RNAi knockdown of caspase-activated DNase inhibits rotenone-induced DNA fragmentation in HeLa cells

Neurochemistry International

Volumn 50, Issue 4, 2007, Pages 601-606

  Tsuruta, Tadamiki ^a   Oh hashi, Kentaro ^a   Ueno, Yoshihito ^a   Kitade, Yukio ^a   Kiuchi, Kazutoshi ^a   Hirata, Yoko ^a  

^a GIFU UNIVERSITY   (Japan)

Author keywords

CAD; ICAD; Rotenone; siRNA

Indexed keywords

CAD PROTEIN; CASPASE; DEOXYRIBONUCLEASE; DNA FRAGMENT; ROTENONE; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; GENETIC LINKAGE; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RNA INTERFERENCE; UTERINE CERVIX CARCINOMA; WESTERN BLOTTING;

APOPTOSIS; CASPASES; DEOXYRIBONUCLEASES; DNA; DNA FRAGMENTATION; DOWN-REGULATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HELA CELLS; HUMANS; NUCLEOSOMES; RNA INTERFERENCE; RNA, SMALL INTERFERING; ROTENONE; TRANSFECTION; UNCOUPLING AGENTS;

EID: 33847322104     PISSN: 01970186     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuint.2006.12.002     Document Type: Article

References (36)

