The expression of p53 and phosphorylation of H2AX in germ cells of varicocele rats

Korean Journal of Urology

Volumn 47, Issue 12, 2006, Pages 1354-1360

  Cho, Won Jin ^a   Yeo, Moon Hwan ^a   You, Ho Jin ^a   Chan, In Youb ^a   Moon, Hyung Yoon ^a   Kim, Chul Sung ^a  

^a Chosun University   (South Korea)

Author keywords

DNA damage; p53; Varicocele; H2AX

Indexed keywords

HISTONE H2AX; PROTEIN P53;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; GERM CELL; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; ORCHIECTOMY; POSTOPERATIVE PERIOD; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SPERM; SPERMATOGENESIS; SPRAGUE DAWLEY RAT; VARICOCELE; WESTERN BLOTTING;

EID: 33847624502     PISSN: 04944747     EISSN: None     Source Type: Journal    
DOI: 10.4111/kju.2006.47.12.1354     Document Type: Article

References (30)

1. Naughton CK, Nangia AK, Agarwal A. Pathophysiology of vaticoceles in mate infertility. Hum Reprod Update 2001; 7:473-91
2. Fujisawa M, Hiramine C, Tanaka H, Okada H, Arakawa S, Kamidono S. Decrease in apoptosis of germ cells in the testes of infertile men with varicocele. World J Urol 1999;17: 296-300
3. Agarwal A, Allamaneni SS. Sperm DNA damage assessment: A test whose time has come. Fertil Steril 2005;84:850-3
4. Ku J, Shim HB, Kim SW, Paick JS. The role of apoptosis in the pathogenesis of varicocele. BJU Int 2005;96:1092-6
5. Saleh RA, Agarwal A, Sharma RK, Said TM, Sikka SC, Thomas AJ. Evaluation of nuclear DNA damage in spermatozoa from infertile men with varicocele. Fertil Steril 2003; 80: 431-6
6. Agarwal A, Said TM. Oxidative stress, DNA damage and apoptosis in male infertility: A clinical approach. BJU Int 2005; 95:503-7
7. Sinha Hikim AP, Swerdloff RS. Hormonal and genetic control of germ cell apoptosis in the testis. Rev Reprod 1999;4:38-47
8. Huckins C. The morphology and kinetics of spermatogonial degeneration in normal adult rats: an analysis using a simplified classification of the gerininal epithelium. Anat Rec 1978;190:905-26
9. Fisher DE. The p53 turnor suppressor: Critical regulator of life and death in cancer. Apoptosis 2001;6:7-15
10. Lugar K, Mader AW, Richmond RK, Sargent DF, Richmond TJ. Crystal structure of the nucleosome core particle at 2.8 Å resolution. Nature 1997;389:251-60
11. Rogakou EP, Pitch DR, Orr AH, Ivanova VS, Bonner WM. DNA double-stranded breaks induce historic H2AX phophorylation on serine 139. J Biol Chem 1998;273:5858-68
12. Rogakou EP, Boon C, Redon C, Bonner WM. Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol 1999;146:905-16
13. Sedelnikova OA, Rogakou EP, Panyutin IG, Bonner WM. Quantitative detection of (125)IdU-induced DNA double-strand breaks with gamma-H2AX antibody. Radiat Res 2002;158: 486-92
14. Gorelick JI, Goldstein M. Loss of infertility in men with varicocele. Fertil Steril 1993;59:613-6
15. Greenberg SM, Lipschultz LI, Wein AJ. Experience with 425 subfertile male patients. J Urol 1978;119:507-12
16. Sayfan J, Halevy A, Oland J, Nathan H. Varicocele and left renal vein compression. Fertil Steril 1984;41:411-7
17. Schneck FX, Bellinger MF. Abnormalities of the testis and scrotum and their surgical management. In: Walsh PC, Retik AB, Vaughan ED Jr, Wein AJ, editors. Campbell's urology. 8th ed. Philadelphia: Saunders; 1998;2384-8
18. Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implication in tissue kinetics. Br J Cancer 1972;26:239-57
19. Barqawi A, Caruso A, Meacham RB. Experimental varicoccle induces testicular germ cell apoptosis in the rat. J Urol 2004; 171:501-3
20. Simsek F, Turkeri L, Cevik I, Bircan K, Akdas A. Role of apoptosis in testicular tissue damage caused by varicocele. Arch Esp Urol 1998;51:947-50
21. Kilinc F, Guvel S, Kayaselcuk F, Aygun C, Egilmez T, Ozkardes H. p53 expression and apoptosis in varicocele in the rat testis. J Urol 2004;172:2475-8
22. Tanaka H, Fujisava M, Tanaka H, Okada H, Kamidono S. Apoptosis-related proteins in the testes of infertile men with varicocele. BJU Int 2002;89:905-9
23. Hendin BN, Kolettis PN, Sharma RK, Thomas AJ, Agarwal A. Varicocele is associated with elevated speratozoal reactive oxygen species production and diminished seminal plasma antioxidant capacity. J Urol 1999;161:1831-4
24. Lane DP. Cancer. p53, guardian of the genome. Nature 1992; 358:15-6
25. Henriksen K, Kangasniemi M, Parvinen M, Kaipia A, Hakovirta H. In vitro, follicle-stimulating hormone prevents apoptosis and stimulates deoxyribomicleic acid synthesis in the rat seminiferous epithelium in a stage-specific fashion. Endocrinology 1996;137:2141-9
26. Khanna KK, Jackson SP. DNA double-strand breaks: signaling, repair and the cancer connection. Nat Genet 2001; 27:247-54
27. Zweidler A. Complexity and variability of the histone complement. Life Sci Res 1976;4:187-96
28. Wu RS, Panusz HT, Hatch CL, Bonner WM. Histories and their modifications, CRC crit. Rev Biochem 1986;20:201-63
29. 2AX. Science 2000;290:1962-5
30. Goldberg M, Stucki M, Falck J, D'Amours D, Rahman D, Pappin D, et al. MDC1 is required for the intra-S-phase DNA damage checkpoint. Nature 2003;421:952-6