메뉴 건너뛰기




Volumn 56, Issue 1, 2007, Pages 32-37

Nitric oxide and pro-inflammatory cytokines correlate with pain intensity in chronic pain patients

Author keywords

Chronic pain; Cytokines; Nitric oxide (NO); Pain intensity; Plasma concentrations

Indexed keywords

ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; CORTICOSTEROID; CYCLOOXYGENASE 2 INHIBITOR; CYTOKINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 8; MUSCLE RELAXANT AGENT; NITRATE; NITRIC OXIDE; NITRITE; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; TUMOR NECROSIS FACTOR ALPHA;

EID: 33847629731     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-007-6088-4     Document Type: Article
Times cited : (162)

References (48)
  • 1
    • 0035696214 scopus 로고    scopus 로고
    • Nociception, pain, and antinociception: Current concepts
    • Riedel W, Neeck G. Nociception, pain, and antinociception: current concepts. Z Rheumatol 2001; 60(6): 404-15.
    • (2001) Z Rheumatol , vol.60 , Issue.6 , pp. 404-415
    • Riedel, W.1    Neeck, G.2
  • 2
    • 0027502194 scopus 로고
    • Nitric oxide (NO) and nociceptive processing in the spinal cord
    • Meller ST, Gebhart GF. Nitric oxide (NO) and nociceptive processing in the spinal cord. Pain 1993; 52(2): 127-36.
    • (1993) Pain , vol.52 , Issue.2 , pp. 127-136
    • Meller, S.T.1    Gebhart, G.F.2
  • 3
    • 0024378999 scopus 로고
    • Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum
    • Bredt DS, Snyder SH. Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum. Proc Natl Acad Sci USA 1989; 86(22): 9030-3.
    • (1989) Proc Natl Acad Sci USA , vol.86 , Issue.22 , pp. 9030-9033
    • Bredt, D.S.1    Snyder, S.H.2
  • 4
    • 0030873515 scopus 로고    scopus 로고
    • Synaptic signaling by nitric oxide
    • Brenman JE, Bredt DS. Synaptic signaling by nitric oxide. Curr Opin Neurobiol 1997; 7(3): 374-8.
    • (1997) Curr Opin Neurobiol , vol.7 , Issue.3 , pp. 374-378
    • Brenman, J.E.1    Bredt, D.S.2
  • 5
    • 0026669125 scopus 로고
    • Nitric oxide: First in a new class of neurotransmitters
    • Snyder SH. Nitric oxide: first in a new class of neurotransmitters. Science 1992; 257(5069): 494-6.
    • (1992) Science , vol.257 , Issue.5069 , pp. 494-496
    • Snyder, S.H.1
  • 6
    • 0034736189 scopus 로고    scopus 로고
    • Localization and regulation of cyclo-oxygenase-1 and -2 and neuronal nitric oxide synthase in mouse spinal cord
    • Maihofner C, Tegeder I, Euchenhofer C, deWitt D, Brune K, Bang R et al. Localization and regulation of cyclo-oxygenase-1 and -2 and neuronal nitric oxide synthase in mouse spinal cord. Neuroscience 2000; 101(4): 1093-108.
    • (2000) Neuroscience , vol.101 , Issue.4 , pp. 1093-1108
    • Maihofner, C.1    Tegeder, I.2    Euchenhofer, C.3    deWitt, D.4    Brune, K.5    Bang, R.6
  • 7
    • 0343953615 scopus 로고    scopus 로고
    • Regulation and immunhistochemical localization of nitric oxide synthases and soluble guanylyl cyclase in mouse spinal cord following nociceptive stimulation
    • Maihofner C, Euchenhofer C, Tegeder I, Beck KF, Pfeilschifter J, Geisslinger G. Regulation and immunhistochemical localization of nitric oxide synthases and soluble guanylyl cyclase in mouse spinal cord following nociceptive stimulation. Neurosci Lett 2000; 290(1): 71-5.
