Callus formation enhanced by BMP-7 ex vivo gene therapy during distraction osteogenesis in rats

Journal of Orthopaedic Research

Volumn 25, Issue 2, 2007, Pages 241-251

  Hu, J ^a   Qi, M C ^b,c   Zou, S J ^b   Li, J H ^a   Luo, E ^b  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

^c NORTH CHINA COAL MEDICAL COLLEGE   (China)

Author keywords

Bone morphogenetic protein 7; Distraction osteogenesis; Gene therapy; Mesenchymal stem cells

Indexed keywords

CALCIUM; OSTEOGENIC PROTEIN 1; PHOSPHORUS; BONE MORPHOGENETIC PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MINERALIZATION; CALLUS; CONTROLLED STUDY; DISTRACTION OSTEOGENESIS; DRUG MECHANISM; EX VIVO GENE TRANSFER; HISTOLOGY; IMMUNOHISTOCHEMISTRY; JAW RADIOGRAPHY; MALE; MANDIBLE; MESENCHYMAL STEM CELL; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SCANNING ELECTRON MICROSCOPY; SPRAGUE DAWLEY RAT; STEM CELL GENE THERAPY; WOUND INFECTION; ANIMAL; BONE DEVELOPMENT; BONE REGENERATION; CYTOLOGY; GENE EXPRESSION REGULATION; GENE THERAPY; GENETIC TRANSFECTION; GENETICS; METABOLISM; METHODOLOGY; PHYSIOLOGY; RADIOGRAPHY; RANDOMIZATION;

ANIMALS; BONE MORPHOGENETIC PROTEINS; BONE REGENERATION; BONY CALLUS; GENE EXPRESSION REGULATION; GENE THERAPY; MALE; MANDIBLE; MESENCHYMAL STEM CELLS; OSTEOGENESIS; OSTEOGENESIS, DISTRACTION; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 33847268721     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1002/jor.20288     Document Type: Article

References (32)

