Gene expression profiling for the diagnosis of acute leukaemia

British Journal of Cancer

Volumn 96, Issue 4, 2007, Pages 535-540

  Haferlach, T ^a   Kohlmann, A ^b   Bacher, U ^c   Schnittger, S ^a   Haferlach, C ^a   Kern, W ^a  

^a MLL MUNICH LEUKEMIA LABORATORY   (Germany)

^b ROCHE MOLECULAR SYSTEMS   (United States)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

Acute leukaemia; Diagnosis; Gene expression profiling; Microarray analysis

Indexed keywords

ACUTE DISEASE; CORRELATION ANALYSIS; CYTOGENETICS; DATA MINING; DIAGNOSTIC PROCEDURE; DISEASE CLASSIFICATION; FUNCTIONAL MORPHOLOGY; GENE EXPRESSION PROFILING; HUMAN; IMMUNOPHENOTYPING; INFORMATION PROCESSING; LEUKEMIA; LYMPHATIC LEUKEMIA; MICROARRAY ANALYSIS; MOLECULAR BIOLOGY; MOLECULAR GENETICS; PRIORITY JOURNAL; REVIEW;

ACUTE DISEASE; GENE EXPRESSION PROFILING; HUMANS; LEUKEMIA; NEOPLASM, RESIDUAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROGNOSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY;

EID: 33847223049     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6603495     Document Type: Review

References (39)

