Relationships between the physicochemical properties of an amphiphilic triblock copolymers/DNA complexes and their intramuscular transfection efficiency

Nucleic Acids Research

Volumn 35, Issue 3, 2007, Pages 728-739

  Bello Roufaï, Mahajoub ^a   Lambert, Olivier ^b   Pitard, Bruno ^a  

^a L INSTITUT DU THORAX   (France)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

COPOLYMER; MACROGOL; POLY(PROPYLENEOXIDE); UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CIRCULAR DICHROISM; COMBINATORIAL CHEMISTRY; CONTROLLED STUDY; CRYOELECTRON MICROSCOPY; DNA BINDING; DNA CONFORMATION; DNA TRANSFECTION; DNA VECTOR; ELECTROPHORETIC MOBILITY; FEMALE; GENE EXPRESSION; HYDRODYNAMICS; HYDROPHOBICITY; LIGHT SCATTERING; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; TISSUE DISTRIBUTION; TRANSGENE;

EID: 33847368155     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkl860     Document Type: Article

References (42)

1. Roemer,K. and Friedmann,T. (1992) Concepts and strategies for human gene therapy. Eur. J. Biochem., 208, 211-225.
2. Miller,A.D. (1992) Human gene therapy comes of age. Nature, 357, 455-460.
3. Mulligan,R.C. (1993) The basic science of gene therapy. Science, 260, 926-932.
4. Morgan,R.A. and Anderson,W.F. (1993) Human gene therapy. Annu. Rev. Biochem., 62, 191-217.
5. Partridge,K.A. and Oreffo,R.O. (2004) Gene delivery in bone tissue engineering: Progress and prospects using viral and nonviral strategies. Tissue Eng., 10, 295-307.
6. Chen,W.C. and Huang,L. (2005) Non-viral vector as vaccine carrier. Adv. Genet., 54, 315-337.
7. Buckley,R.H. (2002) Gene therapy for SCID-a complication after remarkable progress. Lancet, 360, 1185-1186.
8. Lemieux,P., Guerin,N., Paradis,G., Proulx,R., Chistyakova,L., Kabanov,A. and Alakhov,V. (2000) A combination of poloxamers increases gene expression of plasmid DNA in skeletal muscle. Gene Ther., 7, 986-999.
9. Liaw,J., Chang,S.F. and Hsiao,F.C. (2001) In vivo gene delivery into ocular tissues by eye drops of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) polymeric micelles. Gene Ther., 8, 999-1004.
10. Pitard,B., Pollard,H., Agbulut,O., Lainbert,O., Vilquin J.T., Cherel,Y., Abadie,J.,Samuel,J.L., Rigaud,J.L., Menoret,S. et al. (2002) A nonionic amphiphile agent promotes gene delivery in vivo to skeletal and cardiac muscles. Hum. Gene Ther., 13,1767-1775.
11. Kabanov,A.V., Lemieux,P., Vinogradov,S. and Alakhov,V. (2002) Pluronic block copolymers: Novel functional molecules for gene therapy. Adv. Drug Deliv. Rev., 54, 223-233.
12. Richard,P., Bossard,F., Desigaux,L., Lanctin,C., Bello-Roufai,M. and Pitard,B. (2005) Amphiphilic block copolymers promote gene delivery in vivo to pathological skeletal muscles. Hum. Gene Ther., 16, 1318-1324.
13. Desigaux,L., Gourden,C., Bello-Roufai,M., Richard,P., Oudrhiri,N., Lehn,P., Escande,D., Pollard,H. and Pitard,B. (2005) Nonionic amphiphilic block copolymers promote gene transfer to the lung. Hum. Gene Ther., 16, 821-829.
14. Lis,J.T. and Schleif,R. (1975) Size fractionation of double-stranded DNA by precipitation with polyethylene glycol. Nucleic Acids Res., 02, 383-389.
15. Kimpton,C.P., Corbitt,G. and Morris,D.J. (1990) Comparison of polyethylene glycol precipitation and ultracentrifugation for recovery of cytomegalovirus from urine prior to detection of DNA by dot-blot hybridisation. J. Virol. Methods, 28, 141-145.
16. Wanka,G., Hoffmann,H. and Ulbricht,W. (1994) Diagrams and aggregation behavior of poly(oxyethylene)-poly(oxypropylene)-poly(oxyethylene) triblock copolymers in aqueous solutions. Macromolecules, 27, 4145-4159.
17. Alexandridis,P., Zhou,D. and Khan,A. (1996) Lyotropic liquid crystallinity in amphiphilic block copolymers: Temperature effects on phase behavior and structure for poly(ethyleneoxide)-b-poly(propyleneoxide)-b-poly(ethyleneoxide) copolymers of different composition. Langmuir, 12, 2690-2700.
18. Alexandridis,P. (1997) Poly(ethyleneoxide)/poly(propyleneoxide) block copolymer surfactants. Curr. Opin. Colloid Interface Sci., 2, 478-489.
19. Jorgensen,E.B., Hvidt,S., Brown,W. and Schillén,K. (1997) Effects of salts on the micellization and gelation of a triblock copolymer studied by rheology and light scattering. Macromolecules, 30, 2355-2364.
20. Pandit,N., Trygstad,T., Croy,S., Bohorquez,M. and Koch,C. (2000) Effect of salts on the micellization, clouding, and solubilization behavior of pluronic F127 Solutions. J. Colloid Interface Sci., 222, 213-220.
