Atropisomeric 3-(β-hydroxyethyl)-4-arylquinolin-2-ones as maxi-K potassium channel openers

Journal of Medicinal Chemistry

Volumn 50, Issue 5, 2007, Pages 1050-1057

  Vrudhula, Vivekananda M ^a   Dasgupta, Bireshwar ^a   Qian Cutrone, Jingfang ^a   Kozlowski, Edward S ^a   Boissard, Christopher G ^a   Dworetzky, Steven I ^a   Wu, Dedong ^a,b   Gao, Qi ^a   Kimura, Roy ^a   Gribkoff, Valentin K ^a,c   Starrett Jr , John E ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b ASTRAZENECA   (United Kingdom)

^c Scion Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (3 ALLYL 5 CHLORO 2 HYDROXYPHENYL) 3 (2 HYDROXYETHYL) 1 METHYL 6 (TRIFLUOROMETHYL)QUINOLIN 2(1H) ONE; 4 [CHLOROHYDROXY 3 (3 HYDROXYPROPYL)PHENYL] 3 (2 HYDROXYETHYL) 1 METHYL 6 (TRIFLUOROMETHYL)QUINOLIN 2(1H) ONE; BUTANOL; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCULATION; CHIRAL CHROMATOGRAPHY; CRYSTAL STRUCTURE; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROPHYSIOLOGY; ENERGY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH TEMPERATURE; HUMAN; HYDROPHILICITY; HYDROPHOBICITY; ISOMER; NONHUMAN; OOCYTE; REACTION ANALYSIS; ROTATION; SERUM; STEREOCHEMISTRY; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY; XENOPUS LAEVIS;

ANIMALS; CRYSTALLOGRAPHY, X-RAY; FEMALE; HUMANS; ION CHANNEL GATING; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MOLECULAR STRUCTURE; OOCYTES; PATCH-CLAMP TECHNIQUES; QUINOLINES; STEREOISOMERISM; THERMODYNAMICS; XENOPUS LAEVIS;

EID: 33847772270     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm061093j     Document Type: Article

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