Role of microglia in the pathogenesis of osmotic-induced demyelination

Experimental Neurology

Volumn 204, Issue 1, 2007, Pages 88-94

  Takefuji, Seiko ^a,b   Murase, Takashi ^a   Sugimura, Yoshihisa ^a   Takagishi, Yoshiko ^a   Hayasaka, Shizu ^a   Oiso, Yutaka ^b   Murata, Yoshiharu ^a  

^a NAGOYA UNIVERSITY   (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Central pontine myelinolysis; dDAVP; Demyelination; Hyponatremia; IFN ; iNOS; Lovastatin; Microglia; Proinflammatory cytokines; TNF

Indexed keywords

DESMOPRESSIN; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; MEVINOLIN; SODIUM CHLORIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN CORTEX; BRAIN DAMAGE; CONTROLLED STUDY; DEMYELINATION; DISEASE SEVERITY; HYPONATREMIA; MALE; MESENCEPHALON; MICROGLIA; MOTOR DYSFUNCTION; NONHUMAN; OSMOTIC DEMYELINATION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REMISSION;

ANIMALS; BRAIN DISEASES; CYTOKINES; DEMYELINATING DISEASES; HYPONATREMIA; INFLAMMATION MEDIATORS; INJECTIONS; INTERFERON TYPE II; LOVASTATIN; MALE; MICROGLIA; NITRIC OXIDE SYNTHASE TYPE II; OSMOSIS; RATS; RATS, SPRAGUE-DAWLEY; SALINE SOLUTION, HYPERTONIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33847282337     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2006.09.025     Document Type: Article

References (29)

