Antinuclear antibodies and bromoxynil exposure in a rural sample

Journal of Toxicology and Environmental Health - Part A: Current Issues

Volumn 70, Issue 7, 2007, Pages 638-657

  Semchuk, Karen M ^a   Rosenberg, Alan M ^b   McDuffie, Helen H ^b   Cessna, Allan J ^c,d   Pahwa, Punam ^b   Irvine, Donald G ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

^c AGRICULTURE AND AGRI FOOD CANADA   (Canada)

^d ENVIRONMENT CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINUCLEAR ANTIBODY; BROMOXYNIL; FUNGICIDE; PESTICIDE; TRIFLURALIN;

ADULT; AGE DISTRIBUTION; AGRICULTURAL WORKER; ANTIBODY DETECTION; ARTICLE; BLOOD ANALYSIS; BODY MASS; CANADA; CELL STRAIN HEPG2; CEREAL; FEMALE; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNOASSAY; IMMUNOFLUORESCENCE; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE LOGISTIC REGRESSION ANALYSIS; OBESITY; OCCUPATIONAL EXPOSURE; PREVALENCE; PRIORITY JOURNAL; RURAL POPULATION; SELF REPORT; SEX DIFFERENCE; STATISTICAL SIGNIFICANCE;

AGRICULTURE; ANTIBODIES, ANTINUCLEAR; AUTOIMMUNE DISEASES; CROSS-SECTIONAL STUDIES; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; FEMALE; HUMANS; MALE; MIDDLE AGED; NITRILES; PESTICIDES; RURAL HEALTH; SASKATCHEWAN; SEASONS; SEROEPIDEMIOLOGIC STUDIES;

EID: 33847287687     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287390600974593     Document Type: Article

References (110)

1. Agriculture Canada. 1989. CAPCO (Canadian Association of Pesticide Control Officials) note on bromoxynil. Ottawa, ON: Pesticides Directorate, Agriculture Canada.
2. Acquavella, J., Burns, C., Flaherty, D., Holsapple, M., Kimber, I., Ladics, G., Loveless, S., and Tobia, A. 1998. A critique of the World Resources Institutes's report "Pesticides and the Immune system: The Public Health Risks." Environ. Health Perspect. 106:51-54.
3. Arbuckle, M. R., McClain, M. T., Rubertone, M. V., Scofield, R. H., Dennis, G. J., James, J. A., and Harley, J. B. 2003. Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N. Engl. J. Med. 349:1525-1533.
4. Banerjee, B. D., Koner, B. C., Ray, A., and Pasha, S. T. 1996. Influence of subchronic exposure to lindane on humoral immunity in mice. Indian J. Exp. Biol. 34:1109-1113.
5. Banerjee, B. D., Pasha, S. T., Hussain, Q. Z., Koner, B. C., and Ray, A. 1998. A comparative evaluation of immunotoxicity of malathion after subchronic exposure in experimental animals. Indian J. Exp. Biol. 36:273-282.
6. Barnett, J. B., Holcomb, D., Menna, J. H., and Soderberg, L. S. F. 1985a. The effect of prenatal chlordane exposure on specific anti-influenza cell-mediated immunity. Toxicol. Lett. 25:229-238.
7. Barnett, J. B., Soderberg, L. S. F., and Menna, J. H. 1985b. The effect of prenatal chlordane exposure on the delayed hypersensitivity response of BALB/c mice. Toxicol. Lett. 25:173-183.
8. Bazzarre, T. L., Murdoch, S. D., Wu, S. L., and Hopkins, R. G. 1992. Associations of cardiovascular disease risk factors with measures of energy expenditure and caloric intake in a farm population. J. Am. Coll. Nutr. 11:42-49.
9. Blair, A., Tarone, R., Sandler, D., Lynch, C. F., Rowland, A., Wintersteen, W., Steen, W. C., Samanic, C., Dosemeci, M., and Alavanja, M. C. R. 2001. Reliability of reporting on life-style and agricultural factors by a sample of participants in the Agricultural Health Study from Iowa. Epidemiology 13:94-99.
