Bile synthesis in rat models of inflammatory bowel diseases

European Journal of Clinical Investigation

Volumn 37, Issue 3, 2007, Pages 222-230

  Dikopoulos, N ^a   Schmid, R M ^b   Bachem, M ^a   Buttenschoen, K ^a   Adler, G ^a   Chiang, J Y L ^c   Weidenbach, H ^b  

^a UNIVERSITY OF ULM   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c Northeast Ohio Medical University   (United States)

Author keywords

Acute phase response; Bile synthesis; Cholesterol 7 alpha hydroxylase; Inflammatory bowel disease

Indexed keywords

ALPHA 2 MACROGLOBULIN; BILE ACID; CHOLESTEROL 7ALPHA MONOOXYGENASE; CYTOKINE; DEXTRAN SODIUM SULPHATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOMETACIN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MESSENGER RNA; SODIUM SULFATE; TRANSCRIPTION FACTOR AP 1; TRINITROBENZENESULFONIC ACID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ACUTE PHASE RESPONSE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE ACID SYNTHESIS; BINDING AFFINITY; COLITIS; CYTOKINE RELEASE; HEPATITIS; INTESTINE; LIVER; LIVER MICROSOME; MALE; NONHUMAN; PORTAL VEIN BLOOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SMALL BOWEL INFLAMMATION; SMALL INTESTINE DISEASE; STOMACH ACID SECRETION;

ANIMALS; BILE ACIDS AND SALTS; COLITIS; DEXTRAN SULFATE; INDOMETHACIN; INFLAMMATORY BOWEL DISEASES; MALE; MODELS, BIOLOGICAL; NF-KAPPA B; RATS; RATS, WISTAR; TRANSCRIPTION FACTOR AP-1; TRINITROBENZENESULFONIC ACID;

EID: 33847218671     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2007.01779.x     Document Type: Article

References (44)

