Current use of ketamine for the treatment of acute and chronic pain;Utilización de ketamina en el tratamiento del dolor agudo y crónico

Revista de la Sociedad Espanola del Dolor

Volumn 14, Issue 1, 2007, Pages 45-65

  Lopez Millan Infantes J M ^a   Sanchez Blanco C ^a  

^a HOSPITAL UNIVERSITARIO VIRGEN MACARENA   (Spain)

Author keywords

Ketamine; Pain; Treatment

Indexed keywords

ANALGESIC AGENT; ATRACURIUM; ATROPINE; BENZODIAZEPINE DERIVATIVE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CHOLINERGIC RECEPTOR BLOCKING AGENT; CLONIDINE; DOXAPRAM; GLYCOPYRRONIUM BROMIDE; KETAMINE; METRIZAMIDE; N METHYL DEXTRO ASPARTIC ACID; PETHIDINE; SCOPOLAMINE; THEOPHYLLINE; TRAMADOL; VERAPAMIL;

CENTRAL NERVOUS SYSTEM; CHRONIC PAIN; CONTINUOUS INFUSION; DRUG EFFECT; DRUG MECHANISM; HUMAN; MIGRAINE; PAIN; POSTOPERATIVE PAIN; REVIEW; SPINAL PAIN;

EID: 33847414555     PISSN: 11348046     EISSN: 11348046     Source Type: Journal    
DOI: None     Document Type: Review

References (107)

