An Investigation to Dissociate the Analgesic and Anesthetic Properties of Ketamine Using Functional Magnetic Resonance Imaging

Anesthesiology

Volumn 100, Issue 2, 2004, Pages 292-301

  Rogers, Richard ^a,c   Wise, Richard G ^b   Painter, Deborah J ^a   Longe, Sarah E ^b   Tracey, Irene ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

KETAMINE;

ADULT; ANALGESIA; ARTICLE; AUDITORY STIMULATION; BEHAVIOR; BRAIN CORTEX; BRAIN REGION; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT; HUMAN; IMAGE ANALYSIS; MALE; MOTOR ACTIVITY; NOCICEPTIVE STIMULATION; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PAIN ASSESSMENT; PRIORITY JOURNAL; TASK PERFORMANCE; THERMAL STIMULATION;

ACOUSTIC STIMULATION; ADULT; ANALGESIA; ANESTHESIA; ANESTHETICS, DISSOCIATIVE; BRAIN; HUMANS; KETAMINE; MAGNETIC RESONANCE IMAGING; MALE; PAIN; PSYCHOMOTOR PERFORMANCE; REACTION TIME;

EID: 1642540168     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-200402000-00018     Document Type: Article

References (38)

1. Kohrs R, Durieux ME: Ketamine: Teaching an old drug new tricks. Anesth Analg 1998; 87:1186-93
2. Corssen G, Domino EF: Dissociative anesthesia: Further pharmacologic studies and first clinical experience with the phencyclidine derivative CI-581. Anesth Analg 1966; 45:29-40
3. Adler CM, Goldberg TE, Malhotra AK, Pickar D, Breier A: Effects of ketamine on thought disorder, working memory, and semantic memory in healthy volunteers. Biol Psychiatry 1998; 43:811-6
4. Krystal JH, Karper LP, Seibyl JP, Freeman GK, Delaney R, Bremner JD, Heninger GR, Bowers MB Jr, Charney DS: Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans: Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch Gen Psychiatry 1994; 51:199-214
5. Malhotra AK, Pinals DA, Weingartner H, Sirocco K, Missar CD, Pickar D, Breier A: NMDA receptor function and human cognition: The effects of ketamine in healthy volunteers. Neuropsychopharmacology 1996; 14:301-7
6. Melzack R, Casey K: Sensory, motivational and central control determinants of pain: A new conceptual model. The Skin Senses. Edited by Kenshalo DR. Springfield, Charles C Thomas, 1968, pp 423-43
7. International Association for the Study of Pain, Subcommittee on Taxonomy: Pain terms: A list with definitions and notes on usage. Pain 1979; 6:249-52
8. Talbot JD, Marrett S, Evans AC, Meyer E, Bushnell MC, Duncan GH: Multiple representations of pain in human cerebral cortex. Science 1991; 251:1355-8
9. Jones AK, Brown WD, Friston KJ, Qi LY, Frackowiak RS: Cortical and subcortical localization of response to pain in man using positron emission tomography. Proc R Soc Lond B Biol Sci 1991; 244:39-44
10. Peyron R, Laurent B, Garcia-Larrea L: Functional imaging of brain responses to pain: A review and meta-analysis. Neurophysiol Clin 2000; 30:263-88
11. Tracey I: Prospects for human pharmacological functional magnetic resonance imaging (PHMRI). J Clin Pharmacol 2001;July(suppl):21S-28S
12. Wise RG, Rogers R, Painter D, Bantick S, Ploghaus A, Williams P, Rapeport G, Tracey I: Combining fMRI with a pharmacokinetic model to determine which brain areas activated by painful stimulation are specifically modulated by remifentanil. Neuroimage 2002; 16:999-1014
13. Gray JM, Kenny GN: Development of the technology for 'Diprifusor' TCI systems. Anaesthesia 1998; 53(suppl 1):22-7
14. Domino EF, Zsigmond EK, Domino LE, Domino KE, Kothary SP, Domino SE: Plasma levels of ketamine and two of its metabolites in surgical patients using a gas chromatographic mass fragmentographic assay. Anesth Analg 1982; 61:87-92
15. Clements JA, Nimmo WS: Pharmacokinetics and analgesic effect of ketamine in man. Br J Anaesth 1981; 53:27-30
16. Grant IS, Nimmo WS, Clements JA: Pharmacokinetics and analgesic effects of i. m. and oral ketamine. Br J Anaesth 1981; 53:805-10
