메뉴 건너뛰기




Volumn 87, Issue 3, 2002, Pages 292-304

Osteogenic protein-1 (OP-1, BMP-7) induces osteoblastic cell differentiation of the pluripotent mesenchymal cell line C2C12

Author keywords

BMP expression; BMP receptor expression; Bone morphogenetic protein 7; C2C12; Gene expression; Osteoblastic cell differentiation; Osteogenic protein 1

Indexed keywords

ALKALINE PHOSPHATASE; COMPLEMENTARY DNA; MESSENGER RNA; OSTEOCALCIN; OSTEOGENIC PROTEIN 1; RECOMBINANT PROTEIN; RNA;

EID: 0036031931     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcb.10315     Document Type: Article
Times cited : (70)

References (51)
  • 2
    • 0027360838 scopus 로고
    • Human osteogenic protein-1 induces both chondroblastic and osteoblastic differentiation of osteoprogenitor cells derived from newborn rat calvaria
    • Asahina I, Sampath TK, Nishimura I, Hauschka PV. 1993. Human osteogenic protein-1 induces both chondroblastic and osteoblastic differentiation of osteoprogenitor cells derived from newborn rat calvaria. J Cell Biol 123:921-933.
    • (1993) J Cell Biol , vol.123 , pp. 921-933
    • Asahina, I.1    Sampath, T.K.2    Nishimura, I.3    Hauschka, P.V.4
  • 3
    • 0034878782 scopus 로고    scopus 로고
    • Differential regulation of the two principal Runx2/Cbfal N-terminal isoforms in response to bone morphogenetic protein-2 during development of the osteoblast phenotype
    • Banerjee C, Javed A, Choi JY, Green J, Rosen V, van Wijnen AJ, Stein JL, Lian JB, Stein GS. 2001. Differential regulation of the two principal Runx2/Cbfal N-terminal isoforms in response to bone morphogenetic protein-2 during development of the osteoblast phenotype. Endocrinology 142:4026-4039.
    • (2001) Endocrinology , vol.142 , pp. 4026-4039
    • Banerjee, C.1    Javed, A.2    Choi, J.Y.3    Green, J.4    Rosen, V.5    Van Wijnen, A.J.6    Stein, J.L.7    Lian, J.B.8    Stein, G.S.9
  • 4
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.1
  • 5
    • 0028887943 scopus 로고
    • Osteogenic protein-1 promotes growth and maturation of chick sternal chondrocytes in serum-free cultures
    • Chen P, Vukicevic S, Sampath TK, Luyten FP. 1995. Osteogenic protein-1 promotes growth and maturation of chick sternal chondrocytes in serum-free cultures. J Cell Sci 108:105-114.
    • (1995) J Cell Sci , vol.108 , pp. 105-114
    • Chen, P.1    Vukicevic, S.2    Sampath, T.K.3    Luyten, F.P.4
  • 6
    • 0031059353 scopus 로고    scopus 로고
    • Bone morphogenetic protein 2 (BMP-2) enhances BMP-3, BMP-4, and bone cell differentiation marker gene expression during the induction of mineralized bone matrix formation in cultures of fetal rat calvarial osteoblasts
    • Chen D, Harris MA, Rossini G, Dunstan CR, Dallas SL, Feng JQ, Mundy GR, Harris SE. 1997. Bone morphogenetic protein 2 (BMP-2) enhances BMP-3, BMP-4, and bone cell differentiation marker gene expression during the induction of mineralized bone matrix formation in cultures of fetal rat calvarial osteoblasts. Calcif Tissue Int 60:283-290.
    • (1997) Calcif Tissue Int , vol.60 , pp. 283-290
    • Chen, D.1    Harris, M.A.2    Rossini, G.3    Dunstan, C.R.4    Dallas, S.L.5    Feng, J.Q.6    Mundy, G.R.7    Harris, S.E.8
  • 7
    • 0028832707 scopus 로고
    • A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye
    • Dudley AT, Lyons KM, Robertson EJ. 1995. A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye. Genes Dev 9:2795-2807.
