Effect of 4-(5-chloro-2-hydroxyphenyl)-3-(2-hydroxyethyl)-6- (trifluoromethyl)-quinolin-2(1H)-one (BMS-223131), a novel opener of large conductance Ca2+-activated K+ (maxi-K) channels on normal and stress-aggravated colonic motility and visceral nociception

Journal of Pharmacology and Experimental Therapeutics

Volumn 313, Issue 2, 2005, Pages 840-847

  Sivarao, Digavalli V ^a   Newberry, Kimberly ^a   Langdon, Shaun ^a   Lee, Alicia V ^a   Hewawasam, Piyasena ^a   Plym, Mary Jane ^a   Signor, Laura ^a   Myers, Robert ^a   Lodge, Nicholas J ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (5 CHLORO 2 HYDROXYPHENYL) 3 (2 HYDROXYETHYL) 6 (TRIFLUOROMETHYL)QUINOLIN 2(1H) ONE; ALLYL ISOTHIOCYANATE; BMS 223131; CALCIUM ACTIVATED POTASSIUM CHANNEL; LOPERAMIDE; MORPHINE; POTASSIUM CHANNEL STIMULATING AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; BALLOON; BLOOD PRESSURE; COLON DILATATION; COLON MOTILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG INHIBITION; DRUG POTENCY; ENTEROPATHY; FECES; FEMALE; HYPERSENSITIVITY; INTESTINE FUNCTION DISORDER; MOISTURE; MYOELECTRICITY; NEWBORN; NOCICEPTION; NONHUMAN; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL; RAT; STRESS; VISCERAL PAIN;

ANIMALS; BLOOD PRESSURE; COLON; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GASTROINTESTINAL MOTILITY; ION CHANNEL GATING; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; PAIN MEASUREMENT; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; QUINOLINES; QUINOLONES; RATS; RATS, WISTAR; STRESS; VISCERA;

EID: 18044371065     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.079285     Document Type: Article

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