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Volumn 27, Issue 3, 2007, Pages 389-398

Clinical pharmacokinetic monitoring of midazolam in critically ill patients

Author keywords

Critical care; Intensive care unit; Midazolam; Sedation; Therapeutic drug monitoring

Indexed keywords

1,4 DIHYDROXYMIDAZOLAM; ALPHA1 HYDROXYMIDAZOLAM; ALPHA4 HYDROXYMIDAZOLAM; BENZODIAZEPINE DERIVATIVE; CYTOCHROME P450 3A4; MIDAZOLAM; UNCLASSIFIED DRUG;

EID: 33847254988     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1592/phco.27.3.389     Document Type: Review
Times cited : (79)

References (43)
  • 1
    • 0035006382 scopus 로고    scopus 로고
    • Validating the sedation-agitation scale with the bispectral index and visual analog scale in adult ICU patients after cardiac surgery
    • Riker RR, Fraser GL, Simmons LE, Wilkins ML. Validating the sedation-agitation scale with the bispectral index and visual analog scale in adult ICU patients after cardiac surgery. Intensive Care Med 2001;27;853-8.
    • (2001) Intensive Care Med , vol.27 , pp. 853-858
    • Riker, R.R.1    Fraser, G.L.2    Simmons, L.E.3    Wilkins, M.L.4
  • 2
    • 0034867407 scopus 로고    scopus 로고
    • Midazolam disposition in patients undergoing continuous venovenous hemodialysis
    • Bolon M, Bastien O, Flamens C, Paulus S, Boulieu R. Midazolam disposition in patients undergoing continuous venovenous hemodialysis. J Clin Pharmacol 2001;41:959-62.
    • (2001) J Clin Pharmacol , vol.41 , pp. 959-962
    • Bolon, M.1    Bastien, O.2    Flamens, C.3    Paulus, S.4    Boulieu, R.5
  • 3
    • 0026576991 scopus 로고
    • The use of sedative agents in critically ill patients
    • Burns AM, Shelly MP, Park GR. The use of sedative agents in critically ill patients. Drugs 1992;43:507-15.
    • (1992) Drugs , vol.43 , pp. 507-515
    • Burns, A.M.1    Shelly, M.P.2    Park, G.R.3
  • 4
    • 0030754859 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of midazolam given via continuous intravenous infusion in intensive care units
    • discussion 367-8
    • Fragen RJ. Pharmacokinetics and pharmacodynamics of midazolam given via continuous intravenous infusion in intensive care units. Clin Ther 1997;19:405-19; discussion 367-8.
    • (1997) Clin Ther , vol.19 , pp. 405-419
    • Fragen, R.J.1
  • 6
    • 9644273862 scopus 로고    scopus 로고
    • Midazolam therapeutic drug monitoring in intensive care sedation: A 5-year survey
    • Bremer F, Reulbach U, Schwilden H, Schuttler J. Midazolam therapeutic drug monitoring in intensive care sedation: a 5-year survey. Ther Drug Monit 2004;26:643-9.
    • (2004) Ther Drug Monit , vol.26 , pp. 643-649
    • Bremer, F.1    Reulbach, U.2    Schwilden, H.3    Schuttler, J.4
  • 7
    • 0029075289 scopus 로고
    • Prolonged sedation due to accumulation of conjugated metabolites of midazolam
    • Bauer TM, Ritz R, Haberthur C, et al. Prolonged sedation due to accumulation of conjugated metabolites of midazolam. Lancet 1995;346:145-7.
    • (1995) Lancet , vol.346 , pp. 145-147
    • Bauer, T.M.1    Ritz, R.2    Haberthur, C.3
  • 8
    • 0023905872 scopus 로고
    • Clinical pharmacokinetics of midazolam in intensive care patients: A wide interpatient variability?
    • Oldenhof H, de Jong M, Steenhoek A, Janknegt R. Clinical pharmacokinetics of midazolam in intensive care patients: a wide interpatient variability? Clin Pharmacol Ther 1988;43:263-9.