1. Sartor RB. Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. Nat Clin Pract Gastroenterol Hepatol 2006;3 (7):390-407.
2. De Fabiani E, Crestani M, Marrapodi M, Pinelli A, Chiang JY, Galli G. Regulation of the hamster cholesterol 7α-hydroxylase gene (CYP7A): prevalence of negative over positive transcriptional control. Biochem Biophys Res Commun 1996;226 (3):663-71.
3. Li YC, Wang DP, Chiang JY. Regulation of cholesterol 7α-hydroxylase in the liver. Cloning, sequencing, and regulation of cholesterol 7α-hydroxylase mRNA. J Biol Chem 1990;265 (20):12012-9.
4. Foti D, Stroup D, Chiang JY. Basic transcription element binding protein (BTEB) transactivates the cholesterol 7α-hydroxylase gene (CYP7A). Biochem Biophys Res Commun 1998;253 (1):109-13.
5. Stroup D, Crestani M, Chiang JY. Identification of a bile acid response element in the cholesterol 7α-hydroxylase gene CYP7A. Am J Physiol 1997;273 (2 Part 1):G508-17.
6. Wang DP, Stroup D, Marrapodi M, Crestani M, Galli G, Chiang JY. Transcriptional regulation of the human cholesterol 7α-hydroxylase gene (CYP7A) in HepG2 cells. J Lipid Res 1996;37 (9):1831-41.
7. Li T, Jahan A, Chiang JY. Bile acids and cytokines inhibit the human cholesterol 7α-hydroxylase gene via the JNK/c-jun pathway in human liver cells. Hepatology 2006;43 (6):1202-10.
8. Dikopoulos N, Weidenbach H, Adler G, Schmid RM. Lipopolysaccharide represses cholesterol 7-alpha hydroxylase and induces binding activity to the bile acid response element II. Eur J Clin Invest 2003;33 (1):58-64.
9. Feingold KR, Spady DK, Pollock AS, Moser AH, Grunfeld C. Endotoxin, TNF, and IL-1 decrease cholesterol 7α-hydroxylase mRNA levels and activity. J Lipid Res 1996;37 (2):223-8.
10. Streetz KL, Wustefeld T, Klein C, Manns MP, Trautwein C. Mediators of inflammation and acute phase response in the liver. Cell Mol Biol 2001;47 (4):661-73.
11. Ramadori G, Christ B. Cytokines and the hepatic acute-phase response. Semin Liver Dis 1999;19 (2):141-55.
12. Elson CO, Sartor RB, Tennyson GS, Riddell RH. Experimental models of inflammatory bowel disease. Gastroenterology 1995;109 (4):1344-67.
13. Sartor RB. Review article: How relevant to human inflammatory bowel disease are current animal models of intestinal inflammation? Aliment Pharmacol Ther 1997;11 (Suppl. 3):89-96; discussion 96-7.
14. Morris GP, Beck PL, Herridge MS, Depew WT, Szewczuk MR, Wallace JL. Hapten-induced model of chronic inflammation and ulceration in the rat colon. Gastroenterology 1989;96 (3):795-803.
15. Okayasu I, Hatakeyama S, Yamada M, Ohkusa T, Inagaki Y, Nakaya R. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology 1990;98 (3):694-702.
16. Yamada T, Deitch E, Specian RD, Perry MA, Sartor RB, Grisham MB. Mechanisms of acute and chronic intestinal inflammation induced by indomethacin. Inflammation 1993;17 (6):641-62.
17. Yamada T, Hoshino M, Hayakawa T, Kamiya Y, Ohhara H, Mizuno K et al. Bile secretion in rats with indomethacin-induced intestinal inflammation. Am J Physiol 1996;270 (5 Part 1):G804-12.
18. Weidenbach H, Leiz S, Nussler AK, Dikopoulos N, Bachem M, Buttenschoen K et al. Disturbed bile secretion and cytochrome P450 function during the acute state of experimental colitis in rats. J Hepatol 2000;32 (5):708-17.
19. Weidenbach H, Scheibner J, Stange EF, Adler G, Beckh K. Reduction of bile secretion by prostaglandins in the rat in vivo. Life Sci 1996;58 (18):1531-8.
20. Beckh K, Lange AB, Adler G, Weidenbach H. Effects of nitric oxide on leukotriene D4 decreased bile secretion in the perfused rat liver. Life Sci 1997;61 (19):1947-52.
21. Tietz PS, Thistle JL, Miller LJ, LaRusso NF. Development and validation of a method for measuring the glycine and taurine conjugates of bile acids in bile by high-performance liquid chromatography. J Chromatogr 1984;336 (2):249-57.
22. Chiang JY, Yang TP, Wang DP. Cloning and 5′-flanking sequence of a rat cholesterol 7α-hydroxylase gene. Biochim Biophys Acta 1992;1132 (3):337-9.
23. Dikopoulos N, Nussler AK, Liptay S, Bachem M, Reinshagen M, Stiegler M et al. Inhibition of nitric oxide synthesis by aminoguanidine increases intestinal damage in the acute phase of rat TNB-colitis. Eur J Clin Invest 2001;31 (3):234-9.