1. White PF. Ketamine - its pharmacology and therapeutic uses. Anesthesiology 1982; 56:119-36.
2. Reich DL & Silvay G. Ketamine: an update on the first twenty-five years of clinical experience. Can J Anaesth 1989; 36:186-197.
3. Clements JA, Nimmo WS, Grant IS. Bioavailability, pharmacokinetics and analgesic activity of ketamine in humans. J Pharm Sci 1982; 71:539-42.
4. Clements JA & Nimmo WS. Pharmacokinetics and analgesic effect of ketamine in man. Br J Anaesth 1981; 53:27-30.
5. Kronenberg RH. Ketamina as an analgesic: parenteral, oral, rectal, subcutaneous, transdermal and intranasal administration. J Pain Palliat Care Pharmacother 2002; 16:27-35.
6. Grant IS, Nimmo WS, Clements JA. Pharmacokinetics and analgesic effects of im and oral ketamine. Br J Anaesth 1981; 53:805-10.
7. Correll GE, Maleki J, Gracely EJ, Muir JJ, Harbut RE. Subanesthetic ketamine infusion therapy: a retrospecive analysis of a novel therapeutic approach to complex regional pain syndrome. Pain Med 2004. Sept;5(3):263-75.
8. Saint-Maurice C, Laguinie G, Couturier C, et al. Rectal ketamine in paediatric anaesthesia. Br J Anaesth 1979; 51:573-574.
9. Scheller M, et al. Ketamine blocks currents through mammalian nicotinic acetylcholine receptor channels by interaction with both the open and the closed state. Anesth Analg 1996; 83:830-6.
10. Ohtani M, Kikuchi H, Kitahata LM, et al. Effects of ketamine on nociceptive cells in the medial medullary reticular formation of the cat. Anesthesiology 1979; 51:414-7.
11. Miyasaka M & Domino EF. Neural mechanisms of ketamine-induced anesthesia. Int J Neuropharmacol 1968; 7:557-73.
12. Amiot JF, Bouju P, & Palacci JH. Effect of naloxone on loss of consciousness induced by IV ketamine (letter). Br J Anaesth 1985; 57:930.
13. Rogers R, Wise RG, Painter DJ, Longe SE, Tracey I. An investigation to dissociate the analgesic and anesthetic properties of ketamine using functional magnetic resonance imaging. Anesthesiology 2004; 10:292-301.
14. Gardner AE, Dannemiller FJ, & Dean D. Intracranial cerebrospinal fluid pressure in man during ketamine anesthesia. Anesth Analg 1972; 51:741-5.
15. Munro HM, Sleigh JW, & Paxton LD. The cardiovascular response to ketamine: the effects of clonidine and lignocaine. Acta Anaesthesiol Scand 1993; 37:75-78.
16. Hamza J, Ecoffey C, & Gross JB. Ventilatory response to CO 2 following intravenous ketamine in children. Anesthesiology 1989; 70:422-5.
17. Bourke DL, Malit LA, & Smith TC. Respiratory interactions of ketamine and morphine. Anesthesiology 1987; 66:153-156.
18. Jahangir SM, Islam F, & Aziz L. Ketamine infusion for postoperative analgesia in asthmatics: a comparison with intermittent meperidine. Anesth Analg 1993; 76:45-49.
19. Batagol R (Ed). Australian Drug Evaluation Committee: Medicines in Pregnancy-An Australian categorisation of risk of drug use in pregnancy, 4th. Australian Government Publishing Service, Canberra, Australia, 1999.
20. Janeczko GF, el-Etr AA, & Younes S. Low dose ketamine anesthesia for obstetrical delivery. Anesth Analg 1974; 53:828-831.
21. Anon. Breastfeeding and Maternal Medication. World Health Organization, Geneva, Switzerland, 2002.
22. Smith JA & Santer LJ. Respiratory arrest following intramuscular ketamine injection in a 4-year-old child. Ann Emerg Med 1993; 22:613-615.
23. Pandey CK, Mathur N, Singh N, et al: Fulminant pulmonary edema after intramuscular ketamine. Can J Anesth 2000; 47(9):894-896.
24. Hirshman CA, Kreiger W, Littlejohn G, et al. Ketamine-aminophylline- induced decrease in seizure threshold. Anesthesiology 1982; 56:464-467.
25. Kumar V, Mdzinnaishvili A, Kievert C, et al. NMDA Receptor-Antagonist Properties of Hyperforin, a constituent of St. John's Wort. J Pharmacol Sci 2006. Aug 26;[Epub ahead of print].
26. Guit JBM, Koning HM, Coster ML, et al. Ketamine as analgesic for total intravenous anaesthesia with propofol. Anaesthesia 1991; 46:24-27.
27. Badrinath S, Avramov MN, Shadrick M, et al. The use of a ketamine-propofol combination during monitored anesthesia care. Anesth Analg 2000; 90:858-862.
28. Idvall J, Aronsen KF, Stenberg P, et al. Pharmacodynamic and pharmacokinetic interactions between ketamine and diazepam. Eur J Clin Pharmacol 1983; 24:337-343.
