Growth hormone regulation and developmental expression of rat hepatic CYP3A18, CYP3A9, and CYP3A2

Biochemical Pharmacology

Volumn 59, Issue 10, 2000, Pages 1277-1287

  Kawai, Masahiko ^a   Bandiera, Stelvio M ^a   Chang, Thomas K H ^a   Bellward, Gail D ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

CYP3A18; CYP3A2; CYP3A9; Growth hormone; Testosterone 2 hydroxylase; Testosterone 6 hydroxylase

Indexed keywords

CYTOCHROME P450 3A; CYTOCHROME P450 ISOENZYME; GROWTH HORMONE; MESSENGER RNA; OXYGENASE; RECOMBINANT GROWTH HORMONE; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; HYDROXYLATION; HYPOPHYSECTOMY; LIVER; MALE; NONHUMAN; PREPUBERTY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SEX DIFFERENCE;

AGING; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GROWTH HORMONE; HYPOPHYSECTOMY; LIVER; MALE; MICE; OXIDOREDUCTASES, N-DEMETHYLATING; RATS; RATS, SPRAGUE-DAWLEY; SEX FACTORS; STEROID HYDROXYLASES;

EID: 0034658175     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(00)00247-1     Document Type: Article

References (59)

1. Waxman D.J. Interactions of hepatic cytochromes P-450 with steroid hormones. Regioselectivity and stereospecificity of steroid metabolism and hormonal regulation of rat P-450 enzyme expression. Biochem Pharmacol. 37:1988;71-84.
2. Wilkinson G.R., Cytochrome P. 450 3A (CYP3A) metabolism Prediction of in vivo activity in humans . J Pharmacokinet Biopharm. 24:1996;475-490.
3. Gonzalez F.J., Gelboin H.V. Role of human cytochromes P450 in the metabolic activation of chemical carcinogens and toxins. Drug Metab Rev. 26:1994;165-183.
4. Guengerich F.P. Human cytochrome P450 enzymes. Ortiz de Montellano P.R. Cytochrome P450 Structure, Mechanism, and Biochemistry . 1995;473-535 Plenum Press, New York.
5. Jayyosi Z., Cooper K.O., Thomas P.E. Brain cytochrome P450 and testosterone metabolism by rat brain subcellular fractions Presence of cytochrome P450 3A immunoreactive protein in rat brain mitochondria . Arch Biochem Biophys. 298:1992;265-270.
6. Wang H., Kawashima H., Strobel H.W. cDNA cloning of a novel CYP3A from rat brain. Biochem Biophys Res Commun. 221:1996;157-162.
7. Watkins P.B., Wrighton S.A., Schuetz E.G., Molowa D.T. Identification of glucocorticoid-inducible cytochrome P-450 in the intestinal mucosa of rats and man. J Clin Invest. 80:1987;1029-1036.
8. Kolars J.C., Schmiedlin-Ren P., Dobbins W.O. III, Schuetz J., Wrighton S.A., Watkins P.B. Heterogeneity of cytochrome P450 IIIA expression in rat gut epithelia. Gastroenterology. 102:1992;1186-1198.
9. Debri K., Boobis A.R., Davies D.S., Edwards R.J. Distribution and induction of CYP3A1 and CYP3A2 in rat liver and extrahepatic tissues. Biochem Pharmacol. 50:1995;2047-2056.
10. Mahnke A., Roos P.H., Hanstein W.G., Chabot G.G. In vivo induction of cytochrome P450 3A expression in rat leukocytes using various inducers. Biochem Pharmacol. 51:1996;1579-1582.
11. Graves P.E., Kaminsky L.S., Halpert J. Evidence for functional and structural multiplicity of pregnenolone-16α-carbonitrile-inducible cytochrome P-450 isozymes in rat liver microsomes. Biochemistry. 26:1987;3887-3894.
12. Barnes T.S., Shaw P.M., Burke M.D., Melvin W.T. Monoclonal antibodies against human cytochrome P-450 recognizing different pregnenolone 16α-carbonitrile-inducible rat cytochromes P-450. Biochem J. 248:1987;301-304.