    • (1988) Clin Pharmacol Ther , vol.43 , pp. 263-269
    • Oldenhof, H.1    de Jong, M.2    Steenhoek, A.3    Janknegt, R.4
  • 9
    • 0026611310 scopus 로고
    • Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite alpha-hydroxymidazolam in healthy volunteers
    • Mandema JW, Tuk B, van Steveninck AL, Breimer DD, Cohen AF, Danhof M. Pharmacokinetic-pharmacodynamic modeling of the central nervous system effects of midazolam and its main metabolite alpha-hydroxymidazolam in healthy volunteers. Clin Pharmacol Ther 1992;51:715-28.
    • (1992) Clin Pharmacol Ther , vol.51 , pp. 715-728
    • Mandema, J.W.1    Tuk, B.2    van Steveninck, A.L.3    Breimer, D.D.4    Cohen, A.F.5    Danhof, M.6
  • 10
    • 0030668963 scopus 로고    scopus 로고
    • Influence of acute renal failure on FPIA rapid serum assay of midazolam and its main metabolite
    • Bouton V, Bourget P, Lesne-Hulin A, et al. Influence of acute renal failure on FPIA rapid serum assay of midazolam and its main metabolite. Int J Clin Pharmacol Ther 1997;35:531-8.
    • (1997) Int J Clin Pharmacol Ther , vol.35 , pp. 531-538
    • Bouton, V.1    Bourget, P.2    Lesne-Hulin, A.3
  • 11
    • 0642274946 scopus 로고    scopus 로고
    • Possibility of influence of midazolam sedation on the diagnosis of brain death: Concentrations of active metabolites after cessation of midazolam
    • Hirata K, Matsumoto Y, Kurokawa A, et al. Possibility of influence of midazolam sedation on the diagnosis of brain death: concentrations of active metabolites after cessation of midazolam. Yakugaku Zasshi 2003;123:811-15.
    • (2003) Yakugaku Zasshi , vol.123 , pp. 811-815
    • Hirata, K.1    Matsumoto, Y.2    Kurokawa, A.3
  • 12
    • 0036152552 scopus 로고    scopus 로고
    • Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult
    • Jacobi J, Fraser GL, Coursin DB, et al. Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult. Crit Care Med 2002;30:119-41.
    • (2002) Crit Care Med , vol.30 , pp. 119-141
    • Jacobi, J.1    Fraser, G.L.2    Coursin, D.B.3
  • 14
    • 0023181794 scopus 로고
    • Failure of critically ill patients to metabolise midazolam
    • Shelly MP, Mendel L, Park GR. Failure of critically ill patients to metabolise midazolam. Anaesthesia 1987;42:619-26.
    • (1987) Anaesthesia , vol.42 , pp. 619-626
    • Shelly, M.P.1    Mendel, L.2    Park, G.R.3
  • 15
    • 0031665722 scopus 로고    scopus 로고
    • Pharmacokinetics of midazolam and its main metabolite 1-hydroxymidazolam in intensive care patients
    • Boulieu R, Lehmann B, Salord F, Fisher C, Morlet D. Pharmacokinetics of midazolam and its main metabolite 1-hydroxymidazolam in intensive care patients. Eur J Drug Metab Pharmacokinet 1998;23:255-8.
    • (1998) Eur J Drug Metab Pharmacokinet , vol.23 , pp. 255-258
    • Boulieu, R.1    Lehmann, B.2    Salord, F.3    Fisher, C.4    Morlet, D.5
  • 16
    • 0034910736 scopus 로고    scopus 로고
    • Monitoring sedation, agitation, analgesia, neuromuscular blockade, and delirium in adult ICU patients
    • Riker RR, Fraser GL. Monitoring sedation, agitation, analgesia, neuromuscular blockade, and delirium in adult ICU patients. Semin Respir Crit Care Med 2001;22:189-98.
    • (2001) Semin Respir Crit Care Med , vol.22 , pp. 189-198
    • Riker, R.R.1    Fraser, G.L.2
  • 18
    • 0038142852 scopus 로고    scopus 로고
    • Monitoring sedation status over time in ICU patients: Reliability and validity of the Richmond agitation-sedation scale (RASS)
    • Ely EW, Truman B, Shintani A, et al. Monitoring sedation status over time in ICU patients: reliability and validity of the Richmond agitation-sedation scale (RASS). JAMA 2003;289:2983-91.
