Complex feedback regulation of bile acid synthesis in the hamster: The role of newly synthesized cholesterol

Hepatology

Volumn 30, Issue 1, 1999, Pages 230-237

  Scheibner, Jürgen ^a   Fuchs, Michael ^a   Hörmann, Erwin ^a   Stange, Eduard F ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; CHENODEOXYCHOLIC ACID; CHOLESTEROL; CHOLIC ACID; DEOXYCHOLIC ACID; TRITIUM OXIDE;

ANIMAL EXPERIMENT; ARTICLE; BILE ACID SYNTHESIS; BILE DUCT; BILE SECRETION; BODY WATER; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; ENTEROHEPATIC CIRCULATION; FEEDBACK SYSTEM; HAMSTER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROXYLATION; LIPID STORAGE; LIQUID SCINTILLATION COUNTING; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM;

AMINO ACIDS; ANIMALS; BILE; BILE ACIDS AND SALTS; CHOLESTEROL; CHOLIC ACID; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CRICETINAE; DEOXYCHOLIC ACID; ELECTROLYTES; FEEDBACK; FEMALE; GLUCOSE; KINETICS; LIVER; LIVER CIRCULATION; MESOCRICETUS; RADIOISOTOPE DILUTION TECHNIQUE; TRITIUM; WATER;

EID: 0032999308     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510300135     Document Type: Article

References (23)

1. Jelinek DF, Andersson S, Slaughter CA, Russell DW. Cloning and regulation of cholesterol 7 alpha-hydroxylase, the rate-limiting enzyme in bile acid biosynthesis. J Biol Chem 1990;265:8190-8197.
2. Spady DK, Cuthbert JA, Willard MN, Meidell RS. Feedback regulation of hepatic 7alpha-hydroxylase expression by bile salts in the hamster. J Biol Chem 1996;271:18623-18631.
3. Pandak WM, Vlahcevic ZR, Heuman DM, Redford KS, Chiang JYL, Hylemon PB. Effects of different bile salts on steady-state mRNA levels and transcriptional activity of cholesterol 7α-hydroxylase. HEPATOLOGY 1994;19:941-947.
4. Shefer S, Hauser S, Bekersky I, Mosbach EH. Feedback regulation of bile acid biosynthesis in the rat. J Lipid Res 1969;10:646-655.
5. Shefer S, Hauser S, Bekersky I, Mosbach EH. Biochemical site of regulation of bile acid biosynthesis in the rat. J Lipid Res 1970;11:404-411.
6. Botham KM, Lawson ME, Beckett GJ, Percy-Robb IW, Boyd GS. The effect of portal blood bile salt concentrations on bile salt synthesis in rat liver. Studies with isolated hepatocytes. Biochim Biophys Acta 1981;666: 238-245.
7. Kubaska WM, Gurley EC, Hylemon PB, Guzelian PS, Vlahcevic ZR. Absence of negative feedback control of bile acid biosynthesis in cultured rat hepatocytes. J Biol Chem 1985;260:13459-13463.
8. Davis RA, Highsmith WE, McNeal MM, Schexnayder JA, Kuan JC. Bile acid synthesis by cultured hepatocytes. Inhibition by mevinolin, but not by bile acids. J Biol Chem 1983;258:4079-4082.
9. Pandak WM, Heuman DM, Hylemon PB, Chiang JYL, Vlahcevic ZR. Failure of intravenous infusion of taurocholate to down-reguate cholesterol 7α-hydroxylase in rats with biliary fistulas. Gastroenterology 1995;108:533-544.
10. Stange EF, Scheibner J, Ditschuneit H. Role of primary and secondary bile acids as feedback inhibitors of bile acid synthesis in the rat in vivo. J Clin Invest 1989;84:173-180.
11. Davis RA, Musso CA, Malone-McNeal M, Lattier GR, Hyde PM, Archambault-Schexnayder J, Straka M. Examination of bile acid negative feedback regulation in rats. J Lipid Res 1988;29:202-211.
12. Duane WC, McHale AP, Hamilton JN. Studies of feedback suppression of bile salt synthesis in the bile-fistula rat. J Lipid Res 1988;29:212-214.
13. Heuman DM, Hylemon PB, Vlahcevic ZR. Regulation of bile acid synthesis. III. Correlation between biliary bile salt hydrophobicity index and the activities of enzymes regulating cholesterol and bile acid synthesis in the rat. J Lipid Res 1989;30:1161-1171.
14. Crestani M, Karam WG, Chiang JY. Effects of bile acids and steroid/ thyroid hormones on the expression of cholesterol 7 alpha-hydroxylase mRNA and the CYP7 gene in HepG2 cells. Biochem Biophys Res Commun 1994;198:546-553.
15. Pandak WM, Stravitz RT, Lucas V, Heuman DM, Chiang JY. Hep G2 cells: a model for studies on regulation of human cholesterol 7alpha-hydroxylase at the molecular level. Am J Physiol 1996;270:G401-G410.
16. Taniguchi T, Chen J, Cooper AD. Regulation of cholesterol 7 alpha-hydroxylase gene expression in Hep-G2 cells. Effect of serum, bile salts, and coordinate and noncoordinate regulation with other sterol-responsive genes. J Biol Chem 1994;269:10071-10078.
17. Hall R, Kok E, Javitt NB. Bile acid synthesis: down-regulation by monohydroxy bile acids. FASEB J 1988;2:152-156.
18. Redinger RN. The economy of the enterohepatic circulation of bile acids in the baboon. 2. Regulation of bile acid synthesis by enterohepatic circulation of bile acids. J Lipid Res 1984;25:437-447.
19. Tauber G, Empen K, Scheibner J, Fuchs M, Stange EF. Feedback regulation of bile acid synthesis measured by stable isotope kinetics in humans. Eur J Gastroenterol Hepatol 1996;8:23-31.
20. Bertolotti M, Abate N, Loria P, Dilengite M, Carubbi F, Pinetti A, Digrisolo A, et al. Regulation of bile acid synthesis in humans: effect of treatment with bile acids, cholestyramine or simvastatin on cholesterol 7α-hydroxylation rates in vivo. HEPATOLOGY 1991;14:830-837.
21. Pandak WM, Heuman DM, Hylemon PB, Vlahcevic ZR. Regulation of bile acid synthesis. IV. Interrelationship between cholesterol and bile acid biosynthesis pathways. J Lipid Res 1990;31:79-90.
22. Jones MP, Pandak WM, Heuman DM, Chiang JYL, Hylemon PB, Vlahcevic ZR. Cholesterol 7α-hydroxylase: evidence for transcriptional regulation by cholesterol or metabolic products of cholesterol in the rat. J Lipid Res 1993;34:885-892.
23. Vlahcevic ZR, Pandak WM, Hylemon PB, Heuman DM. Role of newly synthesized cholesterol or its metabolites on the regulation of bile acid biosynthesis after short-term biliary diversion in the rat. HEPATOLOGY 1993;18:660-668.