17. Clements JA, Nimmo WS, Grant IS: Bioavailability, pharmacokinetics, and analgesic activity of ketamine in humans. J Pharm Sci 1982; 71:539-42
18. Chodoff P, Stella JG: Use of CI-581 a phencyclidine derivative for obstetric anesthesia. Anesth Analg 1966; 45:527-30
19. Akamatsu TJ, Bonica JJ: Ketamine for obstetric delivery (letter). ANESTHESIOLOGY 1977; 46:78
20. Bowdle TA, Radant AD, Cowley DS, Kharasch ED, Strassman RJ, Roy-Byrne PP: Psychedelic effects of ketamine in healthy volunteers: Relationship to steady-state plasma concentrations. ANESTHESIOLOGY 1998; 88:82-8
21. Talairach J, Tournoux P: Co-planar Stereotaxic Atlas of the Human Brain: 3-dimensional Proportional System: An Approach to Medical Cerebral Imaging, 1st edition. Stuttgart, New York, Thieme Medical Publishers, 1988
22. Ogawa S, Tank DW, Menon R, Ellermann JM, Kim SG, Merkle H, Ugurbil K: Intrinsic signal changes accompanying sensory stimulation: Functional brain mapping with magnetic resonance imaging. Proc Natl Acad Sci U S A 1992; 89:5951-5
23. Smith S, Banister PR, Beckman C, Brady JM, Clare S, Flitney D, Hansen P, Jenkinson M, Leibovici D, Ripley B, Woolrich M, Zhang Y: FSL: A new tool for functional and structural brain image analysis. Neuroimage 2001; 13:S249
24. Jenkinson M, Smith S: A global optimisation method for robust affine registration of brain images. Med Image Anal 2001; 5:143-56
25. Bannister PR, Jenkinson M: Robust affine motion correction in fMRI time series. Neuroimage 2001; 13:S70
26. Woolrich M, Ripley B, Brady JM, Smith S: Temporal autocorrelation in univariate linear modelling of fMRI data. Neuroimage 2001; 14:1370-86
27. Friston KJ, Holmes AP, Worsley KJ, Poline J-B, Frith CD, Frackowiak RS: Statistical parametric maps in functional imaging: A general linear approach. Hum Brain Mapp 1995; 2:189-210
28. Friston KJ, Worsley KJ, Frackowiak RS, Maziotta JC, Evans AC: Assessing the significance of focal activations using their spatial extent. Hum Brain Mapp 1994; 1:214-20
29. Worsley KJ, Evans AC, Marrett S, Neelin P: A three-dimensional statistical analysis for CBF activation studies in human brain. J Cereb Blood Flow Metab 1992; 12:900-18
30. Forman SD, Cohen JD, Fitzgerald M, Eddy WF, Mintun MA, Noll DC: Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): Use of a cluster-size threshold. Magn Reson Med 1995; 33:636-47
31. Shtoyerman E, Arieli A, Slovin H, Vanzetta I, Grinvald A: Long-term optical imaging and spectroscopy reveal mechanisms underlying the intrinsic signal and stability of cortical maps in V1 of behaving monkeys. J Neurosci 2000; 20:8111-21
32. Breier A, Malhotra AK, Pinals DA, Weisenfeld NI, Pickar D: Association of ketamine-induced psychosis with focal activation of the prefrontal cortex in healthy volunteers. Am J Psychiatry 1997; 154:805-11
33. Abel KM, Allin MP, Kucharska-Pietura K, Andrew C, Williams S, David AS, Phillips ML: Ketamine and fMRI BOLD signal: Distinguishing between effects mediated by change in blood flow versus change in cognitive state. Hum Brain Mapp 2003; 18:135-45
34. Coghill RC, Sang CN, Maisog JM, Iadarola MJ: Pain intensity processing within the human brain: A bilateral, distributed mechanism. J Neurophysiol 1999; 82:1934-43
35. Vogt BA, Derbyshire S, Jones AK: Pain processing in four regions of human cingulate cortex localized with co-registered PET and MR imaging. Eur J Neurosci 1996; 8:1461-73
36. Ploghaus A, Tracey I, Gati JS, Clare S, Menon RS, Matthews PM, Rawlins JN: Dissociating pain from its anticipation in the human brain. Science 1999; 284:1979-81
37. Bantick SJ, Wise RG, Ploghaus A, Clare S, Smith SM, Tracey I: Imaging how attention modulates pain in humans using functional MRI. Brain 2002; 125:310-9
38. Rainville P, Carrier B, Hofbauer RK, Bushnell MC, Duncan GH: Dissociation of sensory and affective dimensions of pain using hypnotic modulation. Pain 1999; 82:159-71