13. Hostetler K.A., Wrighton S.A., Kremers P., Guzelian P.S. Immmunochemical evidence for multiple steroid-inducible hepatic cytochromes P-450 in the rat. Biochem J. 245:1987;27-33.
14. Halpert J.R. Multiplicity of steroid-inducible cytochromes P-450 in rat liver microsomes. Arch Biochem Biophys. 263:1988;59-68.
15. Nagata K., Gonzalez F.J., Yamazoe Y., Kato R. Purification and characterization of four catalytically active testosterone 6β-hydroxylase P-450s from rat liver microsomes Comparison of a novel form with three structurally and functionally related forms . J Biochem (Tokyo). 107:1990;718-725.
16. Gemzik B., Greenway D., Nevins C., Parkinson A. Regulation of two electrophoretically distinct proteins recognized by antibody against rat liver cytochrome P450 3A1. J Biochem Toxicol. 7:1992;43-52.
17. Cooper K.O., Reik L.M., Jayyosi Z., Bandiera S., Kelley M., Ryan D.E., Daniel R., McCluskey S.A., Levin W., Thomas P.E. Regulation of two members of the steroid-inducible cytochrome P450 subfamily (3A) in rats. Arch Biochem Biophys. 301:1993;345-354.
18. Nelson D.R., Koymans L., Kamataki T., Stegeman J.J., Feyereisen R., Waxman D.J., Waterman M.R., Gotoh O., Coon M.J., Estabrook R.W., Gunsalus I.C., Nebert D.W. P450 superfamily Update on new sequences, gene mapping, accession numbers and nomenclature . Pharmacogenetics. 6:1996;1-42.
19. Nagata K., Ogino M., Shimada M., Miyata M., Gonzalez F.J., Yamazoe Y. Structure and expression of the rat CYP3A1 gene Isolation of the gene (P450/6βB) and characterization of the recombinant protein . Arch Biochem Biophys. 362:1999;242-253.
20. Strotkamp D., Roos P.H., Hanstein W.G. A novel CYP3 gene from female rats. Biochim Biophys Acta. 1260:1995;341-344.
21. Mahnke A., Strotkamp D., Roos P.H., Hanstein W.G., Chabot G.G., Nef P. Expression and inducibility of cytochrome P450 3A9 (CYP3A9) and other members of the CYP3A subfamily in rat liver. Arch Biochem Biophys. 337:1997;62-68.
22. Kostrubsky V.E., Lewis L.D., Wood S.G., Sinclair P.R., Wrighton S.A., Sinclair J.F. Effect of Taxol on cytochrome P450 3A and acetaminophen toxicity in cultured rat hepatocytes Comparison to dexamethasone . Toxicol Appl Pharmacol. 142:1997;79-86.
23. Ghosal A., Sadrieh N., Reik L., Levin W., Thomas P.E. Induction of the male-specific cytochrome P450 3A2 in female rats by phenytoin. Arch Biochem Biophys. 332:1996;153-162.
24. Schuetz E.G., Wrighton S.A., Safe S.H., Guzelian P.S. Regulation of cytochrome P-450p by phenobarbital and phenobarbital-like inducers in adult rat hepatocytes in primary monolayer culture and in vivo. Biochemistry. 25:1986;1124-1133.
25. Halvorson M., Greenway D., Eberhart D., Fitzgerald K., Parkinson A. Reconstitution of testosterone oxidation by purified rat cytochrome P450p (IIIA1). Arch Biochem Biophys. 277:1990;166-180.
26. 6β2 catalyzing testosterone 6β- and 16α-hydroxylations. Pharmacogenetics. 6:1996;103-111.
27. Gabriel S.M., Roncancio J.R., Ruiz N.S. Growth hormone pulsatility and the endocrine milieu during sexual maturation in male and female rats. Neuroendocrinology. 56:1992;619-628.
28. Jansson J.O., Eden S., Isaksson O. Sexual dimorphism in the control of growth hormone secretion. Endocr Rev. 6:1985;128-150.