    • (1995) Genes Dev , vol.9 , pp. 2795-2807
    • Dudley, A.T.1    Lyons, K.M.2    Robertson, E.J.3
  • 10
    • 0033673311 scopus 로고    scopus 로고
    • Stimulatory effects of cartilage-derived morphogenetic proteins 1 and 2 on osteogenic differentiation of bone marrow stromal cells
    • Gruber R, Mayer C, Schulz W, Graninger W, Peterlik M, Watzek G, Luyten FP, Erlacher L. 2000. Stimulatory effects of cartilage-derived morphogenetic proteins 1 and 2 on osteogenic differentiation of bone marrow stromal cells [in process citation]. Cytokine 12:1630-1638.
    • (2000) Cytokine , vol.12 , pp. 1630-1638
    • Gruber, R.1    Mayer, C.2    Schulz, W.3    Graninger, W.4    Peterlik, M.5    Watzek, G.6    Luyten, F.P.7    Erlacher, L.8
  • 11
    • 0033842229 scopus 로고    scopus 로고
    • Femoral morphology and cross-sectional geometry of adult myostatin-deficient mice
    • Hamrick MW, McPherron AC, Lovejoy CO, Hudson J. 2000. Femoral morphology and cross-sectional geometry of adult myostatin-deficient mice. Bone 27:343-349.
    • (2000) Bone , vol.27 , pp. 343-349
    • Hamrick, M.W.1    McPherron, A.C.2    Lovejoy, C.O.3    Hudson, J.4
  • 12
    • 0030218004 scopus 로고    scopus 로고
    • Bone morphogenetic proteins in development
    • Hogan BL. 1996. Bone morphogenetic proteins in development. Curr Opin Genet Dev 6:432-438.
    • (1996) Curr Opin Genet Dev , vol.6 , pp. 432-438
    • Hogan, B.L.1
  • 13
    • 0031043249 scopus 로고    scopus 로고
    • Osteogenic protein-1 stimulates mRNA levels of BMP-6 and decreases mRNA levels of BMP-2 and -4 in human osteosarcoma cells
    • Honda Y, Knutsen R, Strong DD, Sampath TK, Baylink DJ, Mohan S. 1997. Osteogenic protein-1 stimulates mRNA levels of BMP-6 and decreases mRNA levels of BMP-2 and -4 in human osteosarcoma cells. Calcif Tissue Int 60:297-301.
    • (1997) Calcif Tissue Int , vol.60 , pp. 297-301
    • Honda, Y.1    Knutsen, R.2    Strong, D.D.3    Sampath, T.K.4    Baylink, D.J.5    Mohan, S.6
  • 14
    • 0030585355 scopus 로고    scopus 로고
    • Bone morphogenetic protein-12 and -13 inhibit terminal differentiation of myoblasts, but do not induce their differentiation into osteoblasts
    • Inada M, Katagiri T, Akiyama S, Namika M, Komaki M, Yamaguchi A, Kamoi K, Rosen V, Suda T. 1996. Bone morphogenetic protein-12 and -13 inhibit terminal differentiation of myoblasts, but do not induce their differentiation into osteoblasts. Biochem Biophys Res Commun 222:317-322.
    • (1996) Biochem Biophys Res Commun , vol.222 , pp. 317-322
    • Inada, M.1    Katagiri, T.2    Akiyama, S.3    Namika, M.4    Komaki, M.5    Yamaguchi, A.6    Kamoi, K.7    Rosen, V.8    Suda, T.9
  • 16
    • 0031080176 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2 inhibits terminal differentiation of myogenic cells by suppressing the transcriptional activity of MyoD and myogenin
    • Katagiri T, Akiyama S, Namiki M, Komaki M, Yamaguchi A, Rosen V, Wozney JM, Fujisawa-Sehara A, Suda T. 1997. Bone morphogenetic protein-2 inhibits terminal differentiation of myogenic cells by suppressing the transcriptional activity of MyoD and myogenin. Exp Cell Res 230:342-351.
    • (1997) Exp Cell Res , vol.230 , pp. 342-351
    • Katagiri, T.1    Akiyama, S.2    Namiki, M.3    Komaki, M.4    Yamaguchi, A.5    Rosen, V.6    Wozney, J.M.7    Fujisawa-Sehara, A.8    Suda, T.9
  • 17
    • 0031711718 scopus 로고    scopus 로고
    • Effects of recombinant human bone morphogenetic protein-2 on differentiation of cells isolated from human bone, muscle, and skin
    • Kawasaki K, Aihara M, Honmo J, Sakurai S, Fujimaki Y, Sakamoto K, Fujimaki E, Wozney JM, Yamaguchi A. 1998. Effects of recombinant human bone morphogenetic protein-2 on differentiation of cells isolated from human bone, muscle, and skin. Bone 23:223-231.