1. Alberts A.W. Discovery, biochemistry and biology of lovastatin. Am. J. Cardiol. 62 (1988) 10J-15J
2. Aloisi F. Immune function of microglia. Glia 36 (2001) 165-179
3. Cross A.H., Misko T.P., Lin R.F., Hickey W.F., Trotter J.L., and Tilton R.G. Aminoguanidine, an inhibitor of inducible nitric oxide synthase, ameliorates experimental autoimmune encephalomyelitis in SJL mice. J. Clin. Invest. 93 (1994) 2684-2690
4. Damoiseaux J.G., Dopp E.A., Calame W., Chao D., MacPherson G.G., and Dijkstra C.D. Rat macrophage lysosomal membrane antigen recognized by monoclonal antibody ED1. Immunology 83 (1994) 140-147
5. DeLuca G.C., Nagy Z., Esiri M.M., and Davey P. Evidence for a role for apoptosis in central pontine myelinolysis. Acta. Neuropathol. (Berl) 103 (2002) 590-598
6. Ding M., Zhang M., Wong J.L., Rogers N.E., Ignarro L.J., and Voskuhl R.R. Antisense knockdown of inducible nitric oxide synthase inhibits induction of experimental autoimmune encephalomyelitis in SJL/J mice. J. Immunol. 160 (1998) 2560-2564
7. Greenwood J., Walters C.E., Pryce G., Kanuga N., Beraud E., Baker D., and Adamson P. Lovastatin inhibits brain endothelial cell Rho-mediated lymphocyte migration and attenuates experimental autoimmune encephalomyelitis. FASEB J. 17 (2003) 905-907
8. Heppner F.L., Greter M., Marino D., Falsig J., Raivich G., Hovelmeyer N., Waisman A., Rulicke T., Prinz M., Priller J., Becher B., and Aguzzi A. Experimental autoimmune encephalomyelitis repressed by microglial paralysis. Nat. Med. 11 (2005) 146-152
9. Ito D., Tanaka K., Suzuki S., Dembo T., and Fukuuchi Y. Enhanced expression of Iba1, ionized calcium-binding adapter molecule 1, after transient focal cerebral ischemia in rat brain. Stroke 32 (2001) 1208-1215
10. Kleinschmidt-DeMasters B.K., and Norenberg M.D. Rapid correction of hyponatremia causes demyelination: relation to central pontine myelinolysis. Science 211 (1981) 1068-1070
11. Kleinschmidt-DeMasters B.K., and Norenberg M.D. Neuropathologic observations in electrolyte-induced myelinolysis in the rat. J. Neuropathol. Exp. Neurol. 41 (1982) 67-80
12. Kreutzberg G.W. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 19 (1996) 312-318
13. Marz W., and Koenig W. HMG-CoA reductase inhibition: anti-inflammatory effects beyond lipid lowering?. J. Cardiovasc. Risk 10 (2003) 169-179
14. Merrill J.E., and Benveniste E.N. Cytokines in inflammatory brain lesions: helpful and harmful. Trends Neurosci. 19 (1996) 331-338
15. Merrill J.E., and Scolding N.J. Mechanisms of damage to myelin and oligodendrocytes and their relevance to disease. Neuropathol. Appl. Neurobiol. 25 (1999) 435-458
16. Minagar A., Shapshak P., Fujimura R., Ownby R., Heyes M., and Eisdorfer C. The role of macrophage/microglia and astrocytes in the pathogenesis of three neurologic disorders: HIV-associated dementia, Alzheimer disease, and multiple sclerosis. J. Neurol. Sci. 202 (2002) 13-23
17. Norenberg M.D., Leslie K.O., and Robertson A.S. Association between rise in serum sodium and central pontine myelinolysis. Ann. Neurol. 11 (1982) 128-135
18. Pahan K., Sheikh F.G., Namboodiri A.M., and Singh I. Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages. J. Clin. Invest. 100 (1997) 2671-2679
19. Stanislaus R., Pahan K., Singh A.K., and Singh I. Amelioration of experimental allergic encephalomyelitis in Lewis rats by lovastatin. Neurosci. Lett. 269 (1999) 71-74
20. Stanislaus R., Singh A.K., and Singh I. Lovastatin treatment decreases mononuclear cell infiltration into the CNS of Lewis rats with experimental allergic encephalomyelitis. J. Neurosci. Res. 66 (2001) 155-162
21. Sugimura Y., Murase T., Takefuji S., Hayasaka S., Takagishi Y., Oiso Y., and Murata Y. Protective effect of dexamethasone on osmotic-induced demyelination in rats. Exp. Neurol. 192 (2005) 178-183
22. Tan J., Town T., Paris D., Mori T., Suo Z., Crawford F., Mattson M.P., Flavell R.A., and Mullan M. Microglial activation resulting from CD40-CD40L interaction after beta-amyloid stimulation. Science 286 (1999) 2352-2355
23. Tomlinson B.E., Pierides A.M., and Bradley W.G. Central pontine myelinolysis. Two cases with associated electrolyte disturbance. Q. J. Med. 45 (1976) 373-386
24. Townsend K.P., Shytle D.R., Bai Y., San N., Zeng J., Freeman M., Mori T., Fernandez F., Morgan D., Sanberg P., and Tan J. Lovastatin modulation of microglial activation via suppression of functional CD40 expression. J. Neurosci. Res. 78 (2004) 167-176
25. Townsend K.P., Town T., Mori T., Lue L.F., Shytle D., Sanberg P.R., Morgan D., Fernandez F., Flavell R.A., and Tan J. CD40 signaling regulates innate and adaptive activation of microglia in response to amyloid beta-peptide. Eur. J. Immunol. 35 (2005) 901-910
26. Verbalis J.G., and Gullans S.R. Hyponatremia causes large sustained reductions in brain content of multiple organic osmolytes in rats. Brain Res. 567 (1991) 274-282
27. Weitz-Schmidt G. Statins as anti-inflammatory agents. Trends Pharmacol. Sci. 23 (2002) 482-486
28. Xie Q.W., Kashiwabara Y., and Nathan C. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J. Biol. Chem. 269 (1994) 4705-4708
29. Youssef S., Stuve O., Patarroyo J.C., Ruiz P.J., Radosevich J.L., Hur E.M., Bravo M., Mitchell D.J., Sobel R.A., Steinman L., and Zamvil S.S. The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. Nature 420 (2002) 78-84