29. Green SM, Hummel CB, Wittlake WA, et al. What is the optimal dose of intramuscular ketamine for pediatric sedation? Acad Emerg Med 1999; 6(1):21-26.
30. Ambados F. Compatibility of ketamine hydrochloride and meperidine hydrochloride. Am J Health-Syst Pharm 1997; 54:205.
31. Carr D, Goudas LC, Denman WT, Brookoff D, Staats PS, Brennen L, et al. Safety and efficacy of intranasal ketamine for the treatment of breakthrough pain in patients with chronic pain: a randomized, double-blind, placebo-controlled, crossover study. Pain 2004; 108:17-27.
32. Mok MS, Chan KH, Chung SK, et al. Evaluation of the analgesic effect of epidural ketamine (abstract). Anesth Analg 1987; 66:S121.
33. Mankowitz E, Brock-Utne JG, Cosnett JE, et al. Epidural ketamine: a preliminary report. S Afr Med J 1982; 61:441-442.
34. Gebhardt B. Pharmacology and clinical results with peridural and intrathecal admon of ketamine. Anaesthesist 1994 Nov;43 Suppl 2;S34-40 German.
35. Coates KM, Flood P. Ketamine and its preservative, benzethonium chloride, both inhibit human recombinant _-7 and _-4 _-2 neuronal nicotinic acetylcholine receptors in Xenopus oocytes. Br J Phrmacol 2001;134:18:223-8.
36. Bion JF. Intrathecal ketamine for war surgery: a preliminary study under field conditions. Anaesthesia 1984a; 39:1023-1028.
37. Alderson PJ & Lerman J. Oral premedication for paediatric ambulatory anaesthesia: a comparison of midazolam and ketamine. Can J Anaesth 1994; 41:221-226.
38. Gutstein HB, Johnson KL, Heard MB, et al. Oral ketamine preanesthetic medication in children. Anesthesiology 1992; 76:28-33.
39. Funk W, Jakob W, Riedl T, et al. Oral preanaesthetic medication for children: double-blind randomized study of a combination of midazolam and ketamine vs midazolam or ketamine alone. Br J Anaesth 2000b; 84:335-340.
40. Sekerci S, Donmez A, Ates Y, et al. Oral ketamine premedication in children (placebo controlled double-blind study). Eur J Anaesthesiol 1996; 13:606-611.
41. Marhofer P, Freitag H, Hochtl A, et al. S(+)-ketamine for rectal premedication in children. Anesth Analg 2001; 92:62-65.
42. Petrack EM, Marx CM, & Wright MS. Intramuscular ketamine is superior to meperidine, promethazine, and chlorpromazine for pediatric emergency department sedation. Arch Pediatr Adolesc Med 1996; 150:676-681.
43. McGlone R, Fleet T, Durham S, et al. A comparison of intramuscular ketamine with high dose intramuscular midazolam with and without intranasal flumazenil in children before suturing. Emerg Med J 2001; 18:34-38.
44. Kreter B. Ketamine as an anesthetic agent for interventional radiology. Semin Intervent Radiol 1987a; 4:183-188.
45. Younge PA & Kendall JM. Sedation for children requiring wound repair: a randomised controlled double blind comparison of oral midazolam and oral ketamine. Emerg Med J 2001; 18:30-33.
46. Petros AJ. Oral ketamine: its use for mentally retarded adults requiring day care dental treatment. Anaesthesia 1991; 46:646-647.
47. Green SM & Johnson NE. Ketamine sedation for pediatric procedures: part 2, review and implications. Ann Emerg Med 1990a; 19:1033-1046.
48. Tobias JD, Phipps S, Smith B, et al. Oral ketamine predmedication to alleviate the distress of invasive procedures in pediatric oncology patients. Pediatrics 1992; 90:537-541.
49. Algren JT & Algren CL. Sedation and analgesia for minor pediatric procedures. Pediatr Emerg Care 1996; 12(6):435-441.
50. Cheng EY, Mazzeo AJ, Bosnjak ZJ, et al. Direct relaxant effects of intravenous anesthetics on airway smooth muscle. Anesth Analg 1996; 83:162-8.
51. Sarma VJ. Use of ketamine in acute severe asthma. Acta Anaesthesiol Scand 1992; 36:106-107.
52. Hawksworth C, Serpell M. Intrathecal anesthesia with ketamine. Reg Anesth Pain Med 1997 May-Jun; 23(3):283-88.
53. Rogers R, Wise RG, Painter DJ, longe SE, Tracey I. An investigation to dissociate the analgesic and antesthetic properties of ketamine using functional magnetic resonance imaging. Anesthesiology 2004; 10:292-301.
54. Schmid RL, Sandler AN, & Katz J. Use and efficacy of low-dose ketamine in the management of acute postoperative pain: a review of current techniques and outcomes. Pain 1999; 82:111-125.
55. Islas JA, Astorga J, & Laredo M. Epidural ketamine for control of postoperative pain. Anesth Analg 1985a; 64:1161-1162.