    • (1998) Bone , vol.23 , pp. 223-231
    • Kawasaki, K.1    Aihara, M.2    Honmo, J.3    Sakurai, S.4    Fujimaki, Y.5    Sakamoto, K.6    Fujimaki, E.7    Wozney, J.M.8    Yamaguchi, A.9
  • 18
    • 0028180315 scopus 로고
    • The TGF-beta superfamily: New members, new receptors, and new genetic tests of function in different organisms
    • Kingsley DM. 1994. The TGF-beta superfamily: New members, new receptors, and new genetic tests of function in different organisms. Genes Dev 8:133-146.
    • (1994) Genes Dev , vol.8 , pp. 133-146
    • Kingsley, D.M.1
  • 21
    • 0033120916 scopus 로고    scopus 로고
    • Transient upregulation of CBFA1 in response to bone morphogenetic protein-2 and transforming growth factor beta1 in C2C12 myogenic cells coincides with suppression of the myogenic phenotype but is not sufficient for osteoblast differentiation
    • Lee MH, Javed A, Kim HJ, Shin HI, Gutierrez S, Choi JY, Rosen V, Stein JL, van Wijnen AJ, Stein GS, Lian JB, Ryoo HM. 1999. Transient upregulation of CBFA1 in response to bone morphogenetic protein-2 and transforming growth factor beta1 in C2C12 myogenic cells coincides with suppression of the myogenic phenotype but is not sufficient for osteoblast differentiation. J Cell Biochem 73:114-125.
    • (1999) J Cell Biochem , vol.73 , pp. 114-125
    • Lee, M.H.1    Javed, A.2    Kim, H.J.3    Shin, H.I.4    Gutierrez, S.5    Choi, J.Y.6    Rosen, V.7    Stein, J.L.8    Van Wijnen, A.J.9    Stein, G.S.10    Lian, J.B.11    Ryoo, H.M.12
  • 22
    • 0034460993 scopus 로고    scopus 로고
    • Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12
    • Lee KS, Kim HJ, Li QL, Chi XZ, Ueta C, Komori T, Wozney JM, Kim EG, Choi JY, Ryoo HM, Bae SC. 2000. Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12. Mol Cell Biol 20:8783-8792.
    • (2000) Mol Cell Biol , vol.20 , pp. 8783-8792
    • Lee, K.S.1    Kim, H.J.2    Li, Q.L.3    Chi, X.Z.4    Ueta, C.5    Komori, T.6    Wozney, J.M.7    Kim, E.G.8    Choi, J.Y.9    Ryoo, H.M.10    Bae, S.C.11
  • 23
    • 0026537256 scopus 로고
    • Concepts of osteoblast growth and differentiation: Basis for modulation of bone cell development and tissue formation
    • Lian JB, Stein GS. 1992. Concepts of osteoblast growth and differentiation: Basis for modulation of bone cell development and tissue formation. Crit Rev Oral Biol Med 3:269-305.
    • (1992) Crit Rev Oral Biol Med , vol.3 , pp. 269-305
    • Lian, J.B.1    Stein, G.S.2
  • 24
    • 0029008597 scopus 로고
    • Human type II receptor for bone morphogenic proteins (BMPs): Extension of the two-kinase receptor model to the BMPs
    • Liu F, Ventura F, Doody J, Massague J. 1995. Human type II receptor for bone morphogenic proteins (BMPs): Extension of the two-kinase receptor model to the BMPs. Mol Cell Biol 15:3479-3486.
    • (1995) Mol Cell Biol , vol.15 , pp. 3479-3486
    • Liu, F.1    Ventura, F.2    Doody, J.3    Massague, J.4
  • 25
    • 0028882261 scopus 로고
    • BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning
    • Luo G, Hofmann C, Bronckers AL, Sohocki M, Bradley A, Karsenty G. 1995. BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning. Genes Dev 9:2808-2820.
    • (1995) Genes Dev , vol.9 , pp. 2808-2820
    • Luo, G.1    Hofmann, C.2    Bronckers, A.L.3    Sohocki, M.4    Bradley, A.5    Karsenty, G.6
  • 26
    • 0032475884 scopus 로고    scopus 로고
    • Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2
    • Macias-Silva M, Hoodless PA, Tang SJ, Buchwald M, Wrana JL. 1998. Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2. J Biol Chem 273:25628-25636.