1. Alcalay M, Tiacci E, Bergomas R, Bigerna B, Venturini E, Minardi SP, Meani N, Diverio D, Bernard L, Tizzoni L, Volorio S, Luzi L, Colombo E, Lo Coco F, Mecucci C, Falini B, Pelicci PG (2005) Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance. Blood 106: 899-902
2. Armstrong SA, Staunton JE, Silverman LB, Pieters R, den Boer ML, Minden MD, Sallan SE, Lander ES, Golub TR, Korsmeyer SJ (2002) MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat Genet 30: 41-47
3. Bullinger L, Valk PJ (2005) Gene expression profiling in acute myeloid leukemia. J Clin Oncol 23: 6296-6305
4. Chiaretti S, Li X, Gentleman R, Vitale A, Wang KS, Mandelli F, Foa R, Ritz J (2005) Gene expression profiles of B-lineage adult acute lymphocytic leukemia reveal genetic patterns that identify lineage derivation and distinct mechanisms of transformation. Clin Cancer Res 11: 7209-7219
5. Debernardi S, Lillington DM, Chaplin T, Tomlinson S, Amess J, Rohatiner A, Lister TA, Young BD (2003) Genome-wide analysis of acute myeloid leukemia with normal karyotype reveals a unique pattern of homeobox gene expression distinct from those with translocation-mediated fusion events. Genes Chromosomes Cancer 37: 149-158
6. Ferrando AA, Neuberg DS, Staunton J, Loh ML, Huard C, Raimondi SC, Behm FG, Pui CH, Downing JR, Gilliland DG, Lander ES, Golub TR, Look AT (2002) Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell 1: 75-87
7. Ferrando AA, Look AT (2003) Gene expression profiling: will it complement or replace immunophenotyping? Best Pract Res Clin Haematol 16: 645-652
8. Golub TR, Slonim DK, Tamayo P, Huard C, Gaasenbeek M, Mesirov JP, Coller H, Loh ML, Downing JR, Caligiuri MA, Bloomfield CD, Lander ES (1999) Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 286: 531-537
9. Haferlach T, Kern W, Schnittger S, Schoch C (2005a) Modern diagnostics in acute leukemias. Crit Rev Oncol Hematol 56: 223-234
10. Haferlach T, Kohlmann A, Basso G, Bene MC, Downing JR, Hernandez JM, Hofmann WK, Kipps TJ, Truss te Kronnie T, Liu WM, Ro S, MacIntyre E, Mills M, Preudhomme C, Rassenti LZ, de Vos J, Williams M, Wieczorek L, Foa R (2005) A Multi-Center and Multi-National Program To Assess the Clinical Accuracy of the Molecular Subclassification of Leukemia by Gene Expression Profiling. Blood (ASH Annual Meeting abstracts) 126: 757
11. Haferlach T, Kohlmann A, Dugas M, Schnittger S, Kern W, Hiddemann W, Schoch C (2002) Gene expression profiling is able to reproduce different phenotypes in AML as defined by the FAB classification. Blood (ASH Annual Meeting abstracts) 100: 195a
12. Haferlach T, Kohlmann A, Schnittger S, Dugas M, Hiddemann W, Kern W, Schoch C (2005b) AML M3 and AML M3 variant each have a distinct gene expression signature but also share patterns different from other genetically defined AML subtypes. Genes Chromosomes Cancer 43: 113-127
13. Haferlach T, Kohlmann A, Schnittger S, Dugas M, Hiddemann W, Kern W, Schoch C (2005c) Global approach to the diagnosis of leukemia using gene expression profiling. Blood 106: 1189-1198
14. Haferlach T, Mills K, Kern W, Hofmann W, Te Kronnie T, Hernandez Rivas J, Downing J, De Vos J, Kipps T, Foa R, The MILE study group European leukemia network (2006) An international multicenter study to assess the accuracy of the molecular subclassification of leukemia by gene expression profiling. J Clini Oncol(ASCO Post-Meeting Edition) 24(18S): 6522
15. Jaffe ES, Harris NL, Stein H, Vardiman JWE (2001) World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues. Lyon: ARC Press
16. Kern W, Kohlmann A, Wuchter C, Schnittger S, Schoch C, Mergenthaler S, Ratei R, Ludwig WD, Hiddemann W, Haferlach T (2003) Correlation of protein expression and gene expression in acute leukemia. Cytometry B Clin Cytom 55: 29-36
17. Kohlmann A, Dugas M, Schoch C (2001) Gene expression profiles of distinct AML subtypes in comparison to normal bone marrow. Blood (ASH Annual Meeting abstracts) 98: 91a
18. Kohlmann A, Schoch C, Dugas M, Rauhut S, Weninger F, Schnittger S, Kern W, Haferlach T (2005) Pattern robustness of diagnostic gene expression signatures in leukemia. Genes Chromosomes Cancer 42: 299-307
19. Kohlmann A, Schoch C, Schnittger S, Dugas M, Hiddemann W, Kern W, Haferlach T (2003) Molecular characterization of acute leukemias by use of microarray technology. Genes Chromosomes Cancer 37: 396-405
20. Kohlmann A, Schoch C, Schnittger S, Dugas M, Hiddemann W, Kern W, Haferlach T (2004) Pediatric acute lymphoblastic leukemia (ALL) gene expression signatures classify an independent cohort of adult ALL patients. Leukemia 18: 63-71
21. Lacayo NJ, Meshinchi S, Kinnunen P, Yu R, Wang Y, Stuber CM, Douglas L, Wahab R, Becton DL, Weinstein H, Chang MN, Willman CL, Radich JP, Tibshirani R, Ravindranath Y, Sikic BI, Dahl GV (2004) Gene expression profiles at diagnosis in de novo childhood AML patients identify FLT3 mutations with good clinical outcomes. Blood 104: 2646-2654
