Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells

British Journal of Haematology

Volumn 132, Issue 5, 2006, Pages 615-622

  Bacher, Nicole ^a,b,c   Tiefenthaler, Martin ^d   Sturm, Sonja ^e   Stuppner, Hermann ^e   Ausserlechner, Michael J ^d   Kofler, Reinhard ^b,d   Konwalinka, Günther ^a  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b TYROLEAN CANCER RESEARCH INSTITUTE   (Austria)

^c ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^d INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^e UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Alkaloids; Apoptosis; Cell cycle arrest; Lymphoblastic leukaemia; Uncaria tomentosa

Indexed keywords

ALKALOID DERIVATIVE; CYTOKINE RESPONSE MODIFIER A; DEXAMETHASONE; ISOMITRAPHYLLINE; ISOPTEROPODINE; METRAPHYLLINE; OXINDOLE; PROTEIN BCL 2; PROTEIN P16INK4A; PTEROPODINE; TETRACYCLINE; UNCARIA TOMENTOSA EXTRACT; UNCARINE; UNCLASSIFIED DRUG;

ACUTE LYMPHOCYTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LEUKEMIA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RUBIACEAE; UNCARIA TOMENTOSA;

ALKALOIDS; APOPTOSIS; BLOTTING, WESTERN; CASPASE 9; CASPASES; CAT'S CLAW; CELL PROLIFERATION; COLLAGEN TYPE XI; CYCLIN-DEPENDENT KINASE INHIBITOR P16; G1 PHASE; HUMANS; INDOLE ALKALOIDS; INDOLES; LEUKEMIA, LYMPHOCYTIC, ACUTE; PHYTOTHERAPY; PROTO-ONCOGENE PROTEINS C-BCL-2; SERPINS; SPIRO COMPOUNDS; T-LYMPHOCYTES; TUMOR CELLS, CULTURED; VIRAL PROTEINS;

EID: 33644883914     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2005.05907.x     Document Type: Article

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