    • (2003) JAMA , vol.289 , pp. 2983-2991
    • Ely, E.W.1    Truman, B.2    Shintani, A.3
  • 19
    • 0037111193 scopus 로고    scopus 로고
    • The Richmond agitation-sedation scale: Validity and reliability in adult intensive care unit patients
    • Sessler CN, Gosnell MS, Grap MJ, et al. The Richmond agitation-sedation scale: validity and reliability in adult intensive care unit patients. Am J Respir Crit Care Med 2002;166:1338-44.
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 1338-1344
    • Sessler, C.N.1    Gosnell, M.S.2    Grap, M.J.3
  • 20
    • 0034682246 scopus 로고    scopus 로고
    • Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation
    • Kress JP, Pohlman AS, O'Connor MF, Hall JB. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 2000;342:1471-7.
    • (2000) N Engl J Med , vol.342 , pp. 1471-1477
    • Kress, J.P.1    Pohlman, A.S.2    O'Connor, M.F.3    Hall, J.B.4
  • 21
    • 0031910542 scopus 로고    scopus 로고
    • Therapeutic drug monitoring in special populations
    • Walson PD. Therapeutic drug monitoring in special populations. Clin Chem 1998;44:415-19.
    • (1998) Clin Chem , vol.44 , pp. 415-419
    • Walson, P.D.1
  • 22
    • 0031955468 scopus 로고    scopus 로고
    • Clinical pharmacokinetics in the 21st century: Does the evidence support definitive outcomes?
    • Ensom MH, Davis GA, Cropp CD, Ensom RJ. Clinical pharmacokinetics in the 21st century: does the evidence support definitive outcomes? Clin Pharmacokinet 1998;34:265-79.
    • (1998) Clin Pharmacokinet , vol.34 , pp. 265-279
    • Ensom, M.H.1    Davis, G.A.2    Cropp, C.D.3    Ensom, R.J.4
  • 23
    • 0024364848 scopus 로고
    • Simultaneous determination of midazolam and its three hydroxy metabolites in human plasma by electron-capture gas chromatography without derivatization
    • De Kroon IF, Langendijk PN, De Goede PN. Simultaneous determination of midazolam and its three hydroxy metabolites in human plasma by electron-capture gas chromatography without derivatization. J Chromatogr 1989;491:107-16.
    • (1989) J Chromatogr , vol.491 , pp. 107-116
    • De Kroon, I.F.1    Langendijk, P.N.2    De Goede, P.N.3
  • 24
    • 0025073996 scopus 로고
    • High-performance liquid chromatographic assay to determine midazolam and flumazenil simultaneously in human plasma
    • Vletter AA, Burm AG, Breimer LT, Spierdijk J. High-performance liquid chromatographic assay to determine midazolam and flumazenil simultaneously in human plasma. J Chromatogr 1990;530:177-85.
    • (1990) J Chromatogr , vol.530 , pp. 177-185
    • Vletter, A.A.1    Burm, A.G.2    Breimer, L.T.3    Spierdijk, J.4
  • 25
    • 0031466109 scopus 로고    scopus 로고
    • A rapid high-performance liquid chromatographic method for the measurement of midazolam plasma concentrations during long-term infusion in ICU patients
    • Van Brandt N, Hantson P, Mahieu P, Verbeeck RK. A rapid high-performance liquid chromatographic method for the measurement of midazolam plasma concentrations during long-term infusion in ICU patients. Ther Drug Monit 1997;19:352-7.
    • (1997) Ther Drug Monit , vol.19 , pp. 352-357
    • Van Brandt, N.1    Hantson, P.2    Mahieu, P.3    Verbeeck, R.K.4
  • 26
    • 0031811037 scopus 로고    scopus 로고
    • Analysis of midazolam and metabolites in plasma by high-performance liquid chromatography: Probe of CYP3A
    • Carrillo JA, Ramos SI, Agundez JA, Martinez C, Benitez J. Analysis of midazolam and metabolites in plasma by high-performance liquid chromatography: probe of CYP3A. Ther Drug Monit 1998;20:319-24.
    • (1998) Ther Drug Monit , vol.20 , pp. 319-324
    • Carrillo, J.A.1    Ramos, S.I.2    Agundez, J.A.3    Martinez, C.4    Benitez, J.5
  • 27
    • 20344400117 scopus 로고    scopus 로고
    • Determination of midazolam and its major metabolite 1′-hydroxymidazolam by high-performance liquid chromatography-electrospray mass spectrometry in plasma from children
    • Muchohi SN, Ward SA, Preston L, Newton CR, Edwards G, Kokwaro GO. Determination of midazolam and its major metabolite 1′-hydroxymidazolam by high-performance liquid chromatography-electrospray mass spectrometry in plasma from children. J Chromatogr B Analyt Technol Biomed Life Sci 2005;821:1-7.