    • (1998) J Biol Chem , vol.273 , pp. 25628-25636
    • Macias-Silva, M.1    Hoodless, P.A.2    Tang, S.J.3    Buchwald, M.4    Wrana, J.L.5
  • 27
    • 0030826702 scopus 로고    scopus 로고
    • A kinase domain-truncated type I receptor blocks bone morphogenetic protein-2-induced signal transduction in C2C12 myoblasts
    • Namiki M, Akiyama S, Katagiri T, Suzuki A, Ueno N, Yamaji N, Rosen V, Wozney JM, Suda T. 1997. A kinase domain-truncated type I receptor blocks bone morphogenetic protein-2-induced signal transduction in C2C12 myoblasts. J Biol Chem 272:22046-22052.
    • (1997) J Biol Chem , vol.272 , pp. 22046-22052
    • Namiki, M.1    Akiyama, S.2    Katagiri, T.3    Suzuki, A.4    Ueno, N.5    Yamaji, N.6    Rosen, V.7    Wozney, J.M.8    Suda, T.9
  • 28
    • 0029153741 scopus 로고
    • Identification of a human type II receptor for bone morphogenetic protein-4 that forms differential heteromeric complexes with bone morphogenetic protein type I receptors
    • Nohno T, Ishikawa T, Saito T, Hosokawa K, Noji S, Wolsing DH, Rosenbaum JS. 1995. Identification of a human type II receptor for bone morphogenetic protein-4 that forms differential heteromeric complexes with bone morphogenetic protein type I receptors. J Biol Chem 270:22522-22526.
    • (1995) J Biol Chem , vol.270 , pp. 22522-22526
    • Nohno, T.1    Ishikawa, T.2    Saito, T.3    Hosokawa, K.4    Noji, S.5    Wolsing, D.H.6    Rosenbaum, J.S.7
  • 29
    • 0033533606 scopus 로고    scopus 로고
    • Expression of bone morphogenetic protein-2 via adenoviral vector in C2C12 myoblasts induces differentiation into the osteoblast lineage
    • Okubo Y, Bessho K, Fujimura K, Iizuka T, Miyatake S. 1999. Expression of bone morphogenetic protein-2 via adenoviral vector in C2C12 myoblasts induces differentiation into the osteoblast lineage. Biochem Biophys Res Commun 262:739-743.
    • (1999) Biochem Biophys Res Commun , vol.262 , pp. 739-743
    • Okubo, Y.1    Bessho, K.2    Fujimura, K.3    Iizuka, T.4    Miyatake, S.5
  • 30
    • 0025316785 scopus 로고
    • Progressive development of the rat osteoblast phenotype in vitro: Reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix
    • Owen TA, Aronow M, Shalhoub V, Barone LM, Wilming L, Tassinari MS, Kennedy MB, Pockwinse S, Lian JB, Stein GS. 1990. Progressive development of the rat osteoblast phenotype in vitro: Reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix. J Cell Physiol 143:420-430.
    • (1990) J Cell Physiol , vol.143 , pp. 420-430
    • Owen, T.A.1    Aronow, M.2    Shalhoub, V.3    Barone, L.M.4    Wilming, L.5    Tassinari, M.S.6    Kennedy, M.B.7    Pockwinse, S.8    Lian, J.B.9    Stein, G.S.10
  • 32
    • 0027098032 scopus 로고
    • Recombinant human bone morphogenetic protein 2B stimulates PC12 cell differentiation: Potentiation and binding to type IV collagen
    • Paralkar VM, Weeks BS, Yu YM, Kleinman HK, Reddi AH. 1992. Recombinant human bone morphogenetic protein 2B stimulates PC12 cell differentiation: Potentiation and binding to type IV collagen. J Cell Biol 119:1721-1728.
    • (1992) J Cell Biol , vol.119 , pp. 1721-1728
    • Paralkar, V.M.1    Weeks, B.S.2    Yu, Y.M.3    Kleinman, H.K.4    Reddi, A.H.5
  • 33
    • 0034122107 scopus 로고    scopus 로고
    • Bone morphogenetic proteins and skeletal development: The kidney-bone connection
    • Reddi AH. 2000. Bone morphogenetic proteins and skeletal development: The kidney-bone connection [in process citation]. Pediatr Nephrol 14:598-601.