29. Yamazoe Y., Murayama N., Shimada M., Yamauchi K., Nagata K., Imaoka S., Funae Y., Kato R. A sex-specific form of cytochrome P-450 catalyzing propoxycoumarin O-depropylation and its identity with testosterone 6β-hydroxylase in untreated rat livers Reconstitution of the activity with microsomal lipids . J Biochem (Tokyo). 104:1988;785-790.
30. Ribeiro V., Lechner M.C. Cloning and characterization of a novel CYP3A1 allelic variant Analysis of CYP3A1 and CYP3A2 sex-hormone-dependent expression reveals that the CYP3A2 gene is regulated by testosterone . Arch Biochem Biophys. 293:1992;147-152.
31. Wright M.C., Edwards R.J., Pimenta M., Ribeiro V., Ratra G.S., Lechner M.C., Paine A.J. Developmental changes in the constitutive and inducible expression of cytochrome P450 3A2. Biochem Pharmacol. 54:1997;841-846.
32. Gonzalez F.J., Song B.-J., Hardwick J.P. Pregnenolone 16α-carbonitrile-inducible P-450 gene family Gene conversion and differential regulation . Mol Cell Biol. 6:1986;2969-2976.
33. Wang H., Strobel H.W. Regulation of CYP3A9 gene expression by estrogen and catalytic studies using cytochrome P450 3A9 expressed in Escherichia coli. Arch Biochem Biophys. 344:1997;365-372.
34. Robertson G.R., Farrell G.C., Liddle C. Sexually dimorphic expression of rat CYP3A9 and CYP3A18 genes is regulated by growth hormone. Biochem Biophys Res Commun. 242:1998;57-60.
35. 6β (testosterone 6β-hydroxylase) mRNAs in rat livers. J Biochem (Tokyo). 106:1989;1030-1034.
36. Waxman D.J., Ram P.A., Notani G., LeBlanc G.A., Alberta J.A., Morrissey J.J., Sundseth S.S. Pituitary regulation of the male-specific steroid 6β-hydroxylase P-450 2a (gene product IIIA2) in adult rat liver. Suppressive influence of growth hormone and thyroxine acting at a pretranslational level. Mol Endocrinol. 4:1990;447-454.
37. Waxman D.J., LeBlanc G.A., Morrissey J.J., Staunton J., Lapenson D.P. Adult male-specific and neonatally programmed rat hepatic P-450 forms RLM2 and 2a are not dependent on pulsatile plasma growth hormone for expression. J Biol Chem. 263:1988;11396-11406.
38. Bakke J.L., Lawrence N., Bennett J., Robinson S., Bowers C.Y. Late endocrine effects of administering monosodium glutamate to neonatal rats. Neuroendocrinology. 26:1978;220-228.
39. Waxman D.J., Morrissey J.J., MacLeod J.N., Shapiro B.H. Depletion of serum growth hormone in adult female rats by neonatal monosodium glutamate treatment without loss of female-specific hepatic enzymes P450 2d (IIC12) and steroid 5α-reductase. Endocrinology. 126:1990;712-720.
40. Waxman D.J., Ram P.A., Pampori N.A., Shapiro B.H. Growth hormone regulation of male-specific rat liver P450s 2A2 and 3A2 Induction by intermittent growth hormone pulses in male but not female rats rendered growth hormone deficient by neonatal monosodium glutamate . Mol Pharmacol. 48:1995;790-797.
41. Legraverend C., Mode A., Wells T., Robinson I., Gustafsson J.A. Hepatic steroid hydroxylating enzymes are controlled by the sexually dimorphic pattern of growth hormone secretion in normal and dwarf rats. FASEB J. 6:1992;711-718.
42. Waxman D.J., Chang T.K.H. Hormonal regulation of liver cytochrome P450 enzymes. Ortiz de Montellano P.R. Cytochrome P450 Structure, Mechanism, and Biochemistry . 1995;391-417 Plenum Press, New York.