    • (2005) J Chromatogr B Analyt Technol Biomed Life Sci , vol.821 , pp. 1-7
    • Muchohi, S.N.1    Ward, S.A.2    Preston, L.3    Newton, C.R.4    Edwards, G.5    Kokwaro, G.O.6
  • 28
    • 24044529783 scopus 로고    scopus 로고
    • Analysis of omeprazole, midazolam and hydroxy-metabolites in plasma using liquid chromatography coupled to tandem mass spectrometry
    • Frerichs VA, Zaranek C, Haas CE. Analysis of omeprazole, midazolam and hydroxy-metabolites in plasma using liquid chromatography coupled to tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2005;824:71-80.
    • (2005) J Chromatogr B Analyt Technol Biomed Life Sci , vol.824 , pp. 71-80
    • Frerichs, V.A.1    Zaranek, C.2    Haas, C.E.3
  • 29
    • 10844242068 scopus 로고    scopus 로고
    • A sensitive, rapid and specific determination of midazolam in human plasma and saliva by liquid chromatography/electrospray mass spectrometry
    • Quintela O, Cruz A, Concheiro M, de Castro A, Lopez-Rivadulla M. A sensitive, rapid and specific determination of midazolam in human plasma and saliva by liquid chromatography/electrospray mass spectrometry. Rapid Commun Mass Spectrom 2004;18:2976-82.
    • (2004) Rapid Commun Mass Spectrom , vol.18 , pp. 2976-2982
    • Quintela, O.1    Cruz, A.2    Concheiro, M.3    de Castro, A.4    Lopez-Rivadulla, M.5
  • 30
    • 10144240353 scopus 로고    scopus 로고
    • Comparison of high-performance liquid chromatography and polyclonal fluorescence polarization immunoassay for the monitoring of midazolam in the plasma of intensive care unit patients
    • Bourget P, Bouton V, Lesne-Hulin A, et al. Comparison of high-performance liquid chromatography and polyclonal fluorescence polarization immunoassay for the monitoring of midazolam in the plasma of intensive care unit patients. Ther Drug Monit 1996;18:610-19.
    • (1996) Ther Drug Monit , vol.18 , pp. 610-619
    • Bourget, P.1    Bouton, V.2    Lesne-Hulin, A.3
  • 31
    • 0023624633 scopus 로고
    • Clinical pharmacokinetics of long-term infusion of midazolam in critically ill patients: Preliminary results
    • Dirksen MS, Vree TB, Driessen JJ. Clinical pharmacokinetics of long-term infusion of midazolam in critically ill patients: preliminary results. Anaesth Intensive Care 1987;15:440-4.
    • (1987) Anaesth Intensive Care , vol.15 , pp. 440-444
    • Dirksen, M.S.1    Vree, T.B.2    Driessen, J.J.3
  • 32
    • 0033017570 scopus 로고    scopus 로고
    • The effect of age on the pharmacokinetics and pharmacodynamics of midazolam
    • Albrecht S, Ihmsen H, Hering W, et al. The effect of age on the pharmacokinetics and pharmacodynamics of midazolam. Clin Pharmacol Ther 1999;65:630-9.
    • (1999) Clin Pharmacol Ther , vol.65 , pp. 630-639
    • Albrecht, S.1    Ihmsen, H.2    Hering, W.3
  • 34
    • 18044368188 scopus 로고    scopus 로고
    • Differentiating midazolam over-sedation from neurological damage in the intensive care unit
    • McKenzie CA, McKinnon W, Naughton DP, et al. Differentiating midazolam over-sedation from neurological damage in the intensive care unit. Crit Care 2005;9:R32-6.
    • (2005) Crit Care , vol.9
    • McKenzie, C.A.1    McKinnon, W.2    Naughton, D.P.3
  • 35
    • 0036216815 scopus 로고    scopus 로고
    • Is the bispectral index appropriate for monitoring the sedation level of mechanically ventilated surgical ICU patients?
