Incorporation of acute dynamic ventilation changes into a standardized physiologically based pharmacokinetic model

Inhalation Toxicology

Volumn 19, Issue 3, 2007, Pages 247-263

  Ng, Laurel J ^a,b   Stuhmiller, Louise M ^a   Stuhmiller, James H ^a  

^a Applied Technologies Division   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DICHLORODIFLUOROMETHANE; VOLATILE AGENT;

ARTICLE; BLOOD; BODY MASS; COMPUTER PROGRAM; EXPERIMENTAL MODEL; EXPOSURE; HEART OUTPUT; LUNG VENTILATION; PARAMETER; PRIORITY JOURNAL; TISSUE;

ANESTHETICS; ANIMALS; GASES; HUMANS; HYDROCARBONS, HALOGENATED; MODELS, BIOLOGICAL; PETROLEUM; PHARMACOKINETICS; RATS; RESPIRATION;

RATTUS;

EID: 33847014818     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.1080/08958370601067905     Document Type: Article

References (75)

1. Abbott Laboratories. 2001. Data sheet: Sevoflurane.
2. Andersen, M. E., Clewell, H. J., 3rd, Gargas, M. L., Smith, F. A., and Reitz, R. H. 1987. Physiologically based pharmacokinetics and the risk assessment process for methylene chloride. Toxicol. Appl. Pharmacol. 87:185-205.
3. Arms, A. D., and Travis, C. C. 1988. Reference physiological parameters in pharmacokinetic modeling. NTIS PB 88-196019. Office of Risk Analysis, U.S. Environmental Protection Agency,Washington, DC.
4. Auton, T. R., and Woollen, B. H. 1991. A physiologically based mathematical model for the human inhalation pharmacokinetics of 1,1,2-trichloro-1,2,2-trifluoroethane. Int. Arch. Occup. Environ. Health 63:133-138.
5. Boyes, W. K., Evans, M. V., Eklund, C., Janssen, P., and J. E., S. 2005. Duration adjustment of acute exposure guideline level values for trichloroethylene using a physiologically-based pharmacokinetic model. Risk Anal. 25:667-686.
6. Brown, C. D.,Wong, B. A., and Fennell, T. R. 1996. In vivo and in vitro kinetics of ethylene oxide metabolism in rats and mice. Toxicol. Appl. Pharmacol. 136:8-19.
7. Brown, R. P., Delp, M. D., Lindstedt, S. L., Rhomberg, L. R., and Beliles, R. P. 1997. Physiological parameter values for physiologically based pharmacokinetic models. Toxicol. Ind. Health 13:407-484.
8. Clark, D. G., and Tinston, D. J. 1973. Correlation of the cardiac sensitizing potential of halogenated hydrocarbons with their physicochemical properties. Br. J. Pharmacol. 49:355-357.
9. Clewell, H. J., Andersen, M. E., and Barton, H. A. 2002. A consistent approach for the application of pharmacokinetic modeling in cancer and noncancer risk assessment. Environ. Health Perspect. 110:85-93.
10. Clewell, H. J., Gentry, P. R., Gearhart, J. M., Covington, T. R., Banton, M. I., and Andersen, M. E. 2001. Development of a physiologically based pharmacokinetic model of isopropanol and its metabolite acetone. Toxicol. Sci. 63:160-172.
11. Csanády,G. A., Denk, B., Pütz, C., Kreuzer, P. E.,Kessler,W., Baur, C., Gargas, M. L., and Filser, J. G. 2000. A physiological toxicokinetic model for exogenous and endogenous ethylene and ethylene oxide in rat, mouse, and human: Formation of 2-hydroxyethyl adducts with hemoglobin and DNA. Toxicol. Appl. Pharmacol. 165:1-26.
12. Dallas, C. E., Gallo, J. M., Ramanathan, R., Muralidhara, S., and Bruckner, J. V. 1991. Physiological pharmacokinetic modeling of inhaled trichloroethylene in rats. Toxicol. Appl. Pharmacol. 110:303-314.
13. Davis, N. R., and Mapleson, W. W. 1981. Structure and quantification of a physiological model of the distribution of injected agents and inhaled anaesthetics. Br. J. Anaesth. 53:399-405.
14. Dick, R. B., Setzer, J. V., Taylor, B. J., and Shukla, R. 1989. Neurobehavioural effects of short duration exposures to acetone and methyl ethyl ketone. Br. J. Ind. Med. 46:111-121.
15. DiVincenzo, G. D., Yanno, F. J., and Astill, B. D. 1973. Exposure of man and dog to low concentrations of acetone vapor. Am. Ind. Hyg. Assoc. J. 34:329-336.
16. Dodd, D. E., Brashear, W. T., and Vinegar, A. 1993. Metabolism and pharmacokinetics of selected halon replacement candidates. Toxicol. Lett. 68:37-47.