43. Gertner J.M. Growth hormone treatment in children. Trends Endocrinol Metab. 8:1997;92-97.
44. Waxman D.J., Pampori N.A., Ram P.A., Agrawal A.K., Shapiro B.H. Interpulse interval in circulating growth hormone patterns regulates sexually dimorphic expression of hepatic cytochrome P450. Proc Natl Acad Sci USA. 88:1991;6868-6872.
45. Groesbeck M.D., Parlow A.F., Daughaday W.H. Stimulation of supranormal growth in prepubertal, adult plateaued, and hypophysectomized female rats by large doses of rat growth hormone Physiological effects and adverse consequences . Endocrinology. 120:1987;1963-1975.
46. Thomas P.E., Reik L.M., Ryan D.E., Levin W. Induction of two immunochemically related rat liver cytochrome P-450 isozymes, cytochromes P-450c and P-450d, by structurally diverse xenobiotics. J Biol Chem. 258:1983;4590-4598.
47. Omura T., Sato R. The carbon monoxide binding pigment of liver microsomes. II. Solubilization, purification, and properties. J Biol Chem. 239:1964;2379-2385.
48. Anderson M.D., Bandiera S.M., Chang T.K.H., Bellward G.D. Effect of androgen administration during puberty on hepatic CYP2C11, CYP3A, and CYP2A1 expression in adult female rats. Drug Metab Dispos. 26:1998;1031-1038.
49. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-685.
50. ® on hepatic expression of cytochrome P450 2B in rats. Biochem Pharmacol. 52:1996;735-742.
51. Towbin H., Staehelin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets Procedure and some applications . Proc Natl Acad Sci USA. 76:1979;4350-4354.
52. Zhang Q.-Y., Wikoff J., Dunbar D., Kaminsky L. Characterization of rat small intestine cytochrome P450 composition and inducibility. Drug Metab Dispos. 24:1996;322-328.
53. Morris D.L., Davila J.C. Analysis of rat cytochrome P450 isoenzyme expression using semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR). Biochem Pharmacol. 52:1996;781-792.
54. McClellan-Green P.D., Linko P., Yeowell H.N., Goldstein J.A. Hormonal regulation of male-specific rat hepatic cytochrome P-450g (P-450IIC13) by androgens and the pituitary. J Biol Chem. 264:1989;18960-18965.
55. Sundseth S.S., Waxman D.J. Sex-dependent expression and clofibrate inducibility of cytochrome P450 4A fatty acid ω-hydroxylases. Male specificity of liver and kidney CYP4A2 mRNA and tissue-specific regulation by growth hormone and testosterone. J Biol Chem. 267:1992;3915-3921.
56. Pampori N.A., Shapiro B.H. Gender differences in the responsiveness of the sex-dependent isoforms of hepatic P450 to the feminine plasma growth hormone profile. Endocrinology. 140:1999;1245-1254.
57. Shimada M., Murayama N., Nagata K., Hashimoto H., Ishikawa H., Yamazoe Y. A specific loss of growth hormone abolished sex-dependent expression of hepatic cytochrome P450 in dwarf rats Reversal of the profiles by growth hormone treatment . Arch Biochem Biophys. 337:1997;34-42.
58. Miyata M., Nagata K., Shimada M., Yamazoe Y., Kato R. Structure of a gene and cDNA of a major constitutive form of testosterone 6β-hydroxylase (P450/6βA) encoding CYP3A2 Comparison of the cDNA with P450PCN2 . Arch Biochem Biophys. 314:1994;351-359.
59. Imaoka S., Terano Y., Funae Y. Constitutive testosterone 6β-hydroxylase in rat liver. J Biochem (Tokyo). 104:1988;481-487.