Human safety and pharmacokinetics of the CFC alternative propellants HFC 134a (1,1,1,2-tetrafluoroethane) and HFC 227 (1,1,1,2,3,3,3-heptafluoropropane) following whole-body exposure

Regulatory Toxicology and Pharmacology

Volumn 32, Issue 1, 2000, Pages 22-35

  Emmen, H H ^a   Hoogendijk, E M G ^a   Klopping Ketelaars W A A ^a   Muijser, H ^a   Duistermaat, E ^a   Ravensberg, J C ^a   Alexander, D J ^b   Borkhataria, D ^b   Rusch, G M ^c   Schmit, B ^d  

^a TNO   (Netherlands)

^b International Pharmaceutical Aerosol Consortium for Toxicology Testing of HFA 227 ^*  (United States)

^c HONEYWELL   (United States)

^d SOLVAY S A   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

APAFLURANE; CFC 12; CHLOROFLUOROCARBON; DICHLORODIFLUOROMETHANE; HFC 227; NORFLURANE; UNCLASSIFIED DRUG;

ADULT; AEROSOL; ARTICLE; BLOOD PRESSURE; CENTRAL NERVOUS SYSTEM DISEASE; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG ELIMINATION; DRUG EXCRETION; DRUG SAFETY; ELECTROCARDIOGRAM; EXPOSURE; FEMALE; HUMAN; HUMAN EXPERIMENT; LUNG FUNCTION; MALE; METERED DOSE INHALER; NORMAL HUMAN; PRIORITY JOURNAL; PULSE RATE; RESPIRATORY TRACT DISEASE; SEX DIFFERENCE; STEADY STATE; VAPOR;

EID: 0033771767     PISSN: 02732300     EISSN: None     Source Type: Journal    
DOI: 10.1006/rtph.2000.1402     Document Type: Article

References (17)

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