    • (2000) Neurosci Lett , vol.290 , Issue.1 , pp. 71-75
    • Maihofner, C.1    Euchenhofer, C.2    Tegeder, I.3    Beck, K.F.4    Pfeilschifter, J.5    Geisslinger, G.6
  • 8
    • 0035252354 scopus 로고    scopus 로고
    • The role of neuroinflammation and neuroimmune activation in persistent pain
    • DeLeo JA, Yezierski RP. The role of neuroinflammation and neuroimmune activation in persistent pain. Pain 2001; 90(1-2): 1-6.
    • (2001) Pain , vol.90 , Issue.1-2 , pp. 1-6
    • DeLeo, J.A.1    Yezierski, R.P.2
  • 9
    • 0344305587 scopus 로고    scopus 로고
    • Interferon-gamma induces characteristics of central sensitization in spinal dorsal horn neurons in vitro
    • Vikman KS, Hill RH, Backstrom E, Robertson B, Kristensson K. Interferon-gamma induces characteristics of central sensitization in spinal dorsal horn neurons in vitro. Pain 2003; 106(3): 241-51.
    • (2003) Pain , vol.106 , Issue.3 , pp. 241-251
    • Vikman, K.S.1    Hill, R.H.2    Backstrom, E.3    Robertson, B.4    Kristensson, K.5
  • 11
    • 0035932121 scopus 로고    scopus 로고
    • Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity
    • Samad TA, Moore KA, Sapirstein A, Billet S, Allchorne A, Poole S et al. Interleukin-1beta-mediated induction of Cox-2 in the CNS contributes to inflammatory pain hypersensitivity. Nature 2001; 410(6827): 471-5.
    • (2001) Nature , vol.410 , Issue.6827 , pp. 471-475
    • Samad, T.A.1    Moore, K.A.2    Sapirstein, A.3    Billet, S.4    Allchorne, A.5    Poole, S.6
  • 12
    • 0035932466 scopus 로고    scopus 로고
    • Bartfai T. Immunology. Telling the brain about pain. Nature 2001; 410(6827): 425, 427.
    • Bartfai T. Immunology. Telling the brain about pain. Nature 2001; 410(6827): 425, 427.
  • 14
    • 0347993913 scopus 로고    scopus 로고
    • Nitric oxide and superoxide in inflammation and immune regulation
    • Guzik TJ, Korbut R, Adamek-Guzik T. Nitric oxide and superoxide in inflammation and immune regulation. J Physiol Pharmacol 2003; 54(4): 469-87.
    • (2003) J Physiol Pharmacol , vol.54 , Issue.4 , pp. 469-487
    • Guzik, T.J.1    Korbut, R.2    Adamek-Guzik, T.3
  • 16
    • 0033984448 scopus 로고    scopus 로고
    • Fos expression is induced by increased nitric oxide release in rat spinal cord dorsal horn
    • Wu J, Fang L, Lin Q, Willis WD. Fos expression is induced by increased nitric oxide release in rat spinal cord dorsal horn. Neuroscience 2000; 96(2): 351-7.
    • (2000) Neuroscience , vol.96 , Issue.2 , pp. 351-357
    • Wu, J.1    Fang, L.2    Lin, Q.3    Willis, W.D.4
  • 17
    • 0033016962 scopus 로고    scopus 로고
    • Nitric oxide-mediated spinal disinhibition contributes to the sensitization of primate spinothalamic tract neurons
    • Lin Q, Wu J, Peng YB, Cui M, Willis WD. Nitric oxide-mediated spinal disinhibition contributes to the sensitization of primate spinothalamic tract neurons. J Neurophysiol 1999; 81(3): 1086-94.
    • (1999) J Neurophysiol , vol.81 , Issue.3 , pp. 1086-1094
    • Lin, Q.1    Wu, J.2    Peng, Y.B.3    Cui, M.4    Willis, W.D.5
  • 18
    • 0033529277 scopus 로고    scopus 로고
    • Supraspinal contributions to hyperalgesia
    • Urban MO, Gebhart GF. Supraspinal contributions to hyperalgesia. Proc Natl Acad Sci USA 1999; 96(14): 7687-92.
