Establishment of a cell-based drug screening model for identifying down-regulators of protein tyrosine phosphatase 1B expression

Experimental and Clinical Endocrinology and Diabetes

Volumn 115, Issue 1, 2007, Pages 24-28

  Lian, J H ^a,b   Guo, L ^a,b   Hu, W R ^a,b   Wu, G L ^a,b   Ji, W ^a,b   Gong, B Q ^a,b  

^a EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Shanghai Comman Pharmaceutical Co Ltd   (China)

Author keywords

Diabetes < autoimmunity; Insulin resistance; Protein tyrosine phosphatase 1B

Indexed keywords

6,7 DIHYDROXY 2 PHENYL 1 H QUINOLIN 4 ONE; CM 107; HERBACEOUS AGENT; LUCIFERASE; NEOMYCIN; PLANT EXTRACT; PROTEIN TYROSINE PHOSPHATASE 1B; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL BASED GENE THERAPY; CHINESE HERB; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG INHIBITION; DRUG SCREENING; DRUG STRUCTURE; GENE VECTOR; GENETIC TRANSFECTION; MEDICINAL PLANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; TRANSCRIPTION REGULATION;

CELL LINE; DIABETES MELLITUS, TYPE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; DRUG EVALUATION, PRECLINICAL; DRUGS, CHINESE HERBAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INSULIN RESISTANCE; PROMOTER REGIONS, GENETIC; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; PROTEIN TYROSINE PHOSPHATASES;

EID: 33847148553     PISSN: 09477349     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-949590     Document Type: Article

References (22)

1. Ahmad F, Azevedo JJ, Cortright R, Dohm G, Goldstein B: Alterations in skeketal muscle protein-tyrosine phosphatase activity and expression in insulin-resistant human obesity and diabetes. J Clin Invest 1997; 100: 449-458
2. Ahmad F, Considine RV, Bauer TL, Ohannesian JP, Marco CC, Goldstein BJ: Improved sensitivity to insulin in obese subjects following weight loss is accompanied by reduced protein tyrosine phosphatase in adipose tissue. Metabolism 1997; 46: 1140-1145
3. Ahmad F, Li PM, Meyerovitch J, Goldstein BJ: Osmotic loading of neutralizing antibodies demonstrates a role for protein-tyrosine phosphatase 1B in negative regulation of the insulin action pathway. J Biol Chem 1995; 270: 20503-20508
4. Amacker-Francoys I, Mohanty S, Niessen M, Spinas GA, Trüb T: The metabolisable hexoses D-glucose and D-mannose enhance the expression of IRS-2 but not of IRS-1 in pancreatic β-cells. Exp Clin Endocrinol Diabetes 2005; 113: 423-429
5. Baumann CA, Saltiel AR: Spatial compartmentalization of signal transduction in insulin action. BioEssays 2001; 23: 215-222
6. Bjornholm M, Kawano Y, Lehtihet M, Zierath JR: Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation. Diabetes 1997; 46: 524-527
7. Chen H, Cong LN, Li Y, Yao ZJ, Wu L, Zhang ZY, Burke TR, Quon MJ: A phosphotyrosyl mimetic peptide reverses impairment of insulin-stimulated translocation of GLUT4 caused by overexpression of PTP1B in rat adipose cells. Biochemistry 1999; 38: 384-389
8. Egawa K, Maegawa H, Shimizu S, Morino K, Nishio Y, Ash MB, Cheung AT, Kolls JK, Kikkawa R, Kashiwagi A: Protein-tyrosine phosphatase-1B negatively regulates insulin signaling in L6 myocytes and Fao hepatoma cells. J Biol Chem 2001; 276: 10207-10211
9. Elchebly M, Payette P, Michaliszyn E, Cromlish W, Collins S, Loy AL, Normandin D, Cheng A, Hagen JH, Chan CC, Ramachandran C, Gresser MJ, Tremblay ML, Kennedy BP: Incerased insulin sensitivity and obessity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 1999; 283: 1544-1548
10. Forsell PKAL, Boie Y, Montalibet J, Collins S, Kennedy BP: Genomic characterization of the human and mouse protein tyrosine phosphatase-1B genes. Gene 2000; 260: 145-153
11. Fukada T, Tonks NK: The Reciprocal Role of Egr-1 and Sp Family Proteins in Regulation of the PTP1B Promoter in Response to the p210 Bcr-Abl Oncoprotein-tyrosine Kinase. J Biol Chem 2001; 276: 25512-25519
12. Goldstein BJ, Bittnerkowalczyk A, White MF, Harbeck M: Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein. J Biol Chem 2000; 275: 4283-4289
13. Kahn BB, Flier JS: Obesity and insulin resisitance. J Clin Inv 2000; 106: 473-481
14. Kennedy BP: Role of protein tyrosine phosphatase-1B in diabetes and obesity. Biomed & Pharmacother 1999; 53: 446-470
15. Kenner KA, Anyanwu E, Olefsky JM, Kusari J: Protein-tyrosine phosphatase 1B is a negative regulator of insulin- and insulin-like growth factor-1-stimulated signaling. J Biol Chem 1996; 271: 19810-19816
16. Klaman LD, Boss O, Peroni OD, Kim JK, Martino JL, Zabolotny JM, Moghal N, Lubkin M, Kim YB, Sharpe AH, Krongrad AS, Shulman GI, Neel BG, Kahn BB: Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice. Mol Cell Biol 2000; 20: 5479-5489
17. Moller DE, Flier JS: Insulin resistance - mechanisms, syndromes, and implications. N Engl J Med 1991; 325: 938-948
18. Müssig K, Strack V, Häring HU, Kellerer M: The role of Shp2 serine residues 576 and 591 in insulin signaling. Exp Clin Endocrinol Diabetes 2004; S1
19. Roith DL, Zick Y: Recent advances in our understanding of insulin action and insulin resistance. Diabetes Care 2001; 24: 588-597
20. Salmeen A, Andersen JN, Myers MP, Tonks NK, Barford D: Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B. Mol Cell 2000; 6: 1401-1412
21. Seely B, Staubs P, Reichart D, Berhanu P, Milarski K, Saltiel A, Kusari J, Olefsky J: Protein tyrosine phosphatase 1B interacts with the activated insulin receptor. Diabetes 1996; 45: 1379-1385
22. Zick Y: Insulin resistance: a phosphorylation-based uncoupling of insulin signaling. TRENDS in biology 2000; 11: 437-441