56. Wu CT, Yeh CC, Yu JC, et al. Pre-incisional epidural ketamine, morphine and bupivacaine combined with epidural and general anaesthesia provides pre-emptive analgesia for upper abdominal surgery. Acta Anaesthesiol Scand 2000; 44:63-68.
57. Ravat F, Dorne R, Baechle JP, et al. Epidural ketamine or morphine for postoperative analgesia. Anesthesiology 1987; 66:819-822.
58. Knoche E, Dick W, & Bowdler. Clincial experimental studies of postoperative infusion analgesia. Clin Ther 1983; 5:585-594.
59. Owen H, Reekie RM, Clements JA, et al. Analgesia from morphine and ketamine: a comparison of infusions of morphine and ketamine for postoperative analgesia. Anaesthesia 1987; 42:1051-1056.
60. Peat SJ, Bras P, & Hanna MH. A double-blind comparison of epidural ketamine and diamorphine for postoperative analgesia. Anaesthesia 1989; 44:555-558.
61. Naguib M, Sharif AMY, Seraj M, et al. Ketamine for caudal analgesia in children: comparison with caudal bupivacaine. Br J Anaesth 1991; 67:559-564.
62. Koinig H, Marhofer P, Krenn CG, et al. Analgesic effects of caudal and intramuscular S(+)-ketamine in children. Anesthesiology 2000; 93(4):976-980.
63. Ozbek H, Bilen A, Ozcengiz D, et al. The comparison of caudal ketamine, alfentanil and ketamine plus alfentanil administration for postoperative analgesia in children. Paediatr Anaesth 2002; 12(7):610-616.
64. Nimmo WS & Clements JA. Ketamine on-demand for postoperative analgesia. Anaesthesia 1981; 36:826.
65. Mathisen LC, AAsbo V, & Raeder J. Lack of preemptive analgesic effect of (R)-ketamine in laparoscopic cholecystectomy. Acta Anaesthesiol Scand 1999; 43:220-224.
66. Launo C, Bassi C, Spagnolo L, et al. Preemptive ketamine during general anesthesia for postoperative analgesia in patients undergoing laparoscopic cholecystectomy.Minerva Anestesiol. 2004 Oct;70(10):727-34; 734-8.
67. Lauretti GR, Azevedo VM. Intravenous ketamine or fentanyl prolongs postoperative analgesia after intrethecal neostigmine. Anesth Analg 1996 Oct;83(4):766-70.
68. Schmid R, Koren G, Klein J, et al. The stability of a ketamine-morphine solution. Anesth Analg 2002; 94(4):898-900.
69. Javery KB, Ussery TW, Steger HG, et al. Comparison of morphine and morphine with ketamine for postoperative analgesia. Can J Anaesth 1996; 43:212-215.
70. Levanen J: Ketamine and oxycodone in the management of postoperative pain. Military Med 2000a; 165:450-455.
71. Gurnani A, Sharma PK, Rautela RS, et al. Analgesia for acute musculoskeletal trauma: low-dose subcutaneous infusion of ketamine. Anaesth Intensive Care 1996; 24:32-36.
72. Kaube H, Herzog J, Kaufer T, et al. Aura in some patients with familial hemiplegic migraine can be stopped by intranasal ketamine. Neurology 2000; 55:139-141.
73. Orser BA, Pennefather PS, & Donald JF. Multiple mechanisms of ketamine blockade of N-methyl-D-aspartate receptors. Anesthesiology 1997; 86:903-17.
74. Hughes AM, Rhodes J, Fisher G, Sellers M, Growcott JW. Assessment of the effect of dextromethorphan and ketamine on the acute nociceptive threshold and wind-up of the second pain response in healthy male volunteers. Br J Clin Pharmacol. 2002 Jun; 53(6):604-12.
75. Hocking G, Cousins MJ. Ketamine in chronic pain management: an evidence-based review. Anesth Analg 2003; 97:1730-9.
76. Wiedemann B. Ketamine for treatment of chronic pain: meta-analysis. Schmerz 1997; 11(4):276-81.
77. Haines DR & Gaines SP. N of 1 randomised controlled trials of oral ketamine in patients with chronic pain. Pain 1999; 83:283-287.
78. Enarson MC, Hays H, & Woodroffe MA. Clinical experience with oral ketamine. J Pain Symptom Manage 1999; 17:384-386.
79. Vranken JH, Dijkgraaf MG, Kruis MR, van Dasselaar NT, van der Vegt MH. Iontophoretic administration of S(+)-ketamine in patients with intractable central pain: A placebo-controlled trial. Pain 2005 Nov;118(1-2):224-31. Epub 2005 Oct 3.
80. Furuashi-Yonaha A, Tida H, Asano T, Takeda T, Dohi S. Short -and long- term efficacy of oral ketamine in eight chronic-pain patients. Can J Anesth; 49:886-887.
81. Sakai T, Tomiyasu S, Ono T, Yamada H, Sumikawa K. Multiple Sclerosis with severe pain and allodynia alleviated by oral ketamine. Clinical Journal of Pain 2004; 20(5):375-376.
82. Harden RN. Complex regional pain syndrome. Br J Anaesth 2001;81:99-06.
