Naphthoindole-based analogues of tryptophan and tryptamine: Synthesis and cytotoxic properties

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 7, 2007, Pages 2651-2659

  Shchekotikhin, Andrey E ^a   Dezhenkova, Lyubov G ^a   Susova, Olga Yu ^b   Glazunova, Valeria A ^b   Luzikov, Yuri N ^a   Sinkevich, Yuri B ^c   Buyanov, Vladimir N ^c   Shtil, Alexander A ^b   Preobrazhenskaya, Maria N ^a  

^a GAUSE INSTITUTE OF NEW ANTIBIOTICS   (Russian Federation)

^b N N BLOKHIN RUSSIAN CANCER RESEARCH CENTER   (Russian Federation)

^c MENDELEEV UNIVERSITY OF CHEMICAL TECHNOLOGY OF RUSSIA   (Russian Federation)

Author keywords

Circumvention of drug resistance; Cytotoxic; Derivatives of 4,11 dihydroxynaphtho 2,3 f indole 5,10 dione; Human tumor cells; Inhibitor of topoisomerase I; P glycoprotein; p53; Tryptamine; Tryptophan

Indexed keywords

3 (2 AMINOETHYL) 4,11 DIHYDROXY 1H NAPHTHO[2,3 F]INDOLE 5,10 DIONE; 3 (2 AMINOETHYL) 4,11 DIMETHOXY 1H NAPHTHO[2,3 F]INDOLE 5,10 DIONE; 3 (2 AMINOPROPYL) 4,11 DIHYDROXY 1H NAPHTHO[2,3 F]INDOLE 5,10 DIONE; 3 (2 AMINOPROPYL) 4,11 DIMETHOXY 1H NAPHTHO[2,3 F]INDOLE 5,10 DIONE; 3 (4,11 DIHYDROXY 1H NAPHTHO[2,3 F]INDOLE 5,10 DION 3 YL)ALANINE; 3 (4,11 DIHYDROXY 1H NAPHTHO[2,3 F]INDOLE 5,10 DION 3 YL)ALANINE ETHYL ESTER; 4,11 DIMETHOXY 3 (2 NITROETHYL) 1H NAPHTHO[2,3 F]INDOLE 5,10 DIONE; 4,11 DIMETHOXY 3 (2 NITROPROPYL) 1H NAPHTHO[2,3 F]INDOLE 5,10 DIONE; ANTINEOPLASTIC AGENT; DIETHYL 2 (ACETYLAMINO) 2 [(4,11 DIMETHOXY 1H NAPHTHO[2,3 F]INDOLE 5,10 DION 3 YL)METHYL]MALONATE; DNA TOPOISOMERASE; DOXORUBICIN; GLYCOPROTEIN P; N (TERT BUTOXYCARBONYL) 3 (4,11 DIHYDROXY 1H NAPHTHO[2,3 F]INDOLE 5,10 DION 3 YL)ALANINE; N (TERT BUTOXYCARBONYL) 3 (4,11 DIMETHOXY 1H NAPHTHO[2,3 F]INDOLE 5,10 DION 3 YL)ALANINE; N ACETYL 3 (4,11 DIMETHOXY 1H NAPHTHO[2,3 F]INDOLE 5,10 DION 3 YL)ALANINE; N ACETYL 3 (4,11 DIMETHOXY 1H NAPHTHO[2,3 F]INDOLE 5,10 DION 3 YL)ALANINE ESTER; N ACETYL N (TERT BUTOXYCARBONYL) 3 [1 (TERT BUTOXYCARBONYL) 4,11 DIMETHOXY 1H NAPHTHO[2,3 F]INDOLE 5,10 DION 3 YL]ALANINE ETHYL ESTER; PROTEIN P53; TRYPTAMINE DERIVATIVE; TRYPTOPHAN DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER RESISTANCE; CARCINOMA CELL; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG RESPONSE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKEMIA CELL; PROTEIN EXPRESSION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; INDICATORS AND REAGENTS; INDOLES; MAGNETIC RESONANCE SPECTROSCOPY; TRYPTAMINES; TRYPTOPHAN;

EID: 33847667574     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.01.034     Document Type: Article

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