22. Lockhart DJ, Dong H, Byrne MC, Follettie MT, Gallo MV, Chee MS, Mittmann M, Wang C, Kobayashi M, Horton H, Brown EL (1996) Expression monitoring by hybridization to high-density oligonucleotide arrays. Nat Biotechnol 14: 1675-1680
23. Moos PJ, Raetz EA, Carlson MA, Szabo A, Smith FE, Willman C, Wei Q, Hunger SP, Carroll WL (2002) Identification of gene expression profiles that segregate patients with childhood leukemia. Clin Cancer Res 8: 3118-3130
24. Neben K, Schnittger S, Brors B, Tews B, Kokocinski F, Haferlach T, Muller J, Hahn M, Hiddemann W, Eils R, Lichter P, Schoch C (2005) Distinct gene expression patterns associated with FLT3- and NRAS-activating mutations in acute myeloid leukemia with normal karyotype. Oncogene 24: 1580-1588
25. Nilsson B, Andersson A, Johansson M, Fioretos T (2006) Cross-platform classification in microarray-based leukemia diagnostics. Haematologica 91: 821-824
26. Ramaswamy S, Tamayo P, Rifkin R, Mukherjee S, Yeang CH, Angelo M, Ladd C, Reich M, Latulippe E, Mesirov JP, Poggio T, Gerald W, Loda M, Lander ES, Golub TR (2001) Multiclass cancer diagnosis using tumor gene expression signatures. Proc Natl Acad Sci USA 98: 15149-15154
27. Ross ME, Zhou X, Song G, Shurtleff SA, Girtman K, Williams WK, Liu HC, Mahfouz R, Raimondi SC, Lenny N, Patel A, Downing JR (2003) Classification of pediatric acute lymphoblastic leukemia by gene expression profiling. Blood 102: 2951-2959
28. Schnittger S, Kohlmann A, Dugas M, Schoch C, Kern W, Hiddemann W, Haferlach T (2002a) Acute myeloid leukemia (AML) with FLT3-length mutations (FLT3-LM) can be discrimated from AML without FLT3-LM in distinct AML subtypes based on specific gene expression profiles. Blood (ASH Annual Meeting abstracts) 100: 311a
29. Schnittger S, Kohlmann A, Haferlach T, Dugas M, Kern W, Hiddemann W, Schoch C (2002b) Acute myeloid leukemia (AML) with partial tandem duplication of the MLL gene (MLL-PTD) can be discriminated from MLL-translocations based on specific gene expression profiles. Blood (ASH Annual Meeting abstracts) 100: 310a
30. Schoch C, Kern W, Kohlmann A, Dugas M, Schnittger S, Hiddemann W, Haferlach T (2002a) AML with complex aberrant karyotype can be distinguished from all other AML subtypes by gene expression profiles and are characterized by higher expression of genes involved in DNA repair. Blood (ASH Annual Meeting abstracts) 100: 311a
31. Schoch C, Kohlmann A, Schnittger S, Brors B, Dugas M, Mergenthaler S, Kern W, Hiddemann W, Eils R, Haferlach T (2002b) Acute myeloid leukemias with reciprocal rearrangements can be distinguished by specific gene expression profiles. Proc Natl Acad Sci USA 99: 10008-10013
32. Southern E, Mir K, Shchepinov M (1999) Molecular interactions on microarrays. Nat Genet 21: 5-9
33. Staal FJ, Cario G, Cazzaniga G, Haferlach T, Heuser M, Hofmann WK, Mills K, Schrappe M, Stanulla M, Wingen LU, van Dongen JJ, Schlegelberger B (2006) Consensus guidelines for microarray gene expression analyses in leukemia from three European leukemia networks. Leukemia 20: 1385-1392
34. Staudt LM (2003) Molecular diagnosis of the hematologic cancers. N Engl J Med 348: 1777-1785
35. Valk PJ, Verhaak RG, Beijen MA, Erpelinck CA, Barjesteh van Waalwijk van Doorn-Khosrovani S, Boer JM, Beverloo HB, Moorhouse MJ, van der Spek PJ, Lowenberg B, Delwel R (2004) Prognostically useful gene-expression profiles in acute myeloid leukemia. N Engl J Med 350: 1617-1628
36. Verhaak RG, Goudswaard CS, van Putten W, Bijl MA, Sanders MA, Hugens W, Uitterlinden AG, Erpelinck CA, Delwel R, Lowenberg B, Valk PJ (2005) Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance. Blood 106: 3747-3754
37. Virtaneva K, Wright FA, Tanner SM, Yuan B, Lemon WJ, Caligiuri MA, Bloomfield CD, de La Chapelle A, Krahe R (2001) Expression profiling reveals fundamental biological differences in acute myeloid leukemia with isolated trisomy 8 and normal cytogenetics. Proc Natl Acad Sci USA 98: 1124-1129
38. Wilson CS, Davidson GS, Martin SB, Andries E, Potter J, Harvey R, Ar K, Xu Y, Kopecky KJ, Ankerst DP, Gundacker H, Slovak ML, Mosquera-Caro M, Chen IM, Stirewalt DL, Murphy M, Schultz FA, Kang H, Wang X, Radich JP, Appelbaum FR, Atlas SR, Godwin J, Willman CL (2006) Gene expression profiling of adult acute myeloid leukemia identifies novel biologic clusters for risk classification and outcome prediction. Blood 108: 685-696
39. Yeoh EJ, Ross ME, Shurtleff SA, Williams WK, Patel D, Mahfouz R, Behm FG, Raimondi SC, Relling MV, Patel A, Cheng C, Campana D, Wilkins D, Zhou X, Li J, Liu H, Pui CH, Evans WE, Naeve C, Wong L, Downing JR (2002) Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell 1: 133-143