17. Emmen, H. H., Hoogendijk, E. M., Klopping-Ketelaars,W. A., Muijser, H., Duistermaat, E., Ravensberg, J. C., Alexander,D. J., Borkhataria, D., Rusch, G. M., and Schmit, B. 2000. Human safety and pharmacokinetics of the CFC alternative propellants HFC 134a (1,1,1,2-tetrafluoroethane) and HFC 227 (1,1,1,2,3,3, 3-heptafluoropropane) following whole-body exposure. Regul. Toxicol. Pharmacol. 32:22-35.
18. Evans, M. V., and Andersen, M. E. 1995. Sensitivity analysis and the design of gas uptake inhalation studies. Inhal. Toxicol. 7:1075-1094.
19. Fennell, T. R., and Brown, C. D. 2001. A physiologically based pharmacokinetic model for ethylene oxide in mouse, rat, and human. Toxicol. Appl. Pharmacol. 173:161-175.
20. Fiserova-Bergerova, V. 1995. Extrapolation of physiological parameters for physiologically based simulation models. Toxicol. Lett. 79:77-86.
21. Fiserova-Bergerova, V., and Diaz, M. L. 1986. Determination and prediction of tissue-gas partition coefficients. Int. Arch. Occup. Environ. Health 58:75-87.
22. Fisher, J. W., Gargas, M. L., Allen, B. C., and Andersen, M. E. 1991. Physiologically based pharmacokinetic modeling with trichloroethylene and its metabolite, trichloroacetic acid, in the rat and mouse. Toxicol. Appl. Pharmacol. 109:183-195.
23. Gargas, M. L., Andersen, M. E., and Clewell, H. J., 3rd. 1986. A physiologically based simulation approach for determining metabolic constants from gas uptake data. Toxicol. Appl. Pharmacol. 86:341-352.
24. Gargas, M. L., Burgess, R. J., Voisard, D. E., Cason, G. H., and Andersen,M.E. 1989. Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues. Toxicol. Appl. Pharmacol. 98:87-99.
25. Gargas, M. L., Medinsky, M. A., and Andersen, M. E. 1993. Advances in physiological modeling approaches for understanding the disposition of inhaled vapors. In Toxicology of the lung, chap. 17. New York: Raven Press.
26. Gautier, H., and Bonara, M. 1983. Ventilatory response of intact cats to carbon monoxide hypoxia. J. Appl. Physiol. 55:1064-1071.
27. Gill, M. W., Burleigh-Flayer, H. D., Strother, D. E., Masten, L. W., McKee, R. H., Tyler, T. R., and Gardiner, T. H. 1995. Isopropanol: Acute vapor inhalation neurotoxicity study in rats. J. Appl. Physiol. 15:77-84.
28. Gu, Z., Januszkiewicz, A. J., McKinley, C. D., Mayorga, M. A., Stuhmiller, L. M., and Stuhmiller, J.H. 2000. Biochemical and respiratory changes caused by brief exposure to high concentration carbon monoxide and carbon dioxide in awake rats. Toxicologist 54:19.
29. Haddad, S., Tardif, R., Charest-Tardif, G., and Krishnan, K. 1999. Physiological modeling of the toxicokinetic interactions in a quaternary mixture of aromatic hydrocarbons. Toxicol. Appl. Pharmacol. 161:249-257.
30. Haggard, H. W., Greenberg, L. A., and Turner, J. A. 1944. The physiological principles governing the action of acetone together with determination of toxicity. J. Ind. Hyg. Toxicol. 26:133-151.
31. IPCS INCHEM. 1990. Environmental Health Criteria 113: Fully halogenated chlorofluorocarbons. Document prepared for the United Nations Environment Programme, the International Labour Organization, and the World Health Organization.
32. Jepson, G. W., Hoover, D. K., Black, R. K., McCafferty, J. D., Mahle, D. A., and Gearhart, J. M. 1994. A partition coefficient determination method for nonvolatile chemicals in biological tissues. Fundam. Appl. Toxicol. 22:519-524.
33. Johanson, G., and Filser, J. G. 1992. Experimental data from closed chamber gas uptake studies in rodents suggest lower uptake rate of chemical than calculated from literature values on alveolar ventilation. Arch. Toxicol. 66:291-295.
34. Kaneko, T., Wang, P.-Y., and Sato, A. 1994. Partition coefficients of some acetate esters and alcohols in water, blood, olive oil, and rat tissues. Occup. Environ. Med. 51:68-72.
35. Kaplan, H. L., Switzer, W. G., Hinderer, R. K., and Anzueto, A. 1993. A study on the acute and long-term effects of hydrogen chloride on respiratory response and pulmonary function and morphology in the baboon. J. Fire Sci. 11:459-484.