    • (2000) Pediatr Nephrol , vol.14 , pp. 598-601
    • Reddi, A.H.1
  • 36
    • 0030159796 scopus 로고    scopus 로고
    • BMP-1 and the astacin family of metalloproteinases: A potential link between the extracellular matrix, growth factors and pattern formation
    • Sarras MP, Jr. 1996. BMP-1 and the astacin family of metalloproteinases: A potential link between the extracellular matrix, growth factors and pattern formation. Bioessays 18:439-442.
    • (1996) Bioessays , vol.18 , pp. 439-442
    • Sarras M.P., Jr.1
  • 37
    • 0032970328 scopus 로고    scopus 로고
    • Mechanical tension-stress induces expression of bone morphogenetic protein (BMP)-2 and BMP-4, but not BMP-6, BMP-7, and GDF-5 mRNA, during distraction osteogenesis
    • Sato M, Ochi T, Nakase T, Hirota S, Kitamura Y, Nomura S, Yasui N. 1999. Mechanical tension-stress induces expression of bone morphogenetic protein (BMP)-2 and BMP-4, but not BMP-6, BMP-7, and GDF-5 mRNA, during distraction osteogenesis. J Bone Miner Res 14:1084-1095.
    • (1999) J Bone Miner Res , vol.14 , pp. 1084-1095
    • Sato, M.1    Ochi, T.2    Nakase, T.3    Hirota, S.4    Kitamura, Y.5    Nomura, S.6    Yasui, N.7
  • 38
    • 0033006969 scopus 로고    scopus 로고
    • Myostatin, a transforming growth factor-beta superfamily member, is expressed in heart muscle and is upregulated in cardiomyocytes after infarct
    • Sharma M, Kambadur R, Matthews KG, Somers WG, Devlin GP, Conaglen JV, Fowke PJ, Bass JJ. 1999. Myostatin, a transforming growth factor-beta superfamily member, is expressed in heart muscle and is upregulated in cardiomyocytes after infarct. J Cell Physiol 180:1-9.
    • (1999) J Cell Physiol , vol.180 , pp. 1-9
    • Sharma, M.1    Kambadur, R.2    Matthews, K.G.3    Somers, W.G.4    Devlin, G.P.5    Conaglen, J.V.6    Fowke, P.J.7    Bass, J.J.8
  • 40
    • 0026603456 scopus 로고
    • Recombinant human bone morphogenetic protein-2 induces osteoblastic differentiation in W-20-17 stromal cells
    • Thies RS, Bauduy M, Ashton BA, Kurtzberg L, Wozney JM, Rosen V. 1992. Recombinant human bone morphogenetic protein-2 induces osteoblastic differentiation in W-20-17 stromal cells. Endocrinology 130:1318-1324.
    • (1992) Endocrinology , vol.130 , pp. 1318-1324
    • Thies, R.S.1    Bauduy, M.2    Ashton, B.A.3    Kurtzberg, L.4    Wozney, J.M.5    Rosen, V.6
  • 41
    • 0031594665 scopus 로고    scopus 로고
    • Expression of the PEBP2al-phaA/AML3/CBFA1 gene is regulated by BMP4/7 heterodimer and its overexpression suppresses type I collagen and osteocalcin gene expression in osteoblastic and nonosteoblastic mesenchymal cells
    • Tsuji K, Ito Y, Noda M. 1998. Expression of the PEBP2al-phaA/AML3/CBFA1 gene is regulated by BMP4/7 heterodimer and its overexpression suppresses type I collagen and osteocalcin gene expression in osteoblastic and nonosteoblastic mesenchymal cells. Bone 22:87-92.
    • (1998) Bone , vol.22 , pp. 87-92
    • Tsuji, K.1    Ito, Y.2    Noda, M.3
  • 42
    • 34250019537 scopus 로고
    • Bone: Formation by autoinduction
    • Urist MR. 1965. Bone: Formation by autoinduction. Science 150:893-899.
    • (1965) Science , vol.150 , pp. 893-899
    • Urist, M.R.1
  • 43
    • 0015155737 scopus 로고
    • Bone morphogenetic protein
    • Urist MR, Strates BS. 1971. Bone morphogenetic protein. J Dent Res 50:1392-406.