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.14 , pp. 7687-7692
    • Urban, M.O.1    Gebhart, G.F.2
  • 19
    • 0028953529 scopus 로고
    • Activation of microglial cells by beta-amyloid protein and interferon-gamma
    • Meda L, Cassatella MA, Szendrei GI, Otvos L, Jr., Baron P, Villalba M et al. Activation of microglial cells by beta-amyloid protein and interferon-gamma. Nature 1995; 374(6523): 647-50.
    • (1995) Nature , vol.374 , Issue.6523 , pp. 647-650
    • Meda, L.1    Cassatella, M.A.2    Szendrei, G.I.3    Otvos Jr., L.4    Baron, P.5    Villalba, M.6
  • 20
    • 0030974030 scopus 로고    scopus 로고
    • Cytokine-mediated neuronal apoptosis
    • Hu S, Peterson PK, Chao CC. Cytokine-mediated neuronal apoptosis. Neurochem Int 1997; 30(4-5): 427-31.
    • (1997) Neurochem Int , vol.30 , Issue.4-5 , pp. 427-431
    • Hu, S.1    Peterson, P.K.2    Chao, C.C.3
  • 21
    • 7544248841 scopus 로고    scopus 로고
    • Proinflammatory cytokine profiles in sera and pathological tissues of patients with active untreated adult onset Still's disease
    • Chen DY, Lan JL, Lin FJ, Hsieh TY. Proinflammatory cytokine profiles in sera and pathological tissues of patients with active untreated adult onset Still's disease. J Rheumatol 2004; 31(11): 2189-98.
    • (2004) J Rheumatol , vol.31 , Issue.11 , pp. 2189-2198
    • Chen, D.Y.1    Lan, J.L.2    Lin, F.J.3    Hsieh, T.Y.4
  • 22
    • 0028559232 scopus 로고
    • Cytokine levels in serum and synovial fluid of patients with juvenile rheumatoid arthritis
    • Madson KL, Moore TL, Lawrence JM, III, Osborn TG. Cytokine levels in serum and synovial fluid of patients with juvenile rheumatoid arthritis. J Rheumatol 1994; 21(12): 2359-63.
    • (1994) J Rheumatol , vol.21 , Issue.12 , pp. 2359-2363
    • Madson, K.L.1    Moore, T.L.2    Lawrence III, J.M.3    Osborn, T.G.4
  • 23
    • 0036163288 scopus 로고    scopus 로고
    • Cytokines and depression in cases with fibromyalgia
    • Gur A, Karakoc M, Nas K, Remzi, Cevik, Denli A et al. Cytokines and depression in cases with fibromyalgia. J Rheumatol 2002; 29(2): 358-61.
    • (2002) J Rheumatol , vol.29 , Issue.2 , pp. 358-361
    • Gur, A.1    Karakoc, M.2    Nas, K.3    Remzi, C.4    Denli, A.5
  • 24
    • 0032778504 scopus 로고    scopus 로고
    • Proinflammatory cytokines in cervicogenic headache
    • Martelletti P, Stirparo G, Giacovazzo M. Proinflammatory cytokines in cervicogenic headache. Funct Neurol 1999; 14(3): 159-62.
    • (1999) Funct Neurol , vol.14 , Issue.3 , pp. 159-162
    • Martelletti, P.1    Stirparo, G.2    Giacovazzo, M.3
  • 26
    • 0026253407 scopus 로고
    • Increased spontaneous release of tumor necrosis factor-alpha/cachectin in headache patients. A possible correlation with plasma endotoxin and hypothalamic-pituitary-adrenal axis
    • Covelli V, Massari F, Fallacara C, Munno I, Pellegrino NM, Jirillo E et al. Increased spontaneous release of tumor necrosis factor-alpha/cachectin in headache patients. A possible correlation with plasma endotoxin and hypothalamic-pituitary-adrenal axis. Int J Neurosci 1991; 61(1-2): 53-60.