1. Betarbet R., Sherer T.B., MacKenzie G., Garcia-Osuna M., Panov A.V., and Greenamyre J.T. Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat. Neurosci. 3 (2000) 1301-1306
2. Chinopoulos C., Tretter L., and Adam-Vizi V. Reversible depolarization of in situ mitochondria by oxidative stress parallels a decrease in NAD(P)H level in nerve terminals. Neurochem. Int. 36 (2000) 483-488
3. Earnshaw W.C., Martins L.M., and Kaufmann S.H. Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annu. Rev. Biochem. 68 (1999) 383-424
4. Enari M., Sakahira H., Yokoyama H., Okawa K., Iwamatsu A., and Nagata S. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 391 (1998) 43-50
5. Fischer U., and Schulze-Osthoff K. New approaches and therapeutics targeting apoptosis in disease. Pharmacol. Rev. 57 (2005) 187-215
6. Green D.R., and Evan G.I. A matter of life and death. Cancer Cell 1 (2002) 19-30
7. Hartley A., Stone J.M., Heron C., Cooper J.M., and Schapira A.H. Complex I inhibitors induce dose-dependent apoptosis in PC12 cells: relevance to Parkinson's disease. J. Neurochem. 63 (1994) 1987-1990
8. Heidenreich K.A. Molecular mechanisms of neuronal cell death. Ann. N.Y. Acad. Sci. 991 (2003) 237-250
9. Hirsch E.C., Hunot S., Faucheux B., Agid Y., Mizuno Y., Mochizuki H., Tatton W.G., Tatton N., and Olanow W.C. Dopaminergic neurons degenerate by apoptosis in Parkinson's disease. Mov. Disord. 14 (1999) 383-385
10. Hockenbery D., Nunez G., Milliman C., Schreiber R.D., and Korsmeyer S.J. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348 (1990) 334-336
11. Hoglinger G.U., Feger J., Prigent A., Michel P.P., Parain K., Champy P., Ruberg M., Oertel W.H., and Hirsch E.C. Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats. J. Neurochem. 84 (2003) 491-502
12. King T.D., Bijur G.N., and Jope R.S. Caspase-3 activation induced by inhibition of mitochondrial complex I is facilitated by glycogen synthase kinase-3beta and attenuated by lithium. Brain Res. 919 (2001) 106-114
13. +-induced mitochondrial damage and cell death by trifluoperazine and W-7 in PC12 cells. Neurochem. Int. 46 (2005) 169-178
14. Li J., Spletter M.L., Johnson D.A., Wright L.S., Svendsen C.N., and Johnson J.A. Rotenone-induced caspase 9/3-independent and -dependent cell death in undifferentiated and differentiated human neural stem cells. J. Neurochem. 92 (2005) 462-476
15. Li L.Y., Luo X., and Wang X. Endonuclease G is an apoptotic DNase when released from mitochondria. Nature 412 (2001) 95-99
16. Li N., Ragheb K., Lawler G., Sturgis J., Rajwa B., Melendez J.A., and Robinson J.P. Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production. J. Biol. Chem. 278 (2003) 8516-8525
17. Liu X., Zou H., Slaughter C., and Wang X. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 89 (1997) 175-184
18. Martelli A.M., Zweyer M., Ochs R.L., Tazzari P.L., Tabellini G., Narducci P., and Bortul R. Nuclear apoptotic changes: an overview. J. Cell. Biochem. 82 (2001) 634-646
19. Matsunaga T., Kudo J., Takahashi K., Dohmen K., Hayashida K., Okamura S., Ishibashi H., and Niho Y. Rotenone, a mitochondrial NADH dehydrogenase inhibitor, induces cell surface expression of CD13 and CD38 and apoptosis in HL-60 cells. Leuk. Lymphoma 20 (1996) 487-494
20. McIlroy D., Tanaka M., Sakahira H., Fukuyama H., Suzuki M., Yamamura K., Ohsawa Y., Uchiyama Y., and Nagata S. An auxiliary mode of apoptotic DNA fragmentation provided by phagocytes. Genes Dev. 14 (2000) 549-558
21. Montague J.W., Gaido M.L., Frye C., and Cidlowski J.A. A calcium-dependent nuclease from apoptotic rat thymocytes is homologous with cyclophilin. Recombinant cyclophilins A, B, and C have nuclease activity. J. Biol. Chem. 269 (1994) 18877-18880
22. Nagase H., Fukuyama H., Tanaka M., Kawane K., and Nagata S. Mutually regulated expression of caspase-activated DNase and its inhibitor for apoptotic DNA fragmentation. Cell Death Differ. 10 (2003) 142-143
23. Nagata S. DNA degradation in development and programmed cell death. Annu. Rev. Immunol. 23 (2005) 853-875
24. Nicholson D.W. From bench to clinic with apoptosis-based therapeutic agents. Nature 407 (2000) 810-816
25. Radad K., Rausch W.D., and Gille G. Rotenone induces cell death in primary dopaminergic culture by increasing ROS production and inhibiting mitochondrial respiration. Neurochem. Int. 49 (2006) 379-386
26. Rauch F., Polzar B., Stephan H., Zanotti S., Paddenberg R., and Mannherz H.G. Androgen ablation leads to an upregulation and intranuclear accumulation of deoxyribonuclease I in rat prostate epithelial cells paralleling their apoptotic elimination. J. Cell Biol. 137 (1997) 909-923
27. Reed J.C. Apoptosis-based therapies. Nat. Rev. Drug Discov. 1 (2002) 111-121
28. Reinecke F., Levanets O., Olivier Y., Louw R., Semete B., Grobler A., Hidalgo J., Smeitink J., Olckers A., and Van der Westhuizen F.H. Metallothionein isoform 2A expression is inducible and protects against ROS-mediated cell death in rotenone-treated HeLa cells. Biochem. J. 395 (2006) 405-415
29. Sherer T.B., Betarbet R., Stout A.K., Lund S., Baptista M., Panov A.V., Cookson M.R., and Greenamyre J.T. An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage. J. Neurosci. 22 (2002) 7006-7015
30. Sherer T.B., Kim J.H., Betarbet R., and Greenamyre J.T. Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation. Exp. Neurol. 179 (2003) 9-16
31. Tanuma S., and Shiokawa D. Multiple forms of nuclear deoxyribonuclease in rat thymocytes. Biochem. Biophys. Res. Commun. 203 (1994) 789-797
32. Thompson C.B. Apoptosis in the pathogenesis and treatment of disease. Science 267 (1995) 1456-1462
33. Torriglia A., Negri C., Chaudun E., Prosperi E., Courtois Y., Counis M.F., and Scovassi A.I. Differential involvement of DNases in HeLa cell apoptosis induced by etoposide and long term-culture. Cell Death Differ. 6 (1999) 234-244
34. Ueno Y., Naito T., Kawada K., Shibata A., Kim H.S., Wataya Y., and Kitade Y. Synthesis of novel siRNAs having thymidine dimers consisting of a carbamate or a urea linkage at their 3′ overhang regions and their ability to suppress human RNase L protein expression. Biochem. Biophys. Res. Commun. 330 (2005) 1168-1175
35. van Loo G., Schotte P., van Gurp M., Demol H., Hoorelbeke B., Gevaert K., Rodriguez I., Ruiz-Carrillo A., Vandekerckhove J., Declercq W., Beyaert R., and Vandenabeele P. Endonuclease G: a mitochondrial protein released in apoptosis and involved in caspase-independent DNA degradation. Cell Death Differ. 8 (2001) 1136-1142
36. Wolvetang E.J., Johnson K.L., Krauer K., Ralph S.J., and Linnane A.W. Mitochondrial respiratory chain inhibitors induce apoptosis. FEBS Lett. 339 (1994) 40-44