    • Frenzel D, Greim CA, Sommer C, Bauerle K, Roewer N. Is the bispectral index appropriate for monitoring the sedation level of mechanically ventilated surgical ICU patients? Intensive Care Med 2002;28:178-83.
    • (2002) Intensive Care Med , vol.28 , pp. 178-183
    • Frenzel, D.1    Greim, C.A.2    Sommer, C.3    Bauerle, K.4    Roewer, N.5
  • 36
    • 18044378373 scopus 로고    scopus 로고
    • Bispectral index monitoring in the intensive care unit provides more signal than noise
    • Fraser GL, Riker RR. Bispectral index monitoring in the intensive care unit provides more signal than noise. Pharmacotherapy 2005;25(5 pt 2):19S-27.
    • (2005) Pharmacotherapy , vol.25 , Issue.5 PART 2
    • Fraser, G.L.1    Riker, R.R.2
  • 37
    • 6844230564 scopus 로고
    • Age related changes in pharmacodynamics and pharmacokinetics of midazolam during sedation in ICU patients [abstr]
    • Doi M, Ikeda K. Age related changes in pharmacodynamics and pharmacokinetics of midazolam during sedation in ICU patients [abstr]. Anesthesiology 1994;81:A259.
    • (1994) Anesthesiology , vol.81
    • Doi, M.1    Ikeda, K.2
  • 39
    • 0026332310 scopus 로고
    • The effects of acute changes in renal function on the pharmacokinetics of midazolam during long-term infusion in ICU patients
    • Driessen JJ, Vree TB, Guelen PJ. The effects of acute changes in renal function on the pharmacokinetics of midazolam during long-term infusion in ICU patients. Acta Anaesthesiol Belg 1991;42:149-55.
    • (1991) Acta Anaesthesiol Belg , vol.42 , pp. 149-155
    • Driessen, J.J.1    Vree, T.B.2    Guelen, P.J.3
  • 40
    • 15944387369 scopus 로고    scopus 로고
    • Population pharmacokinetics of lorazepam and midazolam and their metabolites in intensive care patients on continuous venovenous hemofiltration
    • Swart EL, de Jongh J, Zuideveld KP, Danhof M, Thijs LG, Strack van Schijndel RJ. Population pharmacokinetics of lorazepam and midazolam and their metabolites in intensive care patients on continuous venovenous hemofiltration. Am J Kidney Dis 2005;45:360-71.
    • (2005) Am J Kidney Dis , vol.45 , pp. 360-371
    • Swart, E.L.1    de Jongh, J.2    Zuideveld, K.P.3    Danhof, M.4    Thijs, L.G.5    Strack van Schijndel, R.J.6
  • 41
    • 0031898657 scopus 로고    scopus 로고
    • Complications of sedation with midazolam in the intensive care unit and a comparison with other sedative regimens
    • Shafer A. Complications of sedation with midazolam in the intensive care unit and a comparison with other sedative regimens. Crit Care Med 1998;26:947-56.
    • (1998) Crit Care Med , vol.26 , pp. 947-956
    • Shafer, A.1
  • 42
    • 0027050941 scopus 로고
    • The influence of renal failure on the kinetics of intravenous midazolam: An "in vitro" and "in vivo" study
    • Calvo R, Suarez E, Rodriguez-Sasiain JM, Martinez I. The influence of renal failure on the kinetics of intravenous midazolam: an "in vitro" and "in vivo" study. Res Commun Chem Pathol Pharmacol 1992;78:311-20.
    • (1992) Res Commun Chem Pathol Pharmacol , vol.78 , pp. 311-320
    • Calvo, R.1    Suarez, E.2    Rodriguez-Sasiain, J.M.3    Martinez, I.4
  • 43
    • 0031596438 scopus 로고    scopus 로고
    • The use of continuous i.v. sedation is associated with prolongation of mechanical ventilation
    • Kollef MH, Levy NT, Ahrens TS, Schaiff R, Prentice D, Sherman G. The use of continuous i.v. sedation is associated with prolongation of mechanical ventilation. Chest 1998;114:541-8.
    • (1998) Chest , vol.114 , pp. 541-548
    • Kollef, M.H.1    Levy, N.T.2    Ahrens, T.S.3    Schaiff, R.4    Prentice, D.5    Sherman, G.6


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