83. Eide PK, Jorum E, Stubbhaug A, et al. Relief of post-herpetic neuralgia with N-methyl-D-aspartic acid receptor antagonist ketamine: a double-blind, cross-over comparison with morphine and placebo. Pain 1994;58:347-54.
84. Fine PG. Low-dose ketamine in the management of opioid nonresponsive terminal cancer pain. J Pain Symptom Manage 1999; 17:296-300.
85. Yang CY, Wong CS, Chang JY, et al. Intrathecal ketamine reduces morphine requirements in patients with terminal cancer pain. Can J Anaesth 1996; 43:379-383.
86. Mercadante S, Arcuri E, Tireli W, Casuccio A. Analgesic effect of intravenous ketamine in cancer patients on morphine therapy: A randomized, controlled, double-blind, crossover, double-dose study. J Pain Simptom Manage 2000; 20(4):246-52.
87. Friedman R, Jallo J, Young WF. Oral ketamine for opioid-resistant acute pain. J Pain 2001 Feb;2(1):75-6.
88. Lauretti GR, Gomes JMA, Reis MP, et al. Low doses of epidural ketamine or neostigmine, but not midazolam, improve morphine analgesia in epidural terminal cancer pain therapy. J Clin Anesth 1999; 11:663-668.
89. Mercadante S, Arcuri E, Ferrera P, Villari P, Mangione S. Alternative Treatments of breakthrough Pain in Patients Receiving Spinal Analgesics for Cancer Pain. J Pain Symptom Manage. 2005 Nov;30(5):485-491.
90. Kannan TR, Saxena A, Bhatnagar S, Barry A. Oral ketamine as an adjuvant to oral morphine for neuropathic pain in cancer patients. J Pain Smptom Manage 2002; 23(1):60-5.
91. Klepstad P, Borchgrevink P, Hval B, et al. Long-term treatment with ketamine in a 12-year-old girl with severe neuropathic pain caused by a cervical spinal tumor. J Pediatr Hematol Oncol 2001; 23(9):616-619.
92. Fisher K & Hagen NA. Analgesic effect of oral ketamine in chronic neuropathic pain of spinal origin: a case report. J Pain Symptom Manage 1999; 18(1):61-66.
93. Vick PG: Treatment of central poststroke pain with Ketamine. Pain 2002 Feb 95(3):288-9;author reply 289.
94. Correll GE, Maleki J, Gracely EJ, et al. Subanesthetic ketamine infusion therapy: a retrospective analysis of a novel therapeutic a to complex regional pain syndrome. Pain Med 2004 Sep;5(3):263-75.
95. Wolf F, Smithe HA, Yunus MB, et al. The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicentre Criteria Committee. Arthritis Rheum 1990;33:160-72.
96. Persson J, Hasselstrom J, Wuklund B, et al. The analgesic effect of racemic ketamine in patients with chronic ischaemic pain due tu lower extremity arteriosclerosis obliterans. Acta Anaesthesiol Scand 1998;33:160-72.
97. Backonja M, Arndt G, Gombar KA, et al. Response of chronic neuropathic pain syndromes to ketamine: a preliminary study. Pain 1994;42:759-8.
98. Max MB, Byas-Smith M, Gracely RH, et al. Intravenous infusion of the NMDA antagonist, ketamine, in chronic post-traumatic pain with allodynia; a double-blind comparison to alfentanil and placebo. Clin Neuropharmacol 1995;18:360-8.
99. Felsby S, Nielsen J, Arendt-Nielsen L, et al. NMDA receptor blockade in chronic pain: a comparison of ketamine and magnesium chloride. Pain 1995;64:283-91.
100. Broadley KE, Kurosawa A, Tookman A, et al. Ketamine injection used orally. Palliat Med 1996;10:247-50.
101. Rabben T, Skjerlbrad P. Prolonged Analgesic Effect of Ketamine, an N-Methyl-D-Aspartate Receptor Inhibitor, in Patients with Chronic Pain. J Pharm Exp Therap 1999; 289(2):1060-66.
102. Hayes C, Armstrong-Brown A, Burstal R. Perioperative intravenous ketamine infusion for the prevention of persistent post-amputation pain: a randomized, controlled trial. Anaesth Intensive Care 2004; 32(3):330-8.
103. Nikolajsen L, Hansen PO, Jensen TS. Oral ketamine in the treatment of the postamputation sump pain. Acta Anaesthesiol Scand 1997;41:427-9.
104. Franks JF, Olesen AS, Mikkelsen SS, Borgbjerg FM. Ketamine in the management of intractable phantom pain. Ugeskr Laeger 1995;157:3481-2.
105. Eide PK, Stuhaug A, Oye I, et al. Continuous subcutaneous administration of the N-methyl-D-aspartic acid (NMDA) receptor antagonist ketamine in the treatment of post-herpetic neuralgia. Pain 1995;61:221-8.
106. Clements JA, Nimmo WS. Pharmacokinetics and analgesic effect of ketamine in man. Br J Anaesth 1981; 53:27-30.
107. Cohen SP, Audrey SC, Larkin T, et al. The intravenous ketamine test: a predictive response tool for oral dextromethorphan treatment in neuropathic pain. Anesth Analg 2004;99:1753-1759.