10. Blakley, B. R. 1986. The effect of oral exposure to the n-butylester of 2, 4-dichlorophenoxyacetic acid on the immune system in mice. Int. J. Immunopharmacol. 8:93-99.
11. Blakely, B. R., and Blakely, P. M. 1986. The effect of prenatal exposure to the n-butylester of 2, 4-dichlorophenoxyacetic acid (2,4-D) on the immune response in mice. Teratology. 33:15-20.
12. Blakely, B. R., Yole, M. J., Brousseau, P., Boermans, H., and Fournier, M. 1998. Effect of 2,4- dichlorophenoxyacetic acid, trifluralin and triallate herbicides on immune function. Vet. Hum. Toxicol. 40:5-10.
13. Braun-Fahrländer, C. 2001. The role of the farm environment and animal contact for the development of asthma and allergies. Clin. Exp. Allergy. 31:1799-1803.
14. Braun-Fahrländer, C. H., Gassner, M., Grize, L., Neu, U., Sennhauser, F. H., Varonier, H. S., Vuille, J. C., Wüthrich, B., and The SCARPOL Team. 1999. Prevalence of hay fever and allergic sensitization in farmer's children and their peers living in the same rural community. Clin. Exp. Allergy. 29:28-34.
15. Braun-Fahrländer, C., Riedler, J., Herz, U., Eder, W., Waser, M., Grize, L., Maisch, S., Carr, D., Gerlach, F., Bufe, A., Lauener, R. P., Schierl, R., Renz, H., Nowak, D., and von Mutius, E., for the Allergy and Endotoxin Study Team. 2002. Environmental exposure to endotoxin and its relation to asthma in school-age children. N. Eng. J. Med. 347:869-877.
16. Broughton, A., Thrasher, J. D., and Madison, R. 1990. Chronic health effects and immunological alterations associated with exposure to pesticides. Comments Toxicol. 4:59-71.
17. Brown, D. F., McCool, D. K., Papendick, R. I., and McDonough, L. M. 1985. Herbicide residues from winter wheat plots: Effect of tillage and crop management. J. Environ. Qual. 14:521-532.
18. Bruns, G. W., Nelson, S., and Erickson, D. G. 1991. Determination of MCPA, bromoxynil, 2,4-D, trifluralin, triallate, picloram, and diclofop-methyl in soil by GC-MS using selected ion monitoring. J. Assoc. Off. Anal. Chem. 74:550-553.
19. Casale, G. P., Cohen, S. D., and DiCapua, R. A., 1983. The effects of organophosphate-induced cholinergic stimulation on the antibody response to sheep erythrocytes in inbred mice. Toxicol. Appl. Pharmacol. 68:198-205.
20. Cessna, A. J., and Grover, R. 2002. Exposure of ground-rig applicators to the herbicide bromoxynil applied as a 1:1 mixture of the butyrate and octanoate. Arch. Environ. Contam. Toxicol. 42:369-382.
21. Chernoff, N., Rogers, J. M., Turner, C. I.., and Francis, B. M. 1991. Significance of supernumerary ribs in rodent developmental toxicity studies: Postnatal persistence in rats and mice. Fundam. Appl. Toxicol. 17:448-453.
22. Colosio, C., Maroni, M., Barcellini, W., Meroni, P., Alcini, D., Colombi, A., Cavallo, D., and Foa, V. 1993. Toxicological and immune findings in workers exposed to pentachlorophenol (PCP). Arch. Environ. Health 48:81-88.
23. Conso, F., Neel, P., Pouzoulet, C., Efthymiou, M. L., Gervais, P., and Gaultier, M. 1977. Toxicité aiguë chez l'homme des dérivés hologénés de l'hydroxybenzonitrile (ioxynnil, bromoxynil). (Toxicity in man of halogen derivatives of hydroxybenzonitrile (ioxynil, bromoxynil)). Arch. Mal. Prof. Med. Trav. Secur. Soc. 38:674-677.
24. Cooper, G. S., Martin, S. A., Longnecker, M. P., Sandler, D. P., and Germolec, D. R. 2004. Associations between plasma DDE levels and immunologic measures in African-American farmers in North Carolina. Environ. Health Perspect. 112:1080-1084
25. Cooper, G. S., Miller, F. W., and Germolec, D. R. 2002. Occupational exposures and autoimmune diseases. Int. Immunopharmacol. 2:303-313.