    • (1991) Int J Neurosci , vol.61 , Issue.1-2 , pp. 53-60
    • Covelli, V.1    Massari, F.2    Fallacara, C.3    Munno, I.4    Pellegrino, N.M.5    Jirillo, E.6
  • 27
    • 24944558038 scopus 로고    scopus 로고
    • A pilot study of nitric oxide blood levels in patients with chronic orofacial pain
    • Gratt BM, Anbar M. A pilot study of nitric oxide blood levels in patients with chronic orofacial pain. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005; 100(4): 441-8.
    • (2005) Oral Surg Oral Med Oral Pathol Oral Radiol Endod , vol.100 , Issue.4 , pp. 441-448
    • Gratt, B.M.1    Anbar, M.2
  • 29
    • 0036678021 scopus 로고    scopus 로고
    • Release of algesic substances in human experimental muscle pain
    • Tegeder L, Zimmermann J, Meller ST, Geisslinger G. Release of algesic substances in human experimental muscle pain. Inflamm Res 2002; 51(8): 393-402.
    • (2002) Inflamm Res , vol.51 , Issue.8 , pp. 393-402
    • Tegeder, L.1    Zimmermann, J.2    Meller, S.T.3    Geisslinger, G.4
  • 30
    • 0035426434 scopus 로고    scopus 로고
    • Glial activation: A driving force for pathological pain
    • Watkins LR, Milligan ED, Maier SF. Glial activation: a driving force for pathological pain. Trends Neurosci 2001; 24(8): 450-5.
    • (2001) Trends Neurosci , vol.24 , Issue.8 , pp. 450-455
    • Watkins, L.R.1    Milligan, E.D.2    Maier, S.F.3
  • 31
    • 26244444488 scopus 로고    scopus 로고
    • Central proinflammatory cytokines and pain enhancement
    • Wieseler-Frank J, Maier SF, Watkins LR. Central proinflammatory cytokines and pain enhancement. Neurosignals 2005; 14(4): 166-74.
    • (2005) Neurosignals , vol.14 , Issue.4 , pp. 166-174
    • Wieseler-Frank, J.1    Maier, S.F.2    Watkins, L.R.3
  • 32
    • 0033660663 scopus 로고    scopus 로고
    • The role of nitric oxide in nociception
    • Luo ZD, Cizkova D. The role of nitric oxide in nociception. Curr Rev Pain 2000; 4(6): 459-66.
    • (2000) Curr Rev Pain , vol.4 , Issue.6 , pp. 459-466
    • Luo, Z.D.1    Cizkova, D.2
  • 33
    • 0037320840 scopus 로고    scopus 로고
    • Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats
    • Milligan ED, Twining C, Chacur M, Biedenkapp J, O'Connor K, Poole S et al. Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats. J Neurosci 2003; 23(3): 1026-40.
    • (2003) J Neurosci , vol.23 , Issue.3 , pp. 1026-1040
    • Milligan, E.D.1    Twining, C.2    Chacur, M.3    Biedenkapp, J.4    O'Connor, K.5    Poole, S.6
  • 34
    • 0035056034 scopus 로고    scopus 로고
    • Release of glutamate, nitric oxide and prostaglandin E2 and metabolic activity in the spinal cord of rats following peripheral nociceptive stimulation
    • Vetter G, Geisslinger G, Tegeder I. Release of glutamate, nitric oxide and prostaglandin E2 and metabolic activity in the spinal cord of rats following peripheral nociceptive stimulation. Pain 2001; 92(1-2): 213-8.