21. Johnston,T.P. and Miller,S.C. (1985) Toxicological evaluation of poloxamer vehicles for intramuscular use. J. Parenter. Sci. Technol., 39, 83-89.
22. Ferrari,S., Moro,E., Pettenazzo,A., Behr,J-P, Zacchello,F. and Scarpa,M. (1997) ExGen 500 is an efficient vector for gene delivery to lung epithelial cells in vitro and in vivo. Gene Ther., 4, 1100-1106.
23. Pitard,B., Oudrhiri,N., Lambert,O., Vivien,E., Masson,C., Wetzer,B., Hauchecorne,M., Scherman,D., Rigaud,J.L., Vigneron,J.P. et al. (2001) Sterically stabilized BGTC-based lipoplexes: Structural features and gene transfection into the mouse airways in vivo. J. Gene Med., 3, 478-487.
24. Schmutz,M, Durand,D., Debin,A., Palvadeau,Y., Etienne,A. and Thierry,A.R. (1999) DNA packing in stable lipid complexes designed for gene transfer imitates DNA compaction in bacteriophage. Proc. Natl Acad. Sci. USA, 96, 12293-12298.
25. Huebner,S., Battersby,B.J., Grimm,R. and Cevc,G. (1999) Lipid-DNA complex formation: Reorganization and rupture of lipid vesicles in the presence of DNA as observed by cryoelectron microscopy. Biophys. J., 76, 3158-3166.
26. Battersby,B.J., Grimm,R., Huebner,S. and Cevc,G. (1998) Evidence for three-dimensional interlayer correlations in cationic lipid-DNA complexes as observed by cryo-electron microscopy. Biochim. Biophys. Acta, 1372, 379-383.
27. Rädler J.O., Koltover,I., Salditt,T. and Safinya,C.R. (1997) Structure of DNA-cationic liposome complexes: DNA intercalation in multilamellar membranes in distinct interhelical packing regimes. Science, 275, 810-814.
28. Safinya,C.R. (2001) Structures of lipid-DNA complexes: Supramolecular assembly and gene delivery. Curr. Opin. Struct. Biol., 11, 440-448.
29. Laemmli,U.K. (1975) Characterization of DNA condensates induces by poly(ethylene oxide) and polylysine. Proc. Natl Acad. Sci. USA, 72, 4288-4292.
30. Gray,D.M., Ratliff,R.L. and Vaughan,M.R. (1992) Circular dichroism spectroscopy of DNA. Methods Enzymol., 211, 389-406.
31. Akao,T., Fukumoto,T., Ihara,H. and Ito,A. Conformational change in DNA induced by cationic bilayer membranes. FEBS Lett., 391, 215-218.
32. Weiskopf,M. and Li,H.J. (1977) Poly(L-lysine)-DNA interactions in NaCl solutions: B to C and B to psi transitions. Biopolymers, 16, 669-684.
33. Ghirlando,R., Watchel,E.J., Arad,T. and Minsky,A. (1992) DNA packaging induced by micellar aggregates: A novel in vitro DNA condensation system. Biochemistry, 31, 7110-7119.
34. Jordan,C.F., Lerman,L.S. and Venable,J.H. (1972) Structure and circular dichroism of DNA in concentrated polymer solutions. Nature New Biol., 236, 67-70.
35. Yang,Z., Zhu,J., Sriadibhatla,S., Gebhart,C., Alakhov,V. and Kabanov,A. (2005) Promoter- and strain-selective enhancement of gene expression in a mouse skeletal muscle by a polymer excipient Pluronic P85. J. Control. Release, 108(2-3), 496-512.
36. Lopes,J.R and Loh,W. (1998) Investigation of self-assembly and micelle polarity for a wide range of ethylene oxide-propylene oxide-ethylene oxide block copolymers in water. Langmuir, 14, 750-756.
37. Mumper,R.J., Wang,J., Klakamp,S.L., Nitta,H., Anwer,K., Tagliaferri,F. and Rolland,A.P. (1998) Protective interactive noncondensing (PINC) polymers for enhanced plasmid distribution and expression in rat skeletal muscle. J. Control. Release, 52, 191-203.
38. Mumper,R.J., Duguid,J.G., Anwer,K., Barron,M.K., Nitta,H. and Rolland,A.P. (1996) Polyvinyl derivatives as novel interactive polymers for controlled gene delivery to muscle. Pharm. Res., 13, 701-709.
39. Pitard,B. (2002) Supramolecular assemblies of DNA delivery systems. Somat Cell Mol. Genet., 27, 5-15.
40. Choi,Y.H., Liu,F., Choi,J.S., Kim,S.W. and Park,J.S. (1999) Characterization of a targeted gene carrier, lactose-polyethylene glycol-grafted poly-L-lysine and its complex with plasmid DNA. Hum. Gene Ther., 10, 2657-2665.
41. Braun,C.S., Jas,G.S., Choosakoonkriang,S., Koe,G.S., Smith,J.G. and Middaugh,C.R. (2003) The structure of DNA within cationic lipid/DNA complexes. Biophys. J. 84, 1114-1123.
42. Batrakova,E.V., Li,S., Alakhov,V.Y., Miller,D.W. and Kabanov,A.V. (2003) Optimal structure requirements for pluronic block copolymers in modifying P-glycoprotein drug efflux transporter activity in bovine brain microvessel endothelial cells. J. Pharmacol. Exp. Ther., 304, 845-854.