26. Craig, W. Y., Ledue, T. B., Johnson, A. M., and Ritchie, R. F. 1999. The distribution of antinuclear antibody titers in "normal" children and adults. J. Rheumatol. 26:914-919.
27. Czaja, A. J., Carpenter, H. A., Santrach, P. J., and Moore, S. B. 1998. Host-and disease-specific factors affecting steatosis in chronic hepatitis C. J. Hepatol. 29:198-206.
28. Daniel, V., Huber, W., Bauer, K., and Opelz, G. 1995. Impaired in-vitro lymphocyte responses in patients with elevated pentachlorphenol (PCP) blood levels. Arch. Environ. Health 50:287-292.
29. Daniel, V., Huber, W., Bauer, K., Suesal, C., Conradt, C., and Opelz, G. 2001a. Associations of blood levels of PCB, HCHs, and HCB with numbers of lymphocyte subpopulations, in vitro lymphocyte response, plasma cytokine levels, and immunoglobulin autoantibodies. Environ. Health Perspect. 109:173-178.
30. Daniel, V., Huber, W., Bauer, K., Suesal, C., Mytilineos, J., Melk, A., Conradt, C., and Opelz, G. 2001b. Association of elevated blood levels of pentachlorophenol (PCP) with cellular and humoral immunodeficiencies. Arch Environ. Health 56:77-83.
31. Das, S. N., Paul, B. N., Saxena, A. K., and Ray, P. K. 1990. Effect of utero exposure to hexachlorocyclohexane on the developing immune system of mice. Immunopharmacol. Immunotoxicol. 12:293-310.
32. Dêsi, I., Varga, L., and Farkas, I. 1978. Studies on the immunosuppressive effect of organochlorine and organophosphoric pesticides in subacute experiments. J. Hyg. Epidemiol. Microbiol. Immunol. 1:115-122.
33. Diggle, P. J., Heagerty, P. J., Liang, K., and Zeger, S. L. 2002. Analysis of longitudinal data, 2nd ed. New York: Oxford University Press.
34. Eriksson, C., Brandt I., and Brittebo, E. 1992. Tissue-binding and toxicity of compounds structurally related to the herbicide dichlobenil in the mouse olfactory mucosa. Food Chem. Toxicol. 30:871-877.
35. Ernst, P., and Cormier, Y. 2000. Relative scarcity of asthma and atopy among rural adolescents raised on a farm. Am J. Respir. Crit. Care Med. 161:1563-1566.
36. Faustini, A., Settimi, L., Pacifici, R., Fano, V., and Zuccaro, P. 1996. Immunological changes among farmers exposed to phenoxy herbicides. Preliminary observations. Occup. Environ. Med. 53:583-585.
37. Flipo, D., Bernier, J., Girard, D., Krzystyniak, K., and Fournier, M. 1992. Combined effects of selected insecticides on humoral immune response in mice. Int. J. Immunopharmacol. 14:747-752.
38. 2) as a measure of fatness. Int. J. Obesity. 9:147-153.
39. Gilmore, J. 1999. Body mass index and health. Health Rep. 11:31-43. Catalogue no. 82-003-XPE. Ottawa, Ontario: Health Statistics Division, Statistics Canada.
40. Grover, R., Smith, A. E., and Cessna, A. J. 1994. Fate of bromoxynil n-butyrate and iso-octanoate applied as a mixture to a wheat field. J. Environ. Qual. 23:1304-1311.
41. Harrington, M. L., Moore, M. P., Talcott, P. A., Bagley, R. S., and Sandmeier, P. 1996. Suspected herbicide toxicosis in a dog. J. Am. Vet. Med. Assoc. 209:2085-2087.
42. Health Canada. 2003. Canadian guidelines for body weight classification in adults. Catalogue no. H49-179/2003E. Ottawa, Ontario: Her Majesty the Queen in the Right of Canada..