    • (2001) Pain , vol.92 , Issue.1-2 , pp. 213-218
    • Vetter, G.1    Geisslinger, G.2    Tegeder, I.3
  • 35
    • 3242725996 scopus 로고    scopus 로고
    • Peri-sciatic proinflammatory cytokines, reactive oxygen species, and complement induce mirror-image neuropathic pain in rats
    • Twining CM, Sloane EM, Milligan ED, Chacur M, Martin D, Poole S et al. Peri-sciatic proinflammatory cytokines, reactive oxygen species, and complement induce mirror-image neuropathic pain in rats. Pain 2004; 110(1-2): 299-309.
    • (2004) Pain , vol.110 , Issue.1-2 , pp. 299-309
    • Twining, C.M.1    Sloane, E.M.2    Milligan, E.D.3    Chacur, M.4    Martin, D.5    Poole, S.6
  • 36
    • 0026726106 scopus 로고
    • Nitric oxide mediates the thermal hyperalgesia produced in a model of neuropathic pain in the rat
    • Meller ST, Pechman PS, Gebhart GF, Maves TJ. Nitric oxide mediates the thermal hyperalgesia produced in a model of neuropathic pain in the rat. Neuroscience 1992; 50(1): 7-10.
    • (1992) Neuroscience , vol.50 , Issue.1 , pp. 7-10
    • Meller, S.T.1    Pechman, P.S.2    Gebhart, G.F.3    Maves, T.J.4
  • 37
    • 0028361631 scopus 로고
    • The role of nitric oxide in the development and maintenance of the hyperalgesia produced by intraplantar injection of carrageenan in the rat
    • Meller ST, Cummings CP, Traub RJ, Gebhart GF. The role of nitric oxide in the development and maintenance of the hyperalgesia produced by intraplantar injection of carrageenan in the rat. Neuroscience 1994; 60(2): 367-74.
    • (1994) Neuroscience , vol.60 , Issue.2 , pp. 367-374
    • Meller, S.T.1    Cummings, C.P.2    Traub, R.J.3    Gebhart, G.F.4
  • 38
    • 0029096491 scopus 로고
    • Nitric oxide evokes pain at nociceptors of the paravascular tissue and veins in humans
    • Holthusen H, Arndt JO. Nitric oxide evokes pain at nociceptors of the paravascular tissue and veins in humans. J Physiol 1995; 487(Pt 1): 253-8.
    • (1995) J Physiol , vol.487 , Issue.PART 1 , pp. 253-258
    • Holthusen, H.1    Arndt, J.O.2
  • 39
    • 6944255311 scopus 로고    scopus 로고
    • Non-systemic vasculitic neuropathy
    • Collins MP, Periquet MI. Non-systemic vasculitic neuropathy. Curr Opin Neurol 2004; 17(5): 587-98.
    • (2004) Curr Opin Neurol , vol.17 , Issue.5 , pp. 587-598
    • Collins, M.P.1    Periquet, M.I.2
  • 40
    • 23444438720 scopus 로고    scopus 로고
    • Effect of nuclear factor-kappaB inhibition on rheumatoid fibroblast-like synoviocytes and collagen induced arthritis
    • Okazaki Y, Sawada T, Nagatani K, Komagata Y, Inoue T, Muto S et al. Effect of nuclear factor-kappaB inhibition on rheumatoid fibroblast-like synoviocytes and collagen induced arthritis. J Rheumatol 2005; 32(8): 1440-7.
    • (2005) J Rheumatol , vol.32 , Issue.8 , pp. 1440-1447
    • Okazaki, Y.1    Sawada, T.2    Nagatani, K.3    Komagata, Y.4    Inoue, T.5    Muto, S.6
  • 41
    • 30444458848 scopus 로고    scopus 로고
    • GW274150, a novel and highly selective inhibitor of the inducible isoform of nitric oxide synthase (iNOS), shows analgesic effects in rat models of inflammatory and neuropathic pain
    • De Alba J, Clayton NM, Collins SD, Colthup P, Chessell I, Knowles RG. GW274150, a novel and highly selective inhibitor of the inducible isoform of nitric oxide synthase (iNOS), shows analgesic effects in rat models of inflammatory and neuropathic pain. Pain 2006; 120(1-2): 170-81.
