Tryptophan-scanning mutagenesis in the S1 domain of mammalian HCN channel reveals residues critical for voltage-gated activation

Journal of Physiology

Volumn 579, Issue 2, 2007, Pages 291-301

  Ishii, Takahiro M ^a   Nakashima, Noriyuki ^a   Ohmori, Harunori ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; CATION CHANNEL; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL; LEUCINE; TRYPTOPHAN; UNCLASSIFIED DRUG; VALINE; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL 1; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL 4;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; HYPERPOLARIZATION; MEMBRANE CHANNEL; MEMBRANE CURRENT; MEMBRANE POTENTIAL; MUTAGENESIS; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; VOLTAGE CLAMP; WILD TYPE; XENOPUS; BIOSENSOR; CELL MEMBRANE POTENTIAL; ELECTRIC POTENTIAL; FEMALE; IMMUNOFLUORESCENCE; OOCYTE; PROTEIN EXPRESSION; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; ELECTROPHYSIOLOGY; FEMALE; ION CHANNEL GATING; ION CHANNELS; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; MUTATION; OOCYTES; PROTEIN STRUCTURE, TERTIARY; TRYPTOPHAN; XENOPUS LAEVIS;

EID: 33847647052     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2006.124297     Document Type: Article

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