43. Health Canada. 2005. Pest Management Regulatory Agency. ELSE label search. Ottawa, Ontario. Available from http://eddenet.pmra-arla.gc.ca/4.0/ 4.01.asp.
44. Hill, B. D., Harker, K. N., Hasselback, P., Inaba, D. J., Byers, S. D., and Moyer, J. R. 2002. Herbicides in Alberta rainfall as affected by location, use and season: 1999 to 2000. Water Qual. Res. J. Can. 37:515-542.
45. Hill, B. D., Miller, J. J., Chang, C., and Rodvang, S. J. 1996. Seasonal variation in herbicide levels detected in shallow Alberta groundwater. J. Environ. Sci. Health B 31:883-900.
46. Hooper, B., Whittingham, S., Mathews, J. D., Mackay, I. R., and Curnow, D. H. 1972. Autoimmunity in a rural community. Clin. Exp. Immunol. 12:79-87.
47. Johnson, V. J., Rosenberg, A. M., Lee, K., and Blakley, B. R. 2002. Increased T-lymphocyte dependent antibody production in female SJL/J mice following exposure to commercial grade malathion. Toxicology 170:119-129.
48. Kavanaugh, A., Tomar, R., Reveille, J., Solomon, D. H., and Homburger, H. A. 2000. Guidelines for clinical use of the antinuclear antibody test and tests for specific autoantibodies to nuclear antigens. Arch. Pathol. Lab. Med. 124:71-81.
49. Kilpeläinen, M., Terho, E. O., Helenius, H., and Koskenvuo, M. 2000. Farm environment in childhood prevents the development of allergies. Clin. Exp. Allergy 30:201-208.
50. Kowalczyk-Bronisz, S. H., Gieldanowski, J., and Bubak, B. 1990. Immunological profile of animals exposed to pesticide - Deltamethrin. Arch. Immunol. Ther. Exp. 38: 229-238.
51. Krieger, R. I., Ross, J. H., and Thongsinthusak, T. 1992. Assessing human exposures to pesticides. Rev. Environ. Contam. Toxicol. 128:1-15.
52. Larney, F. J., Cessna, A. J., and Bullock, M. S. 1999. Herbicide transport on wind-eroded sediment. J. Environ. Qual. 28:1412-1421.
53. Lee, K., Johnson, V. J., and Blakley, B. R. 2001. The effect of exposure to a commercial 2,4-D formulation during gestation on the immune response in CD-1 mice. Toxicology 165:39-49.
54. Lotzová, E. 1993. Definition and functions of natural killer cells. Nat. Immun. 12:169-176.
55. Lukowicz-Ratajczak, J., and Krechniak, J. 1992. Effects of deltamethrin on the immune system in mice. Environ. Res. 59:467-475.
56. Lundberg, I., Alfredsson, L., Plato, N., Sverdrup, B., Klareskog, L., and Kleinau, S. 1994. Occupation, occupational exposure to chemicals and rheumatological disease. A register based cohort study. Scand. J. Rheumatol. 23:305-310.
57. Madsen, C., Claesson, M. H., and Röpke, C. 1996. Immunotoxicity of the pyrethroid insecticides deltamethrin and α-cypermethrin. Toxicology 107:219-227.
58. Masley, M. L., Semchuk, K. M., Senthilselvan, A., McDuffie, H. H., Hanke, P., Dosman, J. A., Cessna, A. J., Crossley, M. F. O., Irvine, D. G., Rosenberg, A. M., and Hagel, L. M. 2000. Health and environment of rural families: Results of a community canvass survey in the prairie ecosystem study (PECOS). J. Agric. Safety Health 6:103-115.
59. McConnachie, P. R., and Zahalsky, A. C. 1991. Immunological consequences of exposure to pentachlorphenol. Arch. Environ. Health 46: 249-253.
60. McConnachie, P. R., and Zahalsky, A. C. 1992. Immune alterations in humans exposed to the termiticide technical chlordane. Arch. Environ. Health 47:295-301.