    • (2006) Pain , vol.120 , Issue.1-2 , pp. 170-181
    • De Alba, J.1    Clayton, N.M.2    Collins, S.D.3    Colthup, P.4    Chessell, I.5    Knowles, R.G.6
  • 42
    • 33645523617 scopus 로고    scopus 로고
    • Opioid-induced Hyperalgesia in a Murine Model of Postoperative Pain: Role of Nitric Oxide Generated from the Inducible Nitric Oxide Synthase
    • Celerier E, Gonzalez JR, Maldonado R, Cabanero D, Puig MM. Opioid-induced Hyperalgesia in a Murine Model of Postoperative Pain: Role of Nitric Oxide Generated from the Inducible Nitric Oxide Synthase. Anesthesiology 2006; 104(3): 546-55.
    • (2006) Anesthesiology , vol.104 , Issue.3 , pp. 546-555
    • Celerier, E.1    Gonzalez, J.R.2    Maldonado, R.3    Cabanero, D.4    Puig, M.M.5
  • 43
    • 29844455345 scopus 로고    scopus 로고
    • Nitric oxide and its modulators in chronic constriction injury-induced neuropathic pain in rats
    • Naik AK, Tandan SK, Kumar D, Dudhgaonkar SP. Nitric oxide and its modulators in chronic constriction injury-induced neuropathic pain in rats. Eur J Pharmacol 2006; 530(1-2): 59-69.
    • (2006) Eur J Pharmacol , vol.530 , Issue.1-2 , pp. 59-69
    • Naik, A.K.1    Tandan, S.K.2    Kumar, D.3    Dudhgaonkar, S.P.4
  • 44
    • 33847644638 scopus 로고    scopus 로고
    • Nitric oxide-donating aspirin (NCX 4016): An overview of its pharmacological properties and clinical perspectives
    • Bolla M, Momi S, Gresele P, Del Soldato P. Nitric oxide-donating aspirin (NCX 4016): an overview of its pharmacological properties and clinical perspectives. Eur J Clin Pharmacol 2005; 1-10.
    • (2005) Eur J Clin Pharmacol , pp. 1-10
    • Bolla, M.1    Momi, S.2    Gresele, P.3    Del Soldato, P.4
  • 45
    • 0033930488 scopus 로고    scopus 로고
    • NO-naproxen modulates inflammation, nociception and downregulates T cell response in rat Freund's adjuvant arthritis
    • Cicala C, Ianaro A, Fiorucci S, Calignano A, Bucci M, Gerli R et al. NO-naproxen modulates inflammation, nociception and downregulates T cell response in rat Freund's adjuvant arthritis. Br J Pharmacol 2000; 130(6): 1399-405.
    • (2000) Br J Pharmacol , vol.130 , Issue.6 , pp. 1399-1405
    • Cicala, C.1    Ianaro, A.2    Fiorucci, S.3    Calignano, A.4    Bucci, M.5    Gerli, R.6
  • 47
    • 0036791714 scopus 로고    scopus 로고
    • Pharmacology and potential therapeutic applications of nitric oxide-releasing non-steroidal anti-inflammatory and related nitric oxide-donating drugs
    • Keeble JE, Moore PK. Pharmacology and potential therapeutic applications of nitric oxide-releasing non-steroidal anti-inflammatory and related nitric oxide-donating drugs. Br J Pharmacol 2002; 137(3): 295-310.
    • (2002) Br J Pharmacol , vol.137 , Issue.3 , pp. 295-310
    • Keeble, J.E.1    Moore, P.K.2
  • 48
    • 33644876484 scopus 로고    scopus 로고
    • Using pain quality assessment measures for selecting analgesic agents
    • Jensen MP. Using pain quality assessment measures for selecting analgesic agents. Clin J Pain 2006; 22(1 Suppl): S9-13.
    • (2006) Clin J Pain , vol.22 , Issue.1 SUPPL.
    • Jensen, M.P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.