24. Liptay S, Bachem M, Hacker G, Adler G, Debatin KM, Schmid RM. Inhibition of nuclear factor kappa B and induction of apoptosis in T-lymphocytes by sulfasalazine. Br J Pharmacol 1999;128 (7):1361-9.
25. Steinle AU, Weidenbach H, Wagner M, Adler G, Schmid RM. NF-κB/Rel activation in cerulein pancreatitis. Gastroenterology 1999;116 (2):420-30.
26. Baldwin AS Jr. The NF-κB and IκB proteins: new discoveries and insights. Annu Rev Immunol 1996;14:649-83.
27. Porras M, Martin MT, Torres R, Vergara P. Cyclical up-regulated iNOS and long-term down-regulated nNOS are the bases for relapse and quiescent phases in a rat model of IBD. Am J Physiol Gastrointest Liver Physiol 2006;290 (3):G423-30.
28. Piepoli AL, De Salvatore G, De Salvia MA, Mitolo CI, Siro-Brigiani G, Marzullo A et al. Indomethacin-induced ileitis is associated with tensiometric, vascular and oxidative changes in the experimental rat model. Eur J Clin Invest 2005;35 (4):271-8.
29. Chen F, Ma L, Sartor RB, Li F, Xiong H, Sun AQ et al. Inflammatory-mediated repression of the rat ileal sodium-dependent bile acid transporter by c-fos nuclear translocation. Gastroenterology 2002;123 (6):2005-16.
30. Llopis M, Antolin M, Guarner F, Salas A, Malagelada JR. Mucosal colonisation with Lactobacillus casei mitigates barrier injury induced by exposure to trinitronbenzene sulphonic acid. Gut 2005;54 (7):955-9.
31. Gao D, Wagner AH, Fankhaenel S, Stojanovic T, Schweyer S, Panzner S et al. CD40 antisense oligonucleotide inhibition of trinitrobenzene sulphonic acid induced rat colitis. Gut 2005;54 (1):70-7.
32. Shibolet O, Alper R, Zolotarov L, Trop S, Thalenfeld B, Engelhardt D et al. The role of intrahepatic CD8+ T cell trapping and NK1.1+ cells in liver-mediated immune regulation. Clin Immunol 2004;111 (1):82-92.
33. Nishihara T, Matsuda M, Araki H, Oshima K, Kihara S, Funahashi T et al. Effect of adiponectin on murine colitis induced by dextran sulfate sodium. Gastroenterology 2006;131 (3):853-61.
34. Teramoto K, Miura S, Tsuzuki Y, Hokari R, Watanabe C, Inamura T et al. Increased lymphocyte trafficking to colonic microvessels is dependent on MAdCAM-1 and C-C chemokine mLARC/CCL20 in DSS-induced mice colitis. Clin Exp Immunol 2005;139 (3):421-8.
35. Mizoguchi E, Xavier RJ, Reinecker HC, Uchino H, Bhan AK, Podolsky DK et al. Colonic epithelial functional phenotype varies with type and phase of experimental colitis. Gastroenterology 2003;125 (1):148-61.
36. Pandak WM, Heuman DM, Hylemon PB, Chiang JY, Vlahcevic ZR. Failure of intravenous infusion of taurocholate to down-regulate cholesterol 7α-hydroxylase in rats with biliary fistulas. Gastroenterology 1995;108 (2):533-44.
37. Pandak WM, Vlahcevic ZR, Chiang JY, Heuman DM, Hylemon PB. Bile acid synthesis. VI. Regulation of cholesterol 7α-hydroxylase by taurocholate and mevalonate. J Lipid Res 1992;33 (5):659-68.
38. Pandak WM, Li YC, Chiang JY, Studer EJ, Gurley EC, Heuman DM et al. Regulation of cholesterol 7α-hydroxylase mRNA and transcriptional activity by taurocholate and cholesterol in the chronic biliary diverted rat. J Biol Chem 1991;266 (6):3416-21.
39. Scheibner J, Fuchs M, Hormann E, Stange EF. Complex feedback regulation of bile acid synthesis in the hamster: the role of newly synthesized cholesterol. Hepatology 1999;30 (1):230-7.
40. Stange EF, Scheibner J, Ditschuneit H. Role of primary and secondary bile acids as feedback inhibitors of bile acid synthesis in the rat in vivo. J Clin Invest 1989;84 (1):173-80.
41. Rutgeerts P, Ghoos Y, Vantrappen G. Kinetics of primary bile acids in patients with non-operated Crohn's disease. Eur J Clin Invest 1982;12 (2):135-43.
42. Chiang JY, Kimmel R, Stroup D. Regulation of cholesterol 7α-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRα). Gene 2001;262 (1-2):257-65.
43. Silva MA, Porras M, Jury J, Vergara P, Perdue MH. Characterization of ileal dendritic cell distribution in a rat model of acute and chronic inflammation. Inflamm Bowel Dis 2006;12 (6):457-70.
44. Brand HS, Maas MA, Bosma A, Van Ketel RJ, Speelman P, Chamuleau RA. Experimental colitis in rats induces low-grade endotoxinemia without hepatobiliary abnormalities. Dig Dis Sci 1994;39 (6):1210-5.