    • (1971) J Dent Res , vol.50 , pp. 1392-1406
    • Urist, M.R.1    Strates, B.S.2
  • 44
    • 0031974284 scopus 로고    scopus 로고
    • Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair
    • Wozney JM, Rosen V. 1998. Bone morphogenetic protein and bone morphogenetic protein gene family in bone formation and repair. Clin Orthop 346:26-37.
    • (1998) Clin Orthop , vol.346 , pp. 26-37
    • Wozney, J.M.1    Rosen, V.2
  • 45
    • 0030697509 scopus 로고    scopus 로고
    • Effect of osteogenic protein-1 on the development and mineralization of primary cultures of avian growth plate chondrocytes: Modulation by retinoic acid
    • Wu LN, Ishikawa Y, Genge BR, Sampath TK, Wuthier RE. 1997. Effect of osteogenic protein-1 on the development and mineralization of primary cultures of avian growth plate chondrocytes: Modulation by retinoic acid. J Cell Biochem 67:498-513.
    • (1997) J Cell Biochem , vol.67 , pp. 498-513
    • Wu, L.N.1    Ishikawa, Y.2    Genge, B.R.3    Sampath, T.K.4    Wuthier, R.E.5
  • 47
    • 0027954383 scopus 로고
    • Temporal changes in matrix protein synthesis and mRNA expression during mineralized tissue formation by adult rat bone marrow cells in culture
    • Yao KL, Todescan R, Jr, Sodek J. 1994. Temporal changes in matrix protein synthesis and mRNA expression during mineralized tissue formation by adult rat bone marrow cells in culture. J Bone Miner Res 9:231-240.
    • (1994) J Bone Miner Res , vol.9 , pp. 231-240
    • Yao, K.L.1    Todescan R., Jr.2    Sodek, J.3
  • 48
    • 0029989193 scopus 로고    scopus 로고
    • Osteogenic protein-1-mediated insulin-like growth factor gene expression in primary cultures of rat osteoblastic cells
    • Yeh LC, Adamo ML, Kitten AM, Olson MS, Lee JC. 1996. Osteogenic protein-1-mediated insulin-like growth factor gene expression in primary cultures of rat osteoblastic cells. Endocrinology 137:1921-1931.
    • (1996) Endocrinology , vol.137 , pp. 1921-1931
    • Yeh, L.C.1    Adamo, M.L.2    Kitten, A.M.3    Olson, M.S.4    Lee, J.C.5
  • 49
    • 0030885311 scopus 로고    scopus 로고
    • Osteogenic protein-1 and insulin-like growth factor I synergistically stimulate rat osteoblastic cell differentiation and proliferation
    • Yeh LC, Adamo ML, Olson MS, Lee JC. 1997. Osteogenic protein-1 and insulin-like growth factor I synergistically stimulate rat osteoblastic cell differentiation and proliferation. Endocrinology 138:4181-4190.
    • (1997) Endocrinology , vol.138 , pp. 4181-4190
    • Yeh, L.C.1    Adamo, M.L.2    Olson, M.S.3    Lee, J.C.4
  • 50
    • 0031760614 scopus 로고    scopus 로고
    • Inhibition of BMP receptor synthesis by antisense oligonucleotides attenuates OP-1 action in primary cultures of fetal rat calvaria cells
    • Yeh LC, Betchel KP, Lee JC. 1998. Inhibition of BMP receptor synthesis by antisense oligonucleotides attenuates OP-1 action in primary cultures of fetal rat calvaria cells. J Bone Miner Res 13:1870-1879.
    • (1998) J Bone Miner Res , vol.13 , pp. 1870-1879
    • Yeh, L.C.1    Betchel, K.P.2    Lee, J.C.3
  • 51
    • 0033847399 scopus 로고    scopus 로고
    • Osteogenic protein-1 differentially regulates the mRNA expression of bone morphogenetic proteins and their receptors in primary cultures of osteoblasts
    • Yeh LC, Unda R, Lee JC. 2000. Osteogenic protein-1 differentially regulates the mRNA expression of bone morphogenetic proteins and their receptors in primary cultures of osteoblasts. J Cell Physiol 185:87-97.
    • (2000) J Cell Physiol , vol.185 , pp. 87-97
    • Yeh, L.C.1    Unda, R.2    Lee, J.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.