soc. 2002, 124, 11684.
-
(2002)
J Am. Chem. Soc
, vol.124
, pp. 11684
-
-
Antilla, J.C.1
Klapars, A.2
Buchwald, S.L.3
-
29
-
-
0037178121
-
-
Klapars, A.; Huang, X.; Buchwald, S. L. J. Am. Chem. Soc. 2002, 124, 7421.
-
(2002)
J. Am. Chem. Soc
, vol.124
, pp. 7421
-
-
Klapars, A.1
Huang, X.2
Buchwald, S.L.3
-
30
-
-
0001407172
-
-
a data: (a) Bordwell, F. G.; Bartmess, J. E.; Hautala, J. A. J. Org. Chem. 1978, 43, 3095.
-
a data: (a) Bordwell, F. G.; Bartmess, J. E.; Hautala, J. A. J. Org. Chem. 1978, 43, 3095.
-
-
-
-
31
-
-
33847086202
-
-
(b) Olmstead, W. M.; Margolin, Z.; Bordwell, F. G. J. Org. Chem. 1980, 45, 3295.
-
(1980)
J. Org. Chem
, vol.45
, pp. 3295
-
-
Olmstead, W.M.1
Margolin, Z.2
Bordwell, F.G.3
-
32
-
-
0000564185
-
-
(c) Bordwell, F. G.; Drucker, G. E.; Fried, H. E. J. Org. Chem. 1981, 46, 632.
-
(1981)
J. Org. Chem
, vol.46
, pp. 632
-
-
Bordwell, F.G.1
Drucker, G.E.2
Fried, H.E.3
-
35
-
-
0033544782
-
-
For a brief summary, see
-
For a brief summary, see: You, F.; Twieg, R. J. Tetrahedron Lett. 1999, 40, 8759.
-
(1999)
Tetrahedron Lett
, vol.40
, pp. 8759
-
-
You, F.1
Twieg, R.J.2
-
37
-
-
0033615795
-
-
Mederski, W. W. K. R.; Lefort, M.; Germann, M.; Kux, D. Tetrahedron 1999, 55, 12757.
-
(1999)
Tetrahedron
, vol.55
, pp. 12757
-
-
Mederski, W.W.K.R.1
Lefort, M.2
Germann, M.3
Kux, D.4
-
38
-
-
33847771010
-
-
An authentic sample of 4-(3-methoxyphenoxy)pyridine was independently synthesized by uncatalyzed nucleophilic substitution of 4-chloropyridine with 3-methoxyphenol and compared to 1-(3-methoxyphenyl)1H-pyridin-4-one (Table 5, entry 1) to verify that the product of Cu-catalysis was not the O-aryl compound
-
An authentic sample of 4-(3-methoxyphenoxy)pyridine was independently synthesized by uncatalyzed nucleophilic substitution of 4-chloropyridine with 3-methoxyphenol and compared to 1-(3-methoxyphenyl)1H-pyridin-4-one (Table 5, entry 1) to verify that the product of Cu-catalysis was not the O-aryl compound.
-
-
-
-
39
-
-
0037007703
-
-
This ligand was originally reported by Merck chemists for the Cucatalyzed O-arylation of phenol. See: Buck, E, Song, Z. J, Tschaen, D, Dormer, P. G, Volante, R. P, Reider, P. J. Org. Lett. 2002, 4, 1623
-
This ligand was originally reported by Merck chemists for the Cucatalyzed O-arylation of phenol. See: Buck, E.; Song, Z. J.; Tschaen, D.; Dormer, P. G.; Volante, R. P.; Reider, P. J. Org. Lett. 2002, 4, 1623.
-
-
-
-
41
-
-
0032501446
-
-
For an example, see
-
For an example, see: Ma, D.; Yongda, Z.; Yao, J.; Wu, S.; Tao, F. J. Am. Chem. Soc. 1998, 120, 12459.
-
(1998)
J. Am. Chem. Soc
, vol.120
, pp. 12459
-
-
Ma, D.1
Yongda, Z.2
Yao, J.3
Wu, S.4
Tao, F.5
-
42
-
-
0034738131
-
-
Fagan, P. J.; Hauptman, E.; Shapiro, R.; Casalnuovo, A. J. Am. Chem. Soc. 2000, 122, 5043.
-
(2000)
J. Am. Chem. Soc
, vol.122
, pp. 5043
-
-
Fagan, P.J.1
Hauptman, E.2
Shapiro, R.3
Casalnuovo, A.4
-
43
-
-
1642528362
-
-
Cristau, H. J.; Cellier, P. P.; Hamada, S.; Spindler, J. S.; Taillefer, M. Org. Lett. 2004, 6, 913.
-
(2004)
Org. Lett
, vol.6
, pp. 913
-
-
Cristau, H.J.1
Cellier, P.P.2
Hamada, S.3
Spindler, J.S.4
Taillefer, M.5
|