1. Li G. 2004. New developments and insights learned from distraction osteogenesis. Curr Opin Orthop 15:325-330.
2. McCarthy JG, Katzen JT, Hopper R, et al. 2002. The first decade of mandibular distraction: lessons we have learned. Plast Reconstr Surg 110:1704-1713.
3. Ashinoff RL, Cetrulo CL, Galiano RD, et al. 2004. Bone morphogenetic protein-2 gene therapy for mandibular distraction osteogenesis. Ann Plast Surg 52:585-590.
4. Terheyden H, Wang H, Warnke PH, et al. 2003. Acceleration of callus formation using rhOP-1 in mandibular distraction osteogenesis in a rat model. Int J Oral Maxillofac Surg 32:528-533.
5. Campisi P, Hamdy RC, Lauzier D, et al. 2003. Expression of bone morphogenetic proteins during mandibular distraction osteogenesis. Plast Reconstr Surg 111:201-208.
6. Farhadieh RD, Gianoutsos MP, Yu Y, et al. 2004. The role of bone morphogenetic proteins-2 and -4 and their related postreceptor signaling system (Smads) in distraction osteogenesis of the mandible. J Craniofac Surg 15:714-718.
7. Rauch F, Lauzier D, Croteau S, et al. 2000. Temporal and spatial expression of bone morphogenetic protein-2, -4 and -7 during distraction osteogenesis in rabbits. Bone 27: 453-459.
8. Hamdy RC, Amako M, Beckman L, et al. 2003. Effects of osteogenic protein-1 on distraction osteogenesis in rabbits. Bone 33:248-255.
9. Li G, Bouxsein ML, Luppen C, et al. 2002. Bone consolidation is enhanced by rhBMP-2 in a rabbit model of distraction osteogenesis. J Orthop Res 20:779-788.
10. Helm GA, Alden TD, Sheehan JP, et al. 2000. Bone morphogenetic proteins and bone morphogenetic protein gene therapy in neurological surgery: a review. Neurosurgery 46:1213-1222.
11. Rutherford RB, Nussenbaum B, Krebsbach PH. 2003. Bone morphogenetic protein 7 ex vivo gene therapy. Drug News Perspect 16:5-10.
12. Sakou T. 1998. Bone morphogenetic proteins: from basic studies to clinical approaches. Bone 22:591-603.
13. Haynesworth SE, Baber MA, Caplan AI. 1996. Cytokines expression by human marrow-derived mesenchymal progenitor cells in vitro: effects of dexamethasone and IL-1 alpha. J Cell Physiol 166:585-592.
14. Aronson J. 2004. Modulation of distraction osteogenesis in the aged rat by fibroblast growth factor. Clin Orthop Relat Res 425:264-283.
15. Qi MC, Zhou XQ, Hu J, et al. 2004. Oestrogen replacement therapy promotes bone healing around dental implants in osteoporotic rats. Int J Oral Maxillofac Surg 33:279-285.
16. Nussenbaum B, Rutherford RB, Teknos TN, et al. 2003. Ex vivo gene therapy for skeletal regeneration in cranial defects compromised by postoperative radiotherapy. Hum Gene Ther 14:1107-1115.
17. Ganey TM, Klotch DW, Slater-Haase AS, et al. 1994. Evaluation of distraction osteogenesis by scanning electron microscopy. Otolaryngol Head Neck Surg 111:265-272.
18. Mason JM, Breitbart AS, Barcia M, et al. 2000. Cartilage and bone regeneration using gene-enhanced tissue engineering. Clin Orthop 379:S171-S178.
19. Bouletreau PJ, Warren SM, Longaker MT. 2002. The molecular biology of distraction osteogenesis. J Cranio-Maxillofac Surg 30:1-11.
20. Richards M, Huibregtse BA, Caplan AI, et al. 1999, Marrow-derived progenitor cell injections enhance new bone formation during distraction. J Orthop Res 17:900-908.
21. Kitoh H, Kitakoji T, Tsuchiya H, et al. 2004. Transplantation of marrow-derived mesenchymal stem cells and platelet-rich plasma during distraction osteogenesis - a preliminary result of three cases. Bone 35:892-898.
22. Aronson J, Shen XC, Gao GG, et al. 1997. Sustained proliferation accompanies distraction osteogenesis in the rat. J Orthop Res 15:563-569.
23. Li G, Simpson AH, Kenwright J, et al. 1997. Assessment of cell proliferation in regenerating bone during distraction osteogenesis at different distraction rates. J Orthop Res 15:765-772.
24. Mizumoto Y, Moseley T, Drews M, et al. 2003. Acceleration of regenerate ossification during distraction osteogenesis with recombinant human bone morphogenetic protein-7. J Bone Joint Surg Am 85A(Suppl 3):124-130.
25. Attisano L, Wrana JI. 2002. Signal transduction by the TGF-beta superfamily. Science 296:1646-1647.
26. Derynck R, Zhang Y, Feng XH. 1998. Smads: transcriptional activators of TGF-beta responses. Cell 95:737-740.
27. Yeh LC, Tsai AD, Lee JC. 2002. Osteogenic protein-1 (OP-1) induces osteoblastic cell differentiation of the pluripotent mesenchymal cell line C2C12. J Cell Biochem 87:292-304.
28. Ducy P, Zhang R, Geoffroy V, et al. 1997. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell 89:747-754.
29. Ji C, Casinghino S, Chang DJ, et al. 1998. CBFa(AML/PEBP2)-related elements in the TGF-beta type I receptor promoter and expression with osteoblast differentiation. J Cell Biochem 69:353-363.
30. Tou L, Quibria N, Alexander JM. 2003. Transcriptional regulation of the human Runx2/Cbfal gene promoter by bone morphogenetic protein-7. Mol Cell Endocriniol 205:121-129.
31. Tsuji K, Ito Y, Noda M. 1998. Expression of the PEBP2al-phaA/AML3/CBFA1 gene is regulated by BMP4/7 heterodimer and its overexpression suppresses type I collagen and osteocalcin gene expression in osteoblastic and non-osteoblastic mesenchymal cells. Bone 22:87-92.
32. Aronson J, Gao GG, Shen XC, et al. 2001. The effect of aging on distraction osteogenesis in the rat. J Orthop Res 19:421-427.