Identification and quantification of components in extracts of Uncaria tomentosa by HPLC-ES/MS

Phytochemical Analysis

Volumn 15, Issue 1, 2004, Pages 55-64

  Montoro, P ^a   Carbone, V ^b   de Dioz Zuniga Quiroz, J ^c   De Simone, F ^a   Pizza, C ^a  

^a UNIVERSITY OF SALERNO   (Italy)

^b CNR   (Italy)

^c NONE   (Peru)

Author keywords

ES MS; Flow injection assay; HPLC MS; Indole alkaloids; Quinovic acid glycosides; Uncaria tomentosa

Indexed keywords

ALKALOIDS; EXTRACTION; GLYCOSIDES; PHASE SEPARATION; PLANTS (BOTANY); SUGARS;

ANALYTICAL METHOD; ES-MS; FLOW INJECTION; FLOW INJECTION ASSAY; HPLC-MS; INDOLE ALKALOIDS; QUINOVIC ACID GLYCOSIDE; RUBIACEAE; SECONDARY METABOLITES; UNCARIA TOMENTOSA;

METABOLITES;

ALKALOID DERIVATIVE; CATION; GLYCOSIDE; TRITERPENE DERIVATIVE; UNCARIA TOMENTOSA EXTRACT;

ANALYTIC METHOD; ARTICLE; BARK; CHEMICAL PROCEDURES; CONTROLLED STUDY; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION EXCHANGE; PLANT LEAF; QUANTITATIVE ANALYSIS; SEPARATION TECHNIQUE; SOLID PHASE EXTRACTION; STRUCTURE ANALYSIS; UNCARIA TOMENTOSA;

MARTYNIA ANNUA; RUBIACEAE; UNCARIA TOMENTOSA;

EID: 1042280286     PISSN: 09580344     EISSN: None     Source Type: Journal    
DOI: 10.1002/pca.740     Document Type: Article

References (19)

1. Aquino R, De Simone F, Pizza C, Conti C, Stein ML. 1989. Plant metabolites. Structure and in vitro activity of quinovic acid glycosides from Uncaria tomentosa and Guettarda platypoda. J Nat Prod 52: 679-685.
2. Aquino R, De Simone F, Vincieri FF, Pizza C. 1990. New polyhydroxylated triterpenes from Uncaria tomentosa. J Nat Prod 53: 559-564.
3. Aquino R, De Feo V, De Simone F, Pizza C, Cirino G. 1991. Plant metabolites. New compounds and antiinflammatory activity of Uncaria tomentosa. J Nat Prod 54: 433-459.
4. Aquino R, De Tommasi N, De Simone F, Pizza C. 1997. Triterpenes and quinovic acid glycosides from Uncaria tomentosa. Phytochemistry 45: 1035-1040.
5. Cerri R, Aquino R, De Simone F, Pizza C. 1988. New quinovic acid glycosides from Uncaria tomentosa. J Nat Prod 51: 257-261.
6. Ganzera M, Muhammad I, Khan RA, Khan IA. 2001. Improved method for the determination of oxindole alkaloids in Uncaria tomentosa by high performance liquid chromatography. Planta Med 67: 447-450.
7. Keplinger K, Laus G, Wurm M, Dierich MP, Teppner H. 1999. Uncaria tomentosa (Willd) DC.-ethnomedicinal use and new pharmacological, toxicological and botanical results. J Ethnopharmac 64: 23-34.
8. Lamaire I, Assinewe V, Cono P, Awang DVC, Arnason JT. 1999. Stimulation of interleukin-1 and -6 production in alveolar macrophages by the neotropical liana, Uncaria tomentosa (Uña de gato). J Ethnopharmac 64: 109-115.
9. Laus G, Keplinger D. 1994. Separation of stereoisomeric oxindole alkaloids from Uncaria tomentosa by high performance liquid chromatography. J Chromatogr A 662:243-249.
10. Laus G, Brössner D, Senn G, Wurst K. 1996. Analysis of the kinetics of isomerisation of spiro oxindole alkaloids. J Chem Soc Perkin Trans 2: 1931-1936.
11. Laus G, Brössner D, Keplinger K. 1997. Analysis of the kinetics of isomerisation of spiro oxindole alkaloids. Phytochemistry 45: 855-860.
12. Lopez Avila V, Benedicto J., 1992. Supercritical fluid extraction of oxindole alkaloids from Uncaria tomentosa. J High Resol Chromatogr 20: 231-236.
13. Rizzi R, Re F, Bianchi A, De Feo V, De Simone F, Bianchi L, Stivala LA. 1993. Mutagenic and anti-mutagenic activities of Uncaria tomentosa and its extracts. J Ethnopharmac 38: 63-77.
14. Seki H, Takayama H, Aimi N Sakai S, Ponglux D. 1993. A nuclear magnetic resonance study on the eleven stereo-isomers of heteroyohimbine-type oxindole alkaloids. Chem Pharm Bull 41: 2077-2086.
15. Stuppner H, Sturm S. 1992. Capillary electrophoretic analysis of oxindole alkaloids from Uncaria tomentosa. J Chromatogr 609: 375-380.
16. Stuppner H, Sturm S, Konwalinka G. 1992. HPLC analysis of the main oxindole alkaloids from Uncaria tomentosa. Chromatographia 34: 597-600.
17. 13C-NMR chemical shift assignments for some pentacyclic oxindole alkaloids. Spectrosc Lett 25: 293-300.
18. Verpoorte R, Niessen WMA. 1994. Liquid chromatography coupled with mass spectrometry in the analysis of alkaloids. Phytochem Anal 5: 217-232.
19. Wagner H, Kreutzkamp B, Jurcic K. 1984. The alkaloids of Uncaria tomentosa and their phagocytosis-stimulating action. Planta Med 50: 419-423.