NF-AT-mediated expression of TGF-β1 in tolerant T cells

Journal of Immunology

Volumn 178, Issue 5, 2007, Pages 3067-3075

  Nakano, Naoko ^a   Hosokawa, Hiroyuki ^a,b   Kohyama, Masako ^a,c   Hozumi, Nobumichi ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

^b CHIBA UNIVERSITY   (Japan)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; CYCLOSPORIN A; CYTOCHROME C; T LYMPHOCYTE RECEPTOR; TRANSCRIPTION FACTOR GATA; TRANSCRIPTION FACTOR NFAT; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANTIGEN EXPRESSION; ARTICLE; BINDING SITE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; GENETIC TRANSFECTION; HYBRIDOMA CELL CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; RECEPTOR UPREGULATION; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; T LYMPHOCYTE; THYMUS; TRANSGENIC MOUSE;

EID: 33847419580     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.178.5.3067     Document Type: Article

References (36)

1. + suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2: 389-400.
2. Sakaguchi, S. 2000. Regulatory T cells: key controllers of immunologic self-tolerance. Cell 101: 455-458.
3. Schwarz, R. 1996. Models of T cell anergy: is there a common molecular mechanism? J. Exp. Med. 184: 1-8.
4. Sloan-lancaster, J., A. S. Shaw, J. B. Rothbard, and P. M. Allen. 1994. Partial T cell signaling: altered phosph-ζ and lack of Zap70 recruitment in APL-mduced T cell anergy. Cell 79: 913-922.
5. Yamashiro, H., Y. Odani, N. Hozumi, and N. Nakano. 2002. Hierarchical signaling thresholds determine the fates of naive T cells: partial priming leads naive T cells to unresponsiveness. Biochem. Biophys. Res. Commun. 299: 148-154.
6. Macián, F. 2005. NFAT proteins: key regulators of T-cell development and function. Nat. Rev. Immunol. 5: 472-484.
7. Heissmeyer, V., F. Macián, S.-H. Im, R. Varma, S. Feske, K. Venuprasad, H. Gu, Y.-C. Liu, M. L. Dustin, and A. Rao. 2004. Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins. Nat. Immunol. 5: 255-265.
8. Kang, S., B. Beverly, A. Tran, K. Brorson, R. H. Schwartz, and M. J. Lenardo. 1992. Transactivation by AP-1 is a molecular target of T cell clonal anergy. Science 257: 1134-1138.
9. Boussiotis, V. A., G. J. Freeman, A. Berezovskaya, D. L. Barber, and L. M. Nadler. 1997. Maintenance of human T cell anergy: blocking of 1L-2 gene transcription by activated Rap-1. Science 278: 124-127.
10. Tzachanis, D., G. J. Freeman, N. Hirano, A. F. L. van Puijenbroek, M. W. Delfs, A. Berezovskaya, L. M. Nadler, and V. A. Voussiotis. 2001. Tob is a negative regulator of activation that is expressed in anergic and quiescent T cells. Nat. Immunol. 2: 1174-1180.
11. Letterio, J. J., and A. B. Roberts. 1998. Regulation of immune responses by TGF-β1. Annu. Rev. Immunol. 16: 137-161.
12. Letterio, J. J., A.G. Geiser, A. B. Kulkarni, H. Dang, L. Kong, T. Nakabayashi, C. L. Mackall, R. E. Gress, and A. B. Roberts. 1996. Autoimmunity associated with TGF-β1 deficiency in mice is dependent on MHC class II antigen expression. J. Clin. Invest. 98: 2109-2199.
13. + regulatory T cells is mediated by cell surface-bound transforming growth factor β. J. Exp. Med. 194: 62-64.
14. Gorelik, L., and R. A. Flavell. 2000. Abrogation of TGF-β signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity 12: 171-181.
15. + regulatory T cells. J. Exp. Med. 201: 737-746.
16. + regulatory T cells. J. Exp. Med. 201: 1061-1067.
