Effects of continuous ingestion of herbal teas on intestinal CYP3A in the rat

Journal of Pharmacological Sciences

Volumn 103, Issue 2, 2007, Pages 214-221

  Matsuda, Kazuhiro ^a   Nishimura, Yuki ^a   Kurata, Norimitsu ^a   Iwase, Mariko ^a   Yasuhara, Hajime ^a  

^a SHOWA UNIVERSITY   (Japan)

Author keywords

CYP3A; Herb drug interaction; Herbal tea; Rooibos; Tenryocha

Indexed keywords

CYTOCHROME P450; GUAVA EXTRACT; MIDAZOLAM MALEATE; PLANT EXTRACT; ROOIBOS EXTRACT; TENRYOCHA EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG HYDROXYLATION; HERB DRUG INTERACTION; INTESTINE; MALE; NONHUMAN; PROTEIN INTERACTION; RAT; STATISTICAL SIGNIFICANCE; TEA; WESTERN BLOTTING;

EID: 33847097437     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.FP0061311     Document Type: Article

References (45)

1. Watkins PB. Drug metabolism by cytochromes P450 in liver and small bowel. Gastrointerol Clin North Am. 1992;21:511-526.
2. Dresser GK, Spence JD, Bailey DG. Pharmacokinetic-pharmacodynamic consequence and clinical relevance of cytochrome P450 inhibition. Clin Pharmacokinet. 2000;38:41-57.
3. Guengerich FP. Cytochrome P-450 3A4: regulation and role in drug metabolism. Ann Rev Pharmacol Toxicol. 1999;39:1-17.
4. Wilkinson GR. Cytochrome P4503A (CYP3A) metabolism: Prediction of in vivo activity in humans. J Pharmacokinet Biopharm. 1996;24:475-490.
5. Harris RZ, Jang GR, Tsunoda S. Dietary effects on drug metabolism and transport. Clin Pharmacokinet. 2003;42:1071-1088.
6. Von Moltke LL, Weemholff JL, Bedir E, Khan IA, Harmatz JS, Goldman P, et al. Inhibition of human cytochromes P450 by components of Ginkgo biloba. J Pharm Pharmacol. 2004;56:1039-1044.
7. Yale SH, Glurich I. Analysis of inhibitory potential of Ginkgo biloba, Echinacea purpurea, and Serenoa repens on metabolic activity of cytochrome P450 3A4, 2D6, and 2C9. J Altern Complement Med. 2005;75:433-439.
8. Beckmann-Knopp S, Rietbrock S, Weyhenmeyer R, Bocker RH, Beckurts KT, Lang W, et al. Inhibitory effect of silibinin on cytochrome P-450 enzymes in human liver microsomes. Pharmacol Toxicol. 2000;86:250-256.
9. Gorski JC, Huang S, Pinto A, Hamman MA, Hilligoss JK, Zaheer NA, et al. The effect of echinacea (Echinacea purpurea root) on cytochrome P450 activity in vivo. Clin Pharmacol Ther. 2004;75:89-100.
10. Gurley BJ, Gardner SF, Hubbard MA, Williams DK, Gentry WB, Carrier J, et al. In vivo assessment of botanical supplementation on human cytochrome P450 phenotypes: Citrus aurantium, Echinacea purpurea, milk thistle, and saw palmetto. Clin Pharmacol Ther. 2004;76:428-440.
11. Markowitz JS, Donovan JL, Lindsay DC, Sipkes L, Chavin KD. Multiple-dose administration of Ginkgo biloba did not affect cytochrome P-450 2D6 or 3A4 activity in normal volunteers. J Clin Psychopharmacol. 2003;23:576-581.
12. 2 synthesis by mangosteen, a Thai medicinal plant. Biol Pharm Bull. 2002;25:1137-1141.
13. Kunishiro K, Tai A, Yamamoto I. Effects of rooibos tea extract on antigen-specific antibody production and cytokine generation in vitro and in vivo. Biosci Biotechnol Biochem. 2001;65:2137-2145.
14. Hasseling PB, Joubert JR. The effect of rooibos tea on the type I allergic reaction. S Afr Med J. 1982;62:1037-1038.
15. Ojewole JA. Antiinflammatory and analgesic effects of Psidium guajava Linn. (Myrtaceae) leaf aqueous extract in rats and mice. Methods Find Exp Clin Pharmacol. 2006;28:441-446.
16. Akaike A, Uchida N, Hirashima H, Fukazawa I, Lee XP, Nishimura Y, et al. The effects of multiple ingestion of Ten-cha on pharmacokinetics after single oral administration of simvastatin. Showa Univ J Med Sci. 2006;66:340-348.
17. Mandema JW, Tukker E, Danhof M. Pharmacokinetic-pharmacodynamic modeling of the EEG effects of midazolam in individual rats: influence of rate and route of administration. Br J Pharmacol. 1991;102:663-668.
18. Guengerich FP. Analysis and characterization of enzymes. In: Hayes AW, editor. Principles and methods of toxicology. New York: Raven Press; 1994. p. 1259-1313.
19. Bonkovsky HL, Hauri HP, Marti U, Gasser R, Meyer UA. Cytochrome P-450 of small intestinal epithelial cells. Gastroenterol. 1985;88:458-467.
20. Koudriakova T, Iatsimirskaia E, Tulebaev S, Spetie D, Utkin I, Mullet D, et al. In vivo disposition and metabolism by liver and enterocyte microsomes of the antitubercular drug rifabutin in rats. J Pharmacol Exp Ther. 1996;279:1300-1309.
21. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265-275.
22. Nishimura Y, Kurata N, Sakurai E, Yasuhara H. Inhibitory effect of antituberculosis drugs on human cytochrome P450-mediated activities. J Pharmacol Sci. 2004;96:293-300.
23. Omura T, Sato R. The carbon monoxide-binding pigment of liver microsomes. I. evidence for its hemoprotein nature. J Biol Chem. 1964;239:2370-2378.
24. Kobayashi K, Urashima K, Shimada N, Chiba K. Substrate specificity for rat cytochrome P450(CYP) isoforms: screening with cDNA-expressed systems of the rat. Biochem Pharmacol. 2002;63:889-896.
25. Kotegawa T, Laurijssens BE, Von Moltke LL, Cotreau MM, Perloff MD, Venkatakrishnan K, et al. In vitro, pharmacokinetic, and pharmacodynamic interactions of ketoconazole and midazolam in the rat. J Pharmacol Exp Ther. 2002;302:1228-1237.
26. Johnson TN, Tanner MS, Tucker GT. A comparison of the ontogeny of enterocytic and hepatic cytochrome P450 3A in the rat. Biochem Pharamcol. 2000;60:1601-1610.
27. Guengerich FP, Wang P, Davidson NK. Estimation of isozymes of microsomal cytochrome P-450 in rats, rabbits, and humans using immunochemical staining coupled with sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Biochem. 1982;21:1698-1706.
28. Gushchin GV, Gushchin MI, Gerber N, Boyd RT. A novel cytochrome P450 3A isoenzyme in rat intestinal microsomes. Biochem Biophys Res Commun. 1999;255:394-398.
29. Matsubara T, Kim HJ, Miyata M, Shimada M, Nagata K, Yamazoe Y. Isolation and characterization of a new major intestinal CYP3A form, CYP3A62, in the rat. J Pharmacol Exp Ther. 2004;309:1282-1290.
30. Ghosal A, Satoh H, Thomas PE, Bush E, Moore D. Inhibition and kinetics of cytochrome P4503A activity in microsomes from rat, human and cDNA-expressed human cytochrome P450. Drug Metab Dispos. 1996;24:940-947.
31. Lee JI, Chaves-Gnecco D, Amico JA, Kroboth PD, Wilson JW, Frye RF. Application of semisimultaneous midazolam administration for hepatic and intestinal cytochrome P4503A phenotyping. Clin Phramacol Ther. 2002;72:718-728.
32. Nies AS, Shand DG, Willkinsin GR. Altered hepatic blood flow and drug disposition. Clin Pharmacokinet. 1976;1:135.
33. Higashikawa F, Murakami T, Kandeda T, Kato A, Takano M. Dose-dependent intestinal and hepatic first-pass metabolism of midazolam, a cytochrome P450 3A substrate with differently modulated enzyme activity in rats. J Pharm Pharmacol. 1999;51:67-72.
34. Izzo AA, Ernst E. Interactions between herbal medicines and prescribed drugs: a systematic review. Drugs. 2001;61:2163-2175.
35. Kim RB, Wandel C, Leake B, Cvetkovic M, Fromm MF, Dempsey PJ, et al. Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein. Pharm Res. 1999;16:408-414.
36. Guo LQ, Yamazoe Y. Inhibition of cytochrome P450 by furanocoumarins in grapefruit juice and herbal medicines. Acta Pharmacol Sin. 2004;25:129-136.
37. Sridar C, Goosen TC, Kent UM, Williams JA, Hollenberg PF. Silybin inactivates cytochrome P450 3A4 and 2C9 and inhibits major hepatic glucuronocyltransferases. Drug Metab Dispos. 2004;32:587-594.
38. Obach RS. Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression. J Pharmacol Exp Ther. 2000;294:88-95.
39. Chan WK, Nguyen LT, Miller VP, Harris RZ. Mechanism-based inactivation of human cytochrome P450 3A4 by grapefruit juice and red wine. Life Sci. 1998;62:135-142.
40. Sugimoto N, Kikuchi H, Yamazaki T, Maitani T. Polyphenolic constituents from the leaves of rubus suavissimus. Nat Med. 2001;55:219.
41. Tanaka T, Kohda H, Tanaka O, Chen F-H, Chou W-H, Leu J-L. Rubusoside (β-D-glucosyl ester of 13-O-β-D-glucosyl-steviol), a sweet principle of Rubus chingii HU (Rosaceae). Agric Biol Chem. 1981;45:2165-2166.
42. Joubert E. HPLC quantification of the dihydrochalcones, aspalathin and nothofagin in rooibos tea (Aspalatus linearis) as affected by processing. Food Chem. 1996;55:403-411.
43. Pal D, Mitra AK. MDR- and CYP3A4-mediated drug-herbal interactions. Life Sci. 2006;78:2131-2145.
44. Roby CA, Anderson GD, Kantor E, Dryer DA, Burstein AH. St John's Wort: effect on CYP3A4 activity. Clin Pharmacol Ther. 2000;67:451-457.
45. Mohri K, Uesawa Y, Sagawa K. Effects of long-term grapefruit juice ingestion on nifedipine pharmacokinetics: induction of rat hepatic P-450 by grapefruit juice. Drug Metab Dispos. 2000;28:482-486.