36. Knaak, J. B., al-Bayati, M. A., and Raabe, O. G. 1995. Development of partition coefficients, Vmax and Km values, and allometric relationships. Toxicol. Lett. 79:87-98.
37. Krishnan, K., Gargas, M. L., Fennell, T. R., and Andersen, M. E. 1992. A physiologically based description of ethylene oxide dosimetry in the rat. Toxicol. Ind. Health 8:121-140.
38. Kristensen, S., Batt, S., Willcocks, D., and Lee-Steere, C. 2000. 2,2-Dichloro-1,1,1-trifluoroethane (HCFC-123). Concise International Chemical Assessment Document No. 23.
39. Kruhoffer, P. W. 1983. Handling of inspired vaporized ethanol in the airways and lungs (with comments on forensic aspects). Forensic Sci. Int. 21:1-17.
40. Lai, Y. L., Tsuya, Y., and Hildebrandt, J. 1978. Ventilatory response to acute CO2 exposure in the rat. J. Appl. Physiol. 45:611-618.
41. Lam, C. W., Weir, F. W., Williams-Cavender, K., Tan, M. N., Galen, T. J., and Pierson, D. L. 1993. Toxicokinetics of inhaled bromotrifluoromethane (Halon 1301) in human subjects. Fundam. Appl. Toxicol. 20:231-239.
42. Levitt, D. G. 2002. PKQuest: A general physiologically based pharmacokinetic model. Introduction and application to propranolol. BMC Clinical Pharmacology 2:5.
43. McNamara, B. P. 1976. Department of the Army. Estimates of the toxicity of hydrocyanic acid vapors in man. Edgewood Arsenal. Techical Report: EB-TR-76023. http://www.stormingmedia.us/10/1058/A105820.html.
44. Molnar, J., Paksy, K. A., and Naray, M. 1986. Changes in the rat's motor behaviour during 4-hr inhalation exposure to prenarcotic concentrations of benzene and its derivatives. Acta Physiol. Hung. 67:349-354.
45. Muller, G., Spassovski, M., and Henschler, D. 1974. Metabolism of trichloroethylene in man. II. Pharmacokinetics of metabolites. Arch. Toxicol. 32:283-295.
46. National Toxicology Program. 1992. 13-Week toxicity study of styrene (CO2200B) in F344 rats and B6C3F1 mice by inhalation. Pathology Working Group's Chairperson's Report. http://ntpserver.niehs.nih.gov
47. OEHHA. 2000. Appendix A. Toxicity Summaries. OEHHA Report on Ethanol in Gasoline. http://www.oehha.ca.gov
48. Overton, J. H. 1990. A respiratory tract dosimetry model for air toxics. Toxicol. Ind. Health 6:171-180.
49. Overton, J. H., Kimbell, J. S., and Miller, F. J. 2001. Dosimetry modeling of inhaled formaldehyde: The human respiratory tract. Toxicol. Sci. 64:122-134.
50. Pastino, G. M., Asgharian, B., Roberts, K., Medinsky, M. A., and Bond, J. A. 1997. A comparison of physiologically based pharmacokinetic model predictions and experimental data for inhaled ethanol in male and female B6C3F1 mice, F344 rats, and humans. Toxicol. Appl. Pharmacol. 145:147-157.
51. Paustenbach, D. J., Clewell, H. J., 3rd, Gargas, M. L., and Andersen, M. E. 1988. A physiologically based pharmacokinetic model for inhaled carbon tetrachloride. Toxicol. Appl. Pharmacol. 96:191-211.
52. Perleberg, U. R., Keys, D. A., and Fisher, J. W. 2004. Development of a physiologically based pharmacokinetic model for decane, a constituent of jet propellent-8. Inhal. Toxicol. 16:771-783.
53. Purser, D. A., Grimshaw, P., and Berrill, K. R. 1984. Intoxication by cyanide in fires: A study in monkeys using polyacrylonitrile. Arch. Environ. Health 39:394-400.
54. Ramsey, J. C., and Andersen, M. E. 1984. A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans. Toxicol. Appl. Pharmacol. 73:159-175.
55. Ramsey, J. C., and Young, J. D. 1978. Pharmacokinetics of inhaled styrene in rats and humans. Scandin. J. Work Environ. Health 4:84-91.
56. Ramsey, J. C., Young, J. D., Karbowski, R. J., Chenoweth, M. B., McCarty, L. P., and Braun,W. H. 1980. Pharmacokinetics of inhaled styrene in human volunteers. Toxicol. Appl. Pharmacol. 53:54-63.
57. Reinhardt, C. F., Azar, A., Maxfield, M. D., Smith, P. E., and Mullin, L. S. 1971. Cardiac arrhythmias and aerosol "sniffing." Arch. Environ. Health 22:265-279.