61. McDuffie, H. H., Semchuk, K. M., Crossley, M. M., Senthilselvan, A., Rosenberg, A. M., Hagel, L., Cessna, A. J., Irvine, D. G., and Ledingham, D. L. 2003. Prairie ecosystem study (PECOS): From community to chemical elements, the essential role of questionnaires. In Managing for healthy ecosystems, eds. D. J. Rapport, W. L. Lasley, D. E. Rolston, N. O. Nielson, C. O. Qualset, and A. B. Damania, pp. 1169-1182. Washington, DC: Lewis.
62. Meera, P., Rao, P. R., Shanker, R., and Tripathi, O. 1992. Immunomodulatory effects of γ-HCH (lindane) in mice. Immunopharmacol. Immunotoxicol. 14:261-282.
63. Menna, J. H., Barnett, J. B., and Soderberg, L. S. F. 1985. Influenza type A virus infection of mice exposed in utero to chlordane; Survival and antibody studies. Toxicol. Lett. 24:45-52.
64. Milham, S. 1988. Using multiple cause of death coding in occupational mortality studies. Am. J. Indust. Med. 14:341-344.
65. Muir, D. C. G., and Grift, N. P. 1987. Herbicide levels in rivers draining two prairie agricultural watersheds (1984). J. Environ. Sci. Health B22:259-284.
66. Muir, D. C. G., Kenny, D. F., Grift, N. P., Robinson, R. D., Titman, R. D., and Murkin, H. R. 1991. Fate and acute toxicity of bromoxynil esters in an experimental prairie wetland. Environ. Toxicol. Chem. 10:395-406.
67. Nigam, S. K., Karnik, A. B., Chattopadhyay, P., Lakkad, B. C., Venkaiah, K., and Kashyap, S. K. 1993. Clinical and biochemical investigations to evolve early diagnosis in workers involved in the manufacture of hexachlorocyclohexane. Int. Arch. Occup. Environ. Health 65:S193-S196.
68. Olsson, Å. R., Skogh, T., and Wingren, G. 2000. Occupational determinants for rheumatoid arthritis. Scand. J. Work Environ. Health 26:243-249.
69. Parks, C. G., Cooper, G. S., Nylander-French, L. A., Sanderson, W. T., Dement, J. M., Cohen, P. L., Dooley, M. A., Treadwell, E. L., St. Clair, E. W., Gilkeson, G. S., Hoppin, J. A., and Savitz, D. A. 2002. Occupational exposure to crystalline silica and risk of systemic lupus erythematosus. A population-based case-control study in the southern United States. Arthritis Rheumatism 46:1840-1850.
70. Pekkanen, J., Xu, B., and Järvelin, M. R. 2001. Gestational age and occurrence of atopy at age 31 - A prospective birth cohort study in Finland. 2001. Clin. Exp. Allergy. 31:95-102.
71. Pomrehn, P. R., Wallace, R. B., and Burmeister, L. F. 1982. Ischemic heart disease mortality in Iowa farmers: The influence of lifestyle. J. Am. Med. Assoc. 248:1073-1076.
72. Queiroz, M. L. S., Bincoletto, C., Perlingeiro, R. C. R., Quadros, M. R., and Souza, C. A. 1998. Immunoglobulin levels in workers exposed to hexachlorobenzene. Hum. Exp. Toxicol. 17:172-175.
73. Queiroz, M. L. S., Bincoletto, C., Perlingeiro, R. C. R., Souza, C. A., and Toledo, H. 1997. Defective neutrophil function in workers occupationally exposed to hexachlorobenzene. Hum. Exp. Toxicol. 16:322-326.
74. Rantapää-Dahlqvist, S., de Jong, B. A. W., Berglin, E., Hallmans, G., Wadell, G., Stenlund, H., Sundin, U., and van Venrooij, W. J. 2003. Antibodies against cyclic citrullinated peptide and IgA and rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheumatism. 48: 2741-2749.
75. Reed, A., Dzon, L., Loganathan, B. G., and Whalen, M. M. 2004. Immunomodulation of human natural killer cell cytotoxic function by organochlorine pesticides. Hum. Exp. Toxicol. 23:463-471.
76. Relford, R. L., Ainsworth, A. J., and Harkness, J. E. 1989. Effects of a commercial malathion dip preparation on the cellular and humoral immune response of BALB/c mice. Lab. Anim. Sci. 39:56-59.