17. Geiser, A. G., S.-J. Kim, A. B. Roberts, and M. B. Sporn. 1991. Characterization of the mouse transforming growth factor-β1 promoter and activation by the Haras oncogene. Mol. Cell. Biol. 11: 84-92.
18. Yang, Y., M. Mummy, D. Romeo, and L. M. Wakefield. 1998. Identification of the start sites for the 1.9- and 1.4-kb rat transforming growth factor-β1 transcripts and their effect of translational efficiency. Gene 219: 81-89.
19. Kim, S., K. Jeang, A. B. Glick, M. B. Sporn, and A. B. Roberts. 1989. Promoter sequences of the human transforming growth factor-β1 gene responsive to transforming growth factor-β1 autoinduction. J. Biol. Chem. 264: 7041-7045.
20. Kim, S., F. Deahez, K. Y. Kim, J. T. Holt, M. B. Sporn, and A. B. Roberts. 1989. Activation of the second promoter of the transforming growth factor-β1 gene by transforming growth factor β1 and phorbol ester occurs through the same target sequences. J. Biol. Chem. 264: 19373-19378.
21. + T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature 341: 746-749.
22. + T cells secreting transforming growth factor-β1 by altered peptide ligands expressed as self-antigens. Int. Immunol. 14: 857-865.
23. Macián, F., F. García-Cózar, S. Im, H. F. Horton, M. C. Byme, and A. Rao. 2002. Transcriptional mechanisms underlying lymphocyte tolerance. Cell 109: 719-731.
24. Rooney, J. W., T. Hoeny, and L. H. Glimcher. 1995. Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene. Immunity 2: 473-483.
25. Loh, C., J. A. Carew, J. Kim, P. G. Hogan, and A. Rao. 1996. T-cell receptor stimulation elicits an early phase of activation and a later phase of deactivation of the transcription factor NFAT1. Mol. Cell Biol. 16: 3945-3954.
26. Macián, F., C. López-Rodríguez, and A. Rao. 2001. Partners in transcription: NFAT and AP-1. Oncogene 20: 2476-2489.
27. Macián, F., C. García-Rodríguez, and A. Rao. 2000. Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun. EMBO J. 19: 4783-4795.
28. Peng, S. L., A. J. Gerth, A. M. Ranger, and L. H. Glimcher. 2001. NFATc1 and NFATc2 togelher control both T and B cell activalion and differentiation. Immunity 14: 13-20.
29. Bodor, J., and J. F. Habener. 1998. Role of transcriptional repressor ICER in cyclic AMP-mediated attenuation of cytokine gene expression in human thymocytes. J. Biol. Chem. 273: 9544-9551.
30. Bettelli, E., M. Dastrange, and M. Oukka. 2005. Foxp3 interacts with nuclear factor of activated T cells and NF-βB to repress cytokine gene expression and effector functions of T helper cells. Proc. Natl. Acad. Sci. USA 102: 5138-5143.
31. Schubert, L. A., E. Jeffery, Y. Zhang, F. Ramsdell, and S. F. Ziegler. 2001. Scurfin (Foxp3) acts as a repressor of transcription and regulates T cell activation. J. Biol. Chem. 276: 37672-37679.
32. Wu, Y., M. Borde, V. Heissmeyer, M. Feuerer, A. D. Lapan, J. C. Stroud, D. L. Bates, L. Guo, A. Han, S. F. Ziegler, et al. 2006. FOXP3 controls regulatory T cell function through cooperation with NFAT. Cell 126: 375-387.
33. + regulatory T cells. Nat. Immunol. 4: 330-336.
34. Hori, S., T. Nomura, and S. Sakaguchi. 2003. Control of regulatory T cell development by the transcription factor foxp3. Science 299: 1057-1061.
35. Kurata, H., H.-J. Lee, T. McClanahan, R. L. Coffman, A. O'Garra, and N. Arai. 2002. Friend of GATA is expressed in naive Th cells and functions as a repressor of GATA-3-mediated Th2 cell development. J. Immunol. 168: 4538-4545.
36. + T cells. J. Exp. Med. 188: 1849-1857.