58. Sanzgiri, U.Y., Kim, H. J., Muralidhara, S., Dallas, C. E., and Bruckner, J. V. 1995. Effect of route and pattern of exposure on the pharmacokinetics and acute hepatotoxicity of carbon tetrachloride. Toxicol. Appl. Pharmacol. 134:148-154.
59. Sarangapani, R., Teeguarden, J. G., Cruzan, G., Clewell, H. J. and Andersen, M. E. 2002. Physiologically based pharmacokinetic modeling of styrene and styrene oxide respiratory-tract dosimetry in rodents and humans. Inhal. Toxicol. 14:789-834.
60. Sato, A., and Nakajima, T. 1979. Partition coefficients of some aromatic hydrocarbons and ketones in water, blood, and oil. Br. J. Ind. Med. 36:231-234.
61. Simmons, J. E., Boyes, W. K., Bushnell, P. J., Raymer, J. H., Limsakun, T., McDonald, A., Sey, Y. M., and Evans, M. V. 2002. A physiologically based pharmacokinetic model for trichloroethylene in the male Long-Evans rat. Toxicol. Sci. 69:3-15.
62. Slauter, R.W., Coleman, D. P., Gaudette, N. F., McKee, R. H., Masten, L. W., Gardiner, T. H., Strother, D. E., Tyler, T. R., and Jeffcoat, A. R. 1994. Disposition and pharmacokinetics of isopropanol in F-344 rats and B6C3F1 mice. Fundam. Appl. Toxicol. 23:407-420.
63. Snellings, W. M., Weil, C. S., and Maronpot, R. R. 1984. A subchronic inhalation study on the toxicologic potential of ethylene oxide in B6C3F1 mice. Toxicol. Appl. Pharmacol. 76:510-518.
64. Stern, R. C., Towler, S. C., White, P. F., and Evers, A. S. 1990. Elimination kinetics of sevoflurane and halothane from blood, brain, and adipose tissue in the rat. Anesth. Analg. 71:658-664.
65. Stewart, R. D., Fisher, T. N., Hosko, M. J., Peterson, J. E., Baretta, E. D., and Dodd, H. C. 1972. Experimental human exposure to methylene chloride. Arch. Environ. Health 25:342-348.
66. Stopps, G. J., and McLaughlin, M. 1967. Psychophysiological testing of human subjects exposed to solvent vapors. Am. Ind. Hyg. Assoc. J. 28:43-50.
67. Stuhmiller, J. H., and Stuhmiller, L. M. 2002. An internal dose model for interspecies extrapolation of immediate incapacitation risk from inhalation of fire gases. Inhal. Toxicol. 14:929-957.
68. Stuhmiller, J. H., Long, D. W., and Stuhmiller, L. M. 2006. An internal dose model of incapacitation and lethality risk from inhalation of fire gases. Inhal. Toxicol. 18:347-364.
69. Thrall, K. D., Vucelick, M. E., Gies, R. A., Zangar, R. C., Weitz, K. K., Poet, T. S., Springer, D. L., Grant, D. M., and Benson, J. M. 2000. Comparative metabolism of carbon tetrachloride in rats, mice, and hamsters using gas uptake and PBPK modeling. J. Toxicol. Environ. Health, Pt. A 60:531-548.
70. Vernon, R. J., and Ferguson, R. K. 1969. Effects of trichloroethylene on visual-motor performance. Arch. Environ. Health 18:894-900.
71. Vinegar, A., Williams, R. J., Fisher, J. W., and McDougal, J. N. 1994. Dose-dependent metabolism of 2,2-dichloro-1,1,1-trifluoroethane: A physiologically based pharmacokinetic model in the male Fischer 344 rat. Toxicol. Appl. Pharmacol. 129:103-13.
72. Vinegar, A., Jepson, G. W., Cisneros, M., Rubenstein, R., and Brock, W. J. 2000. Setting safe acute exposure limits for halon replacement chemicals using physiologically based pharmacokinetic modeling. Inhal. Toxicol. 12:751-763.
73. Williams, R. J., Vinegar, A., McDougal, J. N., Jarabek, A. M., and Fisher, J. W. 1996. Rat to human extrapolation of HCFC-123 kinetics deduced from halothane kinetics: A corollary approach to physiologically based pharmacokinetic modeling. Fundam. Appl. Toxicol. 30:55-66.
74. World Health Organization. 1999. Carbon tetrachloride. Environ. Health Crit. 208:56.
75. Young, J. D., Ramsey, J. C., Blau, G. E., Karbowski, R. J., Nitschke, K. D., Slauter, R. W., and Braun, W. H. 1979. Pharmacokinetics of inhaled or intraperitoneally administered styrene in rats. In Toxicology and Occupational Medicine: Proceedings of the Tenth Inter-America Conference on Toxicology and Occupational Medicine, pp. Amsterdam: Elsevier North-Holland.