77. Riedler, J., Braun-Fahrländer, C., Eder, W., Schreuer, M., Waser, M., Maisch, S., Carr, D., Schierl, R., Nowak, D., von Mutius, E., and the ALEX Study Team. 2001. Exposure to farming in early life development of asthma and allergy: A cross-sectional survey. Lancet 358:1129-1133.
78. Riedler, J., Eder, W., Oberfeld, G., and Schreuer, M. 2000. Austrian children living on a farm have less hay fever, asthma, and allergic sensitization. Clin. Exp. Allergy 30:194-200.
79. Rogers, J. M., Francis, B. M., Barbee, B. D., and Chernoff, N. 1991. Developmental toxicity of bromoxynil in mice and rats. Fundam. Appl. Toxicol. 17:442-447.
80. Rodgers, K. E., Leung, N., Ware, C. F., Devens, B. H., and Imamura, T. 1986. Lack of immunosuppressive effects of acute and subacute administration of malathion on murine cellular and humoral immune responses. Pestic. Biochem. Physiol. 25:358-365.
81. Rosenberg, A. M. 1988. The clinical associations of antinuclear antibodies in juvenile rheumatoid arthritis. Clin. Immunol. Immunopathol. 49:19-27.
82. Rosenberg, A. M., Semchuk, K. M., McDuffie, H. H., Ledingham, D. L., Cordeiro, D. M., Cessna, A. J., Irvine, D. G., Senthilselvan, A., and Dosman, J. A. 1999. Prevalence of antinuclear antibodies in a rural population. J. Toxicol. Environ. Health A 56:225-236.
83. Ross, R., and Katzmarzyk, P. T. 2003. Cardiorespiratory fitness is associated with diminished total and abdominal obesity independent of body mass index. Int. J. Obesity 27:204-210.
84. Saha, S., and Banerjee, B. G. 1993. Effect of sub-chronic lindane exposure on humoral and cell-mediated immune responses in albino rats. Bull. Environ. Contam. Toxicol. 51:795-802.
85. SAS Institute, Inc. 2004. The SAS® System Release 8.2 (TS2M0) for Windows. Cary, NC: SAS Institute, Inc.
86. Saskatchewan Agriculture and Food. 1995. Crop protection guide 1995. Regina, Saskatchewan: Saskatchewan Agriculture and Food.
87. Semchuk, K. M., McDuffie, H. H., Hanke, P., Senthilselvan, A., Arbuthnott, K., Dosman, J. A., Gillis-Cipywnyk, M., Crossley, M., Cessna, A. J., Gerrard, N., Irvine, D. G., Rosenberg, A. M., and Elliott, J. 1996. Environmental pesticide exposure and human health in Saskatchewan, Canada: I. The community canvass. Epidemiology 7(suppl.):S59.
88. Semchuk, K. M., McDuffie, H. H., Senthilselvan, A., Cessna, A. J., and Irvine, D. G. 2004. Body mass index and bromoxynil exposure in a sample of rural residents during spring herbicide application. J. Toxicol. Environ. Health A 67:1321-1352.
89. Semchuk, K. M., McDuffie, H. H., Senthilselvan, A., Dosman, J. A., Cessna, A. J., and Irvine, D. G. 2003. Factors associated with detection of bromoxynil in a sample of rural residents. J. Toxicol. Environ. Health A 66:103-132.
90. Spiewak, R., and Stojek, N. M. 2003. Antinuclear antibodies among Eastern-Polish rural inhabitants. Ann. Agric. Environ. Med. 10:207-209.
91. SPSS, Inc. 2004. SPSS® 13.0 for Windows. Chicago: SPSS, Inc.
92. Spyker-Cranmer, J. M., Barnett, J. B., Avery, D. L., and Cranmer, M. F. 1982. Immunoteratology of chlordane: Cell-mediated and humoral immune responses in adult mice exposed in utero. Toxicol. Appl. Pharmacol. 62:402-408.
93. Statistics Canada. 1997a. Agricultural profile of Canada. Catalogue no. 93-356-XPB. Ottawa, Ontario: Minister of Industry.
94. Statistics Canada. 1997b. Agricultural profile of Saskatchewan. Catalogue no. 95-179-XPB. Ottawa, Ontario: Minister of Industry.
95. Tan, E. M., Feltkamp, T. E. W., Smolen, J. S., Butcher, B., Dawkins, R., Fritzler, M. J., Gordon, T., Hardin, J. A., Kalden, J. R., Lahita, R. G., Maini, R. N., McDougal, J. S., Rothfield, N. F., Smeenk, R. J., Takasaki, Y., Wiik, A., Wilson, M. R., and Koziol, J. A. 1997. Range of antinuclear antibodies in "healthy" individuals. Arthritis Rheumatism 40: 1601-1611.
96. Thrasher, J. D., Heuser, G., and Broughton, A. 2002. Immunological abnormalities in humans chronically exposed to chlorpyrifos. Arch. Environ. Health 57:181-187.
97. Thrasher, J. D., Madison, R., and Broughton, A. 1993. Immunologic abnormalities in humans exposed to chlorpyrifos: Preliminary observations. Arch. Environ. Health 48:89-93.
98. Tomlin, C. D. S., ed. 1997. The pesticide manual: A world compendium, 11th ed. Farnham, Surrey, UK: British Crop Protection Council.
99. Trayhurn, P., and Wood, I. S. 2005. Signalling role of adipose tissue: Adipokines and inflammation in obesity. Biochem. Soc. Trans. 33:1078-1081.
100. Tryphonas, H., Bondy, G., Hodgen, M., Coady, L., Parenteau, M., Armstrong, C., Hayward, S., and Liston, V. 2003. Effects of cis- nonachlor, trans-nonachlor and chlordane on the immune system of Sprague-Dawley rats following a 28-day oral (gavage) treatment. Food Chem. Toxicol. 41:107-118.
101. U.S. Environmental Protection Agency. 1997. Bromoxynil; Pesticide tolerances. Fed. Reg. 62(85):24065-24073. Available from http://www.epa.gov/fedrgstr/EPA-PEST/1997/May/Day-02/p11504.htm.
102. U.S. Environmental Protection Agency. 1998. Bromoxynil; Pesticide tolerance. Fed. Reg. 63(92):26473-26481. Available from http://www.epa.gov/fedrgstr/EPA-PEST/1998/May/Day-13/p12639.htm.
103. Vial, T., Nicolas, B., and Descotes, J. 1996. Clinical immunotoxicity of pesticides. J. Toxicol. Environ. Health 48:215-229.
104. Von Ehrenstein, O. S., von Mutius, E., Illi, S., Baumann, L., and Böhm, O. 2000. Reduced risk of hay fever and asthma among children of farmers. Clin. Exp. Allergy 30:187-193.
105. Waite, D. T., Cessna, A. J., Grover, R., Kerr, L. A., and Snihura, A. D. 2004. Atmospheric pollutants and trace gases. Environmental concentrations of agricultural herbicides in Saskatchewan, Canada: Bromoxynil, dicamba, diclofop, MCPA, and trifluralin. J. Environ. Qual. 33:1616-1628.
106. Waite, D. T., Bailey, P., Sproull, J. F., Quiring, D. V., Chau, D. F., and Cessna, A. J. 2005. Atmospheric concentrations and dry and wet deposits of some herbicides currently used on the Canadian prairies. Chemosphere 58:693-703.
107. Whalen, M. M., Loganathan, B. G., Yamashita, N., and Saito, T. 2003. Immunomodulation of human natural killer cell cytotoxic function by triazine and carbamate pesticides. Chem. Biol. Interact. 145:311-319.
108. Wilson, S., Dzon, L., Reed, A., Pruitt, M., and Whalen, M. M. 2004. Effects of in vitro exposure to low levels of organotin and carbamate pesticides on human natural killer cell cytotoxic function. Environ. Toxicol. 19:554-563.
109. Woollen, B. H. 1993. Biological monitoring for pesticide absorption. Ann. Occup. Hyg. 37:525-540.
110. World Health Organization. 2000. Obesity: Preventing and managing the global epidemic. Report of a WHO consultation. WHO technical report series: 894. Geneva, Switzerland: World Health Organization.